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View article: P01.18.B MODELING GLIOBLASTOMA TREATMENT RESPONSES: INSIGHTS INTO TUMOR PLASTICITY AND THE ROLE OF THE TUMOR MICROENVIRONMENT
P01.18.B MODELING GLIOBLASTOMA TREATMENT RESPONSES: INSIGHTS INTO TUMOR PLASTICITY AND THE ROLE OF THE TUMOR MICROENVIRONMENT Open
BACKGROUND Glioblastoma relapse remains inevitable, placing these tumors among the most difficult to treat. Treatment challenges include inherent drug resistance, tumour’s plastic nature, and suppressive tumour microenvironment (TME). In o…
View article: OS03.5.A FUNCTIONAL PRECISION MEDICINE SCREENING REVEALS PERSONALIZED THERAPEUTIC VULNERABILITIES IN HIGH-GRADE GLIOMA SUBTYPES
OS03.5.A FUNCTIONAL PRECISION MEDICINE SCREENING REVEALS PERSONALIZED THERAPEUTIC VULNERABILITIES IN HIGH-GRADE GLIOMA SUBTYPES Open
BACKGROUND Precision medicine has transformed cancer treatment by tailoring therapies to the specific molecular aberrations of an individual patient’s tumor. The integration of high-resolution multi-omics with high-throughput functional pr…
View article: OS05.2.A DECIPHERING THE LONGITUDINAL TRAJECTORIES OF GLIOBLASTOMA ECOSYSTEMS BY INTEGRATIVE SINGLE-CELL GENOMICS
OS05.2.A DECIPHERING THE LONGITUDINAL TRAJECTORIES OF GLIOBLASTOMA ECOSYSTEMS BY INTEGRATIVE SINGLE-CELL GENOMICS Open
BACKGROUND The mechanisms governing the progression of IDH-wildtype glioblastoma (GBM) following standard-of-care therapy remain incompletely understood. While recurrence is nearly universal, the cellular and molecular trajectories that un…
View article: P10.21.B Pharmacogenomics profiling of gliomas for precision medicine
P10.21.B Pharmacogenomics profiling of gliomas for precision medicine Open
Background Molecular characterization based on genomic, transcriptomic and epigenetic profiling has led to a better delineation of various glioma subtypes and highlighted the individual paths of glioma evolution upon treatment and recurren…