Avinash V. Karpe
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View article: Biotransformation of Canola Feedstock Waste Using Brassica Pest Microbiome: Proof of Concept for Insects as Bioengineers
Biotransformation of Canola Feedstock Waste Using Brassica Pest Microbiome: Proof of Concept for Insects as Bioengineers Open
The toxicity of glucosinolate, isothiocyanate and sinapin limits canola meal’s use as non-ruminant animal feed. While monoculture microbial biorefining has been explored, the potential and capability of insect-associated microbiomes in thi…
View article: Biotransformation of Canola Feedstock Waste Using Brassica Pest Microbiome: Proof of Concept for Insects as Bioengineers
Biotransformation of Canola Feedstock Waste Using Brassica Pest Microbiome: Proof of Concept for Insects as Bioengineers Open
Glucosinolate, isothiocyanate and sinapin toxicity limits canolameal’s use as non-ruminant animal feed. Although physico-chemical methods are effective in biorefining, they often degrade heat-sensitive, high-value compounds. While monocult…
View article: Biosynthesis of bromoform by Curvularia fungi provides a natural pathway to mitigate enteric methane emissions from ruminants
Biosynthesis of bromoform by Curvularia fungi provides a natural pathway to mitigate enteric methane emissions from ruminants Open
The ruminant livestock industry is the largest agricultural emissions source of anthropogenic greenhouse gases, primarily from enteric methane. Several technologies, both natural and synthetic are being investigated to mitigate enteric met…
View article: Biodegradation of winery biomass wastes by developing a symbiotic multi-fungal consortium
Biodegradation of winery biomass wastes by developing a symbiotic multi-fungal consortium Open
Australia is sixth largest global wine grape producer with an annual production of 1.75 million metric tonnes (2012-13). Due to poor digestibility and minor phenolic toxicity, winery biomass waste has limited use as either animal feed or c…
View article: Multi-omics analysis of hospital-acquired diarrhoeal patients reveals biomarkers of enterococcal proliferation and Clostridioides difficile infection
Multi-omics analysis of hospital-acquired diarrhoeal patients reveals biomarkers of enterococcal proliferation and Clostridioides difficile infection Open
Hospital-acquired diarrhoea (HAD) is common, and often associated with gut microbiota and metabolome dysbiosis following antibiotic administration. Clostridioides difficile is the most significant antibiotic-associated diarrhoeal (AAD) pat…
View article: Unravelling the gut-lung axis: insights into microbiome interactions and Traditional Indian Medicine's perspective on optimal health
Unravelling the gut-lung axis: insights into microbiome interactions and Traditional Indian Medicine's perspective on optimal health Open
The microbiome of the human gut is a complex assemblage of microorganisms that are in a symbiotic relationship with one another and profoundly influence every aspect of human health. According to converging evidence, the human gut is a nod…
View article: Intelligent Biological Networks: Improving Anti-Microbial Resistance Resilience through Nutritional Interventions to Understand Protozoal Gut Infections
Intelligent Biological Networks: Improving Anti-Microbial Resistance Resilience through Nutritional Interventions to Understand Protozoal Gut Infections Open
Enteric protozoan pathogenic infections significantly contribute to the global burden of gastrointestinal illnesses. Their occurrence is considerable within remote and indigenous communities and regions due to reduced access to clean water…
View article: Intelligent Biological Networks: Improving anti-microbial resistance resilience through nutritional interventions to understand protozoal gut infections
Intelligent Biological Networks: Improving anti-microbial resistance resilience through nutritional interventions to understand protozoal gut infections Open
Enteric protozoan pathogenic infections significantly contribute to the global burden of gastrointestinal illnesses. Their occurrence is considerable within remote and indigenous communities and regions due to reduced access to clean water…
View article: A pilot study: Metabolic profiling of plasma and saliva samples from newly diagnosed glioblastoma patients
A pilot study: Metabolic profiling of plasma and saliva samples from newly diagnosed glioblastoma patients Open
Background Despite aggressive treatment, more than 90% of glioblastoma (GBM) patients experience recurrences. GBM response to therapy is currently assessed by imaging techniques and tissue biopsy. However, difficulties with these methods m…
