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View article: Killer toxin K28 resistance in yeast relies on COG complex-mediated trafficking of the defence factor Ktd1
Killer toxin K28 resistance in yeast relies on COG complex-mediated trafficking of the defence factor Ktd1 Open
AB toxins are a diverse family of protein toxins that enter host cells via endocytosis and induce cell death. In yeast, the AB toxin K28 is internalised to endosomes of susceptible yeast, before following the retrograde trafficking pathway…
View article: Knockout of SIN3B modulates transcriptional programs and cell survival in cutaneous melanoma
Knockout of SIN3B modulates transcriptional programs and cell survival in cutaneous melanoma Open
SIN3 is a critical component of the histone deacetylase complex. Utilizing whole transcriptome data from melanoma patient samples we reveal that elevated levels of SIN3B are associated with poor survival outcomes with in vitro studies show…
View article: ARHGAP12 and ARHGAP29 exert distinct regulatory effects on switching between two cell morphological states through GSK-3 activity
ARHGAP12 and ARHGAP29 exert distinct regulatory effects on switching between two cell morphological states through GSK-3 activity Open
Cancer cells undergo morphological changes and phenotype switching to promote invasion into healthy tissues. Manipulating the transitional morphological states in cancer cells to prevent tumor dissemination may enhance survival and improve…
View article: Spatial profiling of central nervous system cellular markers in murine breast cancer to brain metastases
Spatial profiling of central nervous system cellular markers in murine breast cancer to brain metastases Open
Background Brain metastasis occurs in approximately 16% of metastatic breast cancer patients, and incidence is increasing. Patients with breast cancer brain metastases frequently develop neurological problems including cognitive impairment…
View article: Killer Toxin K28 resistance in yeast relies on COG complex mediated trafficking of the defence factor Ktd1
Killer Toxin K28 resistance in yeast relies on COG complex mediated trafficking of the defence factor Ktd1 Open
A/B toxins are a diverse family of protein toxins that enter host cells via endocytosis and induce cell death. In yeast, the A/B toxin K28 is internalised to endosomes of susceptible yeast, before following the retrograde trafficking pathw…
View article: Exploration of the mutational landscape of cutaneous leiomyoma confirms <i>FH</i> as a driver gene and identifies targeting purine metabolism as a potential therapeutic strategy
Exploration of the mutational landscape of cutaneous leiomyoma confirms <i>FH</i> as a driver gene and identifies targeting purine metabolism as a potential therapeutic strategy Open
To comprehensively explore the mutational landscape of cutaneous leiomyoma (cLM) and identify candidate driver events, we performed a retrospective, multi-institutional, whole-exome sequencing and RNA sequencing study. We confirmed that a …
View article: Activation of Wnt/β-catenin signalling by mutually exclusive<i>FBXW11</i>and<i>CTNNB1</i>hotspot mutations drives salivary gland basal cell adenoma
Activation of Wnt/β-catenin signalling by mutually exclusive<i>FBXW11</i>and<i>CTNNB1</i>hotspot mutations drives salivary gland basal cell adenoma Open
Wnt signalling must be ‘just right’ to promote tumour growth. Basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) of the salivary gland are rare tumours that can be difficult to distinguish from each other and other salivary glan…
View article: Comprehensive mutational profiling identifies new driver events in cutaneous leiomyosarcoma
Comprehensive mutational profiling identifies new driver events in cutaneous leiomyosarcoma Open
Background Cutaneous leiomyosarcoma (cLMS) is a rare soft-tissue neoplasm, showing smooth muscle differentiation, that arises from the mesenchymal cells of the dermis. To date, genetic investigation of these tumours has involved studies wi…
View article: Biglycan and reduced glycolysis are associated with breast cancer cell dormancy in the brain
Biglycan and reduced glycolysis are associated with breast cancer cell dormancy in the brain Open
Exit of quiescent disseminated cancer cells from dormancy is thought to be responsible for metastatic relapse and a better understanding of dormancy could pave the way for novel therapeutic approaches. We used an in vivo model of triple ne…
View article: Experimental workflow from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Experimental workflow from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer Open
Details of the male breast cancer samples used at different stages of the experimental workflow
View article: Data from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Data from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
The immune response to melanoma improves the survival in untreated patients and predicts the response to immune checkpoint blockade. Here, we report genetic and environmental predictors of the immune response in a large primary cutaneous m…
View article: Supplementary Data 2 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary Data 2 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
List of 70 genes shared between the signature used to generate the three immune subgroups in this study and the TCGA signature as well as tables of additional results from the analysis of the 3 immune subgroups: Genes and pathways upregula…
View article: Supplementary Data 1 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary Data 1 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
Gene lists per immune cell type after successive filtration steps.
