Explanipedia

Chronic pain selectively reduces the motivation to work for remifentanil but not food reward Open

Lindsay M. Lueptow, Leeza Shashkova, Emma Twombly, Hugo Greenhill, Hongyan Yang , et al. · 2025

Currently, preclinical research has reported conflicting evidence as to whether chronic pain imparts resilience or vulnerability to opioid drug seeking. Here, we investigated the impact of chronic pain on the intravenous self-administratio…

Interfacing with the Brain: How Nanotechnology Can Contribute Open

Abdullah Ahmed Ali Ahmed, Núria Alegret, Bethany Almeida, Ramón A. Álvarez‐Puebla, Anne M. Andrews , et al. · 2025

Interfacing artificial devices with the human brain is the central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain-machine interfaces have changed ov…

SeroWare: An Open-Source Software Suite for Voltammetry Data Acquisition and Analysis Open

Cameron S. Movassaghi, Rahul K. Iyer, Michael Curry, Mila E. Wesely, Miguel Alcañíz , et al. · 2025

Voltammetry is widely used for fast, data-dense measurements of redox-active analytes in versatile environments, including the brain. Voltammetry requires minimal hardware beyond a potentiostat, a front-end amplifier, and a computer. Nonet…

Safety in treatment: Classical pharmacotherapeutics and new avenues for addressing maternal depression and anxiety during pregnancy Open

Merel Dagher, Catherine M. Cahill, Anne M. Andrews · 2025

We aimed to review clinical research on the safety profiles of antidepressant drugs and associations with maternal depression and neonatal outcomes. We focused on neuroendocrine changes during pregnancy and their effects on antidepressant …

Machine-learning-guided design of electroanalytical pulse waveforms Open

Cameron S. Movassaghi, Katie A. Perrotta, Michael Curry, Audrey N. Nashner, K. Nguyen , et al. · 2025

Bayesian optimization outperforms random- and human-designed waveforms for electrochemical detection of serotonin in physiologically-relevant environments.

SeroWare: An Open-Source Software Suite for Voltammetry Data Acquisition and Analysis Open

Cameron S. Movassaghi, Rahul K. Iyer, Michael Curry, Mila E. Wesely, Miguel Alcañíz , et al. · 2024

Voltammetry is widely used for fast, data-dense measurements of redox-active analytes in versatile environments, including the brain. Voltammetry requires minimal hardware beyond a potentiostat, a front-end amplifier, and a computer. Nonet…

Machine-learning-guided design of electroanalytical pulse waveforms Open

Cameron S. Movassaghi, Katie A. Perrotta, Michael Curry, Audrey N. Nashner, K. Nguyen , et al. · 2024

Voltammetry is widely used to detect and quantify oxidizable or reducible species in complex environments. The neurotransmitter serotonin epitomizes an analyte that is challenging to detect in situ due to low concentrations and co-existing…

Maximizing Electrochemical Information: A Perspective on Background-Inclusive Fast Voltammetry Open

Cameron S. Movassaghi, Miguel Alcañíz, Kenneth T. Kishida, Gregory S. McCarty, Leslie A. Sombers , et al. · 2024

This perspective encompasses a focused review of the literature leading to a tipping point in electroanalytical chemistry. We tie together the threads of a "revolution" quietly in the making for years through the work of many authors. Long…

Issue Information Open

Sergio Sanchez‐Martinez, Paula C. Randanne, Ameth Hawkins-Villarreal, Kuorosh Rezaei, Raquel Fucho , et al. · 2023

A functional group–guided approach to aptamers for small molecules Open

Kyung-Ae Yang, N. Mitchell, Saswata Banerjee, Zhenzhuang Cheng, Steven K. Taylor , et al. · 2023

Aptameric receptors are important biosensor components, yet our ability to identify them depends on the target structures. We analyzed the contributions of individual functional groups on small molecules to binding within 27 target-aptamer…

Technology Roadmap for Flexible Sensors Open

Yifei Luo, Mohammad Reza Abidian, Jong‐Hyun Ahn, Deji Akinwande, Anne M. Andrews , et al. · 2023

