Andreas Fritsche
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View article: Superiority of 1 h plasma glucose vs fasting plasma glucose, 2 h plasma glucose and HbA1c for the diagnosis of type 2 diabetes
Superiority of 1 h plasma glucose vs fasting plasma glucose, 2 h plasma glucose and HbA1c for the diagnosis of type 2 diabetes Open
Aims/hypothesis The IDF has proposed 1 h plasma glucose (1 h PG) as a diagnostic test for type 2 diabetes. This study evaluated the utility of 1 h PG in diagnosing type 2 diabetes, compared with fasting plasma glucose (FPG), 2 h plasma glu…
View article: Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes
Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes Open
Background White adipose tissue (WAT) dysfunction including an aberrant expression of miRNAs is strongly associated with the risk of developing type 2 diabetes (T2D), with limited evidence linking early changes in the WAT-derived miRNAs an…
View article: Loci for insulin processing and secretion provide insight into type 2 diabetes risk
Loci for insulin processing and secretion provide insight into type 2 diabetes risk Open
View article: Lifestyle intervention is more effective in high 1-hour post-load glucose than in prediabetes for restoring β-cell function, reducing ectopic fat, and preventing type 2 diabetes
Lifestyle intervention is more effective in high 1-hour post-load glucose than in prediabetes for restoring β-cell function, reducing ectopic fat, and preventing type 2 diabetes Open
High 1 h-PG indicates an intermediate metabolic state with pathophysiological changes more severe than in NGR but milder than in IGR. In people with high 1 h-PG, LI significantly improved insulin sensitivity and β-cell function and reduced…
View article: Prevention of type 2 diabetes through prediabetes remission without weight loss
Prevention of type 2 diabetes through prediabetes remission without weight loss Open
View article: Beyond Glucose—Rethinking Prediabetes for Precision Prevention
Beyond Glucose—Rethinking Prediabetes for Precision Prevention Open
Prediabetes affects more than one-third of U.S. adults, yet represents a biologically heterogeneous state that is only partly captured by traditional glycemic categories (impaired fasting glucose, impaired glucose tolerance, or borderline …
View article: Influence of maternal metabolism on neonate eating behaviour
Influence of maternal metabolism on neonate eating behaviour Open
Perinatal maternal metabolism influences metabolic control in the offspring, but its impact on food intake in neonates is not known. We investigated whether ingestive behaviour in the first days of life is modulated by maternal BMI, matern…
View article: Fetal heart rate variability in relation to maternal physical activity and metabolic health
Fetal heart rate variability in relation to maternal physical activity and metabolic health Open
Physical activity (PA) during pregnancy may have a positive effect on the fetal cardiac maturation which is reflected in a decreasing resting heart rate and increasing heart rate variability (HRV). Different types of PA, for example during…
View article: Elevated Cholinesterase Activity and the Metabolic Syndrome—Dissecting Fatty Liver, Insulin Resistance and Dysglycaemia
Elevated Cholinesterase Activity and the Metabolic Syndrome—Dissecting Fatty Liver, Insulin Resistance and Dysglycaemia Open
Background and Aims While low plasma butyrylcholinesterase (BChE) is a well‐established marker of reduced liver synthesis capacity, the clinical significance of elevated BChE is unclear. In small studies, high BChE has long been suspected …
View article: Subphenotype-dependent benefits of bariatric surgery for individuals at risk for type 2 diabetes
Subphenotype-dependent benefits of bariatric surgery for individuals at risk for type 2 diabetes Open
ObjectiveBariatric surgery (BS) is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of individuals at risk for T2D and/or comorbidities (Tübingen Clusters) differ, …
View article: Subphenotype-Dependent Benefits of Bariatric Surgery for Individuals at Risk for Type 2 Diabetes
Subphenotype-Dependent Benefits of Bariatric Surgery for Individuals at Risk for Type 2 Diabetes Open
OBJECTIVE Bariatric surgery is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of individuals at risk for T2D and/or comorbidities (Tübingen Clusters) differ, is u…
View article: Subphenotype-dependent benefits of bariatric surgery for individuals at risk for type 2 diabetes
Subphenotype-dependent benefits of bariatric surgery for individuals at risk for type 2 diabetes Open
ObjectiveBariatric surgery (BS) is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of individuals at risk for T2D and/or comorbidities (Tübingen Clusters) differ, …
View article: Subphenotype-dependent benefits of bariatric surgery for individuals at risk for type 2 diabetes
Subphenotype-dependent benefits of bariatric surgery for individuals at risk for type 2 diabetes Open
ObjectiveBariatric surgery (BS) is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of individuals at risk for T2D and/or comorbidities (Tübingen Clusters) differ, …
View article: Advantages of DDG-certified hospitals for hospitalized patients with diabetes - A nationwide DRG analysis in Germany
Advantages of DDG-certified hospitals for hospitalized patients with diabetes - A nationwide DRG analysis in Germany Open
Aim Hospital certifications by the German Diabetes Association (DDG) are intended to ensure high-quality diabetological care. We aimed to compare Germany-wide characteristics and outcomes of hospitalized adults with diabetes in diabetes ce…
