Ahmed Ghallab
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View article: Stage-dependent effects of systemic ASBT inhibition in a cholestasis-induced cholemic nephropathy mouse model
Stage-dependent effects of systemic ASBT inhibition in a cholestasis-induced cholemic nephropathy mouse model Open
View article: Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome
Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome Open
Adipocyte hypertrophy during obesity triggers chronic inflammation, leading to metabolic disorders. However, the role of adipocyte-specific inflammatory signaling in metabolic syndrome remains unclear. The linear ubiquitin chain assembly c…
View article: A simplified LC–MS-based method for sensitive analysis of DNA adducts utilizing accessible in vitro metabolism models
A simplified LC–MS-based method for sensitive analysis of DNA adducts utilizing accessible in vitro metabolism models Open
Genetic information of living cells is encoded by the specific arrangement of nucleobases in deoxyribonucleic acid (DNA). Even minor changes or modifications of these nucleobases, favored by many reactive sites, can significantly affect co…
View article: Gut-to-bile transfer of microbially amidated minor bile acids in patients with hepatopancreatobiliary disorders
Gut-to-bile transfer of microbially amidated minor bile acids in patients with hepatopancreatobiliary disorders Open
Background and Aims: During bile acid (BA) intestinal transit, microbially amidated BAs (MABAs) are produced. This study investigated their cholephilic behavior and their presence in the bile of patients with hepatopancreatobiliary disease…
View article: Enteronephrohepatic circulation of bile acids and therapeutic potential of systemic bile acid transporter inhibitors
Enteronephrohepatic circulation of bile acids and therapeutic potential of systemic bile acid transporter inhibitors Open
View article: A novel noninvasive test based on near-infrared fluorescent cholephilic probes for hepatobiliary secretory function assessment
A novel noninvasive test based on near-infrared fluorescent cholephilic probes for hepatobiliary secretory function assessment Open
Routine serum biomarkers do not always accurately reflect impaired liver function. To overcome this limitation, we synthesized novel bile acid (BA) derivatives (NIRBADs) with near-infrared (NIR) fluorescence that can penetrate the abdomina…
View article: Erratum to: ‘Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis’ [J Hepatol (2024) 80:268-281]
Erratum to: ‘Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis’ [J Hepatol (2024) 80:268-281] Open
View article: A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development
A decision point between transdifferentiation and programmed cell death priming controls KRAS-dependent pancreatic cancer development Open
View article: Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA
Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA Open
Most gene therapies exert their actions via manipulation of hepatocytes (parenchymal cells) and the reasons behind the suboptimal performance of synthetic mRNA in non‐parenchymal cells (NPC) such as Kupffer cells (KC), and liver macrophage…
View article: Improved identification of human hepatotoxic potential by summary variables of gene expression
Improved identification of human hepatotoxic potential by summary variables of gene expression Open
Prediction of hepatotoxicity in humans remains an unresolved challenge. Recently, an in vitro/in silico method was established to predict blood concentrations of test compounds with an increased risk of causing human hepatotoxicity. In the…
View article: Role of WISP1 in Stellate Cell Migration and Liver Fibrosis
Role of WISP1 in Stellate Cell Migration and Liver Fibrosis Open
The mechanisms underlying the remarkable capacity of the liver to regenerate are still not completely understood. Particularly, the cross-talk between cytokines and cellular components of the process is of utmost importance because they re…
View article: Regulation of KIF23 by miR-107 controls replicative tumor cell fitness in mouse and human hepatocellular carcinoma
Regulation of KIF23 by miR-107 controls replicative tumor cell fitness in mouse and human hepatocellular carcinoma Open
Our study revealed the central role of the miR-107/KIF23 axis in controlling tumor cell fitness and hepatocellular carcinoma progression. The results demonstrate that the overexpression of miR-107 or silencing of its target, KIF23, markedl…
View article: Validation of NBD-coupled taurocholic acid for intravital analysis of bile acid transport in liver and kidney of mice
Validation of NBD-coupled taurocholic acid for intravital analysis of bile acid transport in liver and kidney of mice Open
Fluorophore-coupled bile acids (BA) represent an important tool for intravital analysis of BA flux in animal models of cholestatic diseases. However, addition of a fluorophore to a BA may alter transport properties. We developed and valida…
View article: Biochar: A Surrogate Approach to Modulating Soil Chemical Properties and Germination Parameters of Barley Seedlings Grown in saline-calcareous soil
Biochar: A Surrogate Approach to Modulating Soil Chemical Properties and Germination Parameters of Barley Seedlings Grown in saline-calcareous soil Open
Owing to its unique features, biochar (BCH) is an excellent surrogate approach to improving the chemical properties of soil with undesirable characteristics. Under multiple abiotic stresses (ECe = 10.8 vs. 10.7 dS.m−1; CaCO3 = 19.1 vs. 18.…
View article: Carbon, Nitrogen, Sulfur, and Phosphorus Mineralization from Sugarcane Residues in Clay Soils
Carbon, Nitrogen, Sulfur, and Phosphorus Mineralization from Sugarcane Residues in Clay Soils Open
