Adelheid Cerwenka
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View article: Colorectal cancer organoids drive hypoxia, TGF-β, and patient-specific diversification of NK cell activation programs
Colorectal cancer organoids drive hypoxia, TGF-β, and patient-specific diversification of NK cell activation programs Open
Background Colorectal carcinoma exhibits high heterogeneity, comprising subtypes that show poor efficacy of T cell-based immunotherapies, such as programmed cell death protein 1 (PD-1) checkpoint inhibitors. Although natural killer (NK) ce…
Modular Droplet‐Based Microfluidic Platform for Functional Phenotypic Screening of Natural Killer Cells Open
Natural Killer (NK) cells, as key effector cells of the innate immune system, display high heterogeneity in their ability to kill target cells. The underlying mechanisms remain poorly understood. Here, a droplet‐based microfluidic platform…
View article: Intrinsic Immune Response of HBV/HDV-Infected Cells and Corresponding Innate (Like) Immune Cell Activation
Intrinsic Immune Response of HBV/HDV-Infected Cells and Corresponding Innate (Like) Immune Cell Activation Open
Infection of hepatitis B (HBV) patients with hepatitis D (HDV) can cause the most severe form of viral hepatitis, leading to liver fibrosis, liver failure, and hepatocellular carcinoma. HDV relies on simultaneous infection with HBV for the…
View article: Empowering Natural Killer Cells to Combat Acute Myeloid Leukemia: Perspective on CAR-NK Cell Therapy
Empowering Natural Killer Cells to Combat Acute Myeloid Leukemia: Perspective on CAR-NK Cell Therapy Open
Background: Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with a high relapse rate and still limited therapeutic options. Natural killer (NK) cell-based immunotherapy has the potential to improve outcomes for patient…
S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling Open
Background Immunotherapies for malignant melanoma are challenged by the resistance developed in a significant proportion of patients. Myeloid-derived suppressor cells (MDSC), with their ability to inhibit antitumor T-cell responses, are a …
IFNγ mediates the resistance of tumor cells to distinct NK cell subsets Open
Background Immune checkpoint blockade targeting the adaptive immune system has revolutionized the treatment of cancer. Despite impressive clinical benefits observed, patient subgroups remain non-responsive underscoring the necessity for co…
Vitamin A‐treated natural killer cells reduce interferon‐gamma production and support regulatory T‐cell differentiation Open
Natural killer (NK) cells are innate cytotoxic lymphocytes that contribute to immune responses against stressed, transformed, or infected cells. NK cell effector functions are regulated by microenvironmental factors, including cytokines, m…
Data from Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages Open
Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic cancers worldwide. EOC cells educate tumor-associated macrophages (TAM) through CD44-mediated cholesterol depletion to generate an immunosuppressive tumor microenvironme…
View article: Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity
Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity Open
Background and aims The co-infection of hepatitis B (HBV) patients with the hepatitis D virus (HDV) causes the most severe form of viral hepatitis and thus drastically worsens the course of the disease. Therapy options for HBV/HDV patients…
View article: The Ig Superfamily Ligand B7H6 Subjects Activated T Cells to NK Cell Surveillance and Limits CAR T Cell Persistence
The Ig Superfamily Ligand B7H6 Subjects Activated T Cells to NK Cell Surveillance and Limits CAR T Cell Persistence Open
Understanding the mechanisms that regulate T cell immunity is critical for the development of effective therapies for diseases associated with T cell dysfunction. Co-inhibitory ‘checkpoint molecules’ are tightly connected to T cell activat…
View article: Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity
Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity Open
The dataset contains bulk RNA-seq read count matrices of NK cells from healthy donors after 48 h of co-culture with hepatitis D virus infected and non-infected HepG2-hNTCP cells. The samples are described in the table RNA-seq_samples.xls t…
View article: Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity
Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity Open