View article: Gut Microbial Perturbation and Host Response Induce Redox Pathway Upregulation along the Gut–Liver Axis during Giardiasis in C57BL/6J Mouse Model
Gut Microbial Perturbation and Host Response Induce Redox Pathway Upregulation along the Gut–Liver Axis during Giardiasis in C57BL/6J Mouse Model Open
Apicomplexan infections, such as giardiasis and cryptosporidiosis, negatively impact a considerable proportion of human and commercial livestock populations. Despite this, the molecular mechanisms of disease, particularly the effect on the…
View article: Gut Microbial Perturbation and Host Response Induces Redox Pathway Upregulation along the Gut-liver Axis during Giardiasis in C57BL/6J Mouse Model
Gut Microbial Perturbation and Host Response Induces Redox Pathway Upregulation along the Gut-liver Axis during Giardiasis in C57BL/6J Mouse Model Open
Apicomplexan infections, such as giardiasis and cryptosporidiosis, negatively impact a considerable proportion of human and commercial livestock populations. Despite this, the molecular mecha-nisms of disease, particularly the effect on th…
View article: A Time-Series Metabolomic Analysis of SARS-CoV-2 Infection in a Ferret Model
A Time-Series Metabolomic Analysis of SARS-CoV-2 Infection in a Ferret Model Open
The global threat of COVID-19 has led to an increased use of metabolomics to study SARS-CoV-2 infections in animals and humans. In spite of these efforts, however, understanding the metabolome of SARS-CoV-2 during an infection remains diff…
View article: CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19
CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19 Open
Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy to get safe, effective, and affordable COVID-19 treatments quickly is to repurpose…
View article: A Time-series Metabolomic Analysis of SARS-CoV-2 Infection in a Ferret Model
A Time-series Metabolomic Analysis of SARS-CoV-2 Infection in a Ferret Model Open
The global threat of COVID-19 has led to the increasing use of metabolomics to study SARS-CoV-2 infection in humans and animals. Despite this, understanding SARS-CoV-2's metabolome during infection remains difficult and incomplete. Here, m…
View article: Multi-Omics, an Integrated Approach to Identify Novel Blood Biomarkers of Alzheimer’s Disease
Multi-Omics, an Integrated Approach to Identify Novel Blood Biomarkers of Alzheimer’s Disease Open
The metabolomic and proteomic basis of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is poorly understood, and the relationships between systemic abnormalities in metabolism and AD/MCI pathogenesis is unclear. This study com…
View article: CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19
CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19 Open
Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy to quickly get safe, effective, and affordable COVID-19 treatment is to repurpose …
View article: Is there any biological insight (or respite) for insects exposed to plastics? Measuring the impact on an insects central carbon metabolism when exposed to a plastic feed substrate
Is there any biological insight (or respite) for insects exposed to plastics? Measuring the impact on an insects central carbon metabolism when exposed to a plastic feed substrate Open
Insects used to treat organic waste streams and produce valuable protein products are increasingly exposed to plastic contaminated source material assimilating plastic carbon into organic biomass, which is pervasive and hazardous to organi…
View article: Salivaomics as a Potential Tool for Predicting Alzheimer’s Disease During the Early Stages of Neurodegeneration
Salivaomics as a Potential Tool for Predicting Alzheimer’s Disease During the Early Stages of Neurodegeneration Open
Background: The metabolomic and proteomic basis of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) is poorly understood and the relationships between systemic abnormalities in metabolism and AD/AMCI pathogenesis are unclear. O…
View article: Cryptosporidiosis Modulates the Gut Microbiome and Metabolism in a Murine Infection Model
Cryptosporidiosis Modulates the Gut Microbiome and Metabolism in a Murine Infection Model Open
Cryptosporidiosis is a major human health concern globally. Despite well-established methods, misdiagnosis remains common. Our understanding of the cryptosporidiosis biochemical mechanism remains limited, compounding the difficulty of clin…
View article: Metabolic Profiling from an Asymptomatic Ferret Model of SARS-CoV-2 Infection
Metabolic Profiling from an Asymptomatic Ferret Model of SARS-CoV-2 Infection Open
Coronavirus disease (COVID-19) is a contagious respiratory disease that is causing significant global morbidity and mortality. Understanding the impact of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection on the ho…
