Alexandre Karras
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View article: Biallelic TMEM72 variants in patients with a nephronophthisis-like phenotype
Biallelic TMEM72 variants in patients with a nephronophthisis-like phenotype Open
Introduction: Nephronophthisis (NPHP) is an autosomal recessive kidney disease resulting mainly from primary cilium defects, with unspecific and variable symptoms that can progress to kidney failure needing replacement therapy at a young a…
View article: #1993 Recommendations on management of adult-onset IgA vasculitis proposed by the European IgA vasculitis study group
#1993 Recommendations on management of adult-onset IgA vasculitis proposed by the European IgA vasculitis study group Open
Background and Aims IgA vasculitis (IgAV) is a small-vessel vasculitis with predominant IgA deposits that involves the skin, the joints, the gastrointestinal tract and the kidneys, causing glomerulonephritis pathologically indistinguishabl…
View article: Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis
Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis Open
Together, our results highlight the common role of MR signaling in the pathophysiology of extra-capillary glomerulopathies, FSGS, and crescentic glomerulonephritis. This supports the use of MR antagonists as potential complementary therape…
View article: Effect of Baseline Dialysis and Plasma Exchange on Renal Prognosis in Patients With Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis
Effect of Baseline Dialysis and Plasma Exchange on Renal Prognosis in Patients With Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis Open
View article: Pathology-oriented multiplexing enables integrative disease mapping
Pathology-oriented multiplexing enables integrative disease mapping Open
View article: Expert perspectives on incorporating glucagon-like peptide-1 receptor agonist in diabetes and chronic kidney disease: challenges and opportunities
Expert perspectives on incorporating glucagon-like peptide-1 receptor agonist in diabetes and chronic kidney disease: challenges and opportunities Open
Chronic kidney disease (CKD) is a complex and progressive condition ultimately leading to premature death. Diabetes is the leading cause of end-stage kidney disease worldwide. Up till 2024, international clinical guidelines have establishe…
View article: Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement
Treatment With Avacopan in ANCA–Associated Vasculitis With Kidney Involvement Open
In patients with GPA or MPA with kidney involvement, treatment with an avacopan regimen compared with a prednisone taper regimen achieved similar rates of remission, improved recovery of kidney function, led to faster reduction in albuminu…
View article: POS0328 EFFICACY AND SAFETY OF AVACOPAN FOR TREATMENT OF PATIENTS WITH ANCA-ASSOCIATED VASCULITIS RECEIVING CYCLOPHOSPHAMIDE
POS0328 EFFICACY AND SAFETY OF AVACOPAN FOR TREATMENT OF PATIENTS WITH ANCA-ASSOCIATED VASCULITIS RECEIVING CYCLOPHOSPHAMIDE Open
View article: POS0385 AA AMYLOIDOSIS IN A COHORT OF 312 PATIENTS: A COMPREHENSIVE STUDY ON ETIOLOGIES, DISEASE PROGRESSION AND MORTALITY
POS0385 AA AMYLOIDOSIS IN A COHORT OF 312 PATIENTS: A COMPREHENSIVE STUDY ON ETIOLOGIES, DISEASE PROGRESSION AND MORTALITY Open
View article: Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity
Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity Open
Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this stu…
View article: WCN25-1242 UPDATE TO THE LONG-TERM SAFETY AND EFFICACY OF IPTACOPAN IN C3G: 33-MONTH EXTENSION STUDY DATA FROM PATIENTS ENROLLED IN A PHASE 2 STUDY
WCN25-1242 UPDATE TO THE LONG-TERM SAFETY AND EFFICACY OF IPTACOPAN IN C3G: 33-MONTH EXTENSION STUDY DATA FROM PATIENTS ENROLLED IN A PHASE 2 STUDY Open
View article: Cognitive considerations for adults with sickle cell disease completing the brief pain inventory
Cognitive considerations for adults with sickle cell disease completing the brief pain inventory Open
Introduction: Accurate assessment of pain severity is important for caring for patients with sickle cell disease (SCD). The Brief Pain Inventory was developed to address limitations of previous pain-rating metrics and is available in a sho…
View article: Iptacopan Reduces Proteinuria and Stabilizes Kidney Function in C3 Glomerulopathy
Iptacopan Reduces Proteinuria and Stabilizes Kidney Function in C3 Glomerulopathy Open
These data provide a clinical rationale for further evaluation of long-term treatment of C3G with iptacopan.
