Andrea Farolfi
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View article: Augmented Reality PSMA-3D guided robotic pelvic lymph node dissection (PLND) in prostate cancer patients
Augmented Reality PSMA-3D guided robotic pelvic lymph node dissection (PLND) in prostate cancer patients Open
Background and objective Intraoperative identification of suspicious lymph node metastases (LNM) detected at PSMA-PET is key to achieve optimal surgical outcomes of robot-assisted radical prostatectomy (RARP) with pelvic lymph node dissect…
View article: New therapeutic strategies for Lafora disease: Evaluation of the safety, efficacy, pharmacokinetics and metabolomic profile of intravenous VAL-1221 treatment
New therapeutic strategies for Lafora disease: Evaluation of the safety, efficacy, pharmacokinetics and metabolomic profile of intravenous VAL-1221 treatment Open
Lafora disease (LD) is a fatal progressive myoclonus epilepsy that affects previously healthy adolescents and lacks effective treatments. It is caused by pathogenic variants in EPM2A or NHLRC1, leading to the accumulation of polyglucosan i…
View article: Clinical added value of LAFOV PET/CT in patients undergoing same-day [18 F]FDG SAFOV PET/CT scans: an initial experience report and explorative study
Clinical added value of LAFOV PET/CT in patients undergoing same-day [18 F]FDG SAFOV PET/CT scans: an initial experience report and explorative study Open
Purpose The uEXPLORER is the first total-body, long-axial field-of-view (LAFOV) PET/CT system available for diagnostic use. The present study aims to assess its clinical impact, with a particular focus on management changes resulting from …
View article: The real-life experience of a general pulmonary transition clinic
The real-life experience of a general pulmonary transition clinic Open
Background: Paediatric-to-adult transition represents an unmet need in many chronic conditions. Data and outcomes on pulmonary transition clinics (PTC) are limited. Methods: We report the structure, organization, and patients’ characteris…
View article: Augmented Reality PSMA-3D guided robotic pelvic lymph node dissection (PLND) in prostate cancer patients
Augmented Reality PSMA-3D guided robotic pelvic lymph node dissection (PLND) in prostate cancer patients Open
Background and objective: Intraoperative identification of suspicious lymph node metastases (LNM) detected at PSMA-PET is key to achieve optimal surgical outcomes of robot assisted radical prostatectomy (RARP) with pelvic lymph node dissec…
View article: Updated Prostate Cancer Risk Groups by Prostate-specific Membrane Antigen Positron Emission Tomography Prostate Cancer Molecular Imaging Standardized Evaluation (PPP2): Results from an International Multicentre Registry Study
Updated Prostate Cancer Risk Groups by Prostate-specific Membrane Antigen Positron Emission Tomography Prostate Cancer Molecular Imaging Standardized Evaluation (PPP2): Results from an International Multicentre Registry Study Open
PPP nomograms were improved in an international multicentre study to predict accurately the 3- and 5-yr overall survival probabilities of prostate cancer. PPP2 yielded superior accuracy to the NCCN risk score. A free software tool has been…
View article: Semiquantitative PET Parameters Refine Prognosis in CAR T–Treated Lymphoma After 1 and 3 Months: A Prospective Single-Center Study
Semiquantitative PET Parameters Refine Prognosis in CAR T–Treated Lymphoma After 1 and 3 Months: A Prospective Single-Center Study Open
Chimeric antigen receptor T-cell (CAR T) therapy has shown remarkable efficacy in treating relapsed or refractory large B-cell lymphoma. However, for nearly half of these patients, the therapy eventually does not achieve durable remission.…
View article: Long-term outcomes of PSMA PET/CT-guided radiotherapy in biochemical failure patients post-radical prostatectomy: a 5-year follow-up analysis
Long-term outcomes of PSMA PET/CT-guided radiotherapy in biochemical failure patients post-radical prostatectomy: a 5-year follow-up analysis Open
Purpose To evaluate the role of PSMA PET/CT-guided salvage radiotherapy (sRT) in improving long-term biochemical recurrence-free survival (bRFS) in patients with biochemical recurrence (BCR) or PSA persistence (PERS) after radical prostate…
View article: The role of PSMA-based radioligand therapy in hormone-sensitive prostate cancer
The role of PSMA-based radioligand therapy in hormone-sensitive prostate cancer Open
Purpose Conventional systemic therapies are valuable options in prostate cancer (PCa); however, such treatments can determine adverse events and toxicity. The observed improvement in overall survival, coupled with PSA reduction and a favor…
View article: Evaluating [68Ga]-Ga PSMA PET/CT for Detecting Prostate Cancer Recurrence Post-High-Intensity Focused Ultrasound and Brachytherapy: A Single-Center Retrospective Study
Evaluating [68Ga]-Ga PSMA PET/CT for Detecting Prostate Cancer Recurrence Post-High-Intensity Focused Ultrasound and Brachytherapy: A Single-Center Retrospective Study Open
