Taryn Donovan
YOU?
Author Swipe
Standardized classification of synchronous gastrointestinal small cell lymphoma and gastrointestinal mast cell tumors in 15 cats Open
Objectives Synchronous primary tumors have been defined as two or more concurrent, yet independent tumors diagnosed within 6 months or less. The primary objective of this study was to investigate the occurrence and clinical findings in cat…
Benchmarking Deep Learning and Vision Foundation Models for Atypical vs. Normal Mitosis Classification with Cross-Dataset Evaluation Open
Atypical mitosis marks a deviation in the cell division process that has been shown be an independent prognostic marker for tumor malignancy. However, atypical mitosis classification remains challenging due to low prevalence, at times subt…
View article: Urethral sarcomatoid urothelial carcinoma with heterologous elements in a dog
Urethral sarcomatoid urothelial carcinoma with heterologous elements in a dog Open
Sarcomatoid carcinoma is a biphasic tumour characterized by the co-existence of epithelial and mesenchymal differentiation that may contain heterologous components. These tumours are rare in domestic animals and have only been reported in …
Molecular detection of Bartonella spp. DNA in dogs with hemangiosarcoma Open
Introduction The potential role of pathogens, particularly vector-transmitted infectious agents, as a cofactor or cause of neoplasia has not been intensively investigated. We previously reported a potential link between Bartonella spp. bac…
Histologic Dataset of Normal and Atypical Mitotic Figures on Human Breast Cancer (AMi-Br) Open
Assessment of the density of mitotic figures (MFs) in histologic tumor sections is an important prognostic marker for many tumor types, including breast cancer. Recently, it has been reported in multiple works that the quantity of MFs with…
View article: Nuclear pleomorphism in canine cutaneous mast cell tumors: Comparison of reproducibility and prognostic relevance between estimates, manual morphometry, and algorithmic morphometry
Nuclear pleomorphism in canine cutaneous mast cell tumors: Comparison of reproducibility and prognostic relevance between estimates, manual morphometry, and algorithmic morphometry Open
Variation in nuclear size and shape is an important criterion of malignancy for many tumor types; however, categorical estimates by pathologists have poor reproducibility. Measurements of nuclear characteristics can improve reproducibility…
When Two Wrongs Don't Make a Right" -- Examining Confirmation Bias and the Role of Time Pressure During Human-AI Collaboration in Computational Pathology Open
Artificial intelligence (AI)-based decision support systems hold promise for enhancing diagnostic accuracy and efficiency in computational pathology. However, human-AI collaboration can introduce and amplify cognitive biases, such as confi…
Neoplasia in pet guinea pigs: a retrospective analysis of 2,474 autopsy examinations Open
Neoplasia is a common disease in guinea pigs ( Cavia porcellus); however, few studies have evaluated the prevalence of neoplasia in all organ systems. We retrospectively analyzed the tumor prevalence in pet guinea pigs and the frequency of…
View article: Artificial intelligence-based quantification of lymphocytes in feline small intestinal biopsies
Artificial intelligence-based quantification of lymphocytes in feline small intestinal biopsies Open
Feline chronic enteropathy is a poorly defined condition of older cats that encompasses chronic enteritis to low-grade intestinal lymphoma. The histological evaluation of lymphocyte numbers and distribution in small intestinal biopsies is …
Feline eosinophilic sclerosing fibroplasia associated with T-/natural killer-cell lymphoma Open
Feline eosinophilic sclerosing fibroplasia (FESF) is a proliferative, inflammatory disease of the gastrointestinal tract and other sites, uncommonly diagnosed in the cat. This entity of uncertain etiology typically presents as a progressiv…
MRI diagnosis of meningioma with marked skeletal hyperostosis and parenchymal infiltration in a 6‐year‐old standard poodle Open
A 6‐year‐old, neutered, male standard poodle was presented for evaluation of behaviour change. Neurological examination was consistent with a prosencephalic lesion. A magnetic resonance imaging study of the brain revealed a large non‐unifo…
View article: Information Mismatch in PHH3-Assisted Mitosis Annotation Leads to Interpretation Shifts in H&E Slide Analysis
Information Mismatch in PHH3-Assisted Mitosis Annotation Leads to Interpretation Shifts in H&E Slide Analysis Open
The count of mitotic figures (MFs) observed in hematoxylin and eosin (H&E)-stained slides is an important prognostic marker, as it is a measure for tumor cell proliferation. However, the identification of MFs has a known low inter-rater ag…
