Explanipedia

Evaluation of [ <sup>11</sup> C]CS1P1 in Healthy Young and Older Adults Open

Karl A. Friedrichsen, Bradley Judge, Lynne A. Jones, Jayashree Rajamanickam, Lin Qiu , et al. · 2025

In this study, we have established a quantitative ¹¹C]CS1P1 PET processing approach by using a 2-tissue compartment model and imaging-derived input function with population metabolite correction. [¹¹C]CS1P1 PET reflec…

Radiation dosimetry and fasting-dependent hepatobiliary clearance of the VAChT-specific PET radioligand 18F-VAT in humans Open

Scott A. Norris, Nelson C. Goldman, Mahdjoub Hamdi, Stephen M. Moerlein, Richard Laforest , et al. · 2025

Background The vesicular acetylcholine transporter ligand (-)-(1-((2R,3R)-8-(2-[(18)F]fluoro-ethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)(4-fluorophenyl)-methanone ( 18 F -VAT) enables positron emission tomography PE…

Development and in silico imaging trial evaluation of a deep-learning-based transmission-less attenuation compensation method for DaT SPECT Open

Zitong Yu, Md Ashequr Rahman, Zekun Li, Chunwei Ying, Hongyu An , et al. · 2025

Quantitative measures of dopamine transporter (DaT) uptake in caudate, putamen, and globus pallidus derived from DaT-single-photon emission computed tomography (SPECT) images are being investigated as biomarkers to diagnose, assess disease…

Radiation dosimetry of [11C]TZ1964B as determined by whole-body PET imaging of nonhuman primates Open

Baijayanta Maiti, Nelson C. Goldman, Mahdjoub Hamdi, Jason Lenox-Krug, Morvarid Karimi , et al. · 2025

Chemokine Receptor 2 Is a Theranostic Biomarker for Abdominal Aortic Aneurysms Open

Santiago Elizondo-Benedetto, Sergio Sastriques-Dunlop, Lisa Detering, Batool Arif, Gyu Seong Heo , et al. · 2025

Pilot first-in-human CCR2 PET/CT to detect abdominal aortic aneurysm wall instability Open

Santiago Elizondo-Benedetto, Deborah Sultan, Ryan Wahidi, Mahdjoub Hamdi, Mohamed S. Zaghloul , et al. · 2025

Objective: In a pilot first-in-human study, we aimed to evaluate the feasibility of Positron Emission Tomography/Computed Tomography (PET/CT) imaging of C-C chemokine receptor type 2 (CCR2) to aid in the diagnosis of abdominal aorti…

Addressing lung truncation in 99mTc-MAA SPECT/CT for 90Y microsphere radioembolization treatment planning Open

M.A. Thomas, Richard Laforest, John Karageorgiou, Dario Giardinà, Tyler J. Fraum , et al. · 2024

LSF and LMD can be estimated for ⁹⁰Y radioembolization using truncated lung coverage data in MAA-SPECT/CT. Empirical models to predict lung counts at full lung coverage produced LSF and LMD estimates with minimal bias and uncert…

Radiation Dosimetry and Fasting-Dependent Hepatobiliary Clearance of the VAChT- Specific PET radioligand 18F-VAT in Humans Open

Scott A. Norris, Nelson C. Goldman, Mahdjoub Hamdi, Stephen M. Moerlein, Richard Laforest , et al. · 2024

Background The vesicular acetylcholine transporter ligand (-)-(1-((2R,3R)-8-(2-[(18)F]fluoro-ethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)(4-fluorophenyl)-methanone (¹⁸F -VAT) enables positron emission tomo…

CTLESS: A Scatter-Window Projection and Deep Learning-Based Transmission-Less Attenuation Compensation Method for Myocardial Perfusion SPECT Open

Zitong Yu, Md Ashequr Rahman, Craig K. Abbey, Richard Laforest, Nancy A. Obuchowski , et al. · 2024

Attenuation compensation (AC), while being beneficial for visual-interpretation tasks in myocardial perfusion imaging (MPI) by SPECT, typically requires the availability of a separate X-ray CT component, leading to additional radiation dos…

Assessment of lesion insertion tool in pelvis PET/MR data with applications to attenuation correction method development Open

Yutaka Natsuaki, Andrew P. Leynes, Kristen A. Wangerin, Mahdjoub Hamdi, Abhejit Rajagopal , et al. · 2024

