David A. Boyd
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View article: A qualitative study of military service members undergoing medical separation
A qualitative study of military service members undergoing medical separation Open
Objective Little research explores military perspectives on medical disability‐related transition. A qualitative study sought to understand transition experiences of United States military Service members found unfit for duty following med…
View article: A Qualitative Study of Military Service Members Undergoing Medical Separation
A Qualitative Study of Military Service Members Undergoing Medical Separation Open
Objective: A qualitative study sought to understand the transition experiences of United States (U.S.) military Service members found “unfit for duty” following medical and physical evaluation boards (MEBs and PEBs). Methods: Confidential …
View article: Genetic and Phenotypic Characterization of the First Canadian Case of Ambler Class A Carbapenemase FRI-8
Genetic and Phenotypic Characterization of the First Canadian Case of Ambler Class A Carbapenemase FRI-8 Open
This study investigated the mechanism of carbapenem resistance in an Enterobacter cloacae complex positive by the modified carbapenem inactivation method (mCIM) but negative by the Rosco Neo-Rapid Carb Kit, β CARBA, and conventional PCR fo…
View article: Association Between Patient Race and Ethnicity and Outcomes With COVID-19: A Retrospective Analysis From a Large Mid-Atlantic Health System
Association Between Patient Race and Ethnicity and Outcomes With COVID-19: A Retrospective Analysis From a Large Mid-Atlantic Health System Open
Background Members of racial and ethnic minority groups have been disproportionately impacted by coronavirus-2019 (COVID-19). The objective of the study is to describe associations between race and ethnicity on clinical outcomes such as ne…
View article: Hydrogen Adsorption and Isotope Mixing on Copper-Functionalized Activated Carbons
Hydrogen Adsorption and Isotope Mixing on Copper-Functionalized Activated Carbons Open
High-specific surface area (SSA) carbons were functionalized with copper nanoclusters and evaluated as potential hydrogen storage materials. The adsorption and desorption behaviors of the copper-functionalized material and pristine high-SS…
View article: Investigating the Low-flux States in Six Intermediate Polars
Investigating the Low-flux States in Six Intermediate Polars Open
We present optical photometry of six intermediate polars that exhibit transitions to a low-flux state. For four of these systems, DW Cnc, V515 And, V1223 Sgr, and RX J2133.7+5107, we are able to perform timing analysis in and out of the lo…
View article: Augmented Reality-Assisted Spine Surgery: An Early Experience Demonstrating Safety and Accuracy with 218 Screws
Augmented Reality-Assisted Spine Surgery: An Early Experience Demonstrating Safety and Accuracy with 218 Screws Open
Study Design Prospective cohort study. Objectives In spine surgery, accurate screw guidance is critical to achieving satisfactory fixation. Augmented reality (AR) is a novel technology to assist in screw placement and has shown promising r…
View article: Analysis of an IncR Plasmid Carrying <i>bla</i> <sub>NDM-1</sub> Linked to an Azithromycin Resistance Region in Enterobacter hormaechei Involved in an Outbreak in Quebec
Analysis of an IncR Plasmid Carrying <i>bla</i> <sub>NDM-1</sub> Linked to an Azithromycin Resistance Region in Enterobacter hormaechei Involved in an Outbreak in Quebec Open
Analyzing the genetic environment of clinically relevant MDR genes can provide information on the way in which such genes are maintained and disseminated. Understanding this phenomenon is of interest for clinicians as it can also provide i…
View article: Absence of transmission of NDM and OXA-48 carbapenemase genes in a chronic care unit of a long-term care facility
Absence of transmission of NDM and OXA-48 carbapenemase genes in a chronic care unit of a long-term care facility Open
Infection prevention and control measures are used to contain outbreaks of carbapenemase-producing Enterobacteriaceae. We report the absence of transmission of Klebsiella pneumoniae carrying New Delhi metallo-β-lactamase and oxacillinase-4…
View article: Emergence of <i>Morganellaceae</i> Harboring <i>bla</i> <sub>IMP-27</sub> Metalloenzyme in Canada
Emergence of <i>Morganellaceae</i> Harboring <i>bla</i> <sub>IMP-27</sub> Metalloenzyme in Canada Open
Over the last decade or so, the frequency of isolation of clinical carbapenemase-producing organisms (CPOs) has increased among health care-associated infections. This may seriously compromise antimicrobial therapy, as carbapenems are cons…
View article: 837. Contamination of Hospital Drains by Carbapenemase-Producing Enterobacterales (CPE) in Ontario, Canada