View article: Kidney Biopsy Findings After Lung Transplantation
Kidney Biopsy Findings After Lung Transplantation Open
View article: Kidney involvement in myelodysplastic syndromes
Kidney involvement in myelodysplastic syndromes Open
Introduction The objective of this study was to describe kidney involvement in patients with myelodysplastic syndromes (MDS), their treatments, and outcomes. Methods We conducted a multicenter retrospective study in seven centers, identify…
View article: #417 Targeting parietal epithelial cell activation with mineralocorticoid receptor antagonism controls FSGS and crescentic glomerulonephritis
#417 Targeting parietal epithelial cell activation with mineralocorticoid receptor antagonism controls FSGS and crescentic glomerulonephritis Open
Background and Aims We have recently demonstrated that targeting specific pathways in parietal epithelial cells (PEC) can markedly alleviate experimental extracapillary glomerular injury [1]. Accumulating evidence has indicated the potenti…
View article: #187 Vasorin (VASN) commands podocyte quiescence and glomerular homeostasis. A novel FSGS mechanism?
#187 Vasorin (VASN) commands podocyte quiescence and glomerular homeostasis. A novel FSGS mechanism? Open
Background and Aims Podocyte dysfunction and loss of quiescence contribute to focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN). Here, we characterized the role of Vasorin (VASN) in podocytes. Method We comb…
View article: #277 Update to the long-term safety and efficacy of iptacopan in C3G: 33-month extension study data from patients enrolled in a phase 2 study
#277 Update to the long-term safety and efficacy of iptacopan in C3G: 33-month extension study data from patients enrolled in a phase 2 study Open
Background and Aims Complement 3 glomerulopathy (C3G), due to dysregulation of the alternative complement pathway (AP), is an ultra-rare primary glomerulonephritis. Iptacopan (LNP023) is an oral, proximal complement inhibitor that specific…
View article: Diagnostic Yield of APOL1 p.N264K Variant Screening in Daily Practice
Diagnostic Yield of APOL1 p.N264K Variant Screening in Daily Practice Open
View article: Non-myeloma light chain cast nephropathy: a multicenter retrospective study on clinicopathological characteristics
Non-myeloma light chain cast nephropathy: a multicenter retrospective study on clinicopathological characteristics Open
Not available.
View article: O24 <i>APOL1</i> genotype is a major determinant of lupus nephritis severity in patients of African ancestry
O24 <i>APOL1</i> genotype is a major determinant of lupus nephritis severity in patients of African ancestry Open
Objective G1 and G2 polymorphisms of APOL1 gene, exclusively found among patients of African ancestry, have been associated with chronic kidney disease (CKD) and collapsing glomerulopathy. We investigated their impact on lupus nephr…
View article: Membranous nephropathy in primary antiphospholipid syndrome
Membranous nephropathy in primary antiphospholipid syndrome Open
View article: Digital Ischemia as a Rare Manifestation of C3 Glomerulopathy Associated With Monoclonal Gammopathy
Digital Ischemia as a Rare Manifestation of C3 Glomerulopathy Associated With Monoclonal Gammopathy Open
C3 glomerulopathy (C3GP) is a group of rare glomerular diseases histologically characterized by isolated or predominant C3 deposits within glomeruli associated with glomerular inflammation. Dysregulation of complement alternative pathway w…
View article: Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy
Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy Open
Iptacopan resulted in statistically significant and clinically important reductions in UPCR and normalization of serum C3 levels in the native cohort and reduced C3 deposit scores in the recurrent KT cohort with favorable safety and tolera…
View article: Rare Variants in Complement Gene in C3 Glomerulopathy and Immunoglobulin-Mediated Membranoproliferative GN
Rare Variants in Complement Gene in C3 Glomerulopathy and Immunoglobulin-Mediated Membranoproliferative GN Open
Background C3 glomerulopathy and idiopathic immunoglobulin-mediated membranoproliferative GN (Ig-MPGN) are rare complement-mediated kidney diseases. Inherited forms of C3 glomerulopathy/Ig-MPGN are rarely described. Methods Three hundred n…
View article: Fibroblast growth factor 23 but not copeptin is independently associated with kidney failure and mortality in patients with chronic kidney disease
Fibroblast growth factor 23 but not copeptin is independently associated with kidney failure and mortality in patients with chronic kidney disease Open
Background Copeptin and intact fibroblast growth factor 23 (iFGF23) increase early during chronic kidney disease (CKD) and may be predictive of unfavourable outcomes. The aim of this study was to evaluate their respective associations with…
View article: The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial
The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial Open
View article: Membranous Nephropathy After Exposure to Immune Checkpoint Inhibitors
Membranous Nephropathy After Exposure to Immune Checkpoint Inhibitors Open
View article: Clinical and Prognostic Factors in Patients with IgG4-Related Kidney Disease
Clinical and Prognostic Factors in Patients with IgG4-Related Kidney Disease Open
Background IgG4-related kidney disease is a major manifestation of IgG4-related disease, a systemic fibroinflammatory disorder. However, the clinical and prognostic kidney-related factors in patients with IgG4-related kidney disease are in…
View article: Combining robust urine biomarkers to assess chronic kidney disease progression
Combining robust urine biomarkers to assess chronic kidney disease progression Open