Martien A. Cohen Stuart
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View article: Rational Design of Cationic Nanogels with Serum Tolerance for Efficient siRNA Delivery and Antitumor Therapy
Rational Design of Cationic Nanogels with Serum Tolerance for Efficient siRNA Delivery and Antitumor Therapy Open
Cationic polymers have been applied widely for siRNA delivery, yet most of the conventional linear or branched polymers make RNA polyplexes with poor serum stability and low delivery efficacy. We here propose cationic nanogels as a better …
View article: Cationic Nanogels Enable Gold Nanoparticle Immobilization and Regulated Catalytic Activity
Cationic Nanogels Enable Gold Nanoparticle Immobilization and Regulated Catalytic Activity Open
Polyelectrolyte nanogel consisting of charged network is a prospective platform for developing nanoreactor due to their integrated features of both polyelectrolyte and hydrogel. In this work, cationic poly (methacrylatoethyl trimethyl ammo…
View article: CCDC 2160653: Experimental Crystal Structure Determination
CCDC 2160653: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Chemical signal regulated injectable coacervate hydrogels
Chemical signal regulated injectable coacervate hydrogels Open
Incorporation of reversible Michael addition controlled coacervate crosslinks in a polymer hydrogel led to injectable gels that are responsive to nucleophilic chemical signals, enabling accelerated degradation in culture media after inject…
View article: The Impact of Polymer Architecture on Polyion Complex (PIC) Micelles: When Topology Matters (and When It Doesn't)
The Impact of Polymer Architecture on Polyion Complex (PIC) Micelles: When Topology Matters (and When It Doesn't) Open
The influence of homopolymer architecture on the properties of polyion complex micelles is reported. Using a combination of dynamic and static light scattering, the authors show how the architecture is only relevant in kinetically trapped …
View article: Switchable Electrostatically Templated Polymerization
Switchable Electrostatically Templated Polymerization Open
We report a switchable, templated polymerization system where the strength of the templating effect can be modulated by solution pH and/or ionic strength. The responsiveness to these cues is incorporated through a dendritic polyamidoamine‐…
View article: Switchable Electrostatically Templated Polymerization
Switchable Electrostatically Templated Polymerization Open
We report a switchable, templated polymerization system where the strength of the templating effect can be modulated by solution pH and/or ionic strength. The responsiveness to these cues is incorporated through a dendritic polyamidoamine‐…
View article: Complex supramolecular fiber formed by coordination-induced self-assembly of benzene-1,3,5-tricarboxamide (BTA)
Complex supramolecular fiber formed by coordination-induced self-assembly of benzene-1,3,5-tricarboxamide (BTA) Open
The formation and structure of the fiber are very similar for various transition metal ions, which enables introducing different functionalities, e.g., magnetic relaxivity, by proper choice of the metal ions. Hence, we obtain a doubly supr…
View article: Control and Preparation of Quaternized Chitosan and Carboxymethyl Chitosan Nanoscale Polyelectrolyte Complexes Based on Reactive Flash Nanoprecipitation
Control and Preparation of Quaternized Chitosan and Carboxymethyl Chitosan Nanoscale Polyelectrolyte Complexes Based on Reactive Flash Nanoprecipitation Open
Nanoscale polyelectrolyte complex materials have been extensively investigated for their promising application in protocell, drug carriers, imaging, and catalysis. However, the conventional preparation approach involving positive and negat…
View article: Pickering Emulsions Based on the pH-Responsive Assembly of Food-Grade Chitosan
Pickering Emulsions Based on the pH-Responsive Assembly of Food-Grade Chitosan Open