Humans rely increasingly on sensors to address grand challenges and to improve quality of life in the era of digitalization and big data. For ubiquitous sensing, flexible sensors are developed to overcome the limitations of conventional ri…

Flexible and Implantable Polyimide Aptamer-Field-Effect Transistor Biosensors Open

Chuanzhen Zhao, Tianxing Man, Yan Cao, Paul S. Weiss, Harold G. Monbouquette , et al. · 2022

Monitoring neurochemical signaling across time scales is critical to understanding how brains encode and store information. Flexible (vs stiff) devices have been shown to improve in vivo monitoring, particularly over longer times, b…

Optogenetic Stimulation of Midbrain Dopamine Neurons Produces Striatal Serotonin Release Open

Merel Dagher, Katie A. Perrotta, Sara A. Erwin, Ayaka Hachisuka, Rahul K. Iyer , et al. · 2022

Targeting neurons with light-driven opsins is widely used to investigate cell-specific responses. We transfected midbrain dopamine neurons with the excitatory opsin Chrimson. Extracellular basal and stimulated neurotransmitter levels in th…

Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring Open

Bo Wang, Chuanzhen Zhao, Zhaoqing Wang, Kyung-Ae Yang, Xuanbing Cheng , et al. · 2022

A smartwatch was developed for noninvasive stress biomarker data acquisition that provides real-time feedback to the wearer.

Implantable aptamer–field-effect transistor neuroprobes for in vivo neurotransmitter monitoring Open

Chuanzhen Zhao, Kevin M. Cheung, Iwen Huang, Hongyan Yang, Nako Nakatsuka , et al. · 2021

Implantable aptamer transistor probes for in vivo neurotransmitter monitoring advance brain activity recording.

Simultaneous serotonin and dopamine monitoring across timescales by rapid pulse voltammetry with partial least squares regression Open

Cameron S. Movassaghi, Katie A. Perrotta, Hongyan Yang, Rahul K. Iyer, Xinyi Cheng , et al. · 2021

Awardees of the IUPAC 2021 Distinguished Women in Chemistry or Chemical Engineering Open

Martina H. Stenzel, Anne M. Andrews, Jingbo Louise Liu, Barbara Baird, Kyoko Nozaki · 2021

On time to celebrate International Day of Women and Girls in Science on February 11, IUPAC announced the awardees of the IUPAC 2021 Distinguished Women in Chemistry or Chemical Engineering:

Divalent Cation Dependence Enhances Dopamine Aptamer Biosensing Open

Nako Nakatsuka, John M. Abendroth, Kyung-Ae Yang, Anne M. Andrews · 2021

Oligonucleotide receptors (aptamers), which change conformation upon target recognition, enable electronic biosensing under high ionic-strength conditions when coupled to field-effect transistors (FETs). Because highly negatively charged a…

Narrower Nanoribbon Biosensors Fabricated by Chemical Lift-off Lithography Show Higher Sensitivity Open

Chuanzhen Zhao, Qingzhou Liu, Kevin M. Cheung, Wenfei Liu, Qing Yang , et al. · 2020

Wafer-scale nanoribbon field-effect transistor (FET) biosensors fabricated by straightforward top-down processes are demonstrated as sensing platforms with high sensitivity to a broad range of biological targets. Nanoribbons with 350 nm wi…

Flexible Multiplexed In2O3 Nanoribbon Aptamer-Field-Effect Transistors for Biosensing Open

Qingzhou Liu, Chuanzhen Zhao, Mingrui Chen, Yihang Liu, Zhiyuan Zhao , et al. · 2020

Flexible sensors are essential for advancing implantable and wearable bioelectronics toward monitoring chemical signals within and on the body. Developing biosensors for monitoring multiple neurotransmitters in real time represents a key <…

Detecting DNA and RNA and Differentiating Single-Nucleotide Variations via Field-Effect Transistors Open

Kevin M. Cheung, John M. Abendroth, Nako Nakatsuka, Bowen Zhu, Yang Yang , et al. · 2020

