Ali Sharif
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View article: Verbascum thapsus L. ethanol fraction mitigates CCl4-induced hepatic damage via inhibition of TNFα-NF-κB signaling and oxidative stress in rats
Verbascum thapsus L. ethanol fraction mitigates CCl4-induced hepatic damage via inhibition of TNFα-NF-κB signaling and oxidative stress in rats Open
Objective: To evaluate the hepatoprotective effects of the ethanol fraction of Verbascum thapsus L. (EFVT) against CCl 4 -induced liver injury and elucidate its underlying mechanisms. Methods: The assessment of antioxidant properties and c…
View article: Mapping Gestational Diabetes Mellitus – A Narrative Review of Key Determinants and Epidemiology
Mapping Gestational Diabetes Mellitus – A Narrative Review of Key Determinants and Epidemiology Open
Gestational diabetes mellitus (GDM) is a glucose intolerance disorder that arises during pregnancy, posing significant risks to both maternal and neonatal health. The global burden of GDM is increasing, reflecting changes in demographic, g…
View article: Synthesis and characterization of ZnO nanorods via hydrothermal route for wastewater recycling
Synthesis and characterization of ZnO nanorods via hydrothermal route for wastewater recycling Open
In this work, highly efficient ZnO nanorods (NRs) were prepared using an easy and costeffective hydrothermal process. The Synthesized ZnO NR have been analyzed for their structure, morphology, and optical characteristics using X-ray diffra…
View article: Mechanistic evaluation of antiarthritic and anti-inflammatory effect of campesterol ester derivatives in complete Freund’s adjuvant-induced arthritic rats
Mechanistic evaluation of antiarthritic and anti-inflammatory effect of campesterol ester derivatives in complete Freund’s adjuvant-induced arthritic rats Open
Background: Current therapies for RA have limitations and side effects, leading to a growing need for safer treatment options. Natural compounds from plants are gaining attention for their therapeutic benefits and fewer side effects. One s…
View article: Mitigation of Diabetes Mellitus Using <i>Euphorbia helioscopia</i> Leaf Ethanolic Extract by Modulating GCK, GLUT4, IGF, and G6P Expressions in Streptozotocin‐Induced Diabetic Rats
Mitigation of Diabetes Mellitus Using <i>Euphorbia helioscopia</i> Leaf Ethanolic Extract by Modulating GCK, GLUT4, IGF, and G6P Expressions in Streptozotocin‐Induced Diabetic Rats Open
Diabetes mellitus is a metabolic disorder. Synthetic antidiabetics are the commonly used treatment options associated with complications. The objective of this study was to explore the antioxidative and antidiabetic potential of Euphorbia …
View article: Mechanistic evaluation of anti-arthritic effects of campesterol through downregulation of TNF-α, IL-1β, IL-6, NF-κB, MMP 3, COX I, and COX II
Mechanistic evaluation of anti-arthritic effects of campesterol through downregulation of TNF-α, IL-1β, IL-6, NF-κB, MMP 3, COX I, and COX II Open
Aims This research aimed to use a rat model of CFA-induced arthritis to evaluate the antiarthritic effects of Campesterol, a phytosterol with therapeutic promise for inflammatory ailments. Methodology : A total of 30 Sprague-Dawley rats, w…
View article: In Vitro, In Silico, and In Vivo Studies of<i>Cardamine hirsuta</i>Linn as a Potential Antidiabetic Agent in a Rat Model
In Vitro, In Silico, and In Vivo Studies of<i>Cardamine hirsuta</i>Linn as a Potential Antidiabetic Agent in a Rat Model Open
Diabetes mellitus (T2DM) is a multifaceted metabolic disorder with no definite treatment. In silico characterization can help to explain the interaction between molecules and predict 3D structures. The aim of the present study was to evalu…
View article: Patient Perspectives and Side-Effects Experience on Chemotherapy of Non-Small Cell Lung Cancer: A Qualitative Study
Patient Perspectives and Side-Effects Experience on Chemotherapy of Non-Small Cell Lung Cancer: A Qualitative Study Open
This study aid healthcare providers when deciding on treatment options that will improve shared decision-making between clinicians and treatment outcomes.
