Alison B. Lansley
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Advances in Nasal Biopharmaceutics to Support Product Development and Therapeutic Needs Open
Background/Objectives: Nasal biopharmaceutics is the scientific understanding of product and patient factors that determine the rate and extent of drug exposure following nasal administration. The authors considered whether current biophar…
Evaluation of <i>in vitro</i> rat and human airway epithelial models for acute inhalation toxicity testing Open
In vivo models (mostly rodents) are currently accepted by regulatory authorities for assessing acute inhalation toxicity. Considerable efforts have been made in recent years to evaluate in vitro human airway epithelial models (HAEM) as rep…
Increasing Cellular Uptake and Permeation of Curcumin Using a Novel Polymer-Surfactant Formulation Open
Several therapeutically active molecules are poorly water-soluble, thereby creating a challenge for pharmaceutical scientists to develop an active solution for their oral drug delivery. This study aimed to investigate the potential for nov…
View article: Stability testing of the Pfizer-BioNTech BNT162b2 COVID-19 vaccine: a translational study in UK vaccination centres
Stability testing of the Pfizer-BioNTech BNT162b2 COVID-19 vaccine: a translational study in UK vaccination centres Open
These results reiterate the importance of adhering to the manufacturer's instructions on handling, especially with regard to shaking and exposing the vaccine to excessive vibration.
Evaluation of the toxicity of sodium dodecyl sulphate (SDS) in the MucilAir™ human airway model in vitro Open
The aim of the study was to use multiple in vitro assays to assess the effects of a model irritant, sodium dodecyl sulphate (SDS) (≤10 mM (0.29 %, w/v)), on an in vitro model of the airway, MucilAir™. The use of MucilAir™ in recovery studi…
Budesonide and Theophylline Co-encapsulated PLA Nanoparticles for Pulmonary Drug Delivery Open
Background: A novel co-encapsulated nanoparticle (NP) system using the anti-asthmatic drugs theophylline and budesonide and the biodegradable polymer poly (lactic acid) (PLA) was synthesised using a modified double emulsification solvent d…