Paul Lips
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View article: Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline
Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline Open
Background Numerous studies demonstrate associations between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and a variety of common disorders, including musculoskeletal, metabolic, cardiovascular, malignant, autoimmune, and infectio…
View article: A Systematic Review Supporting the Endocrine Society Clinical Practice Guidelines on Vitamin D
A Systematic Review Supporting the Endocrine Society Clinical Practice Guidelines on Vitamin D Open
Context Low vitamin D status is common and is associated with various common medical conditions. Objective To support the development of the Endocrine Society's Clinical Practice Guideline on Vitamin D for the Prevention of Disease. Method…
View article: Long-term trajectories of peak expiratory flow rate in older men and women show linear decline mainly determined by baseline levels
Long-term trajectories of peak expiratory flow rate in older men and women show linear decline mainly determined by baseline levels Open
Background Peak expiratory flow rate (PEFR) predicts mortality and other negative health outcomes. However, little evidence exists on how PEFR changes with ageing and how trajectories of change differ among older people. Aims To identify t…
View article: Methodological aspects of <i>in vivo</i> axial loading in rodents: a systematic review.
Methodological aspects of <i>in vivo</i> axial loading in rodents: a systematic review. Open
Axial loading in rodents provides a controlled setting for mechanical loading, because load and subsequent strain, frequency, number of cycles and rest insertion between cycles, are precisely defined. These methodological aspects as well a…
View article: Mechanical loading modulates phosphate related genes in rat bone
Mechanical loading modulates phosphate related genes in rat bone Open
Mechanical loading determines bone mass and bone structure, which involves many biochemical signal molecules. Of these molecules, Mepe and Fgf23 are involved in bone mineralization and phosphate homeostasis. Thus, we aimed to explore wheth…
View article: Vitamin D in the older population: a consensus statement
Vitamin D in the older population: a consensus statement Open
The results of this conference has led to consensus on several issues. Vitamin D supplementation should be combined with calcium to reduce fractures in the older population. The goal for adequate Vitamin D status should be to reach a serum…
View article: Common genetic variant of GC associated with vitamin D deficiency in a Chinese population in the Netherlands
Common genetic variant of GC associated with vitamin D deficiency in a Chinese population in the Netherlands Open
Background Genome-wide association studies among European populations have identified four single nucleotide polymorphisms (SNPs) in genes involved in vitamin D transport and metabolism affecting 25-hydroxyvitamin D [25(OH)D] concentration…
View article: The Association Between the Kyphosis Angle and Physical Performance in Community-Dwelling Older Adults
The Association Between the Kyphosis Angle and Physical Performance in Community-Dwelling Older Adults Open
Background We investigated prospectively among community-dwelling older adults aged 65 years and older whether a larger kyphosis angle is associated with poorer physical performance (balance, muscle strength, or both), and whether this ass…
View article: Vitamin D supplementation in chronic obstructive pulmonary disease patients with low serum vitamin D: a randomized controlled trial
Vitamin D supplementation in chronic obstructive pulmonary disease patients with low serum vitamin D: a randomized controlled trial Open
Vitamin D supplementation did not reduce exacerbation rate in COPD patients with a vitamin D deficiency.This trial was registered at clinicaltrials.gov as NCT02122627.
View article: Trends in Vitamin <scp>D</scp> Status Around the World
Trends in Vitamin <span>D</span> Status Around the World Open
Vitamin D status varies across all continents and countries. Vitamin D status usually is adequate in Latin America and Australia, but in contrast it is very low in the Middle East and some countries in Asia. Trends in vitamin D status, whe…
View article: Vitamin D Supplementation and Fractures in Adults: A Systematic Umbrella Review of Meta-Analyses of Controlled Trials
Vitamin D Supplementation and Fractures in Adults: A Systematic Umbrella Review of Meta-Analyses of Controlled Trials Open
Context The growing number of systematic reviews/meta-analyses (SR/MAs) on vitamin D (± calcium) for fracture prevention has led to contradictory guidelines. Objective This umbrella review aims to assess the quality and explore the reasons…
View article: Titrating Growth Hormone Dose to High-Normal IGF-1 Levels Has Beneficial Effects on Body Fat Distribution and Microcirculatory Function Despite Causing Insulin Resistance
Titrating Growth Hormone Dose to High-Normal IGF-1 Levels Has Beneficial Effects on Body Fat Distribution and Microcirculatory Function Despite Causing Insulin Resistance Open
To clarify the mechanism underlying the described U-shaped relation of both low and high levels of IGF-1 with cardiovascular disease this study explores the effect of decreasing and increasing growth hormone dose in GH deficient adults on …
View article: Controversies in Vitamin D: A Statement From the Third International Conference
Controversies in Vitamin D: A Statement From the Third International Conference Open
The Third International Conference on Controversies in Vitamin D was held in Gubbio, Italy, September 10–13, 2019. The conference was held as a follow‐up to previous meetings held in 2017 and 2018 to address topics of controversy in vitami…
View article: Mechanical stress regulates bone regulatory gene expression independent of estrogen and vitamin D deficiency in rats
Mechanical stress regulates bone regulatory gene expression independent of estrogen and vitamin D deficiency in rats Open
Mechanical stress determines bone mass and structure. It is not known whether mechanical loading affects expression of bone regulatory genes in a combined deficiency of estrogen and vitamin D. We studied the effect of mechanical loading on…
View article: Regimens of vitamin D supplementation for women during pregnancy
Regimens of vitamin D supplementation for women during pregnancy Open
Supplementing pregnant women with more than the current vitamin D recommendation may reduce the risk of gestational diabetes; however, it may make little or no difference to the risk of pre-eclampsia, preterm birth and low birthweight. Sup…
View article: Agreement between measurement of 25-hydroxyvitamin D3 in dried blood spot samples and serum in a Chinese population in the Netherlands
Agreement between measurement of 25-hydroxyvitamin D3 in dried blood spot samples and serum in a Chinese population in the Netherlands Open
Blood for determining 25-hydroxyvitamin D3 [25(OH)D3] is usually obtained through venipuncture although, as an alternative for serum, dried blood spot (DBS) can be considered. The aim of this proof-of-concept study was to investigate level…
View article: Vitamin D: Giveth to Those Who Needeth
Vitamin D: Giveth to Those Who Needeth Open
Severe vitamin D deficiency may cause rickets. While this point is not disputed, the use of vitamin D in the elderly to prevent fractures has been challenged recently by a meta‐analysis of 81 RCTs, suggesting that the effects of vitamin D …
View article: The Effect of a Screening and Treatment Program for the Prevention of Fractures in Older Women: A Randomized Pragmatic Trial
The Effect of a Screening and Treatment Program for the Prevention of Fractures in Older Women: A Randomized Pragmatic Trial Open
Population screening for fracture risk may reduce the fracture incidence. In this randomized pragmatic trial, the SALT Osteoporosis Study (SOS), we studied whether screening for fracture risk and subsequent treatment in primary care can re…