Aleksandra Królicka
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View article: Adventitious and Hairy Root Cultures of Salvia apiana as a Source of Rosmarinic Acid
Adventitious and Hairy Root Cultures of Salvia apiana as a Source of Rosmarinic Acid Open
For the first time, adventitious and hairy root cultures of Salvia apiana (white sage) have been established and analyzed for the content of secondary metabolites. Non-transformed roots derived from sterile seedlings were maintained on a f…
View article: The Substantial Role of Cell and Nanoparticle Surface Properties in the Antibacterial Potential of Spherical Silver Nanoparticles [Response to Letter]
The Substantial Role of Cell and Nanoparticle Surface Properties in the Antibacterial Potential of Spherical Silver Nanoparticles [Response to Letter] Open
Marta Krychowiak-Maśnicka,1,* Weronika Paulina Wojciechowska,1,* Karolina Bogaj,1 Aleksandra Bielicka-Giełdoń,2 Ewa Czechowska,3 Magdalena Ziąbka,4 Magdalena Narajczyk,5 Anna Kawiak,6 Tomasz Mazur,7 Beata…
View article: Reynoutria japonica Houtt. Transformed Hairy Root Cultures as an Effective Platform for Producing Phenolic Compounds with Strong Bactericidal Properties
Reynoutria japonica Houtt. Transformed Hairy Root Cultures as an Effective Platform for Producing Phenolic Compounds with Strong Bactericidal Properties Open
Reynoutria japonica Houtt. is the source of various phenolic compounds: phenolic acids, flawan-3-ols, and stilbenes, with a broad range of biological activity. The rhizome (underground organ of these plants) is abundant in secondary metabo…
View article: The Substantial Role of Cell and Nanoparticle Surface Properties in the Antibacterial Potential of Spherical Silver Nanoparticles
The Substantial Role of Cell and Nanoparticle Surface Properties in the Antibacterial Potential of Spherical Silver Nanoparticles Open
Contrary to previous reports, we found that a moderate surface charge is crucial for the antibacterial activity of AgNPs, and that a significant attraction of the nanoparticle to the cell surface reduces the antibacterial potential of AgNP…
View article: Effect of Agitation and Temporary Immersion on Growth and Synthesis of Antibacterial Phenolic Compounds in Genus Drosera
Effect of Agitation and Temporary Immersion on Growth and Synthesis of Antibacterial Phenolic Compounds in Genus Drosera Open
Sundews (Drosera sp.) are the source of biologically active secondary metabolites: phenolic acids, flavonoids, and 1,4-naphtoquinones. Because obtaining them from the natural environment is impossible (rare and endangered species), in this…
View article: Elicitation of potato plants to increase their resistance against Soft Rot Pectobacteriaceae bacteria
Elicitation of potato plants to increase their resistance against Soft Rot Pectobacteriaceae bacteria Open
The investigation aimed to assess three methods for inducing resistance in Solanum tuberosum L. (potato) plants against Soft Rot Pectobacteriaceae (SRP) bacteria. The approaches involved the incorporation of elicitors into the in vitro nut…
View article: Agitated and temporary immersion bioreactor cultures of Reynoutria japonica Houtt. as a rich source of phenolic compounds
Agitated and temporary immersion bioreactor cultures of Reynoutria japonica Houtt. as a rich source of phenolic compounds Open
Reynoutria japonica Houtt. (Japanese knotweed) is an invasive plant belonging to the Polygonaceae family. However, being native to East Asia, it has been used in natural medicine for ages because of its broad range of biological activity. …
View article: Agitated cultures and temporary immersion bioreactors are effective modes of cultivation for Reynoutria japonica Houtt. and stimulate synthesis of phenolic compounds
Agitated cultures and temporary immersion bioreactors are effective modes of cultivation for Reynoutria japonica Houtt. and stimulate synthesis of phenolic compounds Open
Reynoutria japonica Houtt. (Japanese knotweed) is an invasive plant belonging to the Polygonaceae family. However, being native to east Asia, it has been used in natural medicine since ages because of broad range of biological activity. Al…
View article: Genetic Loci of Plant Pathogenic Dickeya solani IPO 2222 Expressed in Contact with Weed-Host Bittersweet Nightshade (Solanum dulcamara L.) Plants
Genetic Loci of Plant Pathogenic Dickeya solani IPO 2222 Expressed in Contact with Weed-Host Bittersweet Nightshade (Solanum dulcamara L.) Plants Open
Dickeya solani, belonging to the Soft Rot Pectobacteriaceae, are aggressive necrotrophs, exhibiting both a wide geographic distribution and a wide host range that includes many angiosperm orders, both dicot and monocot plants, cultivated u…
View article: Immunomodulatory and antibacterial effect of red wine concentrate rich in a natural complex of polyphenols under diabetes mellitus
