M. A. Bhat
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View article: Transport protein interaction and target pathway analysis of a hybrid antifungal compound synthesized by linking triazolothiadiazine ring system with the pyridine ring
Transport protein interaction and target pathway analysis of a hybrid antifungal compound synthesized by linking triazolothiadiazine ring system with the pyridine ring Open
The present manuscript explores the serum albumin interaction and target pathway analysis of a newly developed antifungal agent, 7-[2-(4-chlorophenyl) hydrazinylidene]-6-methyl-3-(pyridin-4-yl)-7H-[1, 2, 4]triazolo[3,4-b][1, 3, 4]thiadiazi…
View article: Mind-Body Healing - The Ayurvedic Perspective on Mental Health in Post-Surgical Recovery
Mind-Body Healing - The Ayurvedic Perspective on Mental Health in Post-Surgical Recovery Open
Surgical recovery is not merely a physical process; it encompasses profound psychological and emotional dimensions. Despite advancements in operative and perioperative care, mental health remains under-addressed in post-surgical outcomes. …
View article: Purine–Hydrazone Scaffolds as Potential Dual EGFR/HER2 Inhibitors
Purine–Hydrazone Scaffolds as Potential Dual EGFR/HER2 Inhibitors Open
Background/Objectives: The dual targeting of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) represents an effective approach for cancer treatment. The current study involved the design, synthesi…
View article: Amentoflavone from Selaginella bryopteris leaf extracts modulate MAPK signaling - Molecular modeling study for therapeutic target analysis
Amentoflavone from Selaginella bryopteris leaf extracts modulate MAPK signaling - Molecular modeling study for therapeutic target analysis Open
Background: Selaginella bryopteris (L.) is a pteridophytic herbaceous moss plant that grows in the wilderness and possesses phytochemicals that may exhibit therapeutic properties by altering some metabolic processes in the human body. Purp…
View article: 7-Methoxybenzofuran-triazole tethered <i>N</i>-phenylacetamides as a promising class of tyrosinase inhibitors: synthesis, biological evaluation and computational analyses against fungal and human tyrosinases
7-Methoxybenzofuran-triazole tethered <i>N</i>-phenylacetamides as a promising class of tyrosinase inhibitors: synthesis, biological evaluation and computational analyses against fungal and human tyrosinases Open
The current study deals with the synthesis and evaluation of a novel series of 7-methoxybenzofuran-linked N -phenylacetamides 16(a–j) as efficient tyrosinase inhibitors via in vitro and in silico analyses.
View article: Design, Synthesis and Biological Exploration of Novel N-(9-Ethyl-9H-Carbazol-3-yl)Acetamide-Linked Benzofuran-1,2,4-Triazoles as Anti-SARS-CoV-2 Agents: Combined Wet/Dry Approach Targeting Main Protease (Mpro), Spike Glycoprotein and RdRp
Design, Synthesis and Biological Exploration of Novel N-(9-Ethyl-9H-Carbazol-3-yl)Acetamide-Linked Benzofuran-1,2,4-Triazoles as Anti-SARS-CoV-2 Agents: Combined Wet/Dry Approach Targeting Main Protease (Mpro), Spike Glycoprotein and RdRp Open
A novel series of substituted benzofuran-tethered triazolylcarbazoles was synthesized in good to high yields (65–89%) via S-alkylation of benzofuran-based triazoles with 2-bromo-N-(9-ethyl-9H-carbazol-3-yl)acetamide. The inhibitory potency…
View article: Therapeutic Potential of Novel Silver Carbonate Nanostructures in Wound Healing and Antibacterial Activity Against Pseudomonas chengduensis and Staphylococcus aureus
Therapeutic Potential of Novel Silver Carbonate Nanostructures in Wound Healing and Antibacterial Activity Against Pseudomonas chengduensis and Staphylococcus aureus Open
Background/Objectives: Metallic NPs have been explored for various therapeutic uses owing to utilitarian physicochemical characteristics such as antibacterial, anti-inflammatory, and healing properties. The objective of this study is to ev…
