Alexander Haug
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View article: Genomic instability is associated with response to [¹⁷⁷Lu]Lu-PSMA-I&T radioligand therapy: an exploratory, preliminary liquid biopsy analysis
Genomic instability is associated with response to [¹⁷⁷Lu]Lu-PSMA-I&T radioligand therapy: an exploratory, preliminary liquid biopsy analysis Open
Background PSMA-targeted radioligand therapies (PSMA RLT) are an effective and safe option for metastatic castration-resistant prostate cancer, but responsive subtypes and their biomarkers are not fully defined. Methods Plasma samples for …
View article: Guide to 177Lu-Prostate Specific Membrane Antigen Radioligand Therapy for Metastatic Castration-Resistant Prostate Cancer in Slovakia
Guide to 177Lu-Prostate Specific Membrane Antigen Radioligand Therapy for Metastatic Castration-Resistant Prostate Cancer in Slovakia Open
Radioligand therapy with 177 Lu-Prostate Specific Membrane Antigen is a very promising treatment option for patients with prostate cancer. In the past ten years it started to be used as one of the final options in patients with metastatic,…
View article: Postpartum pheochromocytoma crisis associated with cardiogenic shock and Sheehan’s syndrome
Postpartum pheochromocytoma crisis associated with cardiogenic shock and Sheehan’s syndrome Open
We report a case of a woman in her mid-30s who developed severe cardiac shock hours after giving birth to her second child with the need for extracorporeal haemodynamic support. Initially, postpartum cardiomyopathy was suspected, and high-…
View article: Generative artificial intelligence enables the generation of bone scintigraphy images and improves generalization of deep learning models in data-constrained environments
Generative artificial intelligence enables the generation of bone scintigraphy images and improves generalization of deep learning models in data-constrained environments Open
Purpose Advancements of deep learning in medical imaging are often constrained by the limited availability of large, annotated datasets, resulting in underperforming models when deployed under real-world conditions. This study investigated…
View article: Preoperative detection of extraprostatic tumor extension in patients with primary prostate cancer utilizing [68Ga]Ga-PSMA-11 PET/MRI
Preoperative detection of extraprostatic tumor extension in patients with primary prostate cancer utilizing [68Ga]Ga-PSMA-11 PET/MRI Open
Objectives Radical prostatectomy (RP) is a common intervention in patients with localized prostate cancer (PCa), with nerve-sparing RP recommended to reduce adverse effects on patient quality of life. Accurate pre-operative detection of ex…
View article: An instantly applicable machine learning model for extraprostatic extension prediction in prostate cancer: A post-hoc analysis of the RAPID 68Ga-PSMA PET/MRI trial
An instantly applicable machine learning model for extraprostatic extension prediction in prostate cancer: A post-hoc analysis of the RAPID 68Ga-PSMA PET/MRI trial Open
Radical prostatectomy (RP) is a common first-line treatment for patients with localized prostate cancer (PCa), with nerve-sparing techniques recommended to minimize adverse effects on quality of life. Accurate pre-operative detection of ex…
View article: Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancer
Value of follow-up diagnostic radioiodine scans in differentiated thyroid cancer Open
Background The most important part of the follow-up of differentiated thyroid carcinoma (DTC) is the measurement of serum thyroglobulin (Tg). An increase of Tg levels indicates likely tumor recurrence. According to the guidelines of the Eu…
View article: CXCR4-targeted Theranostics in Hematooncology: Opportunities and Challenges
CXCR4-targeted Theranostics in Hematooncology: Opportunities and Challenges Open
C-X-C motif chemokine receptor 4 (CXCR4) is overexpressed in a multitude of cancers, including neoplasms of hematopoietic origin. This feature can be leveraged by a theranostic approach, which provides a read-out of the actual CXCR4 expres…
View article: A novel assessment of whole-mount Gleason grading in prostate cancer to identify candidates for radical prostatectomy: a machine learning-based multiomics study
A novel assessment of whole-mount Gleason grading in prostate cancer to identify candidates for radical prostatectomy: a machine learning-based multiomics study Open
Purpose: This study aims to assess whole-mount Gleason grading (GG) in prostate cancer (PCa) accurately using a multiomics machine learning (ML) model and to compare its performance with biopsy-proven GG (bxGG) assessment. Materials and Me…
View article: Deep learning for [18F]fluorodeoxyglucose-PET-CT classification in patients with lymphoma: a dual-centre retrospective analysis
Deep learning for [18F]fluorodeoxyglucose-PET-CT classification in patients with lymphoma: a dual-centre retrospective analysis Open
National Institutes of Health-National Cancer Institute Cancer Center Support Grant.
