Akira Kanda
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View article: CCL4 Affects Eosinophil Survival via the Shedding of the MUC1 N-Terminal Domain in Airway Inflammation
CCL4 Affects Eosinophil Survival via the Shedding of the MUC1 N-Terminal Domain in Airway Inflammation Open
Eosinophilic chronic rhinosinusitis (ECRS), a CRS with nasal polyps (CRSwNP), is characterized by eosinophilic infiltration with type 2 inflammation and is highly associated with bronchial asthma. Intractable ECRS with poorly controlled as…
View article: CD69 Signaling in Eosinophils Induces IL-10 Production and Apoptosis via the Erk1/2 and JNK Pathways, Respectively
CD69 Signaling in Eosinophils Induces IL-10 Production and Apoptosis via the Erk1/2 and JNK Pathways, Respectively Open
Introduction: Eosinophils contribute to the pathogenesis of allergic diseases, including asthma, allergic rhinitis, and atopic dermatitis. We previously reported that human tissue eosinophils have high CD69 expression compared to blood eos…
View article: Mouse eosinophil‐associated ribonuclease‐2 exacerbates the allergic response
Mouse eosinophil‐associated ribonuclease‐2 exacerbates the allergic response Open
International audience
View article: Exercise to be Joyous Experiences
Exercise to be Joyous Experiences Open
Less than a third (24.2%) of US adults aged 18 and over met the 2018 Physical Activity Guidelines for Americans for both aerobic and muscle-strengthening activities set out by the Department of Health and Human Services, according to Natio…
View article: The Neutralization of the Eosinophil Peroxidase Antibody Accelerates Eosinophilic Mucin Decomposition
The Neutralization of the Eosinophil Peroxidase Antibody Accelerates Eosinophilic Mucin Decomposition Open
Eosinophilic airway inflammation, complicated by bronchial asthma and eosinophilic chronic rhinosinusitis (ECRS), is difficult to treat. The disease may become refractory when eosinophilic mucin associated with eosinophil peroxidase (EPX) …
View article: CCL4 Regulates Eosinophil Activation in Eosinophilic Airway Inflammation
CCL4 Regulates Eosinophil Activation in Eosinophilic Airway Inflammation Open
Eosinophilic chronic rhinosinusitis (ECRS) is a refractory airway disease accompanied by eosinophilic inflammation, the mechanisms of which are unknown. We recently found that CCL4/MIP-1β—a specific ligand for CCR5 receptors—was implicated…
View article: Efficacy of Combination Therapy with Lenvatinib and Radioactive Iodine in Thyroid Cancer Preclinical Model
Efficacy of Combination Therapy with Lenvatinib and Radioactive Iodine in Thyroid Cancer Preclinical Model Open
Patients with differentiated thyroid cancer (DTC) usually have good prognosis, while those with advanced disease have poor clinical outcomes. This study aimed to investigate the antitumor effects of combination therapy with lenvatinib and …
View article: CCL4 Functions as a Biomarker of Type 2 Airway Inflammation
CCL4 Functions as a Biomarker of Type 2 Airway Inflammation Open
Eosinophilic airway inflammatory disease is associated with bronchial asthma, with eosinophilic chronic rhinosinusitis (ECRS) typical of refractory type 2 airway inflammation. CCL4 produced at local inflammatory sites is involved in them v…
View article: Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report
Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report Open
Background Secretory carcinoma (SC) of the salivary gland is a recently described malignant tumor harboring characteristic ETV6-NTRK3 gene fusion. SC generally has a favorable clinical course, and is currently regarded as a low-grade carci…
View article: Additional file 2 of Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report
Additional file 2 of Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report Open
Additional file 2. All sequencing metrics indicating the quality of the samples and libraries.
View article: Additional file 4 of Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report
Additional file 4 of Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report Open
Additional file 4. List of true fusions observed after application of filters to identify only the true and strong fusions.
View article: Additional file 3 of Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report
Additional file 3 of Clinicopathological investigation of secretory carcinoma cases including a successful treatment outcome using entrectinib for high-grade transformation: a case report Open
Additional file 3. All the unfiltered fusions before application of filters to identify strong and true fusions.