Focal therapy offers a promising approach for treating localized prostate cancer (PC) with minimal invasiveness and potential cost benefits. High-intensity focused ultrasound (HIFU) and brachytherapy (BT) are among these options but lack l…
View article: Better Oncological Outcomes After Prostate-specific Membrane Antigen Positron Emission Tomography–guided Salvage Radiotherapy Following Prostatectomy
Better Oncological Outcomes After Prostate-specific Membrane Antigen Positron Emission Tomography–guided Salvage Radiotherapy Following Prostatectomy Open
For patients who experience recurrence of prostate cancer after surgical removal of their prostate, salvage radiotherapy (sRT) is a further treatment option. We found that a type of scan called PSMA PET (prostate-specific membrane antigen …
View article: Lung function trajectories in children with early diagnosis of non-cystic fibrosis bronchiectasis: a retrospective observational study
Lung function trajectories in children with early diagnosis of non-cystic fibrosis bronchiectasis: a retrospective observational study Open
Background Non-cystic fibrosis (non-CF) bronchiectasis (BE) is defined as a clinical syndrome of recurrent, persistent wet cough and abnormal bronchial dilatation on chest High Resolution Computed Tomography (HRCT) scans. The aims of this …
View article: A Machine Learning Approach for Predicting Biochemical Outcome After PSMA-PET–Guided Salvage Radiotherapy in Recurrent Prostate Cancer After Radical Prostatectomy: Retrospective Study
A Machine Learning Approach for Predicting Biochemical Outcome After PSMA-PET–Guided Salvage Radiotherapy in Recurrent Prostate Cancer After Radical Prostatectomy: Retrospective Study Open
Background Salvage radiation therapy (sRT) is often the sole curative option in patients with biochemical recurrence after radical prostatectomy. After sRT, we developed and validated a nomogram to predict freedom from biochemical failure.…
View article: Multiparametric Whole-Body MRI: A Game Changer in Metastatic Prostate Cancer
Multiparametric Whole-Body MRI: A Game Changer in Metastatic Prostate Cancer Open
Prostate cancer ranks among the most prevalent tumours globally. While early detection reduces the likelihood of metastasis, managing advanced cases poses challenges in diagnosis and treatment. Current international guidelines support the …
View article: Whole pelvis vs. hemi pelvis elective nodal radiotherapy in patients with PSMA-positive nodal recurrence after radical prostatectomy - a retrospective multi-institutional propensity score analysis
Whole pelvis vs. hemi pelvis elective nodal radiotherapy in patients with PSMA-positive nodal recurrence after radical prostatectomy - a retrospective multi-institutional propensity score analysis Open
Purpose Despite growing evidence for bilateral pelvic radiotherapy (whole pelvis RT, WPRT) there is almost no data on unilateral RT (hemi pelvis RT, HPRT) in patients with nodal recurrent prostate cancer after prostatectomy. Nevertheless, …
View article: Necrotizing pneumonia in children: a case series
Necrotizing pneumonia in children: a case series Open
Necrotizing pneumoniae (NP) is a serious complication of community acquired pneumonia.Streptococcus pneumoniae is the most common cause of NP.Contrast-enhanced computerized tomography (CT) is more sensitive than plain radiographs for detec…
View article: [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT–Positive Hepatic Inflammatory Pseudotumor: Possible PSMA-Avid Pitfall in Nuclear Imaging
[<sup>68</sup>Ga]Ga-PSMA-11 PET/CT–Positive Hepatic Inflammatory Pseudotumor: Possible PSMA-Avid Pitfall in Nuclear Imaging Open
No abstract available.
View article: Immunohistochemistry analysis of PSMA expression at prostatic biopsy in high-risk prostate cancer: potential implications for PSMA-PET patient selection
Immunohistochemistry analysis of PSMA expression at prostatic biopsy in high-risk prostate cancer: potential implications for PSMA-PET patient selection Open
Introduction Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed by normal prostatic tissue. Therefore, molecular imaging targeting PSMA (PSMA-PET) has gained particular interest and diffusion for PCa staging and…
View article: Recurrent Respiratory Infections in Children with Down Syndrome: A Review
Recurrent Respiratory Infections in Children with Down Syndrome: A Review Open
Down Syndrome (DS) is the most common chromosomal abnormality compatible with life. The life of patients suffering from DS can be strongly impacted by Recurrent Respiratory tract Infections (RRIs), leading to an increased rate of hospitali…
View article: Differences and Common Ground in<sup>177</sup>Lu-PSMA Radioligand Therapy Practice Patterns: International Survey of 95 Theranostic Centers
Differences and Common Ground in<sup>177</sup>Lu-PSMA Radioligand Therapy Practice Patterns: International Survey of 95 Theranostic Centers Open
177Lu-labeled prostate-specific membrane antigen (PSMA) radioligand therapy effectively treats metastatic castration-resistant prostate cancer. Patients requiring treatment, and consequently the number of theranostic centers, are expected …