Anna Durigova
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View article: Soft-tissue metastasis in esophageal cancer managed by dose escalation radiation therapy: a clinical case and review of literature
Soft-tissue metastasis in esophageal cancer managed by dose escalation radiation therapy: a clinical case and review of literature Open
Soft tissue metastasis in esophageal cancer is a very rare entity. A 76-year-old man was referred for a week's history of dysphagia. Upper gastrointestinal endoscopy was performed, and biopsies were consistent with an adenocarcinoma of the…
View article: Recent Progress in Breast Cancer Treatment
Recent Progress in Breast Cancer Treatment Open
Breast cancer remains a significant global health concern and the leading cancer type amongst women worldwide. While significant progress has been made in the field of breast cancer therapy, there are still many unmet goals that require at…
View article: 5-Fluorouracil-associated severe hypertriglyceridaemia with positive rechallenge
5-Fluorouracil-associated severe hypertriglyceridaemia with positive rechallenge Open
Chemotherapy-induced hypertriglyceridaemia (HTG) is a potential serious adverse event. Severe HTG with triglycerides (TG) >11.3 mmol/L (1000 mg/dL) can cause acute pancreatitis in addition to cardiovascular diseases such as coronary artery…
View article: Strategies for clinical development of monoclonal antibodies beyond first-in-human trials: tested doses and rationale for dose selection
Strategies for clinical development of monoclonal antibodies beyond first-in-human trials: tested doses and rationale for dose selection Open
View article: Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study
Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study Open
View article: Tumour biology, metastatic sites and taxanes sensitivity as determinants of eribulin mesylate efficacy in breast cancer: results from the ERIBEX retrospective, international, multicenter study
Tumour biology, metastatic sites and taxanes sensitivity as determinants of eribulin mesylate efficacy in breast cancer: results from the ERIBEX retrospective, international, multicenter study Open
EM is an effective new option in heavily pretreated MBC, with a favourable efficacy/safety ratio in a clinical practice setting. Our results comfort the use of this new molecule and pledge for the evaluation of EM-trastuzumab combination i…
View article: Clinical Development Strategies and Outcomes in First-in-Human Trials of Monoclonal Antibodies
Clinical Development Strategies and Outcomes in First-in-Human Trials of Monoclonal Antibodies Open
Purpose We conducted a comprehensive review of the design, implementation, and outcome of first-in-human (FIH) trials of monoclonal antibodies (mAbs) to clearly determine early clinical development strategies for this class of compounds. M…