Deirdre A. Lane
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View article: Informal Caregiving in Patients With Atrial Fibrillation and Multimorbidity: A Cross-European Study of Caregiver Burden, Health-Related Quality of Life, and Caregiver Engagement
Informal Caregiving in Patients With Atrial Fibrillation and Multimorbidity: A Cross-European Study of Caregiver Burden, Health-Related Quality of Life, and Caregiver Engagement Open
Background: Atrial fibrillation (AF), often accompanied by multimorbidity, places heavy demands on informal caregivers. Although caregiver burden is recognized in other chronic conditions, little is known about burden, health-related quali…
View article: Identifying rehabilitation needs as part of secondary prevention in individuals with atrial fibrillation—a Delphi consensus study
Identifying rehabilitation needs as part of secondary prevention in individuals with atrial fibrillation—a Delphi consensus study Open
Aims This study aimed to establish general consensus on a systematic needs assessment model to determine eligibility for cardiac rehabilitation (CR) as part of secondary prevention in individuals with atrial fibrillation (AF). Specific obj…
View article: 690. SERUM ELEMENTS AND OXIDATIVE STRESS INDICES ARE ALTERED IN TREATMENT-RESISTANT SCHIZOPHRENIA
690. SERUM ELEMENTS AND OXIDATIVE STRESS INDICES ARE ALTERED IN TREATMENT-RESISTANT SCHIZOPHRENIA Open
Background The molecular basis of schizophrenia (Sz) is explained by genetics and environmental factors. Around 30% of individuals with Sz have chronic illness and are often treatment-resistant (TRS). Our postmortem and MRI studies identif…
View article: 695. IRON DYSHOMEOSTASIS IS LINKED TO DOWNREGULATED AMYLOID PRECURSOR PROTEIN IN SCHIZOPHRENIA PREFRONTAL CORTEX: A POSTMORTEM STUDY
695. IRON DYSHOMEOSTASIS IS LINKED TO DOWNREGULATED AMYLOID PRECURSOR PROTEIN IN SCHIZOPHRENIA PREFRONTAL CORTEX: A POSTMORTEM STUDY Open
Background Schizophrenia is a major neuropsychiatric disorder that is often disabling and associated with progressive brain changes, which have been linked to oxidative stress. Iron, the most abundant transition metal in the brain, is crit…
Embedding Preventive Cardiac Screening in Supermarkets: A Qualitative Study of Stakeholder Perspectives on Atrial Fibrillation Detection Open
Background: Atrial fibrillation (AF) often remains undetected due to its asymptomatic nature and limited screening opportunities outside clinical settings. Expanding screening beyond traditional healthcare environments is crucial for impro…
View article: Recent-onset atrial fibrillation: challenges and opportunities
Recent-onset atrial fibrillation: challenges and opportunities Open
Atrial fibrillation (AF) is increasingly diagnosed early, close to its first occurrence due to: (i) increased public awareness with self-screening; (ii) health care initiatives including population screening and opportunistic case finding;…
View article: Coping with a chronic condition that requires lifelong medication: a qualitative study with people living with atrial fibrillation in São Paulo, Brazil
Coping with a chronic condition that requires lifelong medication: a qualitative study with people living with atrial fibrillation in São Paulo, Brazil Open
Objective To provide insight into how people cope with living with atrial fibrillation (AF) and taking oral anticoagulants (OACs), informing how services and healthcare delivery could be improved to offer the appropriate support patients r…
View article: Frailty increases the risk of hospitalization for atrial fibrillation in older adults: a population-based cohort study
Frailty increases the risk of hospitalization for atrial fibrillation in older adults: a population-based cohort study Open
Older adults with frailty present with higher hazards of AF-related hospitalizations, irrespective of the presence of multimorbidity. Further studies are needed to evaluate whether reducing frailty may prevent AF development and improve he…
Patient-reported outcome measures for atrial fibrillation: systematic review and evaluation of psychometric properties of symptom severity measures Open
Background The International Consortium for Health Outcome Measurement (ICHOM) and EHRA advocate collection of patient-reported outcomes (PROs) for benchmarking AF care. However, concerns over the robustness of available patient-reported o…
View article: Personalized Medicine, Public Health and Patient-Centred Aspects in the Prevention of Stroke in Intracerebral Haemorrhage Survivors with Atrial Fibrillation (PRESTIGE-AF) Project
Personalized Medicine, Public Health and Patient-Centred Aspects in the Prevention of Stroke in Intracerebral Haemorrhage Survivors with Atrial Fibrillation (PRESTIGE-AF) Project Open
International audience
View article: Exploring patient engagement in atrial fibrillation with multimorbidity: impact on quality of life, medication adherence and healthcare perceptions—a multicountry cross-sectional study
Exploring patient engagement in atrial fibrillation with multimorbidity: impact on quality of life, medication adherence and healthcare perceptions—a multicountry cross-sectional study Open
Objective To examine patient engagement (PE) levels of atrial fibrillation (AF) patients with multimorbidity, to identify distinct personas based on sociodemographic and clinical characteristics, as well as engagement levels, and to compar…
Qualitative study of patients’ and clinicians’ experiences of an educational intervention for warfarin therapy control in atrial fibrillation in Thailand Open
Objectives We aimed to understand the (1) perspectives of patients with atrial fibrilation (AF) regarding their experience and implementation of The SAMe-TT 2 R 2 score-guided approach in anticoagulant-nave Thai patients with atrial fibril…
View article: Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial
Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF): a multicentre, open-label, randomised, phase 3 trial Open
European Commission.
