Palak Shah
YOU?
Author Swipe
View article: Multimodal molecular testing provides prognostic value for heart transplant recipients
Multimodal molecular testing provides prognostic value for heart transplant recipients Open
Patients with dual positive GEP and dd-cfDNA are at increased risk for subsequent GD and CV death, even in the absence of histological evidence of rejection, indicating circulating multimodal molecular evidence of rejection provides progno…
View article: Donor-Derived Cell-Free DNA in Antibody-Mediated Rejection
Donor-Derived Cell-Free DNA in Antibody-Mediated Rejection Open
The authors document significant context dependent variability of AMR incidence and the utility of dd-cfDNA in predicting biopsy yield. These data complement prior studies on the interpretation of peripheral gene expression profiling and d…
View article: Donor-Derived Cell-Free DNA Stratifies Risk of Mortality and Graft Dysfunction in Severe Acute Cardiac Allograft Rejection
Donor-Derived Cell-Free DNA Stratifies Risk of Mortality and Graft Dysfunction in Severe Acute Cardiac Allograft Rejection Open
Background Cardiac acute rejection (AR) is a risk factor for poor outcomes, however there are limited risk prediction models to stratify patients for death or sustained LV dysfunction. This study assesses the prognostic utility of percenta…
View article: Vericiguat for patients with heart failure and reduced ejection fraction across the risk spectrum: an individual participant data analysis of the VICTORIA and VICTOR trials
Vericiguat for patients with heart failure and reduced ejection fraction across the risk spectrum: an individual participant data analysis of the VICTORIA and VICTOR trials Open
Merck Sharp & Dohme (a subsidiary of Merck) and Bayer.
View article: ESPWA: a deep learning-enabled tool for precision-based use of endocrine therapy in resource-limited settings
ESPWA: a deep learning-enabled tool for precision-based use of endocrine therapy in resource-limited settings Open
Background Cancer morbidity disproportionately affects patients in low- and middle-income countries (LMICs), where timely and accurate tumor profiling is often nonexistent. Immunohistochemistry-based assessment of estrogen receptor (ER) st…
View article: Contemporary Antibody-Mediated Rejection in Heart Transplantation
Contemporary Antibody-Mediated Rejection in Heart Transplantation Open
Heart transplantation remains the definitive therapy for patients with advanced heart failure. Acute and chronic rejection affect both short- and long-term outcomes. Antibody-mediated rejection (AMR) remains a leading cause of graft failur…
View article: SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain
SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain Open
A role for the trafficking receptor SORLA in reducing Aβ levels has been well-established, however, relatively little is known with respect to whether and how SORLA can potentially affect tau pathology in vivo . Here, we show that transgen…
View article: Utility of Plasma Cell-free Chromatin Immunoprecipitation to Detect Cardiac Allograft Rejection
Utility of Plasma Cell-free Chromatin Immunoprecipitation to Detect Cardiac Allograft Rejection Open
Background Antibody-mediated rejection (AMR) remains the major risk factor for allograft loss across all solid organ transplantation. Unfortunately, its diagnosis relies on biopsy, an invasive gold standard that often sample unaffected all…
View article: Evaluation of Women with Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study
Evaluation of Women with Peripartum or Dilated Cardiomyopathy and Their First-Degree Relatives: The DCM Precision Medicine Study Open
Background Rare variant genetics have been associated with peripartum cardiomyopathy (PPCM) but the role of genetics remains unsettled. Objective The study sought to compare dilated cardiomyopathy (DCM) genetic risk in first-degree relativ…
View article: Clinico-Hematological Spectrum of Non-Leukemic Myeloproliferative Disorder
Clinico-Hematological Spectrum of Non-Leukemic Myeloproliferative Disorder Open
Myeloproliferative neoplasms (MPNs) are a group of hematological disorders originating from marrow stem cells, characterised by clonal proliferation of hematopoietic components. The three primary non-leukemic MPNs include Polycythemia Vera…
View article: Preliminary clinical performance of a Cas13a-based lateral flow assay for detecting <i>Neisseria gonorrhoeae</i> in urine specimens
Preliminary clinical performance of a Cas13a-based lateral flow assay for detecting <i>Neisseria gonorrhoeae</i> in urine specimens Open
Nucleic acid amplification testing (NAAT) for N. gonorrhoeae is unavailable in resource-limited settings. We previously developed a CRISPR-based lateral flow assay for detecting N. gonorrhoeae . We aimed to pair that assay with point-of-ca…
View article: Implementing Precision Medicine for Dilated Cardiomyopathy: Insights from The DCM Consortium
Implementing Precision Medicine for Dilated Cardiomyopathy: Insights from The DCM Consortium Open
Background Clinical genetic evaluation of dilated cardiomyopathy (DCM) is implemented variably or not at all. Identifying needs and barriers to genetic evaluations will enable strategies to enhance precision medicine care. Methods An onlin…
View article: Redefining Cardiac Antibody-Mediated Rejection With Donor-Specific Antibodies and Graft Dysfunction
Redefining Cardiac Antibody-Mediated Rejection With Donor-Specific Antibodies and Graft Dysfunction Open
BACKGROUND: Heart transplant recipients with donor-specific antibodies (DSAs) have an increased risk for antibody-mediated rejection. However, many patients with graft dysfunction and DSA do not have evidence of antibody-mediated rejection…
View article: HIV persists in late coronary atheroma and is associated with increased local inflammation and disease progression
HIV persists in late coronary atheroma and is associated with increased local inflammation and disease progression Open
Chronic inflammation contributes to the prevalence of cardiovascular disease in people living with HIV (PLWH). The immune mechanisms driving atherosclerosis progression in PLWH remain unclear. This study conducted comprehensive assessments…
View article: Antecedent flu-like illness and onset of idiopathic dilated cardiomyopathy: The DCM Precision Medicine Study
Antecedent flu-like illness and onset of idiopathic dilated cardiomyopathy: The DCM Precision Medicine Study Open
Background Previous studies have speculated that a viral infection may act as a trigger in the development of idiopathic dilated cardiomyopathy (DCM) among individuals genetically at risk. This study aims to describe the frequency of DCM p…
View article: MON-279 Assessment of Inpatient Glycemic Management in Noncritical Care Settings.
