Adrian A. Suarez
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View article: Instability in the Penta-C and Penta-D Loci in Microsatellite-Unstable Endometrial Cancer
Instability in the Penta-C and Penta-D Loci in Microsatellite-Unstable Endometrial Cancer Open
Endometrial cancer (EC) is the most common gynecologic cancer. Early detection is one of the most important predictors of survival. The cancer is curable if detected early but the five-year survival rate in advanced cases can be as low as …
View article: Understanding context: leveraging the pragmatic robust implementation sustainability model to inform the implementation of a community-based southeastern preconception counseling intervention to improve maternal health equity
Understanding context: leveraging the pragmatic robust implementation sustainability model to inform the implementation of a community-based southeastern preconception counseling intervention to improve maternal health equity Open
Collaborative community partnerships engaged throughout this process surfaced key community priorities, strengths, and needs for PC implementation. Using multiple methods to gather community data and feedback informed iterative revisions t…
View article: Molecular characterization of mixed-histology endometrial carcinoma provides prognostic and therapeutic value over morphologic findings
Molecular characterization of mixed-histology endometrial carcinoma provides prognostic and therapeutic value over morphologic findings Open
We performed molecular analysis of a single-institution cohort of clinically diagnosed mixed-histology endometrial carcinoma (MEC). A gynecologic pathologist confirmed that 72 cases met diagnostic criteria for MEC based on WHO 2020 guideli…
View article: Changes in anthropometry, adiposity, and inflammation in Black and White women engaged in intentional weight loss
Changes in anthropometry, adiposity, and inflammation in Black and White women engaged in intentional weight loss Open
Objective We examined associations among changes in anthropometry, regional adiposity, and inflammatory markers in Black and White women participating in intentional weight loss. Methods A total of 104 women with BMI ≥ 25 kg/m 2 self‐selec…
View article: Obesity-induced extracellular vesicles proteins drive the endometrial cancer pathogenesis: therapeutic potential of HO-3867 and Metformin
Obesity-induced extracellular vesicles proteins drive the endometrial cancer pathogenesis: therapeutic potential of HO-3867 and Metformin Open
View article: Identifying mesonephric‐like adenocarcinoma of the endometrium by combining <scp>SOX17</scp> and <scp>PAX8</scp> immunohistochemistry
Identifying mesonephric‐like adenocarcinoma of the endometrium by combining <span>SOX17</span> and <span>PAX8</span> immunohistochemistry Open
Aims Mesonephric‐like adenocarcinoma (MLA) of the endometrium or ovary is a rare but distinct endometrial carcinoma which has a combination of characteristic morphological, immunohistochemical (IHC) and molecular features. SOX17 has been r…
View article: Centering Birthing Experiences of Women of Color: Protocol for a Qualitative Maternal Near Miss Study
Centering Birthing Experiences of Women of Color: Protocol for a Qualitative Maternal Near Miss Study Open
Background In the United States, Black women are 3-4 times more likely to experience maternal near miss (MNM) or severe maternal morbidity (SMM) than non-Hispanic White women. However, there is a limited narrative-based investigation into …
View article: A Development and Implementation of a Preconception Counseling Program for Black Women and Men in the Southeastern United States: A Pilot Protocol
A Development and Implementation of a Preconception Counseling Program for Black Women and Men in the Southeastern United States: A Pilot Protocol Open
Introduction Racial/ethnic disparities in maternal mortality rates represent one of the most significant areas of disparities amongst all conventional population perinatal health measures in the U.S. The alarming trends and persistent disp…
View article: Exploring the role of obesity-induced extracellular vesicles secretion and associated oncogenic proteins in endometrial cancer pathogenesis.
Exploring the role of obesity-induced extracellular vesicles secretion and associated oncogenic proteins in endometrial cancer pathogenesis. Open
Endometrial cancer (EC) is the leading gynecologic malignancy in the United States with obesity implicated in 57% of cases. This research delves into the molecular complexities of extracellular vesicle (EV) secretion as carriers of oncogen…
View article: Defining “Enlarged” Sentinel Lymph Nodes in the Setting of Endometrial Cancer: What is the Size Cut-Off?