View article: Cryptosporidiosis Modulates the Gut Microbiome Metabolism and Immune Response in an Infected Host
Cryptosporidiosis Modulates the Gut Microbiome Metabolism and Immune Response in an Infected Host Open
Cryptosporidiosis is a major human health concern globally. Despite well-established methods, misdiagnosis remains common. Our understanding of the cryptosporidiosis biochemical mechanism remains limited, compounding the difficulty of clin…
View article: Metabolic Profiling from an Asymptomatic Ferret Model of SARS-CoV-2 Infection
Metabolic Profiling from an Asymptomatic Ferret Model of SARS-CoV-2 Infection Open
COVID-19 is a contagious respiratory disease that is causing significant global morbidity and mortality. Understanding the impact of a SARS-CoV-2 infection on the host metabolism is still in its infancy but of great importance. Herein, we …
View article: Functional analysis of pristine estuarine marine sediments
Functional analysis of pristine estuarine marine sediments Open
Traditional environmental monitoring techniques are well suited to resolving acute exposure effects but lack resolution in determining subtle shifts in ecosystem functions resulting from chronic exposure(s). Surveillance with sensitive omi…
View article: Functional analysis of (pristine) estuarine marine sediments
Functional analysis of (pristine) estuarine marine sediments Open
Traditional environmental monitoring techniques are well suited to resolving acute exposure effects but lack resolution in determining subtle shifts in ecosystem functions resulting from chronic exposure(s). Surveillance with sensitive omi…
View article: Chemoradiation therapy changes oral microbiome and metabolomic profiles in patients with oral cavity cancer and oropharyngeal cancer
Chemoradiation therapy changes oral microbiome and metabolomic profiles in patients with oral cavity cancer and oropharyngeal cancer Open
Background Patients with oral cavity cancer (OCC) and oropharyngeal cancer (OPC) are often seen with locoregionally advanced disease requiring complex multimodality treatments. These treatments may have detrimental effects on the oral micr…
View article: Functional analysis of (pristine) estuarine marine sediments
Functional analysis of (pristine) estuarine marine sediments Open
Traditional environmental monitoring techniques are well suited to resolving acute exposure effects but lack resolution in determining subtle shifts in ecosystem functions resulting from chronic exposure(s). Surveillance with sensitive omi…
View article: Utilizing the Food–Pathogen Metabolome to Putatively Identify Biomarkers for the Detection of Shiga Toxin-Producing E. coli (STEC) from Spinach
Utilizing the Food–Pathogen Metabolome to Putatively Identify Biomarkers for the Detection of Shiga Toxin-Producing E. coli (STEC) from Spinach Open
Shiga toxigenic E. coli (STEC) are an important cause of foodborne disease globally with many outbreaks linked to the consumption of contaminated foods such as leafy greens. Existing methods for STEC detection and isolation are time-consum…
View article: Utilizing the Food-Pathogen Metabolome to Putatively Identify Biomarkers for the Detection of Shiga Toxin-Producing E. coli (STEC) from Spinach
Utilizing the Food-Pathogen Metabolome to Putatively Identify Biomarkers for the Detection of Shiga Toxin-Producing E. coli (STEC) from Spinach Open
Shiga toxigenic E. coli (STEC) are an important cause of foodborne disease globally with many outbreaks linked to the consumption of contaminated foods such as leafy greens. Existing methods for STEC detection and isolation are time-consum…
View article: Cryptosporidiosis modulates gut microbiome metabolism and the immune response in an infected host
Cryptosporidiosis modulates gut microbiome metabolism and the immune response in an infected host Open
Background Cryptosporidiosis is a major global human health concern. Despite well-established methods, misdiagnosis remain common. Resulting incorrect clinical prescription often causes anti-microbial resistance development in the patients…
View article: Modulating the Microbiome and Immune Responses Using Whole Plant Fibre in Synbiotic Combination with Fibre-Digesting Probiotic Attenuates Chronic Colonic Inflammation in Spontaneous Colitic Mice Model of IBD
Modulating the Microbiome and Immune Responses Using Whole Plant Fibre in Synbiotic Combination with Fibre-Digesting Probiotic Attenuates Chronic Colonic Inflammation in Spontaneous Colitic Mice Model of IBD Open
A probiotic and prebiotic food ingredient combination was tested for synergistic functioning in modulation of the colonic microbiome and remediation of the gastrointestinal immune and inflammatory responses in a spontaneous colitic mouse m…