Background In modern positron emission tomography (PET) with multi‐modality imaging (e.g., PET/CT and PET/MR), the attenuation correction (AC) is the single largest correction factor for image reconstruction. One way to assess AC methods a…

Quantitative Assessments of Tumor Activity in a General Oncologic PET/CT Population: Which Metric Minimizes Tracer Uptake Time Dependence? Open

Semra İnce, Richard Laforest, Malak Itani, Vikas Prasad, Paul-Robert Derenoncourt , et al. · 2024

In oncologic PET, the SUV and standardized uptake ratio (SUR) of a viable tumor generally increase during the postinjection period. In contrast, the net influx rate (K_i ), which is derived from dynamic PET data, should re…

FAST (fast analytical simulator of tracer)-PET: an accurate and efficient PET analytical simulation tool Open

Shanwen Li, Mahdjoub Hamdi, Kaushik Dutta, Tyler J. Fraum, Jingqin Luo , et al. · 2024

Objective. Simulation of positron emission tomography (PET) images is an essential tool in the development and validation of quantitative imaging workflows and advanced image processing pipelines. Existing Monte Carlo or analytical PET sim…

Joint Regional Uptake Quantification of Thorium-227 and Radium-223 Using a Multiple-Energy-Window Projection-Domain Quantitative SPECT Method Open

Zekun Li, Nadia Benabdallah, Richard Laforest, Richard L. Wahl, Daniel L.J. Thorek , et al. · 2024

Thorium-227 ( )-based -particle radiopharmaceutical therapies ( -RPTs) are currently being investigated in several clinical and pre-clinical studies. After administration, decays to , another -particle-emitting isotope, which redistributes…

Deep learning generation of preclinical positron emission tomography (PET) images from low‐count PET with task‐based performance assessment Open

Kaushik Dutta, Richard Laforest, Jingqin Luo, Abhinav K. Jha, Kooresh I. Shoghi · 2024

Background Preclinical low‐count positron emission tomography (LC‐PET) imaging offers numerous advantages such as facilitating imaging logistics, enabling longitudinal studies of long‐ and short‐lived isotopes as well as increasing scanner…

Patlak Slope versus Standardized Uptake Value Image Quality in an Oncologic PET/CT Population: A Prospective Cross-Sectional Study Open

Semra İnce, Richard Laforest, Malak Itani, Vikas Prasad, Saeed Ashrafinia , et al. · 2024

Patlak slope (PS) images have the potential to improve lesion conspicuity compared with standardized uptake value (SUV) images but may be more artifact-prone. This study compared PS versus SUV image quality and hepatic tumor-to-background …

#27. First-in-human evaluation of safety and dosimetry of 64Cu-LLP2A for PET imaging Open

Richard Laforest, Anchal Ghai, Tyler J. Fraum, Reiko Oyama, Jennifer B. Frye , et al. · 2024

DEMIST: A Deep-Learning-Based Detection-Task-Specific Denoising Approach for Myocardial Perfusion SPECT Open

Md Ashequr Rahman, Zitong Yu, Richard Laforest, Craig K. Abbey, Barry A. Siegel , et al. · 2024

There is an important need for methods to process myocardial perfusion imaging (MPI) single-photon emission computed tomography (SPECT) images acquired at lower-radiation dose and/or acquisition time such that the processed images improve …

MIRD Pamphlet No. 29: MIRDy90—A<sup>90</sup>Y Research Microsphere Dosimetry Tool Open

Harry Marquis, Juan Camilo Ocampo Ramos, Lukas M. Carter, Pat Zanzonico, Wesley E. Bolch , et al. · 2024

⁹⁰Y-microsphere radioembolization has become a well-established treatment option for liver malignancies and is one of the first U.S. Food and Drug Administration-approved unsealed radionuclide brachytherapy devices to incorporat…

Test-Retest Repeatability of Patlak Slopes versus Standardized Uptake Values for Hypermetabolic Lesions and Normal Organs in an Oncologic PET/CT Population Open

Semra İnce, Richard Laforest, Saeed Ashrafinia, Anne M. Smith, Tyler J. Fraum , et al. · 2024

Purpose: We aimed to determine the test-retest repeatability of quantitative metrics based on the Patlak slope (PS) versus the standardized uptake value (SUV) among lesions and normal organs on oncologic [¹⁸F]FDG-PET/CT. Procedu…