View article: Rostral cranial fossa and sinonasal neoplasms with cribriform plate involvement in 32 dogs and 17 cats
Rostral cranial fossa and sinonasal neoplasms with cribriform plate involvement in 32 dogs and 17 cats Open
The rostral cranial fossa (RCF) consists of the sphenoid and ethmoid bones, which accommodate the olfactory bulbs and nerves along the recesses of the cribriform plate. Neoplasms located in the vicinities of the RCF can compress and/or inv…
Immunophenotype investigation in feline intestinal non-B-cell lymphoma Open
Lymphoma is the most common tumour of domestic cats, developing most frequently in the small intestine. Feline small intestinal lymphoma predominantly demonstrates a T-cell immunophenotype identified by standard immunopositivity for T cell…
View article: On the Value of PHH3 for Mitotic Figure Detection on H&E-stained Images
On the Value of PHH3 for Mitotic Figure Detection on H&E-stained Images Open
The count of mitotic figures (MFs) observed in hematoxylin and eosin (H&E)-stained slides is an important prognostic marker as it is a measure for tumor cell proliferation. However, the identification of MFs has a known low inter-rater agr…
View article: Automated Nuclear Morphometry: A Deep Learning Approach for Prognostication in Canine Pulmonary Carcinoma to Enhance Reproducibility
Automated Nuclear Morphometry: A Deep Learning Approach for Prognostication in Canine Pulmonary Carcinoma to Enhance Reproducibility Open
The integration of deep learning-based tools into diagnostic workflows is increasingly prevalent due to their efficiency and reproducibility in various settings. We investigated the utility of automated nuclear morphometry for assessing nu…
Synovial myxoma or myxosarcoma? Lymph node metastasis in 2 dogs Open
Synovial myxoma, a rare joint tumor in dogs, has traditionally been considered benign, acknowledging that local invasion into regional tissues including bone may be present. Given the diagnostic challenges in distinguishing synovial myxoma…
Flowcytometric data of intermediate-large cell gastrointestinal lymphoma presenting a gross mass in 32 cats – “let them glow in the flow” Open
Gastrointestinal lymphoma is the most common form of lymphoma in domestic cats. Aggressive phenotypes are much less common but do bear and unfavorable prognosis. Immunophenotyping by flow cytometry (FCM) is not systematically performed in …
Short colon syndrome in cats Open
Background Shortening of the colon has been described in cats, but its imaging and clinicopathological features remain poorly understood. Objectives Description of the signalment, clinical presentation, imaging, endoscopic and histological…
Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in feline tumors Open
Increased proliferation is a driver of tumorigenesis, and quantification of mitotic activity is a standard task for prognostication. This systematic review is an analysis of all available references on mitotic activity in feline tumors to …
Mitotic activity: A systematic literature review of the assessment methodology and prognostic value in canine tumors Open
One of the most relevant prognostic indices for tumors is cellular proliferation, which is most commonly measured by the mitotic activity in routine tumor sections. The goal of this systematic review was to analyze the methods and prognost…
View article: Domain generalization across tumor types, laboratories, and species — Insights from the 2022 edition of the Mitosis Domain Generalization Challenge
Domain generalization across tumor types, laboratories, and species — Insights from the 2022 edition of the Mitosis Domain Generalization Challenge Open
Recognition of mitotic figures in histologic tumor specimens is highly relevant to patient outcome assessment. This task is challenging for algorithms and human experts alike, with deterioration of algorithmic performance under shifts in i…
View article: Domain generalization across tumor types, laboratories, and species — Insights from the 2022 edition of the Mitosis Domain Generalization Challenge
Domain generalization across tumor types, laboratories, and species — Insights from the 2022 edition of the Mitosis Domain Generalization Challenge Open
Recognition of mitotic figures in histologic tumor specimens is highly relevant to patient outcome assessment. This task is challenging for algorithms and human experts alike, with deterioration of algorithmic performance under shifts in i…
Atypical Mitotic Figures Are Prognostically Meaningful for Canine Cutaneous Mast Cell Tumors Open
Cell division through mitosis (microscopically visible as mitotic figures, MFs) is a highly regulated process. However, neoplastic cells may exhibit errors in chromosome segregation (microscopically visible as atypical mitotic figures, AMF…