Akira Hara
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View article: Age‑dependent and post‑intraventricular hemorrhage remodeling of the ependymal glycocalyx in mice
Age‑dependent and post‑intraventricular hemorrhage remodeling of the ependymal glycocalyx in mice Open
View article: Canine aldo-keto reductase 1C3 (AKR1C3/PGFS) exhibits 17β/20α-hydroxysteroid dehydrogenase activity and is inhibited by trilostane
Canine aldo-keto reductase 1C3 (AKR1C3/PGFS) exhibits 17β/20α-hydroxysteroid dehydrogenase activity and is inhibited by trilostane Open
Most members of the aldo-keto reductase (AKR) 1 C subfamily are hydroxysteroid dehydrogenases (HSDs), and their numbers are more than four in many individual mammals. In contrast, there is only one gene for the AKR1C protein (AKR1C3) in do…
View article: Imaging findings for differentiating and predicting prognosis in undifferentiated pleomorphic sarcoma and myxofibrosarcoma
Imaging findings for differentiating and predicting prognosis in undifferentiated pleomorphic sarcoma and myxofibrosarcoma Open
The signal intensity on T2-weighted images, ADC value, CT attenuation, and SUVmax were relevant imaging results for distinguishing UPS from MFS. The pathological diagnosis and signal intensity on T2-weighted images were prognostic indicato…
View article: Age‑Dependent and Post‑Intraventricular Hemorrhage Remodeling of the Ependymal Glycocalyx in Mice
Age‑Dependent and Post‑Intraventricular Hemorrhage Remodeling of the Ependymal Glycocalyx in Mice Open
Background The ependymal glycocalyx (Gcx) is a glycan-rich apical structure that lines the ventricular brain surface. It plays a central role in maintaining cerebrospinal fluid (CSF) dynamics and brain homeostasis by forming a selective mo…
View article: A modified cyclosporine enhances lentivector transduction <i>ex vivo</i> and <i>in vivo</i> by degrading IFITM3
A modified cyclosporine enhances lentivector transduction <i>ex vivo</i> and <i>in vivo</i> by degrading IFITM3 Open
Intrinsic innate immune barriers have evolved to suppress viral infection and can reduce effective gene delivery in gene therapy. We have developed BG147, a novel cyclosporine A analogue, optimised via structure-guided design to prevent in…
View article: Targeting the cancer glycocalyx in salivary duct carcinoma: tumor‐associated mucin 1 (Tn‐<scp>MUC1</scp>) as a novel cell surface marker
Targeting the cancer glycocalyx in salivary duct carcinoma: tumor‐associated mucin 1 (Tn‐<span>MUC1</span>) as a novel cell surface marker Open
Despite the use of targeted drugs for human epidermal growth factor receptor type 2 (HER2)‐positive salivary duct carcinoma (SDC) treatment, the overall prognosis for SDC remains poor. In this study, we aimed to investigate whether the gly…
View article: Association between FGF10 expression and gland‑forming differentiation pattern in gastric adenocarcinoma: An immunohistochemical analysis
Association between FGF10 expression and gland‑forming differentiation pattern in gastric adenocarcinoma: An immunohistochemical analysis Open
The histological classification of gastric adenocarcinoma influences its prognostic outcomes and therapeutic strategies. Although fibroblast growth factor (FGF)10 is important for gastric morphogenesis, its use as a molecular marker of gla…
View article: Practical pathological methods for reliable diagnosis of secretory carcinomas of the salivary gland
Practical pathological methods for reliable diagnosis of secretory carcinomas of the salivary gland Open
Secretory carcinomas (SCs) of the salivary gland have recently been recognized as low-grade, malignant tumors. Before this designation, most SCs were diagnosed as variants of acinic cell carcinomas (AciCCs). SCs harbor the t(12;15)(p13;q25…
View article: Visualizing the endothelial glycocalyx in human glioma vasculature
Visualizing the endothelial glycocalyx in human glioma vasculature Open
View article: Influence of sewage effluent discharge on putative pathogen community in drinking water sources: insights from full-length 16S rRNA gene amplicon sequencing
Influence of sewage effluent discharge on putative pathogen community in drinking water sources: insights from full-length 16S rRNA gene amplicon sequencing Open
The discharge of sewage effluent is a major source of microbial contamination in drinking water sources, necessitating a comprehensive investigation of its impact on pathogenic bacterial communities. This study utilized full-length 16S rRN…
View article: Blood pressure variability associated with falls in nursing home residents
