Annelies M. Zwitserloot
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View article: Introduction of Ivacaftor/Lumacaftor in Children With Cystic Fibrosis Homozygous for F508del in the Netherlands: A Nationwide Real‐Life Study
Introduction of Ivacaftor/Lumacaftor in Children With Cystic Fibrosis Homozygous for F508del in the Netherlands: A Nationwide Real‐Life Study Open
Introduction Lumacaftor/ivacaftor (lum/iva) was introduced in the Netherlands in 2017. We investigated 1‐year efficacy of lum/iva on lung function and small airway and structural lung disease evaluated by multiple breath nitrogen washout a…
View article: Global Lung Function Initiative reference values for multiple breath washout indices
Global Lung Function Initiative reference values for multiple breath washout indices Open
Background Multiple breath washout is a lung function test based on tidal breathing that assesses lung volume and ventilation distribution. The aim of this analysis was to use the Global Lung Function Initiative methodology to develop all-…
View article: Medication adherence to CFTR modulators in patients with cystic fibrosis: a systematic review
Medication adherence to CFTR modulators in patients with cystic fibrosis: a systematic review Open
Background In the last decade, a fundamental shift in the treatment of cystic fibrosis (CF) took place due to the introduction of CF transmembrane conductance regulator (CFTR) modulators. Adequate medication adherence is a prerequisite for…
View article: Comparison of particles in exhaled air and multiple breath washout for assessment of small airway function in children with cystic fibrosis
Comparison of particles in exhaled air and multiple breath washout for assessment of small airway function in children with cystic fibrosis Open
Background The introduction of modulator therapy for cystic fibrosis (CF) has led to an increased interest in the detection of small airway disease (SAD) as sensitive marker of treatment response. The particles in exhaled air (PExA) method…
View article: A year in review: Real world evidence, functional monitoring and emerging therapeutics in 2021
A year in review: Real world evidence, functional monitoring and emerging therapeutics in 2021 Open
View article: Asthma, bronchial hyperresponsiveness, allergy and lung function development until early adulthood: A systematic literature review
Asthma, bronchial hyperresponsiveness, allergy and lung function development until early adulthood: A systematic literature review Open
Background It is unclear in which periods of life lung function deficits develop, and whether these are affected by risk factors such as asthma, bronchial hyper‐responsiveness (BHR) and allergic comorbidity. The goal of this systematic rev…
View article: Evaluation of a multiple breath nitrogen washout system in children
Evaluation of a multiple breath nitrogen washout system in children Open
Introduction The multiple breath nitrogen washout (MBW) test offers a sensitive measure of airway function. In this study we aim to (a) assess the validity of the EasyOne Pro LAB (MBW ndd ) in an in vitro lung model, (b) assess the feasibi…
View article: Differences in lung clearance index and functional residual capacity between two commercial multiple-breath nitrogen washout devices in healthy children and adults
Differences in lung clearance index and functional residual capacity between two commercial multiple-breath nitrogen washout devices in healthy children and adults Open
Multiple-breath nitrogen washout (MBNW) and its clinical parameter lung clearance index (LCI) are gaining increasing attention for the assessment of small airway function. Measurement of LCI relies on accurate assessment of functional resi…