Anna‐Maria Hoffmann‐Vold
YOU?
Author Swipe
View article: Deep hierarchical subtyping of multi-organ systemic sclerosis trajectories - a EUSTAR study
Deep hierarchical subtyping of multi-organ systemic sclerosis trajectories - a EUSTAR study Open
View article: Emphysema elevates the DETECT scores: impact on pulmonary hypertension screening and diagnosis in systemic sclerosis
Emphysema elevates the DETECT scores: impact on pulmonary hypertension screening and diagnosis in systemic sclerosis Open
Objectives Combined pulmonary fibrosis and emphysema (CPFE) predicts unfavourable outcomes in systemic sclerosis (SSc). CPFE and emphysema are associated with pulmonary function tests (PFTs) abnormalities. As screening algorithms for pulmo…
View article: The diagnostic utility of lung ultrasound in the assessment of interstitial lung disease associated with rheumatoid arthritis
The diagnostic utility of lung ultrasound in the assessment of interstitial lung disease associated with rheumatoid arthritis Open
View article: The serum levels of specific autoantibodies in systemic sclerosis predict a more severe skin involvement
The serum levels of specific autoantibodies in systemic sclerosis predict a more severe skin involvement Open
Background: Systemic sclerosis is a severe autoimmune disease characterized by fibrosis of the skin and internal organs. Systemic sclerosis is associated with the presence of three specific autoantibodies: anti-topoisomerase I, anti-centro…
View article: ‘Am I doing this right?’ Physician perceptions of the global assessment in clinical trials of systemic sclerosis
‘Am I doing this right?’ Physician perceptions of the global assessment in clinical trials of systemic sclerosis Open
Objectives Physician global assessments (PhyGAs) are commonly performed in randomized controlled trials (RCTs) in SSc. However, there is no single PhyGA applied across RCTs. We performed an exploratory qualitative study to explore percepti…
View article: Lung function and skin fibrosis changes as predictors of survival in SSc-associated interstitial lung disease: a EUSTAR study
Lung function and skin fibrosis changes as predictors of survival in SSc-associated interstitial lung disease: a EUSTAR study Open
Objectives This study assessed how changes in lung function, skin fibrosis and digital ulceration (DU) burden predict mortality in patients with SSc-associated interstitial lung disease (SSc-ILD), the leading cause of death in SSc. Methods…
View article: Evaluation of Systemic Sclerosis Primary Heart Involvement and Chronic Heart Failure in the European Scleroderma Trials and Research Cohort
Evaluation of Systemic Sclerosis Primary Heart Involvement and Chronic Heart Failure in the European Scleroderma Trials and Research Cohort Open
Background Systemic sclerosis (SSc) primary heart involvement (SSc‐pHI) is one of the leading causes of mortality in SSc. We aimed to evaluate risk factors for SSc‐pHI and its progression and the outcomes in the EUSTAR (European Scleroderm…
View article: How to build a framework to establish a patient research partner network in rheumatology research: a report of a 2-year implementation project
How to build a framework to establish a patient research partner network in rheumatology research: a report of a 2-year implementation project Open
Background Patient research partners (PRPs) are people living with a relevant disease who actively contribute to research. Their contribution is beneficial for any research project. Although the inclusion of PRPs in rheumatology research i…
View article: A comparative analysis of risk stratification tools in SSc-associated pulmonary arterial hypertension: a EUSTAR analysis
A comparative analysis of risk stratification tools in SSc-associated pulmonary arterial hypertension: a EUSTAR analysis Open
Objectives The 2022 European Society of Cardiology and European Respiratory Society (ESC/ERS) guidelines for pulmonary arterial hypertension (PAH) recommend risk stratification to optimize management. However, the performance of generic PA…
View article: Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort
Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort Open
Objectives Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its asso…
View article: Validation of a semi-quantitative method to assess interstitial lung disease severity and progression in systemic sclerosis by standard and low-dose HRCT scans
Validation of a semi-quantitative method to assess interstitial lung disease severity and progression in systemic sclerosis by standard and low-dose HRCT scans Open