Blood pressure variability associated with falls in nursing home residents Open
Background High variations in serially measured blood pressures (BPs) portend a variety of adverse clinical events including dementia, cardiovascular sequelae and frailty. In this study, systolic blood pressure variability (BPV) was examin…
View article: Sugar-binding profiles of the mesothelial glycocalyx in frozen tissues of mice revealed by lectin staining
Sugar-binding profiles of the mesothelial glycocalyx in frozen tissues of mice revealed by lectin staining Open
The mesothelium is a non-adhesive protective surface that lines the serosal cavities and organs within the body. The glycocalyx is a complex structure that coats the outer layer of the mesothelium. However, due to the limitations of conven…
View article: Involvement of porcine and human carbonyl reductases in the metabolism of epiandrosterone, 11-oxygenated steroids, neurosteroids, and corticosteroids
Involvement of porcine and human carbonyl reductases in the metabolism of epiandrosterone, 11-oxygenated steroids, neurosteroids, and corticosteroids Open
Porcine carbonyl reductases (pCBR1 and pCBR-N1) and aldo-keto reductases (pAKR1C1 and pAKR1C4) exhibit hydroxysteroid dehydrogenase (HSD) activity. However, their roles in the metabolism of porcine-specific androgens (19-nortestosterone an…
View article: Functional connectivity associated with attention networks differs among subgroups of fibromyalgia patients: an observational case–control study
Functional connectivity associated with attention networks differs among subgroups of fibromyalgia patients: an observational case–control study Open
View article: Prognostic value of radiological T category using conventional MRI in patients with oral tongue cancer: comparison with pathological T category
Prognostic value of radiological T category using conventional MRI in patients with oral tongue cancer: comparison with pathological T category Open
Purpose This study aimed to compare the radiological tumor (T)-category using multiparametric MRI with the pathological T category in patients with oral tongue squamous cell carcinoma (OTSCC) and to examine which is a better predictor of p…
View article: Time-course analysis of liver and serum galectin-3 in acute liver injury after alpha-galactosylceramide injection
Time-course analysis of liver and serum galectin-3 in acute liver injury after alpha-galactosylceramide injection Open
Galectin-3 is a beta-galactoside-binding lectin that plays important roles in diverse physiological functions, such as cell proliferation, apoptosis, and mRNA splicing. This protein is expressed on inflammatory cells and acts as a local in…
View article: Glycocalyx analysis of bladder cancer: three-dimensional images in electron microscopy and vicia villosa lectin as a marker for invasiveness in frozen sections
Glycocalyx analysis of bladder cancer: three-dimensional images in electron microscopy and vicia villosa lectin as a marker for invasiveness in frozen sections Open
Introduction: The abnormal glycocalyx (GCX) on the surface of cancer cells has been reported to be tall and aberrantly glycosylated and has been linked to the progression and spread of cancer—a finding also observed in bladder cancer. Howe…
View article: Endothelial Glycocalyx in the Peripheral Capillaries is Injured Under Oxaliplatin-Induced Neuropathy
Endothelial Glycocalyx in the Peripheral Capillaries is Injured Under Oxaliplatin-Induced Neuropathy Open
Oxaliplatin, a platinum-based anticancer drug, is associated with peripheral neuropathy (oxaliplatin-induced peripheral neuropathy, OIPN), which can lead to worsening of quality of life and treatment interruption. The endothelial glycocaly…
View article: Peritumoral Edema in Gliomas: A Review of Mechanisms and Management
Peritumoral Edema in Gliomas: A Review of Mechanisms and Management Open
Treating malignant glioma is challenging owing to its highly invasive potential in healthy brain tissue and the formation of intense surrounding edema. Peritumoral edema in gliomas can lead to severe symptoms including neurological dysfunc…
View article: Detection of transient abnormal myelopoiesis blasts in a liver biopsy specimen by double-immunostaining for full-length GATA1 and CD42b
Detection of transient abnormal myelopoiesis blasts in a liver biopsy specimen by double-immunostaining for full-length GATA1 and CD42b Open
This simple and cost-effective method can be applied in routine practice to detect TAM blasts during assessment in a TAM crisis.