Few natural, biocompatible, and inexpensive emulsifiers are available because such emulsifiers must satisfy severe requirements, be produced synthetically rather than naturally, be nontoxic, and require minimal effort to produce. Therefore…
View article: Facile Preparation of Tilmicosin-Loaded Polymeric Nanoparticle with Controlled Properties and Functions
Facile Preparation of Tilmicosin-Loaded Polymeric Nanoparticle with Controlled Properties and Functions Open
As one of the effective broad-spectrum antimicrobial and anti-inflammatory drugs, tilmicosin (TIM) is applied extensively in a wide range of veterinary treatments. However, the low bioavailability typically leads to overuse of TIM in pract…
View article: Efficient and Generic Preparation of Diverse Polyelectrolyte Nanogels by Electrostatic Assembly Directed Polymerization
Efficient and Generic Preparation of Diverse Polyelectrolyte Nanogels by Electrostatic Assembly Directed Polymerization Open
Open AccessCCS ChemistryRESEARCH ARTICLE1 Dec 2020Efficient and Generic Preparation of Diverse Polyelectrolyte Nanogels by Electrostatic Assembly Directed Polymerization Peng Ding, Jianan Huang, Cheng Wei, Wei Liu, Wenjuan Zhou, Jiahua Wan…
View article: Controlled Synthesis of Manganese Oxide Nanoparticles Encaged in Hollow Mesoporous Silica Nanoreactors and Their Enhanced Dye Degradation Activity
Controlled Synthesis of Manganese Oxide Nanoparticles Encaged in Hollow Mesoporous Silica Nanoreactors and Their Enhanced Dye Degradation Activity Open
In this study, controlled synthesis of hollow mesoporous silica nanoreactors with small manganese oxide nanoparticles in their cavities (Mn x O y @HMSNs) is reported, and the dye degradation performance in the presence of hydrogen peroxide…
View article: Dendrimicelles with pH-controlled aggregation number of core-dendrimers and stability
Dendrimicelles with pH-controlled aggregation number of core-dendrimers and stability Open
We present a simple way to build up well-controlled coacervate-core dendrimicelles by assembly of anionic PAMAM dendrimers with a cationic-neutral diblock copolymer.
View article: Front Cover: Template‐Free Self‐Assembly of Artificial De Novo Viral Coat Proteins into Nanorods: Effects of Sequence, Concentration, and Temperature (Chem. Eur. J. 47/2019)
Front Cover: Template‐Free Self‐Assembly of Artificial De Novo Viral Coat Proteins into Nanorods: Effects of Sequence, Concentration, and Temperature (Chem. Eur. J. 47/2019) Open
How do physical chemical variables affect the self-assembly of de novo designed viromimetic proteins? Above a critical concentration, proteins alone form regular nanorods, which was also dependent on self-assembly block length. High temper…
View article: Cationic Hofmeister Series of Wettability Alteration in Mica–Water–Alkane Systems
Cationic Hofmeister Series of Wettability Alteration in Mica–Water–Alkane Systems Open
The specific interaction of ions with macromolecules and solid-liquid interfaces is of crucial importance to many processes in biochemistry, colloid science, and engineering, as first pointed out by Hofmeister in the context of (de)stabili…
View article: Electrostatic stiffening and induced persistence length for coassembled molecular bottlebrushes
Electrostatic stiffening and induced persistence length for coassembled molecular bottlebrushes Open
A self-consistent field analysis for tunable contributions to the persistence length of isolated semiflexible polymer chains including electrostatically driven coassembled deoxyribonucleic acid (DNA) bottlebrushes is presented. When a chai…
View article: Correction to Force and Scale Dependence of the Elasticity of Self-Assembled DNA Bottle Brushes
Correction to Force and Scale Dependence of the Elasticity of Self-Assembled DNA Bottle Brushes Open
[This corrects the article DOI: 10.1021/acs.macromol.7b01795.].