View article: Anticancer, Cardio-Protective and Anti-Inflammatory Potential of Natural-Sources-Derived Phenolic Acids
Anticancer, Cardio-Protective and Anti-Inflammatory Potential of Natural-Sources-Derived Phenolic Acids Open
Phenolic acids (PAs) are one of the utmost prevalent classes of plant-derived bioactive chemicals. They have a specific taste and odor, and are found in numerous medicinal and food plants, such as Cynomorium coccineum L., Prunus domestica …
View article: Aqueous Ethanolic Extract of <i>Adiantum incisum</i> Forssk. Protects against Type 2 Diabetes Mellitus via Attenuation of α-Amylase and Oxidative Stress
Aqueous Ethanolic Extract of <i>Adiantum incisum</i> Forssk. Protects against Type 2 Diabetes Mellitus via Attenuation of α-Amylase and Oxidative Stress Open
Purpose : This study was designed to investigate the antidiabetic effects of the aqueous ethanolic extract of Adiantum incisum Forssk. whole plant (AE-AI) in order to validate the folkloric claim. Methods : Streptozotocin (STZ) was used to…
View article: Antidiabetic Potential and Antioxidant Activity of Olea europaea subsp. Cuspidata (Indian Olive) Seed Extracts
Antidiabetic Potential and Antioxidant Activity of Olea europaea subsp. Cuspidata (Indian Olive) Seed Extracts Open
The aim of the present study was to evaluate the antioxidant and antidiabetic potential of Indian olive seed extracts. Plant seeds were sequentially extracted with n-hexane, chloroform, methanol, and water. 2,2-Diphenyl-1-picrylhydrazyl (D…
View article: Therapeutic potential of Ceratonia siliqua extract for the management of asthma and hypertension
Therapeutic potential of Ceratonia siliqua extract for the management of asthma and hypertension Open
The current work was performed to explore the pharmacological mechanisms involved in the management of asthma and hypertension along with the safety profile of the Ceratonia siliqua (C. siliqua/Carob) pods. The bronchorelaxant, vasorelaxan…
View article: Influence of different formulation variables on the performance of transdermal drug delivery system containing tizanidine hydrochloride: in vitro and ex vivo evaluations
Influence of different formulation variables on the performance of transdermal drug delivery system containing tizanidine hydrochloride: in vitro and ex vivo evaluations Open
The present study was aimed at preparation of transdermal patches of tizanidine HCl, evaluation of the effect of polymers on in vitro release pattern of the drug, and the effect of permeation enhancers on the penetration of the drug throug…
View article: Fabrication and Characterization of Molecularly Imprinted Microspheres as Highly Effective Sorbent for Fast and Selective Solid Phase Extraction of Nicotinamide in Beef and Wheat Flour Samples
Fabrication and Characterization of Molecularly Imprinted Microspheres as Highly Effective Sorbent for Fast and Selective Solid Phase Extraction of Nicotinamide in Beef and Wheat Flour Samples Open
Fabrication and Characterization of Molecularly Imprinted Microspheres as Highly Effective Sorbent for Fast and Selective Solid Phase Extraction of Nicotinamide in Beef and Wheat Flour Samples
View article: Genotoxic and cytotoxic assessment of sitagliptin and simvastatin alone and in combination.
Genotoxic and cytotoxic assessment of sitagliptin and simvastatin alone and in combination. Open
Type 2 Diabetes Mellitus (T2DM) patients are at high risk of Coronary Heart Disease (CHD) and need a global therapeutic intervention. A fixed-dose combination prescription medication containing anti-diabetic drug (Sitagliptin) and lipid lo…
View article: Tylophora hirsuta L. leaf extract attenuates alloxan-induced diabetes in mice by suppressing oxidative stress and α-amylase
Tylophora hirsuta L. leaf extract attenuates alloxan-induced diabetes in mice by suppressing oxidative stress and α-amylase Open
Objective: To evaluate the antidiabetic potential of leaf extracts of Tylophora hirsuta (T. hirsuta) . Methods: The methanolic and ethyl acetate extracts of T. hirsuta leaves were analyzed by high pressure liquid chromatography. In vitro a…
View article: Argemone mexicana extract alleviates gastrointestinal disorders by stimulating muscarinic receptors and blocking voltage-gated L-type calcium channels
Argemone mexicana extract alleviates gastrointestinal disorders by stimulating muscarinic receptors and blocking voltage-gated L-type calcium channels Open
Objective: To investigate the pharmacological potential of Argemone mexicana in treating constipation and emesis by using in vitro and in vivo models. Methods: The spasmogenic and spasmolytic effects were evaluated on isolated rabbit jejun…
View article: Cyperus Iria Aqueous-Ethanol Extract Ameliorated Hyperglycemia, Oxidative Stress and Regulated Inflammatory Cytokines in Streptozotocin Induced Diabetic Rats
Cyperus Iria Aqueous-Ethanol Extract Ameliorated Hyperglycemia, Oxidative Stress and Regulated Inflammatory Cytokines in Streptozotocin Induced Diabetic Rats Open
Present study is involved in identification of biophenolic and flavonoids from the aqueous-ethanol extract of Cyperus iria and appraisal of inflammatory and stress markers involved in endocrine dysfunction based upon its folktale use. Sign…
View article: Berberis lycium Royle. extracts attenuate inflammation and modulates hyperglycemia in alloxan induced diabetic rats.
Berberis lycium Royle. extracts attenuate inflammation and modulates hyperglycemia in alloxan induced diabetic rats. Open
Berberis lycium Royle (Berberidaceae) is traditionally used for the treatment of diabetes mellitus. Present study was conducted to determine the antioxidant, antidiabetic and anti-inflammatory effects of aqueous and methanolic whole plant …