View article: Examining the Relationship and Prognostic Significance of Cell-Free DNA Levels and the PSMA-Positive Tumor Volume in Men with Prostate Cancer: A Retrospective–Prospective [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT Study
Examining the Relationship and Prognostic Significance of Cell-Free DNA Levels and the PSMA-Positive Tumor Volume in Men with Prostate Cancer: A Retrospective–Prospective [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT Study Open
Functional imaging with prostate-specific membrane antigen (PSMA) ligands has emerged as the standard imaging method for prostate cancer (PCA). In parallel, the analysis of blood-derived, cell-free DNA (cfDNA) has been shown to be a promis…
View article: Metabolic tumor volume and sites of organ involvement predict outcome in NSCLC immune-checkpoint inhibitor therapy
Metabolic tumor volume and sites of organ involvement predict outcome in NSCLC immune-checkpoint inhibitor therapy Open
The MTV and the number of SOI are simple imaging markers that provide complementary information to facilitate risk stratification in NSCLC patients scheduled for ICIT.
View article: Antihormonal-Treatment Status Affects<sup>68</sup>Ga-PSMA-HBED-CC PET Biodistribution in Patients with Prostate Cancer
Antihormonal-Treatment Status Affects<sup>68</sup>Ga-PSMA-HBED-CC PET Biodistribution in Patients with Prostate Cancer Open
Androgen deprivation therapy (ADT) is known to influence the prostate-specific membrane antigen (PSMA) expression of prostate cancer, potentially complicating the interpretation of PSMA ligand PET findings and affecting PSMA radioligand th…
View article: Direct Patlak Reconstruction of [68Ga]Ga-PSMA PET for the Evaluation of Primary Prostate Cancer Prior Total Prostatectomy: Results of a Pilot Study
Direct Patlak Reconstruction of [68Ga]Ga-PSMA PET for the Evaluation of Primary Prostate Cancer Prior Total Prostatectomy: Results of a Pilot Study Open
To investigate the use of kinetic parameters derived from direct Patlak reconstructions of [68Ga]Ga-PSMA-11 positron emission tomography/computed tomography (PET/CT) to predict the histological grade of malignancy of the primary tumor of p…
View article: A Prognostic Risk Score for Prostate Cancer Based on PSMA PET–derived Organ-specific Tumor Volumes
A Prognostic Risk Score for Prostate Cancer Based on PSMA PET–derived Organ-specific Tumor Volumes Open
Background Prostate-specific membrane antigen (PSMA) PET has high specificity in localizing primary tumors and metastases in patients with prostate cancer, but the individual overall survival probability is still difficult to estimate. Pur…
View article: 68Ga-Pentixafor PET/MRI for Treatment Response Assessment in Mantle Cell Lymphoma
68Ga-Pentixafor PET/MRI for Treatment Response Assessment in Mantle Cell Lymphoma Open
Purpose The aim of this study was to compare CXCR4 imaging with 68 Ga-pentixafor PET to MRI for treatment response assessment in patients with mantle cell lymphoma (MCL). Patients and Methods Twenty-two posttreatment 68 Ga-pentixafor PET/M…
View article: Data from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift
Data from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift Open
Bruton tyrosine kinase inhibitor ibrutinib is effective in treating chronic lymphocytic leukemia (CLL). However, after ibrutinib treatment initiation, patients frequently experience an increase of CLL blood cell count. This phenomenon in c…
View article: Supplementary Figures and Legends from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift
Supplementary Figures and Legends from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift Open
Supplementary Figures 1-3 and Supplementary Figure Legends
View article: Supplementary Table 3 from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift
Supplementary Table 3 from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift Open
Imaging parameters and white blood cell counts before and at mid- and long-term follow-up on ibrutinib treatment
View article: Supplementary Figures and Legends from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift
Supplementary Figures and Legends from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift Open
Supplementary Figures 1-3 and Supplementary Figure Legends
View article: Supplementary Table 2 from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift
Supplementary Table 2 from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift Open
Imaging parameters and white blood cell counts before and at short-term follow-up on ibrutinib treatment
View article: Data from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift
Data from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift Open
Bruton tyrosine kinase inhibitor ibrutinib is effective in treating chronic lymphocytic leukemia (CLL). However, after ibrutinib treatment initiation, patients frequently experience an increase of CLL blood cell count. This phenomenon in c…
View article: Supplementary Table 1 from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift
Supplementary Table 1 from In Human Visualization of Ibrutinib-Induced CLL Compartment Shift Open
Patients' characteristics