View article: Omalizumab Restores Response to Corticosteroids in Patients with Eosinophilic Chronic Rhinosinusitis and Severe Asthma
Omalizumab Restores Response to Corticosteroids in Patients with Eosinophilic Chronic Rhinosinusitis and Severe Asthma Open
Eosinophilic chronic rhinosinusitis (ECRS), which is a subgroup of chronic rhinosinusitis with nasal polyps, is characterized by eosinophilic airway inflammation extending across both the upper and lower airways. Some severe cases are refr…
View article: Odontogenic Maxillary Sinusitis: Therapeutic Management of Cases with Oroantral Fistulae
Odontogenic Maxillary Sinusitis: Therapeutic Management of Cases with Oroantral Fistulae Open
Odontogenic maxillary sinusitis (OMS) is a disease in which inflammation from the teeth extend into the maxillary sinus, causing symptoms of unilateral sinusitis. OMS can recur, with some being resistant to antibiotics. In intractable case…
View article: Effects of Inhaled Corticosteroid Exhalation Through the Nose on the Nasal Bacterial Flora
Effects of Inhaled Corticosteroid Exhalation Through the Nose on the Nasal Bacterial Flora Open
好酸球性副鼻腔炎 (eosinophilic chronic rhinosinusitis: ECRS) は高率に気管支喘息を合併するため上気道から下気道まで包括的に治療する必要がある. われわれの施設では呼吸器アレルギー専門医と耳鼻咽喉科アレルギー専門医が同時に診察を行う気道アレルギー外来を設立し, 喘息合併 ECRS 症例に対し吸入ステロイド (inhaled corticosteroids: ICS) 経鼻呼出療法を中心とした局所治療を積極的に施行してきた. 炎症局所…
View article: Role of activated eosinophils on Eosinophilic chronic rhinosinusitis
Role of activated eosinophils on Eosinophilic chronic rhinosinusitis Open
好酸球性副鼻腔炎(Eosinophilic chronic rhinosinusitis: ECRS)は,高頻度に喘息を合併する難治性の慢性副鼻腔炎であり,上下気道にわたる好酸球性気道炎症である.炎症局所に浸潤している組織好酸球は,活性化し病態形成に重要な役割を果たしている.好酸球の活性化マーカーとしてCD69分子が知られているが,CD69分子の機能的役割は,十分に解明されていない.そのため我々は,好酸球性副鼻腔炎患者の組織から好酸球を単離し,好酸球の活性化とCD69の発現…
View article: Seventh Report of the Hands-on Seminar on Basic Research for Clinicians at the 59th Annual Meeting of the Japanese Rhinologic Society
Seventh Report of the Hands-on Seminar on Basic Research for Clinicians at the 59th Annual Meeting of the Japanese Rhinologic Society Open
日本鼻科学会では,鼻科学会会員を対象とした『鼻科基礎ハンズオンセミナー』を2014年より開催している。鼻科基礎ハンズオンセミナーは,研究技術の向上や研究に対するモチベーションの向上,そして各施設間の研究を通じた横断的連携を図る目的で企画された。本セミナーは,基礎研究を行っている全国の各施設の医師より構成されている。今回で7回目となる本セミナーを第59回日本鼻科学会総会・学術講演会(東京)において企画した。今年度は,①末梢血からの単核球細胞の分離,②鼻茸組織からの単核球細胞の…
View article: The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions
The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions Open
Eosinophils not only play a critical role in the pathogenesis of eosinophil-associated diseases, but they also have multiple important biological functions, including the maintenance of homeostasis, host defense against infections, immune …
View article: Reduced Local Response to Corticosteroids in Eosinophilic Chronic Rhinosinusitis with Asthma
Reduced Local Response to Corticosteroids in Eosinophilic Chronic Rhinosinusitis with Asthma Open
Eosinophilic chronic rhinosinusitis (ECRS), a subgroup of chronic rhinosinusitis with nasal polyps, is recognized as a refractory eosinophilic disorder characterized by both upper and lower airway inflammation. In some severe cases, diseas…
View article: Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings
Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings Open
These data suggest that increased CD69 expression by eosinophils is not only a biomarker for nasal obstruction and pulmonary dysfunction, but also a potential therapeutic target for patients with ECRS and asthma.
View article: Airway Medicine; Total Care for Upper and Lower Airway Inflammation, in Patients with Eosinophilic Chronic Rhino-sinusitis
Airway Medicine; Total Care for Upper and Lower Airway Inflammation, in Patients with Eosinophilic Chronic Rhino-sinusitis Open
Eosinophilic chronic rhinosinusitis (ECRS) is a known subtype of chronic rhinosinusitis, characterized by the presence of nasal polyps with eosinophilic infiltration. It is a refractory disease that often fails to resolve even with endosco…
View article: Multiple Biological Aspects of Eosinophils in Host Defense, Eosinophil-Associated Diseases, Immunoregulation, and Homeostasis: Is Their Role Beneficial, Detrimental, Regulator, or Bystander?