Background While the presence of distinct imaging abnormalities by high-resolution CT (HRCT) defines interstitial lung disease (ILD), there is a relative lack of validated methods to quantify these abnormalities in clinical practice, limit…
View article: Rationale for phosphodiesterase-4 inhibition as a treatment strategy for interstitial lung diseases associated with rheumatic diseases
Rationale for phosphodiesterase-4 inhibition as a treatment strategy for interstitial lung diseases associated with rheumatic diseases Open
Interstitial lung disease (ILD) associated with rheumatoid arthritis or with connective tissue diseases such as systemic sclerosis can be collectively named systemic autoimmune rheumatic disease-associated ILDs (SARD-ILDs) or rheumatic mus…
View article: Cure as a treatment target in rheumatoid arthritis and systemic sclerosis—achievable aim or mission impossible? FOREUM stimulates new industry-academia collaboration
Cure as a treatment target in rheumatoid arthritis and systemic sclerosis—achievable aim or mission impossible? FOREUM stimulates new industry-academia collaboration Open
No abstract
View article: A Phase II study of avenciguat, a novel soluble guanylate cyclase activator, in patients with systemic sclerosis: Study design and rationale of the VITALISScE™ study
A Phase II study of avenciguat, a novel soluble guanylate cyclase activator, in patients with systemic sclerosis: Study design and rationale of the VITALISScE™ study Open
Introduction: Systemic sclerosis is a rare autoimmune connective tissue disease characterised by (1) microvasculopathy; (2) immune dysregulation; and (3) progressive fibrosis of the skin and internal organs. Soluble guanylate cyclase plays…
View article: EULAR recommendations for the treatment of systemic sclerosis: 2023 update
EULAR recommendations for the treatment of systemic sclerosis: 2023 update Open
These updated recommendations include the first set of synthetic and biological targeted therapies recommended for key fibrotic manifestations of SSc as well as first-line combination treatment for newly diagnosed pulmonary artery hyperten…
View article: A versatile role for lung ultrasound in systemic autoimmune rheumatic diseases related pulmonary involvement: a narrative review
A versatile role for lung ultrasound in systemic autoimmune rheumatic diseases related pulmonary involvement: a narrative review Open
Systemic autoimmune rheumatic diseases (SARDs) related pulmonary disease is highly prevalent, with variable clinical presentation and behavior, and thus is associated with poor outcomes and negatively impacts quality of life. Chest high re…
View article: Development of a multivariable prediction model for progression of systemic sclerosis-associated interstitial lung disease
Development of a multivariable prediction model for progression of systemic sclerosis-associated interstitial lung disease Open
Objective To develop a multivariable model for predicting the progression of systemic sclerosis-associated interstitial lung disease (SSc-ILD) over 52 weeks. Methods We used logistic regression models to analyse associations between candid…
View article: Semi-Supervised Generative Models for Disease Trajectories: A Case Study on Systemic Sclerosis
Semi-Supervised Generative Models for Disease Trajectories: A Case Study on Systemic Sclerosis Open
We propose a deep generative approach using latent temporal processes for modeling and holistically analyzing complex disease trajectories, with a particular focus on Systemic Sclerosis (SSc). We aim to learn temporal latent representation…
View article: Design of ANCHOR-RA: a multi-national cross-sectional study on screening for interstitial lung disease in patients with rheumatoid arthritis
Design of ANCHOR-RA: a multi-national cross-sectional study on screening for interstitial lung disease in patients with rheumatoid arthritis Open
View article: Arthritis in patients with very early systemic sclerosis: a comprehensive clinical and prognostic analysis
Arthritis in patients with very early systemic sclerosis: a comprehensive clinical and prognostic analysis Open
Objective Arthritis is associated with a worse prognosis in established SSc. However, knowledge about its relevance in very early SSc (veSSc) is scarce. We aimed to assess the prevalence and phenotype of arthritis, as well as its prognosti…
View article: Predicting interstitial lung disease progression in patients with systemic sclerosis using attentive neural processes - a EUSTAR study