View article: Differential risk assessment in persons at risk of type 2 diabetes using urinary peptidomics
Differential risk assessment in persons at risk of type 2 diabetes using urinary peptidomics Open
Urinary peptidome classifiers support the increased risk of CKD and suggest an elevated risk of heart failure and coronary artery disease in the high-risk prediabetes cluster 6. Urine peptidomics show promising potential as a tool for iden…
View article: A short-term, high-caloric diet has prolonged effects on brain insulin action in men
A short-term, high-caloric diet has prolonged effects on brain insulin action in men Open
Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insuli…
View article: Fetal heart rate variability in relation to maternal physical activity and metabolic health
Fetal heart rate variability in relation to maternal physical activity and metabolic health Open
Physical activity (PA) during pregnancy may have a positive effect on the fetal autonomic nervous system maturation which are reflected in a decreasing resting heart rate and increasing heart rate variability (HRV). Different types of PA, …
View article: Comparison of GFR estimation in patients with diabetes mellitus using the EKFC and CKD-EPI equations
Comparison of GFR estimation in patients with diabetes mellitus using the EKFC and CKD-EPI equations Open
View article: <b>Proteomic and metabolomic signatures in prediabetes progressing to diabetes or reversing to normoglycemia within one-year</b>
<b>Proteomic and metabolomic signatures in prediabetes progressing to diabetes or reversing to normoglycemia within one-year</b> Open
Objective: Progression of prediabetes to type 2 diabetes has been associated with beta cell dysfunction, whereas its remission to normoglycemia has been related to improvement of insulin sensitivity. To understand the mechanisms and identi…
View article: <b>Proteomic and metabolomic signatures in prediabetes progressing to diabetes or reversing to normoglycemia within one-year</b>
<b>Proteomic and metabolomic signatures in prediabetes progressing to diabetes or reversing to normoglycemia within one-year</b> Open
Objective: Progression of prediabetes to type 2 diabetes has been associated with beta cell dysfunction, whereas its remission to normoglycemia has been related to improvement of insulin sensitivity. To understand the mechanisms and identi…
View article: Prediabetes Remission and Cardiovascular Morbidity and Mortality: A Post-Hoc Analysis from Dppos and Daqingdpos
Prediabetes Remission and Cardiovascular Morbidity and Mortality: A Post-Hoc Analysis from Dppos and Daqingdpos Open
View article: Mechanisms of Early-Onset Prediabetes in Women after Pregnancy
Mechanisms of Early-Onset Prediabetes in Women after Pregnancy Open
View article: Accelerating eSource scale-up in oncology clinical trials: The i~HD Task Force initiative
Accelerating eSource scale-up in oncology clinical trials: The i~HD Task Force initiative Open
eSource – particularly EHR-to-EDC – is an emerging paradigm in clinical research that enables automated transfer of electronic health record (EHR) data into electronic data capture (EDC) systems, with the potential to reduce site burden, i…
View article: Carrageenan and insulin resistance in humans: a randomised double-blind cross-over trial
Carrageenan and insulin resistance in humans: a randomised double-blind cross-over trial Open
View article: Blood coagulation in Prediabetes clusters–impact on all-cause mortality in individuals undergoing coronary angiography
Blood coagulation in Prediabetes clusters–impact on all-cause mortality in individuals undergoing coronary angiography Open
View article: Oxytocin does not acutely improve glucose tolerance in men with type 2 diabetes
Oxytocin does not acutely improve glucose tolerance in men with type 2 diabetes Open
Aim To assess oxytocin's acute glucoregulatory impact in men with type 2 diabetes in the context of our previous findings that oxytocin improves β‐cell responsivity in healthy men. Methods In a double‐blind, crossover comparison, intranasa…
View article: Surrogate measures of first-phase insulin secretion versus reference methods intravenous glucose tolerance test and hyperglycemic clamp: a systematic review and meta-analyses
Surrogate measures of first-phase insulin secretion versus reference methods intravenous glucose tolerance test and hyperglycemic clamp: a systematic review and meta-analyses Open
Introduction In this systematic review, we investigated the diagnostic accuracy of surrogate measures of insulin secretion based on fasting samples and the oral glucose tolerance test (OGTT). The first phase of insulin secretion was calcul…
View article: HIT: Estimating Internal Human Implicit Tissues from the Body Surface
HIT: Estimating Internal Human Implicit Tissues from the Body Surface Open
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View article: Inhaltsverzeichnis / Table of Contents
Inhaltsverzeichnis / Table of Contents Open
View article: Effect of Breastfeeding Duration on Coagulation in Women With and Without History of Gestational Diabetes Mellitus
Effect of Breastfeeding Duration on Coagulation in Women With and Without History of Gestational Diabetes Mellitus Open
Context Breastfeeding is associated with a reduced maternal risk for cardiovascular diseases (CVDs). Objective Since the underlying mechanisms are still poorly understood, we here examined the effect of breastfeeding on the plasmatic coagu…