Davide Lelli
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View article: Are we doing our best to contain the spread of West Nile virus? Evaluating intervention efficacy through mathematical modelling
Are we doing our best to contain the spread of West Nile virus? Evaluating intervention efficacy through mathematical modelling Open
Background West Nile virus (WNV) is an emerging vector-borne pathogen that is becoming increasingly prevalent in temperate regions. The development of effective intervention strategies is crucial for limiting its spread; however, the adapt…
View article: From North to South: transmission dynamics of H1N1pdm09 swine influenza A viruses in Italy
From North to South: transmission dynamics of H1N1pdm09 swine influenza A viruses in Italy Open
The influenza A H1N1pdm09 virus continues to pose a significant zoonotic threat, with implications for both animal and human health. Italy, which hosts one of the largest swine populations in Europe, is strategically positioned to monitor …
View article: Identification of Reassortant Mammalian Orthoreovirus Strains in European Hedgehogs (Erinaceus europaeus): Genomic Insights and Host Association
Identification of Reassortant Mammalian Orthoreovirus Strains in European Hedgehogs (Erinaceus europaeus): Genomic Insights and Host Association Open
Thanks to its ethological and physiological characteristics, the hedgehog is a synanthropic species of particular importance for the maintenance and possible spread of pathogens, some of which are zoonotic. Among these, we can include the …
View article: Exploring Bat–Virus Interactions: Insights from a Study in the Gobi Desert
Exploring Bat–Virus Interactions: Insights from a Study in the Gobi Desert Open
In May 2022, an expedition was conducted in the Gobi Desert, Mongolia, to investigate the viral diversity of bats, recognized as reservoirs of emerging zoonotic viruses. Bats were captured in six oases using mist nets and were identified m…
View article: Angiotensin Converting Enzyme 2 is a molecular decoy for targeted photodynamic SARS-CoV-2 inactivation
Angiotensin Converting Enzyme 2 is a molecular decoy for targeted photodynamic SARS-CoV-2 inactivation Open
The Angiotensin Converting Enzyme 2 (ACE2) is the obligate receptor for the entry of SARS-CoV-2 into host cells, through high affinity interaction with the viral protein Spike. In this work, ACE2 is exploited to devise a supramolecular con…
View article: Sequential use of electrochemical and myco-remediation for sustainable depollution of hydrocarbon contaminated soils
Sequential use of electrochemical and myco-remediation for sustainable depollution of hydrocarbon contaminated soils Open
During the past decade, electrokinetic remediation and its associated hybrid technologies have emerged as new technologies for removal of organic pollutants from contaminated soils. To address hydrocarbon-contaminated soils, a novel myco-e…
View article: Evidence of autophagic and Wnt/β-catenin signaling occurrence during Schmallenberg virus (SBV) infection on BHK-21 cells
Evidence of autophagic and Wnt/β-catenin signaling occurrence during Schmallenberg virus (SBV) infection on BHK-21 cells Open
Schmallenberg virus (SBV) is a ruminant pathogen that is widely distributed around the world, but little is known about its interactions with permissive cells or about its pathogenetic mechanisms. This study highlighted, through a phenotyp…
View article: Development of a novel amplicon based whole-genome sequencing framework for improved surveillance of Toscana virus
Development of a novel amplicon based whole-genome sequencing framework for improved surveillance of Toscana virus Open
Toscana virus (TOSV), a Phlebovirus transmitted by sandflies, is a leading cause of aseptic meningitis in the Mediterranean region. Despite its clinical significance, underreporting and limited availability of complete genomic data hinder …
View article: Virological Passive Surveillance of Avian Influenza and Arboviruses in Wild Birds: A Two-Year Study (2023–2024) in Lombardy, Italy
Virological Passive Surveillance of Avian Influenza and Arboviruses in Wild Birds: A Two-Year Study (2023–2024) in Lombardy, Italy Open
Avian influenza (AI), caused by Alphainfluenzavirus (family Orthomyxoviridae), poses significant threats to poultry, biodiversity, and public health. AI outbreaks in poultry lead to severe economic losses, while highly pathogenic strains (…
View article: Pushing Forward West Nile Virus Understanding: An Integrated One Health Genomic Surveillance Journey in Romagna (Italy)
Pushing Forward West Nile Virus Understanding: An Integrated One Health Genomic Surveillance Journey in Romagna (Italy) Open
Introduction: In Italy, despite the existence of an epidemiological surveillance system for Arboviruses, managed in a One Health perspective, the implementation of genomic characterisation remains fragmented and no systematic genomic surve…
View article: Neurotropic Tick-Borne Flavivirus in Alpine Chamois (Rupicapra rupicapra rupicapra), Austria, 2017, Italy, 2023
Neurotropic Tick-Borne Flavivirus in Alpine Chamois (Rupicapra rupicapra rupicapra), Austria, 2017, Italy, 2023 Open
The European subtype of tick-borne encephalitis virus (TBEV-Eur; species Orthoflavivirus encephalitidis, family Flaviviridae) was the only tick-borne flavivirus present in central Europe known to cause neurologic disease in humans and seve…
View article: The 2023 dengue outbreak in Lombardy, Italy: A one-health perspective
The 2023 dengue outbreak in Lombardy, Italy: A one-health perspective Open
This report highlights the importance of synergic surveillance, including virological, entomological and public health measures to control the spread of arboviral infections.