Immunomodulatory and antibacterial effect of red wine concentrate rich in a natural complex of polyphenols under diabetes mellitus Open
Changes in immunocompetent cells influence the course of diabetes mellitus and contribute to its complications. Thus, correction of diabetes-induced immune system disorders is vital for normalizing the state of the organism. Red wine polyp…
View article: Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by <i>Staphylococcus aureus</i> in a TLR2‐dependent fashion
Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by <i>Staphylococcus aureus</i> in a TLR2‐dependent fashion Open
Filaggrin (FLG) protein is indispensable for multiple aspects of the epidermal barrier function but its accumulation in a monomeric filaggrin form may initiate premature keratinocytes death; it is unclear how filaggrin levels are controlle…
View article: In Vitro and In Vivo Studies of Antibacterial Coatings on Titanium Alloy Implants for Veterinary Application
In Vitro and In Vivo Studies of Antibacterial Coatings on Titanium Alloy Implants for Veterinary Application Open
The aim of this work was the evaluation of biological properties of hybrid coatings modified with Ag, Cu, and Zn nanoparticles (NPs) applied on TPLO medical implants by the sol-gel process. The implant coatings enriched with various concen…
View article: Temporary immersion bioreactors as a useful tool for obtaining high productivity of phenolic compounds with strong antioxidant properties from Pontechium maculatum
Temporary immersion bioreactors as a useful tool for obtaining high productivity of phenolic compounds with strong antioxidant properties from Pontechium maculatum Open
Pontechium maculatum (Russian bugloss) is a medical plant belonging to the family Boraginaceae. Although this species is known as a medical plant rich in biologically active secondary metabolites, biotechnological studies about this valuab…
View article: Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2-dependent fashion
Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2-dependent fashion Open
Filaggrin (FLG) protein is indispensable for multiple aspects of the epidermal barrier function but its accumulation in a monomeric filaggrin form may initiate premature keratinocytes death; it is unclear how filaggrin levels are controlle…
View article: Polish Achievements in Bioactive Compound Production From In Vitro Plant Cultures
Polish Achievements in Bioactive Compound Production From In Vitro Plant Cultures Open
Plant cell and organ cultures are potential sources of valuable secondary metabolites that can be used as food additives, nutraceuticals, cosmeceuticals, and pharmaceuticals. Phytochemical biosynthesis in various in vitro plant cultures, i…
View article: Exposure of Keratinocytes to Candida Albicans in the Context of Atopic Milieu Induces Changes in the Surface Glycosylation Pattern of Small Extracellular Vesicles to Enhance Their Propensity to Interact With Inhibitory Siglec Receptors
Exposure of Keratinocytes to Candida Albicans in the Context of Atopic Milieu Induces Changes in the Surface Glycosylation Pattern of Small Extracellular Vesicles to Enhance Their Propensity to Interact With Inhibitory Siglec Receptors Open
Candida albicans (C. albicans) infection is a potential complication in the individuals with atopic dermatitis (AD) and can affect clinical course of the disease. Here, using primary keratinocytes we determined that atopic milieu promotes …
View article: Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study
Stimulation of Sulfonamides Antibacterial Drugs Activity as a Result of Complexation with Ru(III): Physicochemical and Biological Study Open
Antibiotic resistance is a global problem, and one promising solution to overcome this issue is using metallodrugs, which are drugs containing metal ions and ligands. These complexes are superior to free ligands in various characteristics …
View article: Response of physiological parameters in Dionaea muscipula J. Ellis teratomas transformed with rolB oncogene
Response of physiological parameters in Dionaea muscipula J. Ellis teratomas transformed with rolB oncogene Open
Background Plant transformation with rol oncogenes derived from wild strains of Rhizobium rhizogenes is a popular biotechnology tool. Transformation effects depend on the type of rol gene, expression level, and the number of gene copies in…
View article: Potential of Silver Nanoparticles in Overcoming the Intrinsic Resistance of Pseudomonas aeruginosa to Secondary Metabolites from Carnivorous Plants
Potential of Silver Nanoparticles in Overcoming the Intrinsic Resistance of Pseudomonas aeruginosa to Secondary Metabolites from Carnivorous Plants Open
