A. Ian Smith
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View article: CNSC-89. BRAF/MEK INHIBITION IN THE TREATMENT OF BRAF-MUTANT HIGH-GRADE GLIOMAS: A FIVE-YEAR INSTITUTIONAL EXPERIENCE
CNSC-89. BRAF/MEK INHIBITION IN THE TREATMENT OF BRAF-MUTANT HIGH-GRADE GLIOMAS: A FIVE-YEAR INSTITUTIONAL EXPERIENCE Open
Treatment for high-grade gliomas following surgical resection usually involves administration of temozolomide and radiotherapy. However, small case series and few case reports have increasingly reported survival benefits in the usage of an…
View article: Predictive Capacity of Mismatch Repair Status in the Use of Immune Checkpoint Inhibitors for the Treatment of Aggressive Pituitary Adenomas and Pituitary Carcinomas: Illustrative Case Report and Literature Review
Predictive Capacity of Mismatch Repair Status in the Use of Immune Checkpoint Inhibitors for the Treatment of Aggressive Pituitary Adenomas and Pituitary Carcinomas: Illustrative Case Report and Literature Review Open
Introduction Aggressive pituitary adenomas (APAs) and pituitary carcinomas (PCs) are rare tumors that often recur despite surgery and radiation. Immune checkpoint inhibitors (ICI) present a promising treatment alternative for these tumors;…
View article: <scp>NT</scp> ‐ <scp>proBNP</scp> and <scp>BNP</scp> Testing in Pulmonary Arterial Hypertension: Point‐of‐Care and Remote Monitoring
<span>NT</span> ‐ <span>proBNP</span> and <span>BNP</span> Testing in Pulmonary Arterial Hypertension: Point‐of‐Care and Remote Monitoring Open
Background and Objectives Brain natriuretic peptide (BNP) and N‐terminal prohormone of BNP (NT‐proBNP) are important biomarkers in pulmonary arterial hypertension (PAH). However, results are rarely available at the time of clinical assessm…
View article: Do Hemodynamic Definitions of Chronic Thromboembolic Pulmonary Hypertension Distinguish between Distinct Phenotypes of Chronic Thromboembolic Pulmonary Disease?
Do Hemodynamic Definitions of Chronic Thromboembolic Pulmonary Hypertension Distinguish between Distinct Phenotypes of Chronic Thromboembolic Pulmonary Disease? Open
Rationale: Chronic thromboembolic pulmonary disease (CTEPD) is defined by chronic organized thrombi in the pulmonary circulation without or with pulmonary hypertension. The current definition of chronic thromboembolic pulmonary hypertensio…
View article: Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic Omalizumab in Severe Asthma in Adults: Results of the SoMOSA Study
Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic Omalizumab in Severe Asthma in Adults: Results of the SoMOSA Study Open
Background: The anti-IgE monoclonal antibody omalizumab is widely used for severe asthma. This study aimed to identify biomarkers that predict clinical improvement during 1 year of omalizumab treatment. Methods: One-year open-label Study o…
View article: Pulmonary Hypertension and Measurement of Exercise Capacity Remotely: Evaluation of the 1-min Sit-to-Stand Test (PERSPIRE) – a cohort study
Pulmonary Hypertension and Measurement of Exercise Capacity Remotely: Evaluation of the 1-min Sit-to-Stand Test (PERSPIRE) – a cohort study Open
Background Multiparameter risk assessment is recommended to aid treatment decisions in patients with pulmonary arterial hypertension. The 1-min sit-to-stand test (1MSTS) has been validated for use in other respiratory illnesses. The aim of…
View article: The characterization and regulation of n-acetyl endorphin and aMSH processing in the sheep pituitary
The characterization and regulation of n-acetyl endorphin and aMSH processing in the sheep pituitary Open
This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. M…
View article: Maximal Exercise Testing Using the Incremental Shuttle Walking Test Can Be Used to Risk-Stratify Patients with Pulmonary Arterial Hypertension
Maximal Exercise Testing Using the Incremental Shuttle Walking Test Can Be Used to Risk-Stratify Patients with Pulmonary Arterial Hypertension Open
Rationale: Exercise capacity predicts mortality in pulmonary arterial hypertension (PAH), but limited data exist on the routine use of maximal exercise testing.Objectives: This study evaluates a simple-to-perform maximal test (the incremen…
View article: A Deep Learning-Based Method for Identification of Bacteriophage-Host Interaction
A Deep Learning-Based Method for Identification of Bacteriophage-Host Interaction Open
Multi-drug resistance (MDR) has become one of the greatest threats to human health worldwide, and novel treatment methods of infections caused by MDR bacteria are urgently needed. Phage therapy is a promising alternative to solve this prob…
View article: Procleave: Predicting Protease-Specific Substrate Cleavage Sites by Combining Sequence and Structural Information
Procleave: Predicting Protease-Specific Substrate Cleavage Sites by Combining Sequence and Structural Information Open
Proteases are enzymes that cleave and hydrolyse the peptide bonds between two specific amino acid residues of target substrate proteins. Protease-controlled proteolysis plays a key role in the degradation and recycling of proteins, which i…
View article: Observed and projected intra‐seasonal variability of Australian monsoon rainfall
Observed and projected intra‐seasonal variability of Australian monsoon rainfall Open
Indices derived from daily rainfall time series are used to measure “burst” features of the northern Australia monsoon, corresponding to one or more days of heavy rainfall. These indices include number of burst days, numbers and durations …
View article: DeepCleave: a deep learning predictor for caspase and matrix metalloprotease substrates and cleavage sites
DeepCleave: a deep learning predictor for caspase and matrix metalloprotease substrates and cleavage sites Open
Motivation Proteases are enzymes that cleave target substrate proteins by catalyzing the hydrolysis of peptide bonds between specific amino acids. While the functional proteolysis regulated by proteases plays a central role in the ‘life an…
View article: A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction
A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction Open