View article: From North to South: Transmission Dynamics of H1N1pdm09 Swine Influenza A Viruses in Italy
From North to South: Transmission Dynamics of H1N1pdm09 Swine Influenza A Viruses in Italy Open
The influenza A H1N1pdm09 virus continues to be a significant pathogen, posing potential risks to both animal and human health due to its zoonotic potential. Italy, which has one of the largest swine populations in Europe, plays a crucial …
View article: Distribution and abundance of Aedes caspius (Pallas, 1771) and Aedes vexans (Meigen, 1830) in the Po Plain (northern Italy)
Distribution and abundance of Aedes caspius (Pallas, 1771) and Aedes vexans (Meigen, 1830) in the Po Plain (northern Italy) Open
Background Knowledge of the distribution and abundance of disease-causing mosquito vectors is fundamental for assessing the risk of disease circulation and introduction. Aedes caspius (Pallas, 1771) and Aedes vexans (Meigen, 1830) have bee…
View article: Human-swine interface: is the hepatitis E virus a real risk for humans?
Human-swine interface: is the hepatitis E virus a real risk for humans? Open
Background Hepatitis E virus (HEV) is the agent of hepatitis E, an emerging public-health infection with an increasing incidence in Europe. Due to the apparent lack of species barriers, HEV is considered a zoonotic agent, with swine as the…
View article: Development of two competitive ELISAs based on monoclonal antibodies for the serological detection of Bovine ephemeral fever virus
Development of two competitive ELISAs based on monoclonal antibodies for the serological detection of Bovine ephemeral fever virus Open
Bovine ephemeral fever virus (BEFV) is a member of the genus Ephemerovirus in the family Rhabdoviridae. It is an arthropod-borne virus transmitted by many species of midges and mosquitoes. It can cause severe economic consequences due to l…
View article: Isolation and Molecular Evidence of Tunisian Sheep-like Pestivirus (Pestivirus N) in Persistently Infected Sheep in Northern Italy, 2023
Isolation and Molecular Evidence of Tunisian Sheep-like Pestivirus (Pestivirus N) in Persistently Infected Sheep in Northern Italy, 2023 Open
Over the last few decades, several pestiviruses have been discovered in ruminants, pigs, and, more recently, in non-ungulate hosts. Consequently, the nomenclature and taxonomy of pestiviruses have been updated. The Tunisian sheep-like pest…
View article: Strategic Challenges to the Eradication of African Swine Fever Genotype II in Domestic Pigs in North Italy
Strategic Challenges to the Eradication of African Swine Fever Genotype II in Domestic Pigs in North Italy Open
African swine fever (ASF) is a severe viral disease characterized by high lethality in suids and caused by the African Swine Fever Virus (ASFV). The ASF genotype I virus was introduced to Europe in 1957, marking the onset of the first Euro…
View article: Molecular and Serological Detection of Bovine Coronaviruses in Marmots (Marmota marmota) in the Alpine Region
Molecular and Serological Detection of Bovine Coronaviruses in Marmots (Marmota marmota) in the Alpine Region Open
In this study, virological surveillance focused on coronaviruses in marmots in the Alpine region in 2022, captured as part of a population control reduction program in the Livigno area. Seventy-six faecal samples were randomly collected fr…
View article: First Reported Circulation of Equine Influenza H3N8 Florida Clade 1 Virus in Horses in Italy
First Reported Circulation of Equine Influenza H3N8 Florida Clade 1 Virus in Horses in Italy Open
Background: Equine influenza (EI) is a highly contagious viral disease of equids characterized by pyrexia and respiratory signs. Like other influenza A viruses, antigenic drift or shift could lead to a vaccine-induced immunity breakdown if…
View article: Tick-Borne Encephalitis, Lombardy, Italy
Tick-Borne Encephalitis, Lombardy, Italy Open
Tick-borne encephalitis was limited to northeast portions of Italy. We report in Lombardy, a populous region in the northwest, a chamois displaying clinical signs of tickborne encephalitis virus that had multiple virus-positive ticks attac…
View article: Presence and Characterisation of Porcine Respirovirus 1 (PRV1) in Northern Italy
Presence and Characterisation of Porcine Respirovirus 1 (PRV1) in Northern Italy Open
Porcine Respirovirus 1 (PRV1) is an enveloped, single-stranded, negative-sense RNA virus belonging to the genus Respirovirus within the Paramyxoviridae family. Since its first detection in China in 2013, PRV1 has been identified in several…