MON-279 Assessment of Inpatient Glycemic Management in Noncritical Care Settings. Open
S. K c: None. A. Sharma: None. N.K. Rai: None. N. Aslam: None. S. Lincoln: None. K. Singla: None. P. Shah: None. A. Rana: None. P. Gandikota: None. Introduction: Adult patients with diabetes or newly recognized hyperglycemia account for ov…
View article: Derivation and validation of a multicenter model to identify candidates for advanced HF therapies with high potential to achieve post-LVAD reverse cardiac remodeling
Derivation and validation of a multicenter model to identify candidates for advanced HF therapies with high potential to achieve post-LVAD reverse cardiac remodeling Open
Background A subset of advanced heart failure (HF) patients can experience significant improvement in their cardiac structure and function while on left ventricular assist device (LVAD) support, which is among the prerequisites for LVAD we…
View article: Guideline‐directed medical therapy implementation during hospitalization for cardiogenic shock
Guideline‐directed medical therapy implementation during hospitalization for cardiogenic shock Open
Aims Despite significant morbidity and mortality, recent advances in cardiogenic shock (CS) management have been associated with increased survival. However, little is known regarding the management of patients who survive CS with heart fa…
View article: Abnormal TSH level as a predictor of severe outcomes among patients hospitalized with COVID-19
Abnormal TSH level as a predictor of severe outcomes among patients hospitalized with COVID-19 Open
OBJECTIVE: To assess the association between thyroid dysfunction and mortality among patients hospitalized with COVID-19. Design: This is a retrospective multi-center study, which examined all patients admitted with Covid-19 diagnoses, and…
View article: Smart City Community Watch—Camera-Based Community Watch for Traffic and Illegal Dumping
Smart City Community Watch—Camera-Based Community Watch for Traffic and Illegal Dumping Open
The United States is the second-largest waste generator in the world, generating 4.9 pounds (2.2 kg) of Municipal Solid Waste (MSW) per person each day. The excessive amount of waste generated poses serious health and environmental risks, …
View article: Biomarker profiles associated with reverse ventricular remodelling in patients with heart failure and a reduced ejection fraction: Insights from the echocardiographic substudy of the <scp>VICTORIA</scp> trial
Biomarker profiles associated with reverse ventricular remodelling in patients with heart failure and a reduced ejection fraction: Insights from the echocardiographic substudy of the <span>VICTORIA</span> trial Open
Aims Reverse ventricular remodelling, defined as a decrease in left ventricular end‐systolic volume indexed to body surface area (LVESVI) or an increase in left ventricular ejection fraction (LVEF), is associated with improved clinical out…
View article: RNAseq of INOCA patients identifies innate, invariant, and acquired immune changes: potential autoimmune microvascular dysfunction
RNAseq of INOCA patients identifies innate, invariant, and acquired immune changes: potential autoimmune microvascular dysfunction Open
Background Ischemia with non-obstructive coronary arteries (INOCA) is a major clinical entity that involves potentially 20%–30% of patients with chest pain. INOCA is typically attributed either to coronary microvascular disease and/or vaso…
View article: Surveillance with dual noninvasive testing for acute cellular rejection after heart transplantation: Outcomes from the Surveillance HeartCare Outcomes Registry
Surveillance with dual noninvasive testing for acute cellular rejection after heart transplantation: Outcomes from the Surveillance HeartCare Outcomes Registry Open
Dual molecular testing demonstrated improved performance for ACR surveillance compared to single molecular testing. The use of dual noninvasive testing was associated with lower biopsy rates over time, excellent survival, and low incidence…
View article: Evaluation of the Hemocompatibility of the Direct Oral Anticoagulant Apixaban in Left Ventricular Assist Devices
Evaluation of the Hemocompatibility of the Direct Oral Anticoagulant Apixaban in Left Ventricular Assist Devices Open
Anticoagulation with apixaban was feasible in patients with an LVAD without an excess of HRAEs or deaths. This study informs future pivotal clinical trials evaluating the safety and efficacy of apixaban in LVAD recipients. (Evaluation of t…