837. Contamination of Hospital Drains by Carbapenemase-Producing Enterobacterales (CPE) in Ontario, Canada Open
Background The hospital water environment is a CPE reservoir, and transmission of CPE from drains to patients is a risk. Methods We cultured sink and shower drains in patient rooms and communal shower rooms that were exposed to inpatients …
View article: A Growing Concern: The Emergence and Dissemination of Carbapenemase-producing Enterobacterales (CPE) in Canada
A Growing Concern: The Emergence and Dissemination of Carbapenemase-producing Enterobacterales (CPE) in Canada Open
Background: Carbapenemase-producing Enterobacterales (CPE) have rapidly become a global health concern and are associated with substantial morbidity and mortality due to limited treatment options. Travel to endemic areas, especially health…
View article: Household Transmission of Carbapenemase-producing Enterobacterales in Ontario, Canada
Household Transmission of Carbapenemase-producing Enterobacterales in Ontario, Canada Open
Background Data on household transmission of carbapenemase-producing Enterobacterales (CPE) remain limited. We studied risk of CPE household co-colonization and transmission in Ontario, Canada. Methods We enrolled CPE index cases (identifi…
View article: Detection of Antimicrobial Resistance Using Proteomics and the Comprehensive Antibiotic Resistance Database: A Case Study
Detection of Antimicrobial Resistance Using Proteomics and the Comprehensive Antibiotic Resistance Database: A Case Study Open
Purpose Antimicrobial resistance (AMR), especially multidrug resistance, is one of the most serious global threats facing public health. The authors proof‐of‐concept study assessing the suitability of shotgun proteomics as an additional ap…
View article: 1224. Factors Associated with Aerosolization of Gammaproteobacteria from Intensive Care Unit (ICU) Sinks in a Randomized Trial of Copper Alloy vs. Standard Chrome Sink Drains
1224. Factors Associated with Aerosolization of Gammaproteobacteria from Intensive Care Unit (ICU) Sinks in a Randomized Trial of Copper Alloy vs. Standard Chrome Sink Drains Open
Background Hospital wastewater environments are recognized as reservoirs for multi-drug-resistant bacteria, and sink drains in ICUs have been implicated in numerous outbreaks. The mechanism of pathogen transmission to patients, and the bes…
View article: 1228. Risk Factors for Contamination with Carbapenemase-Producing Enterobacteriales (CPE) in Exposed Hospital Drains in Ontario, Canada
1228. Risk Factors for Contamination with Carbapenemase-Producing Enterobacteriales (CPE) in Exposed Hospital Drains in Ontario, Canada Open
Background Hospital drains may be a source of CPE in patients. We determined prevalence of and risk factors for CPE contamination of hospital drains exposed to patients with CPE colonization/infection. Methods We cultured hand hygiene and …
View article: Two Hypervirulent Klebsiella pneumoniae Isolates Producing a <i>bla</i> <sub>KPC-2</sub> Carbapenemase from a Canadian Patient
Two Hypervirulent Klebsiella pneumoniae Isolates Producing a <i>bla</i> <sub>KPC-2</sub> Carbapenemase from a Canadian Patient Open
This report describes two hypervirulent Klebsiella pneumoniae isolates that produced K. pneumoniae carbapenemase (KPC), which were identified from a rectal swab and a urine culture upon hospital admission. The patient had recently traveled…
View article: Identification of a novel metallo-β-lactamase, CAM-1, in clinical Pseudomonas aeruginosa isolates from Canada
Identification of a novel metallo-β-lactamase, CAM-1, in clinical Pseudomonas aeruginosa isolates from Canada Open
To identify the β-lactamase responsible for the positive detection of carbapenemase production in four clinical isolates of Pseudomonas aeruginosa that were negative by PCR for KPC, OXA-48, NDM, VIM, IMP, GES and NMC/IMI carbapenemase gene…
View article: Results from the Canadian Nosocomial Infection Surveillance Program for detection of carbapenemase-producing<i>Acinetobacter</i>spp. in Canadian hospitals, 2010–16
Results from the Canadian Nosocomial Infection Surveillance Program for detection of carbapenemase-producing<i>Acinetobacter</i>spp. in Canadian hospitals, 2010–16 Open
CRA remains uncommon in Canadian hospitals and the incidence did not increase from 2010 to 2016. Almost half of the cases were from two clusters harbouring OXA-235-group enzymes. Previous medical treatment during travel outside of Canada w…
View article: Characterization of OXA-48-like carbapenemase producers in Canada, 2011–14
Characterization of OXA-48-like carbapenemase producers in Canada, 2011–14 Open
Enterobacteriaceae with OXA-48-like carbapenemases are emerging in Canada. This study highlights the complexity of OXA-48-types identified in Canada owing to travel and the successful clones and plasmids harbouring the OXA-48-like enzyme.