For a total of 90 days, two incubation experiments were conducted to study the mineralization of C, N, P and S form clay soil treated by sugarcane residues. The first experiment involved incubating soil samples in incubator at 30 °C to stu…
View article: Cholangiocyte RAGE drives the ductular reaction which provides biliary drainage but fuels liver injury
Cholangiocyte RAGE drives the ductular reaction which provides biliary drainage but fuels liver injury Open
Ductular reactions inevitably co-occur with liver tissue injury along with inflammation, cholestasis, and fibrosis. However, it remains unknown whether they represent an adaptive response facilitating bile drainage, or if they exacerbate d…
View article: Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease
Basal MET phosphorylation is an indicator of hepatocyte dysregulation in liver disease Open
View article: Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice
Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice Open
Rationale: Liver cirrhosis is known to affect drug pharmacokinetics, but the functional assessment of the underlying pathophysiological alterations in drug metabolism is difficult. Methods: Cirrhosis in mice was induced by repeated treatme…
View article: Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis
Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis Open
View article: Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS
Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS Open
Aflatoxin B 1 (AFB 1 ) is a highly hepatotoxic and carcinogenic mycotoxin produced by Aspergillus species. The compound is mainly metabolized in the liver and its metabolism varies between species. The present study quantified relevant AFB…
View article: A liver digital twin for in silico testing of cellular and inter-cellular mechanisms in regeneration after drug-induced damage
A liver digital twin for in silico testing of cellular and inter-cellular mechanisms in regeneration after drug-induced damage Open
This communication presents a mathematical mechanism-based model of the regenerating liver after drug-induced pericentral lobule damage resolving tissue microarchitecture. The consequence of alternative hypotheses about the interplay of di…
View article: Cognitive Functions, Neurotransmitter Alterations, and Hippocampal Microstructural Changes in Mice Caused by Feeding on Western Diet
Cognitive Functions, Neurotransmitter Alterations, and Hippocampal Microstructural Changes in Mice Caused by Feeding on Western Diet Open
Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is the most common chronic liver disease in Western countries. It is becoming increasingly evident that peripheral organ-centered inflammatory diseases, including liver disea…
View article: Alleviation of Water-Deficit Stress on Seed Germination of Barley and Fenugreek in a Sandy Soil Using Superabsorbent Polymer
Alleviation of Water-Deficit Stress on Seed Germination of Barley and Fenugreek in a Sandy Soil Using Superabsorbent Polymer Open
Water deficit is one of the major limiting factors of seed crop germination and productivity. Consequently, superabsorbent polymers (SAPs) are among several technologies that enhance water use efficiency, leading to worthy seed germination…
View article: Basic concepts of mixture toxicity and relevance for risk evaluation and regulation
Basic concepts of mixture toxicity and relevance for risk evaluation and regulation Open
View article: Biochar: A Surrogate Approach to Modulating Soil Chemical Properties and Germination Parameters of Barley Plants Grown under Multi-Stress Conditions
Biochar: A Surrogate Approach to Modulating Soil Chemical Properties and Germination Parameters of Barley Plants Grown under Multi-Stress Conditions Open
Background Owing to its unique features, biochar (BC) is an excellent surrogate approach to improve the chemical properties of soil with undesirable characteristics. Methods . Under multiple abiotic stresses (ECe = 10.8 vs. 10.7 dS.m −1 ; …
View article: Basal MET Phosphorylation is an Indicator of Hepatocyte Dysregulation in Liver Disease
Basal MET Phosphorylation is an Indicator of Hepatocyte Dysregulation in Liver Disease Open
Chronic liver diseases are worldwide on the rise. Due to the rapidly increasing incidence, in particular in Western countries, Non-alcoholic fatty liver disease (NAFLD) is gaining importance as the disease can develop into hepatocellular c…
View article: Sublethal necroptosis signaling promotes inflammation and liver cancer
Sublethal necroptosis signaling promotes inflammation and liver cancer Open
View article: In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin
In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin Open
In vitro to in vivo extrapolation represents a critical challenge in toxicology. In this paper we explore extrapolation strategies for acetaminophen (APAP) based on mechanistic models, comparing classical (CL) homogeneous compartment pharm…
View article: In-vitro to in-vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmaco-dynamic models and a multiscale spatial-temporal liver twin
In-vitro to in-vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmaco-dynamic models and a multiscale spatial-temporal liver twin Open
In vitro to in vivo extrapolation represents a critical challenge in toxicology. In this paper we explore extrapolation strategies for acetaminophen (APAP) based on mechanistic models, comparing classical homogeneous compartment pharmaco-d…
View article: Hepatobiliary Thyroid Hormone Deficiency Impacts Bile Acid Hydrophilicity and Aquaporins in Cholestatic C57BL/6J Mice
Hepatobiliary Thyroid Hormone Deficiency Impacts Bile Acid Hydrophilicity and Aquaporins in Cholestatic C57BL/6J Mice Open
Women are more prone to develop either hypothyroidism or cholesterol gallstones than men. However, a male predominance in cholesterol gallstones under hypothyroidism was reported. Recently, a novel pathogenic link between thyroid hormone (…