The dataset contains bulk RNA-seq read count matrices of NK cells from healthy donors after 48 h of co-culture with hepatitis D virus infected and non-infected HepG2-hNTCP cells. The samples are described in the table RNA-seq_samples.xls t…
Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury Open
Liver sinusoidal endothelial cells (LSECs) rapidly clear lipopolysaccharide (LPS) from the bloodstream and establish intimate contact with immune cells. However, their role in regulating liver inflammation remains poorly understood. We sho…
Microenvironmental signals shaping NK‐cell reactivity in cancer Open
Since the postulation of the “missing‐self” concept, much progress has been made in defining requirements for NK‐cell activation. Unlike T lymphocytes that process signals from receptors in a hierarchic manner dominated by the T‐cell recep…
Data from CD16A Activation of NK Cells Promotes NK Cell Proliferation and Memory-Like Cytotoxicity against Cancer Cells Open
CD16A is a potent cytotoxicity receptor on human natural killer (NK) cells, which can be exploited by therapeutic bispecific antibodies. So far, the effects of CD16A-mediated activation on NK cell effector functions beyond classical antibo…
Supplementary Figures 1-4 from CD16A Activation of NK Cells Promotes NK Cell Proliferation and Memory-Like Cytotoxicity against Cancer Cells Open
S1. NK cell cytotoxicity and IFNγ are enhanced by AFM13 towards different types of lymphoma cells. S2. Pre-activation by rituximab increases IL2-dependent NK cell proliferation and expansion. S3. Recovery of NK cell function by IL2 or IL15…
Supplementary Figures 1-4 from CD16A Activation of NK Cells Promotes NK Cell Proliferation and Memory-Like Cytotoxicity against Cancer Cells Open
S1. NK cell cytotoxicity and IFNγ are enhanced by AFM13 towards different types of lymphoma cells. S2. Pre-activation by rituximab increases IL2-dependent NK cell proliferation and expansion. S3. Recovery of NK cell function by IL2 or IL15…
Data from CD16A Activation of NK Cells Promotes NK Cell Proliferation and Memory-Like Cytotoxicity against Cancer Cells Open
CD16A is a potent cytotoxicity receptor on human natural killer (NK) cells, which can be exploited by therapeutic bispecific antibodies. So far, the effects of CD16A-mediated activation on NK cell effector functions beyond classical antibo…
Supplementary material from Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages Open
It includes extended material and methods, and supplementary figures
Supplementary material from Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages Open
It includes extended material and methods, and supplementary figures
Data from Endothelial RBPJ Is Essential for the Education of Tumor-Associated Macrophages Open
Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic cancers worldwide. EOC cells educate tumor-associated macrophages (TAM) through CD44-mediated cholesterol depletion to generate an immunosuppressive tumor microenvironme…
Data from Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30 Open
Natural killer (NK) cells are potent immune effector cells capable of mediating antitumor responses. Thus, during immunoediting, tumor cell populations evolve strategies to escape NK-cell–mediated recognition. In this study, we report a no…
Supplementary Figure 1 from Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30 Open
PDF file - 127KB, Tumor cell supernatants modulate NKp30 expression regardless of the presence or absence of soluble B7-H6.
Supplementary Figure 1 from Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30 Open
PDF file - 127KB, Tumor cell supernatants modulate NKp30 expression regardless of the presence or absence of soluble B7-H6.
Supplementary Figure 2 from Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30 Open
PDF file - 79KB, Pharmacological inhibition of protein disulfide isomerases reduces soluble B7-H6.
Supplementary Methods and Materials from Natural Killer Cell Accumulation in Tumors Is Dependent on IFN-γ and CXCR3 Ligands Open
Supplementary Methods and Materials from Natural Killer Cell Accumulation in Tumors Is Dependent on IFN-γ and CXCR3 Ligands
Supplementary Figure Legends from Metalloprotease-Mediated Tumor Cell Shedding of B7-H6, the Ligand of the Natural Killer Cell–Activating Receptor NKp30 Open
PDF file - 70KB
Supplementary Methods and Materials from Natural Killer Cell Accumulation in Tumors Is Dependent on IFN-γ and CXCR3 Ligands Open
Supplementary Methods and Materials from Natural Killer Cell Accumulation in Tumors Is Dependent on IFN-γ and CXCR3 Ligands