View article: Enterobacter cloacae Complex Isolates Harboring <i>bla</i> <sub>NMC-A</sub> or <i>bla</i> <sub>IMI</sub> -Type Class A Carbapenemase Genes on Novel Chromosomal Integrative Elements and Plasmids
Enterobacter cloacae Complex Isolates Harboring <i>bla</i> <sub>NMC-A</sub> or <i>bla</i> <sub>IMI</sub> -Type Class A Carbapenemase Genes on Novel Chromosomal Integrative Elements and Plasmids Open
Carbapenem-resistant Enterobacter cloacae complex isolates submitted to a reference laboratory from 2010 to 2015 were screened by PCR for seven common carbapenemase gene groups, namely, KPC, NDM, OXA-48, VIM, IMP, GES, and NMC-A/IMI. Ninet…
View article: Retrospective Evaluation of Accelerate Pheno™ System (AXDX, Version 1.1) for Identification/Antimicrobial Susceptibility Testing (ID/AST) of Gram-Negative Bacilli (GNB) including Carbapenemase-Producing Organisms (CPO) from Seeded Blood Culture Bottles (SBCB) Tested using AXDX PhenoTestTM BC Kits
Retrospective Evaluation of Accelerate Pheno™ System (AXDX, Version 1.1) for Identification/Antimicrobial Susceptibility Testing (ID/AST) of Gram-Negative Bacilli (GNB) including Carbapenemase-Producing Organisms (CPO) from Seeded Blood Culture Bottles (SBCB) Tested using AXDX PhenoTestTM BC Kits Open
AXDX reports ID/AST in <7h from positive blood cultures. Prospective pre-FDA clinical trials were conducted in areas where CPO bacteremia was rare. This study challenged AXDX to detect CPO from SBCB. 53 GNB including 31 CPO (10 KPC, 8 OXA4…
View article: Results from the Canadian Nosocomial Infection Surveillance Program on Carbapenemase-Producing <i>Enterobacteriaceae</i> , 2010 to 2014
Results from the Canadian Nosocomial Infection Surveillance Program on Carbapenemase-Producing <i>Enterobacteriaceae</i> , 2010 to 2014 Open
Carbapenemase-producing Enterobacteriaceae (CPE) are increasing globally; here we report on the investigation of CPE in Canada over a 5-year period. Participating acute care facilities across Canada submitted carbapenem-nonsusceptible Ente…
View article: Carbapenem-Resistant<i>Enterobacter</i>spp. in Retail Seafood Imported from Southeast Asia to Canada
Carbapenem-Resistant<i>Enterobacter</i>spp. in Retail Seafood Imported from Southeast Asia to Canada Open
To the Editor: Carbapenems, antimicrobial drugs of last resort, are recommended only for severe community- and healthcare-associated multidrug-resistant bacterial infections. In Canada, carbapenem-resistant infection rates in hospitals rem…
View article: Erratum for Mangat et al., Characterization of VCC-1, a Novel Ambler Class A Carbapenemase from Vibrio cholerae Isolated from Imported Retail Shrimp Sold in Canada
Erratum for Mangat et al., Characterization of VCC-1, a Novel Ambler Class A Carbapenemase from Vibrio cholerae Isolated from Imported Retail Shrimp Sold in Canada Open
Volume 60, no. 3, p. [1819–1825][1], 2016. Page 1823, [Figure 3][2]: It was brought to our attention that the Ambler numbering in this figure was incorrect. [Figure 3][2] and its legend should appear as shown below, with corrected Ambler c…
View article: New Delhi metallo-β-lactamase in Jamaica
New Delhi metallo-β-lactamase in Jamaica Open
Introduction: The global dissemination of the New Delhi metallo-beta-lactamase (NDM) gene among certain strains of bacteria has serious implications since the infections caused by such organisms pose a therapeutic challenge. Although the N…