We detect short oligonucleotides and distinguish between sequences that differ by a single base, using label-free, electronic field-effect transistors (FETs). Our sensing platform utilizes ultrathin-film indium oxide FETs chemically functi…

Correction to “<i>In Utero</i> Exposure to Citalopram Mitigates Maternal Stress Effects on Fetal Brain Development” Open

Juan C. Velasquez, Qiuying Zhao, Yen Chan, Lígia Cristina Monteiro Galindo, Christelle Simasotchi , et al. · 2020

ADVERTISEMENT RETURN TO ISSUEPREVCorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "In Utero Exposure to Citalopram Mitigates Maternal Stress Effects on Fetal Brain Development"Juan C. VelasquezJuan C. VelasquezMore by…

Chemical Lift-Off Lithography of Metal and Semiconductor Surfaces Open

Kevin M. Cheung, Dominik Stemer, Chuanzhen Zhao, Thomas D. Young, Jason N. Belling , et al. · 2019

Chemical lift-off lithography (CLL) is a subtractive soft-lithographic technique that uses polydimethylsiloxane (PDMS) stamps to pattern self-assembled monolayers of functional molecules for applications ranging from biomolecule patterning…

Phenylalanine Monitoring via Aptamer-Field-Effect Transistor Sensors Open

Kevin M. Cheung, Kyung-Ae Yang, Nako Nakatsuka, Chuanzhen Zhao, Mao Ye , et al. · 2019

Determination of the amino acid phenylalanine is important for lifelong disease management in patients with phenylketonuria, a genetic disorder in which phenylalanine accumulates and persists at levels that alter brain development and caus…

<i>In Utero</i> Exposure to Citalopram Mitigates Maternal Stress Effects on Fetal Brain Development Open

Juan C. Velasquez, Qiuying Zhao, Yen Chan, Lígia Cristina Monteiro Galindo, Christelle Simasotchi , et al. · 2019

Human epidemiological and animal-model studies suggest that separate exposure to stress or serotonin-selective reuptake inhibitor (SSRI) antidepressants during pregnancy increases risks for neurodevelopmental disorders in offspring. Yet, l…

Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain Open

Shiwei Liu, Sarah R. Pickens, Nicole E. Burma, Inés Ibarra‐Lecue, Hongyan Yang , et al. · 2019

Pain is a multidimensional experience and negative affect, or how much the pain is “bothersome”, significantly impacts the sufferers' quality of life. It is well established that the κ opioid system contributes to depressive and dysphoric …

Aptamer–field-effect transistors overcome Debye length limitations for small-molecule sensing Open

Nako Nakatsuka, Kyung-Ae Yang, John M. Abendroth, Kevin M. Cheung, Xiaobin Xu , et al. · 2018

Transistor sensing in salt solutions Molecular binding to receptors on the surface of field-effect transistors (FETs) can be sensed through changes in transconductance. However, the saline solutions typically used with biomolecules create …

Large-Area, Ultrathin Metal-Oxide Semiconductor Nanoribbon Arrays Fabricated by Chemical Lift-Off Lithography Open

Chuanzhen Zhao, Xiaobin Xu, Sang‐Hoon Bae, Qing Yang, Wenfei Liu , et al. · 2018

Nanoribbon- and nanowire-based field-effect transistors (FETs) have attracted significant attention due to their high surface-to-volume ratios, which make them effective as chemical and biological sensors. However, the conventional nanofab…

Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine Open

Lee E. Dunlap, Anne M. Andrews, David E. Olson · 2018

Better known as "ecstasy", 3,4-methylenedioxymethamphetamine (MDMA) is a small molecule that has played a prominent role in defining the ethos of today's teenagers and young adults, much like lysergic acid diethylamide (LSD) did in the 196…

Aptamer Recognition of Multiplexed Small-Molecule-Functionalized Substrates Open

Nako Nakatsuka, Huan H. Cao, Stéphanie Deshayes, Arin L. Melkonian, Andrea M. Kasko , et al. · 2018

Aptamers are chemically synthesized oligonucleotides or peptides with molecular recognition capabilities. We investigated recognition of substrate-tethered small-molecule targets, using neurotransmitters as examples, and fluorescently labe…

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