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View article: Adolescent Chronic Sleep Disruption Increases Blood–Brain Barrier Permeability, but in a Time‐, Region‐ and Sex‐Dependent Manner in CD‐1 Mice
Adolescent Chronic Sleep Disruption Increases Blood–Brain Barrier Permeability, but in a Time‐, Region‐ and Sex‐Dependent Manner in CD‐1 Mice Open
During puberty and adolescence, there is a natural change in the circadian rhythm, which could result in inadequate sleep and increase the likelihood of physical and mental health issues. Previously, we have developed a mouse model showing…
View article: Correction: Non-guided, mobile, CBT-I-based sleep intervention in War-torn Ukraine: A feasibility study
Correction: Non-guided, mobile, CBT-I-based sleep intervention in War-torn Ukraine: A feasibility study Open
[This corrects the article DOI: 10.1371/journal.pone.0310070.].
View article: The Effects of a CBT-I Based App-Program on Sleep Quality, Insomnia Severity, Psychological Strain and Quality of Life: A Pilot Study
The Effects of a CBT-I Based App-Program on Sleep Quality, Insomnia Severity, Psychological Strain and Quality of Life: A Pilot Study Open
The app-program was largely feasible and potentially effective in improving sleep and well-being. PSG-derived WASO changes highlight the value of objective sleep measures. Future studies should refine protocols and include control conditio…
View article: Validation of SUV thresholds in [¹⁸F]SiTATE PET/CT for accurate meningioma segmentation
Validation of SUV thresholds in [¹⁸F]SiTATE PET/CT for accurate meningioma segmentation Open
Purpose Somatostatin receptor (SSTR)-targeted PET/CT provides valuable clinical insights beyond standard imaging in meningioma patients. Due to its excellent diagnostic capabilities and favorable logistics, the 18 F-labeled SSTR-targeting …
View article: Non-guided, mobile, CBT-I-based sleep intervention in War-torn Ukraine: A feasibility study
Non-guided, mobile, CBT-I-based sleep intervention in War-torn Ukraine: A feasibility study Open
Background War conditions can severely impact sleep and mental health at the population level, especially in the conflicts of such tremendous scale as in Ukraine. The aim of this research was to study whether a mobile, unguided Cognitive B…
View article: Non-guided, Mobile, CBT-I-based Sleep Training in War-torn Ukraine: A Feasibility Study
Non-guided, Mobile, CBT-I-based Sleep Training in War-torn Ukraine: A Feasibility Study Open
Objectives To study whether a mobile, unguided Cognitive Behavior Therapy-based Intervention for Sleep Disturbance, Sleep 2 is feasible, acceptable, and reduces mental health/sleep disturbance symptoms among the Ukrainian population during…
View article: Validation of the standardization framework SSTR-RADS 1.0 for neuroendocrine tumors using the novel SSTR‑targeting peptide [18F]SiTATE
Validation of the standardization framework SSTR-RADS 1.0 for neuroendocrine tumors using the novel SSTR‑targeting peptide [18F]SiTATE Open
Objectives Somatostatin receptor positron emission tomography/computed tomography (SSTR-PET/CT) using [ 68 Ga]-labeled tracers is a widely used imaging modality for neuroendocrine tumors (NET). Recently, [ 18 F]SiTATE, a SiFAlin tagged [Ty…
View article: 0437 The Effects of a 6-week Single-blind Online CBT-I Program on Daily Subjective and Objective Sleep Parameters
0437 The Effects of a 6-week Single-blind Online CBT-I Program on Daily Subjective and Objective Sleep Parameters Open
Introduction Insomnia exerts a substantial impact on a considerable portion of the population, resulting in significant detriments to health, workplace safety, and overall quality of life. Digital treatment programs have currently made eff…
View article: Investigating the subjective and objective efficacy of a cognitive behavioural therapy for insomnia (<scp>CBT‐I</scp>)‐based smartphone app on sleep: A randomised controlled trial
Investigating the subjective and objective efficacy of a cognitive behavioural therapy for insomnia (<span>CBT‐I</span>)‐based smartphone app on sleep: A randomised controlled trial Open
Summary Due to insufficient treatment options for insomnia, effective solutions are urgently needed. We evaluated the effects of a CBT‐I‐based app combining sleep training with subjective and objective sleep monitoring on (i) sleep and (ii…
View article: From Pulses to Sleep Stages: Towards Optimized Sleep Classification Using Heart-Rate Variability
From Pulses to Sleep Stages: Towards Optimized Sleep Classification Using Heart-Rate Variability Open
More and more people quantify their sleep using wearables and are becoming obsessed in their pursuit of optimal sleep (“orthosomnia”). However, it is criticized that many of these wearables are giving inaccurate feedback and can even lead …
View article: From Pulses to Sleep Stages: Towards Optimised Sleep Classification Using Heart-Rate Variability
From Pulses to Sleep Stages: Towards Optimised Sleep Classification Using Heart-Rate Variability Open
More and more people quantify their sleep using wearables and are getting obsessed in their pursuit of optimal sleep (“orthosomnia”). However, it is criticized that many of these wearables are giving inaccurate feedback and even can lead t…
View article: Diagnostic accuracy of SSR-PET/CT compared to histopathology in the identification of liver metastases from well-differentiated neuroendocrine tumors
Diagnostic accuracy of SSR-PET/CT compared to histopathology in the identification of liver metastases from well-differentiated neuroendocrine tumors Open
Background Histopathology is the reference standard for diagnosing liver metastases of neuroendocrine tumors (NETs). Somatostatin receptor-positron emission tomography / computed tomography (SSR-PET/CT) has emerged as a promising non-invas…
View article: Investigating the subjective and objective efficacy of a cognitive behavioral therapy for insomnia (CBT-I)-based smartphone app on sleep: a randomized controlled trial
Investigating the subjective and objective efficacy of a cognitive behavioral therapy for insomnia (CBT-I)-based smartphone app on sleep: a randomized controlled trial Open
Due to insufficient treatment options for sleep disorders, effective solutions are urgently needed. We evaluate the effects of a CBT-I-based app combining sleep training with subjective and objective sleep monitoring on i) sleep and ii) su…
View article: The effects of a CBT-I based app-program on sleep quality, insomnia severity, psychological strain and quality of life: A first efficacy study
The effects of a CBT-I based app-program on sleep quality, insomnia severity, psychological strain and quality of life: A first efficacy study Open
Given rising numbers in sleep disorders and insufficient availability of treatment options, the need for well-validated digital interventions rises. This study aims at assessing the efficacy of an app-program which combines sleep-training …
View article: The Virtual Sleep Lab—A Novel Method for Accurate Four-Class Sleep Staging Using Heart-Rate Variability from Low-Cost Wearables
The Virtual Sleep Lab—A Novel Method for Accurate Four-Class Sleep Staging Using Heart-Rate Variability from Low-Cost Wearables Open
Sleep staging based on polysomnography (PSG) performed by human experts is the de facto “gold standard” for the objective measurement of sleep. PSG and manual sleep staging is, however, personnel-intensive and time-consuming and it is thus…
View article: Impact Of Restrictions Due To Covid -19 On A Quality Assured Screening Colonoscopy Program
Impact Of Restrictions Due To Covid -19 On A Quality Assured Screening Colonoscopy Program Open
Background and study aims On February 25, 2020, the first patient was diagnosed with COVID-19 in Austria. On March 16, 2020, the Austrian government imposed restrictions and subsequently the Austrian Medical Association recommended minimiz…