View article: Force and Scale Dependence of the Elasticity of Self-Assembled DNA Bottle Brushes
Force and Scale Dependence of the Elasticity of Self-Assembled DNA Bottle Brushes Open
As a model system to study the elasticity of bottle-brush polymers, we here introduce self-assembled DNA bottle brushes, consisting of a DNA main chain that can be very long and still of precisely defined length, and precisely monodisperse…
View article: Illuminating the Reaction Pathways of Viromimetic Assembly
Illuminating the Reaction Pathways of Viromimetic Assembly Open
The coassembly of well-defined biological nanostructures relies on a delicate balance between attractive and repulsive interactions between biomolecular building blocks. Viral capsids are a prototypical example, where coat proteins exhibit…
View article: Navigating in foldonia: Using accelerated molecular dynamics to explore stability, unfolding and self-healing of the β-solenoid structure formed by a silk-like polypeptide
Navigating in foldonia: Using accelerated molecular dynamics to explore stability, unfolding and self-healing of the β-solenoid structure formed by a silk-like polypeptide Open
The β roll molecules with sequence (GAGAGAGQ)10 stack via hydrogen bonding to form fibrils which have been themselves been used to make viral capsids of DNA strands, supramolecular nanotapes and pH-responsive gels. Accelerated molecular dy…
View article: Harnessing the advantages of hard and soft colloids by the use of core–shell particles as interfacial stabilizers
Harnessing the advantages of hard and soft colloids by the use of core–shell particles as interfacial stabilizers Open
The ability of colloidal particles to penetrate fluid interfaces is a crucial factor in the preparation of particle stabilized disperse systems such as foams and emulsions. For hard micron-sized particles the insertion into fluid interface…
View article: Reaction Pathways in Catechol/Primary Amine Mixtures: A Window on Crosslinking Chemistry
Reaction Pathways in Catechol/Primary Amine Mixtures: A Window on Crosslinking Chemistry Open
Catechol chemistry is used as a crosslinking tool abundantly in both natural organisms (e.g. mussels, sandcastle worms) and synthetic systems to achieve the desired mechanical properties. Despite this abundance and success, the crosslinkin…
View article: Inside Back Cover: Supramolecular Virus‐Like Nanorods by Coassembly of a Triblock Polypeptide and Reversible Coordination Polymers (Chem. Eur. J. 2/2017)
Inside Back Cover: Supramolecular Virus‐Like Nanorods by Coassembly of a Triblock Polypeptide and Reversible Coordination Polymers (Chem. Eur. J. 2/2017) Open
Viruses are often called ‘Trojan horses’, in reference to Homer's Iliad. Laocoon, a Trojan priest, warned the Trojans not to take the horse into the city, as he prophesied soldiers were hiding inside; he and his two sons were subsequently …
View article: Design of block-copolymer-based micelles for active and passive targeting
Design of block-copolymer-based micelles for active and passive targeting Open
A self-consistent field study is presented on the design of active and passive targeting block-copolymeric micelles. These micelles form in water by self-assembly of triblock copolymers with a hydrophilic middle block and two hydrophobic o…
View article: Nanofibrillar hydrogel scaffolds from recombinant protein‐based polymers with integrin‐ and proteoglycan‐binding domains
Nanofibrillar hydrogel scaffolds from recombinant protein‐based polymers with integrin‐ and proteoglycan‐binding domains Open
This study describes the design, production, and testing of functionalized variants of a recombinant protein-based polymer that forms nanofibrillar hydrogels with self-healing properties. With a view to bone tissue engineering applications…
View article: Nanoparticle-Templated Formation and Growth Mechanism of Curved Protein Polymer Fibrils
Nanoparticle-Templated Formation and Growth Mechanism of Curved Protein Polymer Fibrils Open
We investigated the growth of biosynthetic protein polymers with templated curvature on pluronic nanospheres. The protein has a central silk-like block containing glutamic residues (SE) and collagen-like end-blocks (C). The SE blocks stack…
View article: Fibrous Hydrogels for Cell Encapsulation: A Modular and Supramolecular Approach
Fibrous Hydrogels for Cell Encapsulation: A Modular and Supramolecular Approach Open
Artificial 3-dimensional (3D) cell culture systems, which mimic the extracellular matrix (ECM), hold great potential as models to study cellular processes under controlled conditions. The natural ECM is a 3D structure composed of a fibrous…