Andrew Hope
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View article: Radiation-specific Automated Dosimetric dental, Mandible, and maxilla Annotation for Predicting Periodontal Problems (RADMAP): A semi-automated tool for dosimetric oral risk communication and osteoradionecrosis assessment
Radiation-specific Automated Dosimetric dental, Mandible, and maxilla Annotation for Predicting Periodontal Problems (RADMAP): A semi-automated tool for dosimetric oral risk communication and osteoradionecrosis assessment Open
Purpose/Objective(s) Osteoradionecrosis of the jaw (ORN) is a severe complication of head and neck cancer (HNC) radiotherapy (RT), significantly impacting patient quality of life. Current dose assessment relies on whole-mandible dosimetry,…
View article: Computed Tomography Orodental Sub-volume Imaging Annotation Dataset of Head and Neck Cancer Radiation Therapy Patients
Computed Tomography Orodental Sub-volume Imaging Annotation Dataset of Head and Neck Cancer Radiation Therapy Patients Open
Accurate delineation of orodental structures on computed tomography (CT) is critical for image-guided assessments of radiation-associated bone injury. This dataset comprises curated CT imaging and expert-defined segmentation masks for 60 p…
Image-based mandibular and maxillary parcellation and annotation using computed tomography (IMPACT): a deep learning-based clinical tool for orodental dose estimation and osteoradionecrosis assessment Open
We present a novel DL-based auto-segmentation framework of orodental structures, enabling spatial localization of dose-related differences. This tool may enhance image-based bone injury detection and improve clinical decision-making in rad…
View article: External Validation of a CT-Based Radiogenomics Model for the Detection of EGFR Mutation in NSCLC and the Impact of Prevalence in Model Building by Using Synthetic Minority Over Sampling (SMOTE): Lessons Learned
External Validation of a CT-Based Radiogenomics Model for the Detection of EGFR Mutation in NSCLC and the Impact of Prevalence in Model Building by Using Synthetic Minority Over Sampling (SMOTE): Lessons Learned Open
External validation failed to reproduce prior radiogenomics model performance, while clinical variables alone retained strong predictive value. SMOTE-based oversampling did not improve diagnostic accuracy, suggesting that, in EGFR predicti…
View article: Image-based Mandibular and Maxillary Parcellation and Annotation using Computer Tomography (IMPACT): A Deep Learning-based Clinical Tool for Orodental Dose Estimation and Osteoradionecrosis Assessment
Image-based Mandibular and Maxillary Parcellation and Annotation using Computer Tomography (IMPACT): A Deep Learning-based Clinical Tool for Orodental Dose Estimation and Osteoradionecrosis Assessment Open
Background Accurate delineation of orodental structures on radiotherapy CT images is essential for dosimetric assessments and dental decisions. We propose a deep-learning auto-segmentation framework for individual teeth and mandible/maxill…
View article: The prognostic and predictive value of pre-treatment hematologic markers for oropharyngeal carcinoma stratified by HPV status and treated with definitive (chemo) radiation
The prognostic and predictive value of pre-treatment hematologic markers for oropharyngeal carcinoma stratified by HPV status and treated with definitive (chemo) radiation Open
In this large and homogenous cohort of OPC patients receiving definitive (C)RT, TLC was found to be a prognostic and predictive biomarker for patients with HPV-positive OPC receiving CRT, but not RT alone nor in HPV-negative disease. No ot…
View article: Retrospective cohort study assessing clinical outcomes of patients with extensive-stage small cell lung cancer treated with and without consolidative thoracic radiotherapy at the Princess Margaret Cancer Centre
Retrospective cohort study assessing clinical outcomes of patients with extensive-stage small cell lung cancer treated with and without consolidative thoracic radiotherapy at the Princess Margaret Cancer Centre Open
Objectives Most patients with small cell lung cancer present with extensive-stage (ES-SCLC) disease. An international randomised trial demonstrated a survival benefit in patients treated with consolidative thoracic radiotherapy (cTRT). We …
Association between dose to cardiac structures and overall survival: A multivariable analysis in a large, multi-institutional database of stage III NSCLC patients with external validation Open
Although significant associations between cardiovascular parameters and survival were found, their small effect sizes should be considered when prioritizing cardiac sparing in stage III NSCLC treatment.