View article: Exploring the Vital Link Between Glioma, Neuron, and Neural Activity in the Context of Invasion
Exploring the Vital Link Between Glioma, Neuron, and Neural Activity in the Context of Invasion Open
View article: Table of Contents
Table of Contents Open
View article: Supplementary Figure 1 Legend from Development of Gastric Tumors in <i>Apc</i><sup>Min/+</sup> Mice by the Activation of the β-Catenin/Tcf Signaling Pathway
Supplementary Figure 1 Legend from Development of Gastric Tumors in <i>Apc</i><sup>Min/+</sup> Mice by the Activation of the β-Catenin/Tcf Signaling Pathway Open
Supplementary Figure 1 Legend from Development of Gastric Tumors in ApcMin/+ Mice by the Activation of the β-Catenin/Tcf Signaling Pathway
View article: Data from Development of Gastric Tumors in <i>Apc</i><sup>Min/+</sup> Mice by the Activation of the β-Catenin/Tcf Signaling Pathway
Data from Development of Gastric Tumors in <i>Apc</i><sup>Min/+</sup> Mice by the Activation of the β-Catenin/Tcf Signaling Pathway Open
Although several lines of evidence suggest the involvement of the Wnt pathway in the development of gastric cancers, the functional significance of the pathway in gastric carcinogenesis is still poorly defined. To examine the role of the A…
View article: Data from Development of Gastric Tumors in <i>Apc</i><sup>Min/+</sup> Mice by the Activation of the β-Catenin/Tcf Signaling Pathway
Data from Development of Gastric Tumors in <i>Apc</i><sup>Min/+</sup> Mice by the Activation of the β-Catenin/Tcf Signaling Pathway Open
Although several lines of evidence suggest the involvement of the Wnt pathway in the development of gastric cancers, the functional significance of the pathway in gastric carcinogenesis is still poorly defined. To examine the role of the A…
View article: Supplementary Figure 1 Legend from Development of Gastric Tumors in <i>Apc</i><sup>Min/+</sup> Mice by the Activation of the β-Catenin/Tcf Signaling Pathway
Supplementary Figure 1 Legend from Development of Gastric Tumors in <i>Apc</i><sup>Min/+</sup> Mice by the Activation of the β-Catenin/Tcf Signaling Pathway Open
Supplementary Figure 1 Legend from Development of Gastric Tumors in ApcMin/+ Mice by the Activation of the β-Catenin/Tcf Signaling Pathway
View article: Cochlear implants in Japan: Results of cochlear implant reporting system over more than 30 years
Cochlear implants in Japan: Results of cochlear implant reporting system over more than 30 years Open
View article: Conditional ablation of heparan sulfate expression in stromal fibroblasts promotes tumor growth in vivo
Conditional ablation of heparan sulfate expression in stromal fibroblasts promotes tumor growth in vivo Open
Heparan sulfate (HS) is a glycocalyx component present in the extracellular matrix and cell-surface HS proteoglycans (HSPGs). Although HSPGs are known to play functional roles in multiple aspects of tumor development and progression, the e…
View article: TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility
TMPRSS2 gene polymorphism common in East Asians confers decreased COVID-19 susceptibility Open
COVID-19 has a wide range of clinical presentations, and the susceptibility to SARS-CoV-2 infection and the mortality rate also vary by region and ethnicity. Here, we found that rs12329760 in the TMPRSS2 gene, a missense variant common in …
View article: Development of extrahepatic bile ducts and mechanisms of tumorigenesis: Lessons from mouse models
Development of extrahepatic bile ducts and mechanisms of tumorigenesis: Lessons from mouse models Open
The biliary system is a highly branched tubular network consisting of intrahepatic bile ducts (IHBDs) and extrahepatic bile ducts (EHBDs). IHBDs are derived from hepatic progenitor cells, while EHBDs originate directly from the endoderm th…