André Lamy
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View article: Prevention of Infections in Cardiac Surgery (PICS)-Prevena Study – A pilot/vanguard factorial cluster cross-over RCT
Prevention of Infections in Cardiac Surgery (PICS)-Prevena Study – A pilot/vanguard factorial cluster cross-over RCT Open
Sternal surgical site infections after cardiac surgery can lead to significant morbidity, mortality, and cost. The effects of negative pressure wound management and adding vancomycin as perioperative antimicrobial prophylaxis are unknown. …
View article: Association Between Electrocardiographic Changes and Myocardial Injury or Death After Cardiac Surgery
Association Between Electrocardiographic Changes and Myocardial Injury or Death After Cardiac Surgery Open
After cardiac surgery, potential ischemic ECG changes are common and have divergent associations with mortality. ST depression was associated with a higher risk of death, whereas new Q waves and T-wave inversions were associated with a low…
View article: Cost-effectiveness of apixaban vs. aspirin for the reduction of thrombo-embolism in high-risk patients with device-detected atrial fibrillation: insights from the ARTESiA trial
Cost-effectiveness of apixaban vs. aspirin for the reduction of thrombo-embolism in high-risk patients with device-detected atrial fibrillation: insights from the ARTESiA trial Open
Aims Apixaban was superior to aspirin for the prevention of stroke or systemic embolism in participants with subclinical atrial fibrillation (SCAF) in the Apixaban for the Reduction of Thromboembolism in Patients With Device-Detected Subcl…
View article: A phase 3 study of ravulizumab to protect patients with chronic kidney disease from cardiac surgery-associated acute kidney injury and major adverse kidney events (ARTEMIS)
A phase 3 study of ravulizumab to protect patients with chronic kidney disease from cardiac surgery-associated acute kidney injury and major adverse kidney events (ARTEMIS) Open
Background Cardiac procedures, particularly those requiring cardiopulmonary bypass (CPB), are associated with the development of cardiac surgery-associated acute kidney injury (CSA-AKI). Development of CSA-AKI occurs as a result of inflamm…
View article: Polygenic risk scores for risk prediction of atrial fibrillation in cardiac surgery patients: Insights from the prospective, multinational VISION cardiac surgery cohort
Polygenic risk scores for risk prediction of atrial fibrillation in cardiac surgery patients: Insights from the prospective, multinational VISION cardiac surgery cohort Open
Background New-onset postoperative atrial fibrillation (POAF) complicates 1 in 3 cardiac surgeries and is associated with morbidity, mortality and clinical AF in long-term follow-up. Clinical risk scores have modest performance for predict…
View article: Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium
Benzodiazepine-Free Cardiac Anesthesia for Reduction of Postoperative Delirium Open
Importance Delirium is common after cardiac surgery and associated with adverse outcomes. Intraoperative benzodiazepines may increase postoperative delirium but restricting intraoperative benzodiazepines has not yet been evaluated in a ran…
View article: A sub-study of the POISE-3 randomized trial examined effects of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of acute kidney injury
A sub-study of the POISE-3 randomized trial examined effects of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of acute kidney injury Open
In this pre-specified sub-study of the POISE-3 trial, we examined the effect of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of postoperative acute kidney injury (AKI). Altogether, 730…
View article: RBT-1 reduces blood product utilization in patients undergoing nonemergency coronary artery bypass grafting and/or valve surgery
RBT-1 reduces blood product utilization in patients undergoing nonemergency coronary artery bypass grafting and/or valve surgery Open
Central MessageIn this Phase 2 study, patients undergoing CABG and/or valve surgery treated with RBT-1 required less blood transfusion/blood product use compared with placebo.See Commentary on page XXX. In this Phase 2 study, patients unde…
View article: Association between overweight and obesity with coronary artery bypass graft failure: an individual patient data analysis of clinical trials
Association between overweight and obesity with coronary artery bypass graft failure: an individual patient data analysis of clinical trials Open
OBJECTIVES The association between obesity and graft failure after coronary artery bypass grafting has not been previously investigated. METHODS We pooled individual patient data from randomized clinical trials with systematic postoperativ…
View article: Cost effectiveness analysis of a fixed dose combination pill for primary prevention of cardiovascular disease from an individual participant data meta-analysis
Cost effectiveness analysis of a fixed dose combination pill for primary prevention of cardiovascular disease from an individual participant data meta-analysis Open
Population Health Research Institute.