View article: Genetic and in-silico approaches for investigating the mechanisms of ciprofloxacin resistance in Salmonella typhi: Mutations, extrusion, and antimicrobial resistance
Genetic and in-silico approaches for investigating the mechanisms of ciprofloxacin resistance in Salmonella typhi: Mutations, extrusion, and antimicrobial resistance Open
View article: Studying strangeness and baryon production mechanisms through angular correlations between charged Ξ baryons and identified hadrons in pp collisions at $$ \sqrt{s} $$ = 13 TeV
Studying strangeness and baryon production mechanisms through angular correlations between charged Ξ baryons and identified hadrons in pp collisions at $$ \sqrt{s} $$ = 13 TeV Open
A bstract The angular correlations between charged Ξ baryons and associated identified hadrons (pions, kaons, protons, Λ baryons, and Ξ baryons) are measured in pp collisions at $$ \sqrt{s} $$ = 13 TeV with the ALICE detector to give in…
View article: Synthesis and characterization of curcumin-encapsulated loaded on carboxymethyl cellulose with docking validation as α-amylase and α-glucosidase inhibitors
Synthesis and characterization of curcumin-encapsulated loaded on carboxymethyl cellulose with docking validation as α-amylase and α-glucosidase inhibitors Open
In reaction to the expanding predominance of diabetes mellitus, curcumin nanoparticles stacked on carboxymethyl cellulose (CMC) composite were effectively synthesized, characterized, and examined utilizing UV/Vis and FTIR spectroscopy comb…
View article: Antioxidant and Antibacterial Screening and Hg(II) Sensing, Activities of Cu(II)pyridine‐2,6‐dicarboxylate Complexes
Antioxidant and Antibacterial Screening and Hg(II) Sensing, Activities of Cu(II)pyridine‐2,6‐dicarboxylate Complexes Open
In this study five different complexes of Cu(II) were synthesized for the purpose of environmentally notorious mercury sensing and preliminary biological screening. Pyridine‐2,6‐dicarboxylic acid (also known as dipicolinic acid, and abbrev…
View article: Synthesis, molecular modelling and choline esterase enzyme inhibitory activity of novel enaminone derivatives of sulfonamides
Synthesis, molecular modelling and choline esterase enzyme inhibitory activity of novel enaminone derivatives of sulfonamides Open
The enaminone derivatives of sulfonamides (1–11) were obtained in good yield and high purity. Choline esterase (ChE) inhibitory activities of the novel compounds against AChE and BChE were determined by Ellman’s method. Ki values of compou…
View article: Identification of Benzothiazoles Bearing 1,3,4-Thiadiazole as Antiproliferative Hybrids Targeting VEGFR-2 and BRAF Kinase: Design, Synthesis, BIO Evaluation and In Silico Study
Identification of Benzothiazoles Bearing 1,3,4-Thiadiazole as Antiproliferative Hybrids Targeting VEGFR-2 and BRAF Kinase: Design, Synthesis, BIO Evaluation and In Silico Study Open
Cancer remains a leading cause of death worldwide, often resulting from uncontrolled growth in various organs. Protein kinase inhibitors represent an important class of targeted cancer therapies. Recently, the kinases BRAF and VEGFR-2 have…
View article: Multicentric assessment of empagliflozin, sitagliptin and cholestyramine on n-2 streptozotocin diabe tic rats
Multicentric assessment of empagliflozin, sitagliptin and cholestyramine on n-2 streptozotocin diabe tic rats Open
Diabetes mellitus stands as a major global epidemic, rapidly spreading across the world.WHO reports a continuous and concerning upsurge in both the number of cases and prevalence.In India alone, diabetes prevalence escalated from 7.1% in 2…
View article: Correction: Using Selenium-enriched Mutated Probiotics as Enhancer for Fertility Parameters in Mice
Correction: Using Selenium-enriched Mutated Probiotics as Enhancer for Fertility Parameters in Mice Open
View article: Thiazolidinone-linked-1,2,3-triazoles with (R)-Carvone as new potential anticancer agents