Human leukocyte antigen class I (HLA-I) molecules are encoded by major histocompatibility complex (MHC) class I loci in humans. The binding and interaction between HLA-I molecules and intracellular peptides derived from a variety of proteo…
View article: PRISMOID: a comprehensive 3D structure database for post-translational modifications and mutations with functional impact
PRISMOID: a comprehensive 3D structure database for post-translational modifications and mutations with functional impact Open
Post-translational modifications (PTMs) play very important roles in various cell signaling pathways and biological process. Due to PTMs’ extremely important roles, many major PTMs have been studied, while the functional and mechanical cha…
View article: The incremental shuttle walk test predicts mortality in non‐group 1 pulmonary hypertension: results from the ASPIRE Registry
The incremental shuttle walk test predicts mortality in non‐group 1 pulmonary hypertension: results from the ASPIRE Registry Open
Pulmonary hypertension (PH) is classified into five groups based on disease etiology but there is only limited information on the prognostic value of exercise testing in non‐group 1 PH. In group 1 PH, the incremental shuttle walking test (…
View article: PRISMOID: a comprehensive 3D structure database for post-translational modifications and mutations with functional impact
PRISMOID: a comprehensive 3D structure database for post-translational modifications and mutations with functional impact Open
Post-translational modifications (PTMs) play very important roles in various cell signalling pathways and biological process. Due to PTMs’ extremely important roles, many major PTMs have been thoroughly studied, while the functional and me…
View article: Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathy
Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathy Open
New Findings What is the central question of this study? The aim was to determine the renoprotective effects of serelaxin in the setting of chronic heart failure. What are the main findings and its importance? Our data indicate that serela…
View article: Issue Information
Issue Information Open
In vitro quality of apheresis platelets divided into paediatric-sized
View article: Large-scale comparative assessment of computational predictors for lysine post-translational modification sites
Large-scale comparative assessment of computational predictors for lysine post-translational modification sites Open
Lysine post-translational modifications (PTMs) play a crucial role in regulating diverse functions and biological processes of proteins. However, because of the large volumes of sequencing data generated from genome-sequencing projects, sy…
View article: Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods
Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods Open
The roles of proteolytic cleavage have been intensively investigated and discussed during the past two decades. This irreversible chemical process has been frequently reported to influence a number of crucial biological processes (BPs), su…
View article: <i>Quokka</i>: a comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome
<i>Quokka</i>: a comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome Open
Motivation Kinase-regulated phosphorylation is a ubiquitous type of post-translational modification (PTM) in both eukaryotic and prokaryotic cells. Phosphorylation plays fundamental roles in many signalling pathways and biological processe…
View article: Incremental Shuttle Walking Test Distance Is Reduced in Patients With Pulmonary Hypertension in World Health Organisation Functional Class I
Incremental Shuttle Walking Test Distance Is Reduced in Patients With Pulmonary Hypertension in World Health Organisation Functional Class I Open
Background: There is increasing interest in screening for and diagnosing pulmonary hypertension earlier in the course of disease. However, there is limited data on cardiopulmonary abnormalities in patients with pulmonary hypertension newly…
View article: <i>iFeature</i>: a Python package and web server for features extraction and selection from protein and peptide sequences
<i>iFeature</i>: a Python package and web server for features extraction and selection from protein and peptide sequences Open
Summary Structural and physiochemical descriptors extracted from sequence data have been widely used to represent sequences and predict structural, functional, expression and interaction profiles of proteins and peptides as well as DNAs/RN…
View article: Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell’s Viper (Daboia russelii) Envenoming
Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell’s Viper (Daboia russelii) Envenoming Open
The study shows that myotoxicity in Sri Lankan Russell's viper envenoming is mild and non-life threatening, and due to two PLA2 toxins with weak myotoxic properties.
View article: Apparent limitations in the ability of CMIP5 climate models to simulate recent multi-decadal change in surface temperature: implications for global temperature projections
Apparent limitations in the ability of CMIP5 climate models to simulate recent multi-decadal change in surface temperature: implications for global temperature projections Open
Observed surface temperature trends over the period 1998–2012/2014 have attracted a great deal of interest because of an apparent slowdown in the rate of global warming, and contrasts between climate model simulations and observations of s…
View article: The NEAT Domain-Containing Proteins of Clostridium perfringens Bind Heme
The NEAT Domain-Containing Proteins of Clostridium perfringens Bind Heme Open
The ability of a pathogenic bacterium to scavenge iron from its host is important for its growth and survival during an infection. Our studies on C. perfringens gas gangrene strain JIR325, a derivative of strain 13, showed that it is capab…
View article: Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper Venoms
Canopy Venom: Proteomic Comparison among New World Arboreal Pit-Viper Venoms Open
Central and South American pitvipers, belonging to the genera Bothrops and Bothriechis, have independently evolved arboreal tendencies. Little is known regarding the composition and activity of their venoms. In order to close this knowledg…