Julie A. Schneider
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View article: Nose-to-brain translocation of inhaled ultrafine elongated particles: facts and mysteries
Nose-to-brain translocation of inhaled ultrafine elongated particles: facts and mysteries Open
In this study, we report that inhaled nanosized elongated mineral particles (EMPs) reach the human central nervous system (CNS) via two neuronal pathways, cranial nerve I (olfactorius) and cranial nerve V (trigeminus), from deposits on the…
View article: Gene module-trait network analysis uncovers cell type specific systems and genes relevant to Alzheimer's Disease
Gene module-trait network analysis uncovers cell type specific systems and genes relevant to Alzheimer's Disease Open
View article: Automated image segmentation uncovers the role of CD74 high human microglia in cognitive decline
Automated image segmentation uncovers the role of CD74 high human microglia in cognitive decline Open
The role of activated microglia in Alzheimer’s disease (AD) is well established; the proportion of stage III activated microglia has been associated with AD and cognitive decline, but this morphologically defined subtype is relatively unco…
View article: Sex-specific associations of gene expression with Alzheimer’s disease neuropathology and ante-mortem cognitive performance
Sex-specific associations of gene expression with Alzheimer’s disease neuropathology and ante-mortem cognitive performance Open
View article: Multi-scale integration of human brain vascular and CSF proteomes reveals biomarkers of cerebral amyloid angiopathy linked to Alzheimer’s disease risk
Multi-scale integration of human brain vascular and CSF proteomes reveals biomarkers of cerebral amyloid angiopathy linked to Alzheimer’s disease risk Open
Summary Cerebrovascular disease frequently co-occurs with amyloid-β (Aβ) plaques and tau tangles, the pathological hallmarks of Alzheimer’s disease (AD), compounding cognitive decline. Aβ deposition is also central to cerebral amyloid angi…
View article: Cytokine expression profile in the human brain of older adults
Cytokine expression profile in the human brain of older adults Open
View article: Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer’s disease heterogeneity
Integration of aged brain multi-omics reveals cross-system mechanisms underlying Alzheimer’s disease heterogeneity Open
The molecular correlates of Alzheimer’s disease (AD) are increasingly being defined by omics. Yet, the findings from different data types or cohorts are often difficult to reconcile. Collecting multiple omics from the same individuals allo…
View article: PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia
PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia Open
View article: Automated image segmentation uncovers the role of CD74<sup>high</sup> human microglia in cognitive decline
Automated image segmentation uncovers the role of CD74<sup>high</sup> human microglia in cognitive decline Open
The role of activated microglia in Alzheimer’s disease (AD) is well established; the proportion of stage III activated microglia has been associated with AD and cognitive decline, but this morphologically defined subtype is relatively unco…
View article: Vascular Contributions to Cognitive Impairment and Dementia in the United States: Prevalence and Incidence: A Scientific Statement From the American Heart Association
Vascular Contributions to Cognitive Impairment and Dementia in the United States: Prevalence and Incidence: A Scientific Statement From the American Heart Association Open
Vascular contributions to cognitive impairment and dementia (VCID) are common and may be the most preventable cause of clinically significant cognitive decline. However, an estimate of the prevalence and incidence of VCID in the United Sta…
View article: MIND Diet and Hippocampal Sclerosis Among Community-Based Older Adults
MIND Diet and Hippocampal Sclerosis Among Community-Based Older Adults Open
Importance Hippocampal sclerosis (HS), defined as severe neuronal loss and astrogliosis in coronal sections of the midhippocampus cornu ammonis 1 or subiculum, is an important pathology associated with limbic-predominant age-related transa…
View article: Cognitive decline in community-dwelling older persons with primary age-related tauopathy: role of anatomical location of tangles and other co-existing brain pathologies
Cognitive decline in community-dwelling older persons with primary age-related tauopathy: role of anatomical location of tangles and other co-existing brain pathologies Open
View article: Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex
Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex Open
Tau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer’s disease, which is associated with neurodegeneration and cognitive decline. Understanding how demographic, clinical and genetic fact…
View article: Cognitive decline across five cognitive batteries: Sample size implications for clinical trials.