Predicting interstitial lung disease progression in patients with systemic sclerosis using attentive neural processes - a EUSTAR study Open
A bstract Background Systemic sclerosis (SSc) is an autoimmune disease with high mortality with lung involvement being the primary cause of death. Progressive interstitial lung disease (ILD) leads to a decline in lung function (forced vita…
View article: Adaptive multi-interventional trial platform to improve patient care for fibrotic interstitial lung diseases
Adaptive multi-interventional trial platform to improve patient care for fibrotic interstitial lung diseases Open
Background Fibrotic interstitial lung diseases (fILDs) are a heterogeneous group of lung diseases associated with significant morbidity and mortality. Despite a large increase in the number of clinical trials in the last 10 years, current …
View article: Therapeutic management of fibrosis in systemic sclerosis patients – an analysis from the Swiss EUSTAR cohort
Therapeutic management of fibrosis in systemic sclerosis patients – an analysis from the Swiss EUSTAR cohort Open
OBJECTIVES: Systemic sclerosis is a chronic autoimmune connective tissue disease leading to microvascular and fibrotic manifestations in multiple organs. Several treatment options and recommendations from different European countries are a…
View article: The Performance of Pulmonary Function Tests in Predicting Systemic Sclerosis—Interstitial Lung Disease in the European Scleroderma Trial and Research Database
The Performance of Pulmonary Function Tests in Predicting Systemic Sclerosis—Interstitial Lung Disease in the European Scleroderma Trial and Research Database Open
Background and Objectives: In SSc, ILD is a major cause of morbidity and mortality. We aimed to investigate the performance of DLCO (diffusing capacity of lung carbon monoxide) and FVC (forced vital capacity) delta change (Δ) and baseline …
View article: Characteristics and disease course of untreated patients with interstitial lung disease associated with systemic sclerosis in a real-life two-centre cohort
Characteristics and disease course of untreated patients with interstitial lung disease associated with systemic sclerosis in a real-life two-centre cohort Open
Background Interstitial lung disease (ILD) is the leading cause of death in systemic sclerosis (SSc). According to expert statements, not all SSc-ILD patients require pharmacological therapy. Objectives To describe disease characteristics …
View article: Modeling Complex Disease Trajectories using Deep Generative Models with Semi-Supervised Latent Processes
Modeling Complex Disease Trajectories using Deep Generative Models with Semi-Supervised Latent Processes Open
In this paper, we propose a deep generative time series approach using latent temporal processes for modeling and holistically analyzing complex disease trajectories. We aim to find meaningful temporal latent representations of an underlyi…
View article: Sex-specific difference in cardiac function in patients with systemic sclerosis: association with cardiovascular outcomes
Sex-specific difference in cardiac function in patients with systemic sclerosis: association with cardiovascular outcomes Open
Background Cardiovascular involvement is one of the leading causes of mortality in systemic sclerosis (SSc) and is reported to be higher in men as compared with women. However, the cause of this difference is largely unknown. The objective…
View article: Editorial Board
Editorial Board Open
View article: Phenotyping by persistent inflammation in systemic sclerosis associated interstitial lung disease: a EUSTAR database analysis
Phenotyping by persistent inflammation in systemic sclerosis associated interstitial lung disease: a EUSTAR database analysis Open
Background Systemic sclerosis (SSc) is a heterogeneous disease with frequently associated interstitial lung disease (SSc-ILD). We aimed to determine the prognostic potential of phenotyping patients with SSc and SSc-ILD by inflammation and …
View article: Does the Impact of <scp>COVID</scp>‐19 on Patients With Systemic Sclerosis Change Over Time?
Does the Impact of <span>COVID</span>‐19 on Patients With Systemic Sclerosis Change Over Time? Open
Objective The outcome of patients with COVID‐19 improved over the pandemic, including patients with systemic rheumatic diseases. However, data on patients with systemic sclerosis (SSc) are lacking. This study aimed to assess the outcome of…