Very-low-density lipoprotein triglyceride and free fatty acid plasma kinetics in women with high or low brown adipose tissue volume and overweight/obesity Open

Maria Chondronikola, Jun Yoshino, R. Ramaswamy, Joseph Daniel Giardina, Richard Laforest , et al. · 2024

Although a high amount of brown adipose tissue (BAT) is associated with low plasma triglyceride concentration, the mechanism responsible for this relationship in people is not clear. Here, we evaluate the interrelationships among BAT, very…

An automatic pipeline for PET/MRI attenuation correction validation in the brain Open

Mahdjoub Hamdi, Chunwei Ying, Hongyu An, Richard Laforest · 2023

Chemokine Receptor 2 Is A Theranostic Biomarker for Abdominal Aortic Aneurysms Open

Santiago Elizondo-Benedetto, Sergio Sastriques-Dunlop, Lisa Detering, Batool Arif, Gyu Seong Heo , et al. · 2023

Abdominal aortic aneurysm (AAA) is a degenerative vascular disease impacting aging populations with a high mortality upon rupture. There are no effective medical therapies to prevent AAA expansion and rupture. We previously demonstrated th…

DEMIST: A deep-learning-based task-specific denoising approach for myocardial perfusion SPECT. Open

Md Ashequr Rahman, Zitong Yu, Richard Laforest, Craig K. Abbey, Barry A. Siegel , et al. · 2023

There is an important need for methods to process myocardial perfusion imaging (MPI) SPECT images acquired at lower radiation dose and/or acquisition time such that the processed images improve observer performance on the clinical task of …

CCR2 imaging in human ST-segment elevation myocardial infarction Open

Kory J. Lavine, Deborah Sultan, Hannah Luehmann, Lisa Detering, Xiaohui Zhang , et al. · 2023

A list-mode multi-energy window low-count SPECT reconstruction method for isotopes with multiple emission peaks Open

Md Ashequr Rahman, Zekun Li, Zitong Yu, Richard Laforest, Daniel L.J. Thorek , et al. · 2023

SNMMI Procedure Standard/EANM Practice Guideline for Palliative Nuclear Medicine Therapies of Bone Metastases Open

Austin R. Pantel, Matthias Eiber, Dmitry Beyder, A. Tuba Kendi, Richard Laforest , et al. · 2023

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is an international scientific and professional organization founded in 1954 to promote the science, technology, and practical application of nuclear medicine. The European Asso…

A list-mode multi-energy window low-count SPECT reconstruction method for isotopes with multiple emission peaks Open

Md Ashequr Rahman, Zekun Li, Zitong Yu, Richard Laforest, Daniel L.J. Thorek , et al. · 2023

SPECT provides a mechanism to perform absorbed-dose quantification tasks for $α$-particle radiopharmaceutical therapies ($α$-RPTs). However, quantitative SPECT for $α$-RPT is challenging due to the low number of detected counts, the comple…

Joint regional uptake quantification of Thorium-227 and Radium-223 using a multiple-energy-window projection-domain quantitative SPECT method Open

Zekun Li, Nadia Benabdallah, Richard Laforest, Richard L. Wahl, Daniel L.J. Thorek , et al. · 2023

Thorium-227-based alpha-particle radiopharmaceutical therapies (α-RPTs) are being investigated in several clinical and pre-clinical studies. After administration, Thorium-227 decays to Radium-223, another alpha-particle-emitting isotope, w…

An automatic pipeline for PET/MRI attenuation correction validation in the brain Open

Mahdjoub Hamdi, Chunwei Ying, Hongyu An, Richard Laforest · 2023

Purpose PET/MRI quantitative accuracy for neurological applications is challenging due to accuracy of the PET attenuation correction. In this work, we proposed and evaluated an automatic pipeline for assessing the quantitative accuracy of …

Co-Clinical Imaging Metadata Information (CIMI) for Cancer Research to Promote Open Science, Standardization, and Reproducibility in Preclinical Imaging Open

Stephen Moore, James D. Quirk, Andrew W. Lassiter, Richard Laforest, Gregory D. Ayers , et al. · 2023

Preclinical imaging is a critical component in translational research with significant complexities in workflow and site differences in deployment. Importantly, the National Cancer Institute’s (NCI) precision medicine initiative emphasizes…

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