Cognitive decline across five cognitive batteries: Sample size implications for clinical trials. Open
We evaluated statistical power of a theoretical 5-year randomized trial testing anti-amyloid treatments in early Alzheimer's across five cognitive composite endpoints.We leveraged annual cognitive assessment in Rush Alzheimer's Disease Cen…
View article: Neuropathological Correlates of Volume and Shape of Deep Gray Matter Structures in Community‐Based Older Adults
Neuropathological Correlates of Volume and Shape of Deep Gray Matter Structures in Community‐Based Older Adults Open
Age‐related neurodegenerative and cerebrovascular neuropathologies often coexist in the brain of older adults and contribute to brain abnormalities, cognitive decline and dementia. While deep gray matter structures are implicated early and…
View article: Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia
Publisher Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia Open
View article: Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia
Author Correction: GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia Open
Correction to: Nature Genetics 10.1038/s41588-024-01939-9, published online 8 October 2024. After publication of the article, several collaborators helpfully pointed out issues with genetic variant ID harmonization and effect allele coding…
View article: White Matter Abnormalities and Cognition in Aging and Alzheimer Disease
White Matter Abnormalities and Cognition in Aging and Alzheimer Disease Open
Importance There has yet to be a large-scale study quantifying the association between white matter microstructure and cognitive performance and decline in aging and Alzheimer disease (AD). Objective To investigate the associations between…
View article: Timing and intraindividual variability of daytime napping and Alzheimer’s disease in older adults
Timing and intraindividual variability of daytime napping and Alzheimer’s disease in older adults Open
View article: Cytokine expression profile in the human brain of older adults
Cytokine expression profile in the human brain of older adults Open
Alzheimer’s disease (AD) is a complex neurodegenerative condition linked to chronic neuroinflammation. This study investigates the cytokine gene expression profile in cortical tissue samples from elderly individuals with and without AD to …
View article: Warfarin Treatment is Associated With Lower Postmortem Brain Vitamin K Concentrations in Older Adults
Warfarin Treatment is Associated With Lower Postmortem Brain Vitamin K Concentrations in Older Adults Open
View article: A proteogenomic tool uncovers protein markers for human microglial states
A proteogenomic tool uncovers protein markers for human microglial states Open
Human microglial heterogeneity has been largely described using transcriptomic data. Here, we introduce a microglial proteomic data resource and a Cellular Indexing of Transcriptomes and Epitopes by Sequencing panel enhanced with antibodie…
View article: The MIND Diet Association With Reduced Lower Microglial Inflammation in the Hippocampus: A Community-Based Neuropathologic Study
The MIND Diet Association With Reduced Lower Microglial Inflammation in the Hippocampus: A Community-Based Neuropathologic Study Open
View article: Arteriolosclerosis in CNS Tissues Outside the Cerebrum and Late-Life Motor Impairment
Arteriolosclerosis in CNS Tissues Outside the Cerebrum and Late-Life Motor Impairment Open
BACKGROUND: The pathological basis underlying motor impairment in older adults is partially accounted for by Alzheimer disease and related dementias pathologies. We tested the hypothesis that arteriolosclerosis, a pathological correlate of…
View article: The temporal onset of associations of cortical proteins with cognitive resilience vary during late life
The temporal onset of associations of cortical proteins with cognitive resilience vary during late life Open
View article: Genotyping TOMM40’523 Poly-T Polymorphisms Using Whole-Genome Sequencing
Genotyping TOMM40’523 Poly-T Polymorphisms Using Whole-Genome Sequencing Open
The TOMM40’523 poly-T repeat polymorphism (rs10524523), located in the TOMM40 gene and in linkage disequilibrium with APOE , has been associated with cognitive decline and Alzheimer’s disease (AD) progression. Accurate genotyping of this p…
View article: Cerebral Amyloid Angiopathy Is Associated With Higher <scp>R<sub>2</sub></scp> Relaxation Rate: An <scp>MRI</scp> and Pathology Study
Cerebral Amyloid Angiopathy Is Associated With Higher <span>R<sub>2</sub></span> Relaxation Rate: An <span>MRI</span> and Pathology Study Open
Objective Cerebral amyloid angiopathy (CAA) involves β‐amyloid deposition in the walls of cortical and leptomeningeal small vessels. Transverse relaxation rate (R 2 ) is a major source of contrast in MRI. This study tested the hypothesis t…
View article: A proteogenomic tool uncovers protein markers for human microglial states
A proteogenomic tool uncovers protein markers for human microglial states Open
Human microglial heterogeneity has been largely described using transcriptomic data. Here, we introduce a microglial proteomic data resource and a Cellular Indexing of Transcriptomes and Epitopes by Sequencing panel enhanced with antibodie…
View article: A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature
A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature Open
Human microglial heterogeneity is only beginning to be appreciated at the molecular level. Here, we present a large, single-cell atlas of expression signatures from 441,088 live microglia broadly sampled across a diverse set of brain regio…
View article: Multi-omic subtypes of Alzheimer’s dementia are differentially associated with psychological traits
Multi-omic subtypes of Alzheimer’s dementia are differentially associated with psychological traits Open
Psychological traits reflecting neuroticism, depressive symptoms, loneliness, and purpose in life are risk factors of AD dementia; however, the underlying biologic mechanisms of these associations remain largely unknown. In this study we e…