Finlay A. McAlister
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View article: Therapy gaps for patients with heart failure and reduced kidney function: A prospective cohort study
Therapy gaps for patients with heart failure and reduced kidney function: A prospective cohort study Open
Aims Despite emerging evidence for new pharmacotherapies to improve outcomes in patients with heart failure (HF) and kidney dysfunction, data on contemporary HF therapy use in this population are lacking. This study evaluated contemporary …
View article: Association between immune checkpoint inhibitor treatment in individuals with cancer and risk of hospitalisation after SARS-CoV-2 infection: a population-based retrospective cohort study
Association between immune checkpoint inhibitor treatment in individuals with cancer and risk of hospitalisation after SARS-CoV-2 infection: a population-based retrospective cohort study Open
Introduction Immune checkpoint inhibitor (ICI)-treated patients exhibit greater serological conversion rates following COVID-19 vaccinations compared with those receiving cytotoxic chemotherapy and healthy subjects, but whether those recei…
View article: Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With 3‐Vessel Coronary Artery Disease and Diabetes
Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With 3‐Vessel Coronary Artery Disease and Diabetes Open
Background Coronary artery bypass grafting (CABG) has been associated with reduced mortality, myocardial infarction, and repeat revascularization compared with percutaneous coronary intervention (PCI) for patients with 3‐vessel coronary ar…
View article: Antihypertensive Medication Timing and Cardiovascular Events and Death
Antihypertensive Medication Timing and Cardiovascular Events and Death Open
Importance Whether administration of blood pressure medications at bedtime instead of in the morning reduces cardiovascular risk is unknown, as findings from large clinical trials have not been consistent. There is also concern that bedtim…
View article: Bedtime vs Morning Antihypertensive Medications in Frail Older Adults
Bedtime vs Morning Antihypertensive Medications in Frail Older Adults Open
Importance The effect of antihypertensive administration time on major adverse cardiovascular events is unclear, and has never been studied in frail older adults, for whom risks and benefits may differ from the general population. Objectiv…
View article: Prescribing Patterns and Impact of Sedatives in Hospitalized Older Adults: A Secondary Analysis of the <scp>MedSafer</scp> Study
Prescribing Patterns and Impact of Sedatives in Hospitalized Older Adults: A Secondary Analysis of the <span>MedSafer</span> Study Open
Background We aimed to examine the impact of sedative prescription patterns in hospitalized older adults on post‐discharge adverse drug events (ADEs), falls, and sleep. Methods We conducted a secondary analysis of the MedSafer randomized c…
View article: Outcomes and Patterns Related to Magnesium in Acute Heart Failure: A Population-Based Study
Outcomes and Patterns Related to Magnesium in Acute Heart Failure: A Population-Based Study Open
Importance The significance of magnesium as a treatment or prognostic factor is unknown in heart failure despite its frequent use. Objective To assess the frequency and outcomes of magnesium testing, hypomagnesemia and intravenous (IV) rep…
View article: Hyperkalemia-related Heart Failure Therapy Discontinuation and the Association with Outcomes in Patients with Heart Failure
Hyperkalemia-related Heart Failure Therapy Discontinuation and the Association with Outcomes in Patients with Heart Failure Open
Background Renin-angiotensin-aldosterone system (RAAS) inhibitors are essential treatments for heart failure (HF) patients, but their use is often limited by hyperkalemia. Objective This study assesses the incidence of hyperkalemia in chro…
View article: Myocardial Revascularization in Patients With 3 Vessel Coronary Artery Disease and Chronic Kidney Disease: Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention
Myocardial Revascularization in Patients With 3 Vessel Coronary Artery Disease and Chronic Kidney Disease: Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention Open
Coronary artery disease (CAD) and chronic kidney disease (CKD) commonly co-exist. Superior outcomes with coronary artery bypass grafting(CABG) compared to percutaneous coronary intervention (PCI) have been identified in patients with 3 ves…
View article: The relationship of diuretics and dietary sodium in patients with heart failure: an analysis of the SODIUM-HF trial
The relationship of diuretics and dietary sodium in patients with heart failure: an analysis of the SODIUM-HF trial Open
Although a higher baseline diuretic dose was associated with worse clinical outcomes, no association was found between dietary sodium restriction, baseline or change in diuretic dose and the primary outcomes.
View article: Machine Learning For Risk Prediction After Heart Failure Emergency Department Visit or Hospital Admission Using Administrative Health Data
Machine Learning For Risk Prediction After Heart Failure Emergency Department Visit or Hospital Admission Using Administrative Health Data Open
Aims Patients visiting the emergency department (ED) or hospitalized for heart failure (HF) are at increased risk for subsequent adverse outcomes, however effective risk stratification remains challenging. We utilized a machine-learning (M…
View article: IMPACT OF THE COVID-19 PANDEMIC ON ADHERENCE TO CARDIOVASCULAR MEDICATIONS AMONG CHRONICALLY TREATED PATIENTS IN ALBERTA
IMPACT OF THE COVID-19 PANDEMIC ON ADHERENCE TO CARDIOVASCULAR MEDICATIONS AMONG CHRONICALLY TREATED PATIENTS IN ALBERTA Open
Background: Some studies have suggested that the COVID-19 pandemic negatively impacted patient adherence with chronic therapies. We designed this study to explore whether cardiovascular drug adherence patterns changed in chronically treate…
View article: Stroke Risk Reduction in Atrial Fibrillation Through Pharmacist Prescribing
Stroke Risk Reduction in Atrial Fibrillation Through Pharmacist Prescribing Open
Importance Major gaps in the delivery of appropriate oral anticoagulation therapy (OAC) exist, leaving a large proportion of persons with atrial fibrillation (AF) unnecessarily at risk for stroke and its sequalae. Objective To investigate …
View article: Targeted Coaching to Improve Osteoporosis Therapy Adherence: A Single Arm Variation of the C-STOP Study
Targeted Coaching to Improve Osteoporosis Therapy Adherence: A Single Arm Variation of the C-STOP Study Open
Background: In this pre-planned variation of the Comparing Strategies Targeting Osteoporosis to Prevent Fractures After an Upper Extremity Fracture (C-STOP) trial, we investigated whether adherence-specific coaching by the case manager (CM…