Multiple Biological Aspects of Eosinophils in Host Defense, Eosinophil-Associated Diseases, Immunoregulation, and Homeostasis: Is Their Role Beneficial, Detrimental, Regulator, or Bystander? Open
Eosinophils are innate immune leukocytes and play important roles as terminal effector cells owing to their mediators, such as tissue-destructive cationic proteins, cytokines, chemokines, and lipid mediators. Historically, they are not onl…
View article: A Novel Approach for Investigating Upper Airway Hyperresponsiveness Using Micro-CT in Eosinophilic Upper Airway Inflammation such as Allergic Rhinitis Model
A Novel Approach for Investigating Upper Airway Hyperresponsiveness Using Micro-CT in Eosinophilic Upper Airway Inflammation such as Allergic Rhinitis Model Open
Airway hyperresponsiveness (AHR) has been proposed as a feature of pathogenesis of eosinophilic upper airway inflammation such as allergic rhinitis (AR). The measurement system for upper AHR (UAHR) in rodents is poorly developed, although …
View article: Regulation of Interaction Between the Upper and Lower Airways in United Airway Disease
Regulation of Interaction Between the Upper and Lower Airways in United Airway Disease Open
The concept of united airway disease comprises allergic rhinitis (AR) with asthma, and eosinophilic chronic rhinosinusitis (ECRS) with asthma. It embodies a comprehensive approach to the treatment of upper and lower airway inflammation. Th…
View article: Eosinophilic Upper Airway Inflammation in a Murine Model Using an Adoptive Transfer System Induces Hyposmia and Epithelial Layer Injury with Convex Lesions
Eosinophilic Upper Airway Inflammation in a Murine Model Using an Adoptive Transfer System Induces Hyposmia and Epithelial Layer Injury with Convex Lesions Open
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a refractory upper airway disease, accompanied mainly by eosinophilia and/or asthma. In addition, the disease correlates with a high rate of hyposmia, following a marked infi…
View article: Eosinophilic Cholecystitis Occurred in a Patient With Refractory Eosinophilic Airway Inflammation: A Case Report
Eosinophilic Cholecystitis Occurred in a Patient With Refractory Eosinophilic Airway Inflammation: A Case Report Open
Background Eosinophilic cholecystitis (EC) is a rare condition that presents in a manner comparable to acute cholecystitis. The diagnosis is based on classical symptoms of cholecystitis with excessive eosinophilic infiltration within the g…
View article: Fifth Report of Hands-on Seminar on Basic Research for Clinicians at the 57<sup>th</sup> Annual Meeting of the Japanese Rhinologic Society
Fifth Report of Hands-on Seminar on Basic Research for Clinicians at the 57<sup>th</sup> Annual Meeting of the Japanese Rhinologic Society Open
日本鼻科学会では,2014年より学会主導による『鼻科基礎ハンズオンセミナー』を開催している。これは,耳鼻咽喉科臨床医の基礎研究に対するモチベーションや研究技術の向上,ひいては各大学間の研究を通じた横断的連携を図る目的で企画された。幸いなことに本セミナーへの期待度は非常に高く,セミナー後のアンケート調査ではこれまで継続を希望する意見が多数であった。今回で5回目となる本セミナーを第57回日本鼻科学会総会・学術講演会(旭川)において企画した。今年度は①鼻・副鼻腔サンプルからの細胞…
View article: Fourth Report on the Hands-on Seminar on Basic Research for Clinicians at the 56th Annual Meeting of the Japanese Rhinologic Society ~ Expanding the Range of Rhinologic Basic Research ~
Fourth Report on the Hands-on Seminar on Basic Research for Clinicians at the 56th Annual Meeting of the Japanese Rhinologic Society ~ Expanding the Range of Rhinologic Basic Research ~ Open
日本鼻科学会では,2014年より学会主導による『鼻科基礎ハンズオンセミナー』を開催している。これは,耳鼻咽喉科臨床医の基礎研究に対するモチベーションや研究技術の向上,ひいては各大学間の研究を通じた横断的連携を図る目的で企画された。幸いなことに本セミナーへの期待度は非常に高く,セミナー後のアンケート調査ではこれまで継続を希望する意見が多数であった。今回で4回目となる本セミナーを第56回日本鼻科学会総会・学術講演会(甲府)において企画した。前回を踏襲し,3つの異なったテーマをそ…