P. Aiden McCormick
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Community prevalence of blood-borne viruses (hepatitis B and HIV) in Ireland Open
Background Chronic infection with hepatitis B virus and HIV causes significant morbidity and mortality. Effective antiviral treatment is available for both. Ireland has historically been considered a low prevalence country. However, with i…
Hepatitis C community prevalence is over-estimated: a prospective, birth cohort study Open
Background Hepatitis C virus infection is often asymptomatic, and many patients may be unaware they are infected. Community-based, birth cohort screening has been advocated to identify these patients. It has been estimated that 0.7–1% of i…
View article: The natural history of cystic fibrosis liver disease a prospective cohort study
The natural history of cystic fibrosis liver disease a prospective cohort study Open
The incidence of CFLD was highest in children under10 years. Children over10 years, with normal hepatic function did not develop CFLD. Research to identify the cause and improve outcome should focus on young children.
Milestones in the discovery of hepatitis C Open
The discovery of hepatitis C has been a landmark in public health as it brought the opportunity to save millions of lives through the diagnosis, prevention and cure of the disease. The combined work of three researchers, Alter H, Houghton …
View article: Interventions for increasing immunosuppressant medication adherence in solid organ transplant recipients
Interventions for increasing immunosuppressant medication adherence in solid organ transplant recipients Open
Interventions to increase taking and dosing adherence to immunosuppressant therapy may be effective; however, our findings suggest that current evidence in support of interventions to increase adherence to immunosuppressant therapy is over…
Another Step Toward Hepatitis C Elimination: An Economic Evaluation of an Irish National Birth Cohort Testing Program Open
Both systematic and opportunistic birth cohort testing would be considered an efficient use of resources, but systematic testing was the optimal strategy at willingness-to-pay threshold values typically used in Ireland. Although cost-effec…
Andrew K. Burroughs: a research hepatologist extraordinaire Open
Andrew K (Andy) Burroughs passed away in March 2014 at the early age of 60 years. Andy was one of the last of the great all round giants of hepatology. He was a consummate physician, clinical investigator and educator. Over a period of 35 …
View article: A population-based comparison of organ transplant recipients in whom cutaneous squamous cell develops versus those in whom basal cell carcinoma develops
A population-based comparison of organ transplant recipients in whom cutaneous squamous cell develops versus those in whom basal cell carcinoma develops Open
To the Editor: Basal cell carcinomas (BCC) occur more frequently than cutaneous squamous cell carcinomas (cSCC) with a general population ratio of 2.5:1.1NCRI Cancer trends.https://www.ncri.ie/sites/ncri/files/pubs/Trends%20report%20skin%2…
The impact of switching to mTOR inhibitor-based immunosuppression on long-term non-melanoma skin cancer incidence and renal function in kidney and liver transplant recipients Open
Background: Solid organ transplantation is associated with increased risk of non-melanoma skin cancer. Studies with short follow up times have suggested a reduced occurrence of these cancers in recipients treated with mammalian target of r…
View article: Graphical Abstract: Angew. Chem. Int. Ed. 50/2019
Graphical Abstract: Angew. Chem. Int. Ed. 50/2019 Open
can be found at www.gdch.
View article: Wilms tumour: Long-term survival of patients treated at Mbingo Baptist Hospital in Cameroon between 2007 and 2012
Wilms tumour: Long-term survival of patients treated at Mbingo Baptist Hospital in Cameroon between 2007 and 2012 Open
Background: The survival rate of Wilms tumour (WT) in low-income sub-Saharan countries in Africa is below 50%. Thirty-five consecutive children diagnosed with WT between 2007 and 2012 at Mbingo Baptist Hospital, Cameroon, were observed in …
Keratinocyte carcinoma in organ transplant recipients Open
Skin cancer commonly affects people who have received a solid organ transplant (heart, lung, liver and kidney). Transplant patients can get multiple skin cancers, some of which can grow very quickly. The commonest types of skin cancer are …
Interventions for improving medication adherence in solid organ transplant recipients Open
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: This review aims to look at the benefits and harms of using interventions for improving adherence to immunosuppressant therapies in solid organ transpl…
View article: OC-010 Final efficacy and safety in hcv genotype 1-infected patients receiving ombitasvir/paritaprevir/ritonavir and dasabuvir ± ribavirin: topaz-i results from the united kingdom and ireland
OC-010 Final efficacy and safety in hcv genotype 1-infected patients receiving ombitasvir/paritaprevir/ritonavir and dasabuvir ± ribavirin: topaz-i results from the united kingdom and ireland Open
Introduction Ombitasvir/paritaprevir*/ritonavir (*identified by AbbVie and Enanta) and dasabuvir (3-DAA) ± ribavirin (RBV) treatment is effective and safe for patients infected with hepatitis C genotype 1 (HCV GT1), including those with co…
3 Mortality on orthotopic liver transplantation waiting list at national liver transplant unit ireland Open
Background Orthotopic liver transplantation is indicated in patients with end-stage liver disease, hepatocellular carcinoma (HCC) within transplant criteria and acute fulminant hepatic failure. Progression to end stage liver failure with …
Short article: Impact of genetic variation in the vasopressin 1a receptor on the development of organ failure in patients admitted for acute decompensation of liver cirrhosis Open
Background Vasopressin receptor-mediated vasoconstriction is considered to be involved in the pathogenesis of organ failure in acute-on-chronic liver failure (ACLF). Patients and methods We studied the association between six single nucleo…
Liver transplantation in Ireland Open
The Irish National Liver Transplant program commenced in 1993 in St. Vincent's University Hospital in Dublin. It is an adult‐only program and is the only liver transplant program in Ireland. Pediatric recipients are referred to King's Coll…
Liver transplantation for hepatocellular carcinoma in Ireland: Pre-operative alpha-fetoprotein predicts tumour recurrence in a 14-year single-centre national experience Open
Patients undergoing OLT for HCC had excellent survival even when conventional listing criteria were exceeded. Pre-operative AFP predicts recurrence independent of tumour size and its role in selection criteria should be investigated in lar…