Thiazolidinone-linked-1,2,3-triazoles with (R)-Carvone as new potential anticancer agents Open
Aim: This study explores the cytotoxic and apoptotic effects of novel thiazolidinone-1,2,3-triazole hybrids on HT-1080, A-549, and MDA-MB-231 cancer cell lines.Methods & results: The synthesized compounds underwent comprehens…
View article: Exploring the Therapeutic Potential of Petiveria alliacea L. Phytochemicals: A Computational Study on Inhibiting SARS-CoV-2’s Main Protease (Mpro)
Exploring the Therapeutic Potential of Petiveria alliacea L. Phytochemicals: A Computational Study on Inhibiting SARS-CoV-2’s Main Protease (Mpro) Open
The outbreak of SARS-CoV-2, also known as the COVID-19 pandemic, is still a critical risk factor for both human life and the global economy. Although, several promising therapies have been introduced in the literature to inhibit SARS-CoV-2…
View article: Exploration of morpholine-thiophene hybrid thiosemicarbazones for the treatment of ureolytic bacterial infections via targeting urease enzyme: Synthesis, biochemical screening and computational analysis
Exploration of morpholine-thiophene hybrid thiosemicarbazones for the treatment of ureolytic bacterial infections via targeting urease enzyme: Synthesis, biochemical screening and computational analysis Open
An important component of the pathogenicity of potentially pathogenic bacteria in humans is the urease enzyme. In order to avoid the detrimental impact of ureolytic bacterial infections, the inhibition of urease enzyme appears to be an app…
View article: Molecular Detection and Phylogenetic Analysis of Ovine Herpesvirus-2 in Subclinical Infections of Cattle and Sheep
Molecular Detection and Phylogenetic Analysis of Ovine Herpesvirus-2 in Subclinical Infections of Cattle and Sheep Open
Ovine herpesvirus-2 (OvHV-2) is the causative agent of malignant catarrhal fever (MCF), a serious and often fatal disease that affects cattle and other ruminants.This study aimed to investigate the molecular epidemiology and genetic divers…
View article: Metal-urea complexes as primary precursors to generate VO2, ZrO2, NbO2, TaO2, Ga2O3 and TeO2 oxides in the nanoscale range by thermal decomposition route
Metal-urea complexes as primary precursors to generate VO2, ZrO2, NbO2, TaO2, Ga2O3 and TeO2 oxides in the nanoscale range by thermal decomposition route Open
Six metal chlorides of vanadium, zirconium, niobium, tantalum, gallium, and tellurium (i.e., VCl3, ZrOCl2×8H2O, NbCl5, TaCl5, GaCl3, and TeCl4) were reacted with urea (referred to as U) in aqueous media at ~ 50 oC. The resulting metal-urea…
View article: Unraveling the Nephroprotective Potential of Papaverine against Cisplatin Toxicity through Mitigating Oxidative Stress and Inflammation: Insights from In Silico, In Vitro, and In Vivo Investigations
Unraveling the Nephroprotective Potential of Papaverine against Cisplatin Toxicity through Mitigating Oxidative Stress and Inflammation: Insights from In Silico, In Vitro, and In Vivo Investigations Open
Cisplatin is a potent compound in anti-tumor chemotherapy; however, its clinical utility is hampered by dose-limiting nephrotoxicity. This study investigated whether papaverine could mitigate cisplatin-induced kidney damage while preservin…
View article: Synergistic Biomedical Potential and Molecular Docking Analyses of Coumarin–Triazole Hybrids as Tyrosinase Inhibitors: Design, Synthesis, In Vitro Profiling, and In Silico Studies
Synergistic Biomedical Potential and Molecular Docking Analyses of Coumarin–Triazole Hybrids as Tyrosinase Inhibitors: Design, Synthesis, In Vitro Profiling, and In Silico Studies Open
The tyrosinase enzyme has a vital role in the browning of vegetables and fruits and the biosynthesis of melanin. In this work, we synthesized a diverse library of coumarin–triazole hybrids, and these compounds were characterized by using s…
View article: Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis
Acyl pyrazole sulfonamides as new antidiabetic agents: synthesis, glucosidase inhibition studies, and molecular docking analysis Open
Diabetes mellitus is a multi-systematic chronic metabolic disorder and life-threatening disease resulting from impaired glucose homeostasis. The inhibition of glucosidase, particularly α -glucosidase, could serve as an effective methodolog…
View article: Investigating Potential Cancer Therapeutics: Insight into Histone Deacetylases (HDACs) Inhibitions
Investigating Potential Cancer Therapeutics: Insight into Histone Deacetylases (HDACs) Inhibitions Open
Histone deacetylases (HDACs) are enzymes that remove acetyl groups from ɛ-amino of histone, and their involvement in the development and progression of cancer disorders makes them an interesting therapeutic target. This study seeks to disc…
View article: Discovery of Bacterial Key Genes from 16S rRNA-Seq Profiles That Are Associated with the Complications of SARS-CoV-2 Infections and Provide Therapeutic Indications
Discovery of Bacterial Key Genes from 16S rRNA-Seq Profiles That Are Associated with the Complications of SARS-CoV-2 Infections and Provide Therapeutic Indications Open
SARS-CoV-2 infections, commonly referred to as COVID-19, remain a critical risk to both human life and global economies. Particularly, COVID-19 patients with weak immunity may suffer from different complications due to the bacterial co-inf…
View article: Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents
Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents Open
Benzimidazole-based pyrrole/piperidine analogs (1–26) were synthesized and then screened for their acetylcholinesterase and butyrylcholinesterase activities. All the analogs showed good to moderate cholinesterase activities. Synthesized co…
View article: Synthesis, characterization, and molecular modeling of novel 1,3,4-oxadiazole derivatives of mefenamic acid
Synthesis, characterization, and molecular modeling of novel 1,3,4-oxadiazole derivatives of mefenamic acid Open
A novel series of 1,3,4-oxadiazole derivatives of mefenamic acid was obtained by reacting hydrazones of mefenamic acid with anhydrous acetic anhydride. The mefenamic hydrazones were obtained by reacting different substituted aldehydes with…
View article: Determination of IL-6 Gene Promoter Polymorphism in Patients with Hepatitis C and Its Impact on RNA Secondary Structure
Determination of IL-6 Gene Promoter Polymorphism in Patients with Hepatitis C and Its Impact on RNA Secondary Structure Open
Background and Objectives: A polymorphism in the promoter region of the IL-6 gene would influence the level of IL-6 expression in patients with HCV, resulting in a pro-inflammatory response. Few studies have shown the association between −…
View article: In Silico Analysis of Mutations in Quinolone Resistance Determinant Region for Flouroquinolone Resistance in <em>Salmonella typhi</em>
In Silico Analysis of Mutations in Quinolone Resistance Determinant Region for Flouroquinolone Resistance in <em>Salmonella typhi</em> Open
Salmonella enterica serovar Typhi, is one of the major infection spreading from consuming contaminated food and water. The poor sanitation is one the major cause for successful infection. S. typhi is responsible for causing typhoid fever, …
View article: Exploring Potentilla nepalensis Phytoconstituents: Integrated Strategies of Network Pharmacology, Molecular Docking, Dynamic Simulations, and MMGBSA Analysis for Cancer Therapeutic Targets Discovery
Exploring Potentilla nepalensis Phytoconstituents: Integrated Strategies of Network Pharmacology, Molecular Docking, Dynamic Simulations, and MMGBSA Analysis for Cancer Therapeutic Targets Discovery Open
Potentilla nepalensis belongs to the Rosaceae family and has numerous therapeutic applications as potent plant-based medicine. Forty phytoconstituents (PCs) from the root and stem through n-hexane (NR and NS) and methanolic (MR and MS) ext…