View article: Association of the pattern of new-onset post-operative atrial fibrillation with adverse clinical events over 1 year follow-up: insights from the VISION Cardiac Surgery Cohort
Association of the pattern of new-onset post-operative atrial fibrillation with adverse clinical events over 1 year follow-up: insights from the VISION Cardiac Surgery Cohort Open
Background New-onset post-operative atrial fibrillation (AF) affects approximately 1 in 3 patients after cardiac surgery and is associated with adverse outcomes. Whether the amount of time spent in AF is associated with outcomes is unknown…
View article: The ROMA trial: 7 years of trial activities and the development of the ROMA trial network
The ROMA trial: 7 years of trial activities and the development of the ROMA trial network Open
Journal Article The ROMA trial: 7 years of trial activities and the development of the ROMA trial network Get access Mario Gaudino, Mario Gaudino Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY, USA Corresponding…
View article: Selecting conduits for coronary artery bypass grafting: caution regarding the right internal mammary artery
Selecting conduits for coronary artery bypass grafting: caution regarding the right internal mammary artery Open
This narrative review summarizes the angiographic and clinical outcome results of the most common coronary artery bypass grafting (CABG) conduits. The left internal mammary artery is the preferred first conduit to bypass the left anterior …
View article: Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial
Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial Open
BACKGROUND: Although intravenous tranexamic acid is used in cardiac surgery to reduce bleeding and transfusion, topical tranexamic acid results in lower plasma concentrations compared with intravenous tranexamic acid, which may lower the r…
View article: One-month DAPT with ticagrelor and aspirin for patients undergoing coronary artery bypass grafting: rationale and design of the randomised, multicentre, double-blind, placebo-controlled ODIN trial
One-month DAPT with ticagrelor and aspirin for patients undergoing coronary artery bypass grafting: rationale and design of the randomised, multicentre, double-blind, placebo-controlled ODIN trial Open
The optimal antiplatelet strategy after coronary artery bypass graft (CABG) surgery in patients with chronic coronary syndromes (CCS) is unclear. Adding the P2Y12 inhibitor, ticagrelor, to low-dose aspirin for 1 year is associated with a r…
View article: Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial
Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial Open
Renibus Therapeutics, Inc.
View article: One-year Outcomes after Discharge from Noncardiac Surgery and Association between Predischarge Complications and Death after Discharge: Analysis of the VISION Prospective Cohort Study
One-year Outcomes after Discharge from Noncardiac Surgery and Association between Predischarge Complications and Death after Discharge: Analysis of the VISION Prospective Cohort Study Open
Background In previous analyses, myocardial injury after noncardiac surgery, major bleeding, and sepsis were independently associated with most deaths in the 30 days after noncardiac surgery, but most of these deaths occurred during the in…
View article: Cost Implications of Left Atrial Appendage Occlusion During Cardiac Surgery: A Cost Analysis of the LAAOS III Trial
Cost Implications of Left Atrial Appendage Occlusion During Cardiac Surgery: A Cost Analysis of the LAAOS III Trial Open
Background The LAAOS III (Left Atrial Appendage Occlusion Study) clinical trial demonstrated that concomitant left atrial appendage (LAA) occlusion leads to a lower risk of ischemic stroke or systemic embolism compared with no occlusion in…
View article: Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery
Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery Open
Canadian Institutes of Health Research, National Health and Medical Research Council (Australia), and Research Grant Council of Hong Kong.
View article: Five‐Year Hospital Readmission After Coronary Artery Bypass Surgery and the Association With Off‐Pump Surgery and Sex
Five‐Year Hospital Readmission After Coronary Artery Bypass Surgery and the Association With Off‐Pump Surgery and Sex Open
Background Limited data exist on long‐term readmission and its association with patient and procedural characteristics after coronary artery bypass grafting. We aimed to investigate 5‐year readmission after coronary artery bypass grafting …
View article: Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial)
Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial) Open
Introduction Acute kidney injury (AKI) is a common complication after cardiac surgery (CS) and is associated with adverse short-term and long-term outcomes. Alpha-1-microglobulin (A1M) is a circulating glycoprotein with antioxidant, heme b…
View article: Omnia munda mundis (‘to the pure, all things are pure’)
Omnia munda mundis (‘to the pure, all things are pure’) Open
We are grateful for the opportunity to reply and comment on the Taggart et al. [1] and Freemantle et al. [2] pieces
View article: Comparison of Investigator-Reported vs Centrally Adjudicated Major Adverse Cardiac Events
Comparison of Investigator-Reported vs Centrally Adjudicated Major Adverse Cardiac Events Open
Importance In the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial, there was a significant reduction in the adjudicated primary outcome among patients with stable atherosclerotic vascular disease randomi…