View article: Supplementary methods and results from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary methods and results from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
Additional information on methods used and supplementary figures and tables. Figure S1: Schematic summary of consensus clustering; Figure S2: Comparison of the newly obtained immune subgroups with two published melanoma molecular signature…
View article: Table S1 from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Table S1 from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer Open
Relationship between eIF4E, eIF5 and clinico-pathological parameters
View article: Experimental workflow from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Experimental workflow from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer Open
Details of the male breast cancer samples used at different stages of the experimental workflow
View article: Cut-off determination and representative staining profiles for eIF proteins determined by immunohistochemistry from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Cut-off determination and representative staining profiles for eIF proteins determined by immunohistochemistry from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer Open
R.O.C curve analysis was used to determine the cut-off value for each antibody to determine a point of dichotomisation (graphs). Gradation of intensity of immunohistochemical staining (weak, moderate, strong) for eIF1 (A), eIF2 (B), eIF4E …
View article: Supplementary Data 1 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary Data 1 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
Gene lists per immune cell type after successive filtration steps.
View article: Data from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Data from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer Open
Purpose: Breast cancer affects both genders, but is understudied in men. Although still rare, male breast cancer (MBC) is being diagnosed more frequently. Treatments are wholly informed by clinical studies conducted in women, based on assu…
View article: Interrogation of Oncomine{trade mark, serif} from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Interrogation of Oncomine{trade mark, serif} from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer Open
Interrogation of Oncomine{trade mark, serif} (https://www.oncomine.org/) showed higher expression of eIF4E and eIF5 in breast (top panel) and lung cancer (bottom panel) compared to normal tissue. When these biomarkers were compared for gen…
View article: Supplementary Data 2 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary Data 2 from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
List of 70 genes shared between the signature used to generate the three immune subgroups in this study and the TCGA signature as well as tables of additional results from the analysis of the 3 immune subgroups: Genes and pathways upregula…
View article: Table S1 from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Table S1 from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer Open
Relationship between eIF4E, eIF5 and clinico-pathological parameters
View article: Supplementary methods and results from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Supplementary methods and results from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
Additional information on methods used and supplementary figures and tables. Figure S1: Schematic summary of consensus clustering; Figure S2: Comparison of the newly obtained immune subgroups with two published melanoma molecular signature…
View article: Data from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Data from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer Open
Purpose: Breast cancer affects both genders, but is understudied in men. Although still rare, male breast cancer (MBC) is being diagnosed more frequently. Treatments are wholly informed by clinical studies conducted in women, based on assu…
View article: Cut-off determination and representative staining profiles for eIF proteins determined by immunohistochemistry from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Cut-off determination and representative staining profiles for eIF proteins determined by immunohistochemistry from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer Open
R.O.C curve analysis was used to determine the cut-off value for each antibody to determine a point of dichotomisation (graphs). Gradation of intensity of immunohistochemical staining (weak, moderate, strong) for eIF1 (A), eIF2 (B), eIF4E …
View article: Interrogation of Oncomine{trade mark, serif} from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Interrogation of Oncomine{trade mark, serif} from A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer Open
Interrogation of Oncomine{trade mark, serif} (https://www.oncomine.org/) showed higher expression of eIF4E and eIF5 in breast (top panel) and lung cancer (bottom panel) compared to normal tissue. When these biomarkers were compared for gen…
View article: Data from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma
Data from Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma Open
The immune response to melanoma improves the survival in untreated patients and predicts the response to immune checkpoint blockade. Here, we report genetic and environmental predictors of the immune response in a large primary cutaneous m…
View article: IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy
IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy Open
Glioblastoma (GBM) brain tumours lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumours almost always fatally recur. Using RNAseq data from 107 pairs of pr…