View article: Early Imaging Identification of Osteoradionecrosis and Classification Using the Novel ClinRad System: Results from A Retrospective Observational Cohort
Early Imaging Identification of Osteoradionecrosis and Classification Using the Novel ClinRad System: Results from A Retrospective Observational Cohort Open
Objective Osteoradionecrosis of the jaw (ORNJ) is a chronic radiation-associated toxicity that lacks standardized classification criteria and treatment guidelines. Understanding early signs of tissue injury could help us better predict, pr…
View article: Development of a prediction model for tube feeding dependence in HPV-associated oropharyngeal cancer patients undergoing chemoradiotherapy
Development of a prediction model for tube feeding dependence in HPV-associated oropharyngeal cancer patients undergoing chemoradiotherapy Open
Despite a sizable cohort and comprehensive capture of dosimetric information, our prediction model, and external validation of previously published models, showed moderate performance. This suggests that additional factors beyond disease a…
View article: Evaluation of a nurse practitioner-led post-discharge transitional care program for patients with liver disease: A retrospective cohort study
Evaluation of a nurse practitioner-led post-discharge transitional care program for patients with liver disease: A retrospective cohort study Open
Background: We evaluated an outpatient, nurse practitioner-led transitional care program with respect to its efficacy in reducing unplanned readmission rates for patients with liver disease. Methods: We conducted a retrospective cohort stu…
View article: Impact of Postoperative Neck Radiotherapy Volumes on Long‐Term Unstimulated Saliva Flow Following Primary Surgery and Ipsilateral Neck Dissection for Oral Cavity Squamous Cell Carcinoma
Impact of Postoperative Neck Radiotherapy Volumes on Long‐Term Unstimulated Saliva Flow Following Primary Surgery and Ipsilateral Neck Dissection for Oral Cavity Squamous Cell Carcinoma Open
Background We investigate the association of postoperative radiotherapy (PORT) volumes and salivary function in oral cavity SCC (OSCC). Methods OSCC patients undergoing PORT 2005–2021 underwent modified Schirmer test (MST) pre‐PORT, 6 and/…
View article: Performance of Multimodal Artificial Intelligence Chatbots Evaluated on Clinical Oncology Cases
Performance of Multimodal Artificial Intelligence Chatbots Evaluated on Clinical Oncology Cases Open
Importance Multimodal artificial intelligence (AI) chatbots can process complex medical image and text-based information that may improve their accuracy as a clinical diagnostic and management tool compared with unimodal, text-only AI chat…
View article: Computed tomography radiomics-based cross-sectional detection of mandibular osteoradionecrosis in head and neck cancer survivors
Computed tomography radiomics-based cross-sectional detection of mandibular osteoradionecrosis in head and neck cancer survivors Open
Purpose This study aims to identify radiomic features extracted from contrast-enhanced CT scans that differentiate osteoradionecrosis (ORN) from normal mandibular bone in patients with head and neck cancer (HNC) treated with radiotherapy (…
The prognostic value of image-identified extranodal extension in laryngeal and hypopharyngeal carcinoma following definitive (chemo-)radiotherapy Open
Our study confirms the independent prognostic importance of iENE for LHC following definitive (chemo-)radiotherapy beyond TNM-8 cN status that already contains the cENE parameter. Further research is needed to explore whether iENE could re…
View article: Mandibular dose-volume predicts time-to-osteoradionecrosis in an actuarial normal-tissue complication probability (NTCP) model: External validation of right-censored clinico-dosimetric and competing risk application across international multi-institutional observational cohorts and online graphical user interface clinical support tool assessment
Mandibular dose-volume predicts time-to-osteoradionecrosis in an actuarial normal-tissue complication probability (NTCP) model: External validation of right-censored clinico-dosimetric and competing risk application across international multi-institutional observational cohorts and online graphical user interface clinical support tool assessment Open
Background Existing studies on osteoradionecrosis of the jaw (ORNJ) have primarily used cross-sectional data, assessing risk factors at a single time point. Determining the time-to-event profile of ORNJ has important implications to monito…
View article: The role of genetic variants in the prediction of hearing loss due to cisplatin chemoradiotherapy
The role of genetic variants in the prediction of hearing loss due to cisplatin chemoradiotherapy Open
Background Concomitant high‐dose cisplatin with radiotherapy is commonly used for treating head and neck squamous cell carcinoma (HNSCC). Cisplatin, often used with radiotherapy, is known for causing irreversible sensorineural hearing loss…
View article: Clinical Predictors of Cisplatin Chemoradiation-Induced Ototoxicity in HPV-Positive Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study
Clinical Predictors of Cisplatin Chemoradiation-Induced Ototoxicity in HPV-Positive Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study Open
Background Cisplatin-based chemoradiation is a standard treatment for many patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC), an etiologically distinct subset of head and neck cancer. Although …