Patients’ views on stroke prevention for atrial fibrillation after an intracerebral haemorrhage: a qualitative study Open
Aim (i) To explore the attitudes of patients with atrial fibrillation (AF) towards oral anti-coagulation (OAC) for stroke prevention post-intracerebral haemorrhage (ICH) and (ii) to explore factors that influence patients’ decision-making …
View article: Prevention of Stroke in Intracerebral Haemorrhage Survivors with Atrial Fibrillation: Rationale and Design for PRESTIGE-AF Trial
Prevention of Stroke in Intracerebral Haemorrhage Survivors with Atrial Fibrillation: Rationale and Design for PRESTIGE-AF Trial Open
Adequate secondary prevention in survivors of intracerebral hemorrhage (ICH) who also have atrial fibrillation (AF) is a long-standing clinical dilemma because these patients are at increased risk of recurrent ICH as well as of ischemic st…
View article: A European network to develop virtual twin technology for personalized stroke management in atrial fibrillation: the TARGET consortium
A European network to develop virtual twin technology for personalized stroke management in atrial fibrillation: the TARGET consortium Open
Atrial fibrillation (AF) is a prevalent heart arrhythmia thatincreases stroke risk, leading to severe complications,high costs, and poor recovery outcomes. To address this,the European Union’s Horizon Europe research programme has funded t…
Relationship between systolic blood pressure and renal function on clinical outcomes in patients with atrial fibrillation: a report from the prospective AF-GEN-UK Registry Open
Background: Blood pressure (BP) extremes and renal (dys)function contribute to poor outcomes in patients with atrial fibrillation (AF). Using data from the prospective AF-GEN-UK study, we investigated the effect of systolic BP and interact…
Exercise-based cardiac rehabilitation for adults with atrial fibrillation Open
Due to few randomised participants and typically short-term follow-up, the impact of ExCR on all-cause mortality or serious adverse events for people with AF is uncertain. ExCR likely improves AF-specific measures including reduced AF recu…
View article: Key needs, quality performance indicators and outcomes for patients with atrial fibrillation and multimorbidity: The AFFIRMO study
Key needs, quality performance indicators and outcomes for patients with atrial fibrillation and multimorbidity: The AFFIRMO study Open
Background Patients with atrial fibrillation (AF) often have concomitant long-term conditions that negatively impact their quality of life and the clinical management they receive. The AFFIRMO study aimed to identify the needs, quality per…
Impact of bridging thrombolysis versus endovascular thrombectomy alone on outcomes in anticoagulated patients with atrial fibrillation and acute ischaemic stroke Open
Background and purpose The impact of bridging thrombolysis prior to endovascular thrombectomy (EVT) compared to EVT alone on intracerebral haemorrhage (ICH), subarachnoid haemorrhage (SAH), and death in anticoagulated atrial fibrillation (…
Patient engagement in multimorbidity: a systematic review of patient-reported outcome measures Open
Background People with multimorbidity are increasingly engaged, enabled, and empowered to take responsibility for managing their health status. The purpose of the study was to systematically review and appraise the psychometric properties …
View article: Development of a quality of life measure for left ventricular assist device recipients using a mixed methods approach
Development of a quality of life measure for left ventricular assist device recipients using a mixed methods approach Open
Background Left ventricular assist device (LVAD) recipients report symptom improvement but find adjusting to life with the LVAD challenging. These challenges are unique, and existing patient‐reported outcome measures (PROMs) do not reflect…
Systematic Review and Meta‐Analysis of Prehospital Machine Learning Scores as Screening Tools for Early Detection of Large Vessel Occlusion in Patients With Suspected Stroke Open
Background Enhanced detection of large vessel occlusion (LVO) through machine learning (ML) for acute ischemic stroke appears promising. This systematic review explored the capabilities of ML models compared with prehospital stroke scales …
View article: Standardized assessment of evidence supporting the adoption of mobile health solutions: A Clinical Consensus Statement of the ESC Regulatory Affairs Committee
Standardized assessment of evidence supporting the adoption of mobile health solutions: A Clinical Consensus Statement of the ESC Regulatory Affairs Committee Open
Mobile health (mHealth) solutions have the potential to improve self-management and clinical care. For successful integration into routine clinical practice, healthcare professionals (HCPs) need accepted criteria helping the mHealth soluti…
107 Implementation of health qigong and Tai Chi exercises on quality of life and physical functioning in patients with atrial fibrillation: a feasibility study Open
Introduction Cardiac rehabilitation programmes have demonstrated the benefits of exercise for people with atrial fibrillation (AF). Traditional Chinese low to moderate-intensity exercises like Tai Chi and Qi Gong may be suitable for older …
Quality of life in patients with atrial fibrillation and multimorbidity, and their caregivers: results from the AFFIRMO international online survey Open
Introduction Patients with atrial fibrillation (AF) often have additional concomitant chronic conditions that affect their clinical management and quality of life (QoL). The AFFIRMO study aims to examine ways of optimising care and self-ma…
View article: Effectiveness and cost-effectiveness of a web-based cardiac rehabilitation programme for people with chronic stable angina: protocol for the ACTIVATE (Angina Controlled Trial Investigating the Value of the ‘Activate your heart’ Therapeutic E-intervention) randomised controlled trial
Effectiveness and cost-effectiveness of a web-based cardiac rehabilitation programme for people with chronic stable angina: protocol for the ACTIVATE (Angina Controlled Trial Investigating the Value of the ‘Activate your heart’ Therapeutic E-intervention) randomised controlled trial Open
Introduction Chronic stable angina is common and disabling. Cardiac rehabilitation is routinely offered to people following myocardial infarction or revascularisation procedures and has the potential to help people with chronic stable angi…