Defining “Enlarged” Sentinel Lymph Nodes in the Setting of Endometrial Cancer: What is the Size Cut-Off? Open
View article: Cold Ischemia Time and Formalin Fixation Time in Endometrial Cancer: Should Breast Cancer Guidelines for Preanalytical Variables Be Applied to Hysterectomy Specimens?
Cold Ischemia Time and Formalin Fixation Time in Endometrial Cancer: Should Breast Cancer Guidelines for Preanalytical Variables Be Applied to Hysterectomy Specimens? Open
View article: Intraluminal tumor cells and prognostic accuracy of endometrial cancer stage criteria: A multi-institution study
Intraluminal tumor cells and prognostic accuracy of endometrial cancer stage criteria: A multi-institution study Open
View article: Characterization of mismatch‐repair/microsatellite instability‐discordant endometrial cancers
Characterization of mismatch‐repair/microsatellite instability‐discordant endometrial cancers Open
Background Mismatch‐repair (MMR)/microsatellite instability (MSI) status has therapeutic implications in endometrial cancer (EC). The authors evaluated the concordance of testing and factors contributing to MMR expression heterogeneity. Me…
View article: Supplementary Figure 5 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Supplementary Figure 5 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors Open
Levels of inhibin B
View article: Supplementary Figure 5 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Supplementary Figure 5 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors Open
Levels of inhibin B
View article: Supplementary Tables 1-3 from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube
Supplementary Tables 1-3 from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube Open
Role of STAT3 in high-grade serous carcinoma
View article: Supplementary Materials and Methods from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Supplementary Materials and Methods from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors Open
Supplementary materials and methods.
View article: Supplementary Figure 4 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Supplementary Figure 4 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors Open
Gross morphology (A) and histology (B) of GCT grafts.
View article: Supplementary Figure 4 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Supplementary Figure 4 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors Open
Gross morphology (A) and histology (B) of GCT grafts.
View article: Data from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube
Data from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube Open
The initial molecular events that lead to malignant transformation of the fimbria of the fallopian tube (FT) through high-grade serous ovarian carcinoma (HGSC) remain poorly understood. In this study, we report that increased expression of…
View article: Supplementary Figures 1-11 from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube
Supplementary Figures 1-11 from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube Open
Role of STAT3 in high-grade serous carcinoma
View article: Supplementary Figure 2 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Supplementary Figure 2 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors Open
EGFP was detected in the oocytes of all follicle classes in Cre+ ovaries after PD5.
View article: Data from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Data from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors Open
Cell–cell interactions play crucial roles in the maintenance of tissue homeostasis, a loss of which often leads to varying diseases, including cancer. Here, we report that uncontrolled PI3K activity within oocytes irreversibly transforms g…
View article: Supplementary Figure 1 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Supplementary Figure 1 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors Open
Serum concentrations of ActA in tumor host were significantly higher than those of adult normal female mice (PD65 Cre-).
View article: Data from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube
Data from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube Open
The initial molecular events that lead to malignant transformation of the fimbria of the fallopian tube (FT) through high-grade serous ovarian carcinoma (HGSC) remain poorly understood. In this study, we report that increased expression of…
View article: Supplementary Figures 1-11 from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube
Supplementary Figures 1-11 from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube Open
Role of STAT3 in high-grade serous carcinoma
View article: Supplementary Materials and Methods from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Supplementary Materials and Methods from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors Open
Supplementary materials and methods.
View article: Supplementary Figure Legends from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Supplementary Figure Legends from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors Open
Supplementary Figure Legends
View article: Supplementary Tables 1-3 from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube
Supplementary Tables 1-3 from <i>STAT3/PIAS3</i> Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube Open
Role of STAT3 in high-grade serous carcinoma
View article: Supplementary Figure 3 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Supplementary Figure 3 from Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors Open
FOXO1 and PTEN expression patterns in developing ovaries.