Carnivorous plants are exemplary natural sources of secondary metabolites with biological activity. However, the therapeutic antimicrobial potential of these compounds is limited due to intrinsic resistance of selected bacterial pathogens,…
View article: Short-Term Reaction of Dionaea muscipula J. Ellis Photosynthetic Apparatus after UV-A Radiation Treatment
Short-Term Reaction of Dionaea muscipula J. Ellis Photosynthetic Apparatus after UV-A Radiation Treatment Open
Dionaea muscipula J. Ellis is a South and North Carolina carnivorous endemic plant with medicinal properties. Its natural habitat is characterized by low availability of nutrients and poor plant cover, resulting in Venus flytrap exposure t…
View article: Transformed tissue of Dionaea muscipula J. Ellis as a source of biologically active phenolic compounds with bactericidal properties
Transformed tissue of Dionaea muscipula J. Ellis as a source of biologically active phenolic compounds with bactericidal properties Open
The Venus flytrap ( Dionaea muscipula J. Ellis) is a carnivorous plant able to synthesize large amounts of phenolic compounds, such as phenylpropanoids, flavonoids, phenolic acids, and 1,4-naphtoquinones. In this study, the first genetic t…
View article: Elicitation-Based Method for Increasing the Production of Antioxidant and Bactericidal Phenolic Compounds in Dionaea muscipula J. Ellis Tissue
Elicitation-Based Method for Increasing the Production of Antioxidant and Bactericidal Phenolic Compounds in Dionaea muscipula J. Ellis Tissue Open
The carnivorous plant Dionaea muscipula J. Ellis (Venus flytrap) is a widely known medical herb, capable of producing various phenolic compounds known for their strong antioxidant and antibacterial properties. In the pharmaceutical industr…
View article: Antibacterial composite hybrid coatings of veterinary medical implants
Antibacterial composite hybrid coatings of veterinary medical implants Open
The aim of the work was to develop innovative antibacterial hybrid coatings applied on implants that are used for anastomoses of animals' long bones and to assess their physicochemical and biological properties. Plates made of the titanium…
View article: 3-Chloroplumbagin Induces Cell Death in Breast Cancer Cells Through MAPK-Mediated Mcl-1 Inhibition
3-Chloroplumbagin Induces Cell Death in Breast Cancer Cells Through MAPK-Mediated Mcl-1 Inhibition Open
Resistance acquired toward anti-cancer agents is a significant drawback in breast cancer therapy. A key factor contributing to drug resistance is apoptosis suppression associated with the upregulation of anti-apoptotic Bcl-2 family protein…
View article: The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles
The Impact of Surface Functionalization on the Biophysical Properties of Silver Nanoparticles Open
Among metal-based nanoparticles, silver nanoparticles (AgNPs) are particularly appealing because of their stability, functionality, and documented antimicrobial properties. AgNPs also offer the possibility of different surface modification…
View article: Interactions of newly synthesized platinum nanoparticles with ICR-191 and their potential application
Interactions of newly synthesized platinum nanoparticles with ICR-191 and their potential application Open
One of the greatest challenges of modern medicine is to find cheaper and easier ways to produce transporters for biologically active substances, which will provide selective and efficient drug delivery to the target cells, while causing lo…
View article: Biological and Physicochemical Assessment of Middle Ear Prosthesis
Biological and Physicochemical Assessment of Middle Ear Prosthesis Open
Polymers modified with bioactive nanoparticles are a promising solution for patients who need a tissue replacement. Modern implants, thanks to bioactive and bactericidal functions, facilitate the healing and regeneration process of the rep…
View article: XV Overall Polish in vitro Culture and Plant Biotechnology Conference "Biotechnological utilization of in vitro variability"
XV Overall Polish in vitro Culture and Plant Biotechnology Conference "Biotechnological utilization of in vitro variability" Open
in Poznań where he completed the studies in biology and started to teach in 1956.He graduated in 1957 with a master's degree in botany working on the root tissue culture of carrot.Then he continued studies on male sterility in carrot which…
View article: Silver Nanoparticles Combined With Naphthoquinones as an Effective Synergistic Strategy Against Staphylococcus aureus
Silver Nanoparticles Combined With Naphthoquinones as an Effective Synergistic Strategy Against Staphylococcus aureus Open
Staphylococcus aureus is a human pathogen responsible for many antibiotic-resistant infections, for instance burn wound infections, which pose a threat to human life. Exploring possible synergy between various antimicrobial agents, like na…