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View article: A novel technique for direct verification of Ir‐192 source position in a multi‐channel vaginal cylinder using a mobile CBCT
A novel technique for direct verification of Ir‐192 source position in a multi‐channel vaginal cylinder using a mobile CBCT Open
Background For gynecological brachytherapy, multichannel vaginal cylinders (MCVC) offer improved control of the dose distribution as compared to single channel cylinders due to their peripheral channels. Evaluation of the source position i…
View article: FOLR1-targeted Actinium-225-based Alpha-particle Therapy Eliminates Ovarian Cancer
FOLR1-targeted Actinium-225-based Alpha-particle Therapy Eliminates Ovarian Cancer Open
Despite the advancement in therapies, ovarian cancer treatment is challenging due to poor prognosis and high relapse associated with acquired resistance. Targeting overexpression of FOLR1 in ovarian cancers has proven to be an attractive s…
View article: Evaluation of image quality in mobile cone‐beam CT with dose modulation using automatic exposure control: A phantom study
Evaluation of image quality in mobile cone‐beam CT with dose modulation using automatic exposure control: A phantom study Open
Background The integration of mobile cone‐beam computed tomography (CBCT) into brachytherapy workflows offers clinical advantages such as immediate verification of applicator placement and adaptive treatment planning. These benefits requir…
View article: Clinical test cases for model-based dose calculation algorithm commissioning, QA and benchmarking, for 192Ir HDR brachytherapy of gynecologic cancers
Clinical test cases for model-based dose calculation algorithm commissioning, QA and benchmarking, for 192Ir HDR brachytherapy of gynecologic cancers Open
Purpose: To develop clinically relevant test cases for commissioning Model-Based Dose Calculation Algorithms (MBDCAs) for 192Ir High Dose Rate (HDR) gynecologic brachytherapy following the workflow proposed by the TG-186 report and the WGD…
View article: Uncovering the Unexpected Role of Proteasome Activator PA200 in Regulating Immunoproteasome Expression and Activity
Uncovering the Unexpected Role of Proteasome Activator PA200 in Regulating Immunoproteasome Expression and Activity Open
The proteasome activator PA200 binds to the catalytic core of both standard proteasome (s20S) and the immunoproteasome (i20S); however, whether PA200 uses the same mechanisms to activate i20S remains unknown. Our cryo-EM structures of the …
View article: 3D-Printed Organ-Realistic Phantoms to Verify Quantitative SPECT/CT Accuracy for 177Lu-PSMA-617 Treatment Planning
3D-Printed Organ-Realistic Phantoms to Verify Quantitative SPECT/CT Accuracy for 177Lu-PSMA-617 Treatment Planning Open
Background/Objectives: Accurate patient-specific dosimetry is essential for optimizing radiopharmaceutical therapy (RPT), but current tools lack validation in clinically realistic conditions. This work aimed to develop a workflow for desig…
View article: Revealing the unexpected interplay between the Proteasome Activator PA200 and the immunoproteasome
Revealing the unexpected interplay between the Proteasome Activator PA200 and the immunoproteasome Open
The proteasome activator PA200 binds to the catalytic core of the proteasome, the 20S, and activates its proteolytic activities. The cellular function of PA200 is poorly understood and appears to be cell type and differentiation specific. …
View article: Optimization Processes of Clinical Chelation-Based Radiopharmaceuticals for Pathway-Directed Targeted Radionuclide Therapy in Oncology
Optimization Processes of Clinical Chelation-Based Radiopharmaceuticals for Pathway-Directed Targeted Radionuclide Therapy in Oncology Open
Targeted radionuclide therapy (TRT) for internal pathway-directed treatment is a game changer for precision medicine. TRT improves tumor control while minimizing damage to healthy tissue and extends the survival for patients with cancer. T…
View article: Novel 3D printed universal conical holder for eye plaque quality assurance
Novel 3D printed universal conical holder for eye plaque quality assurance Open
Purpose For the custom‐built construction of eye plaques, the iodine (I‐125) seeds of different source strengths are recycled in our eye plaque program. To return I‐125 seeds to the correct lot, we developed a novel 3D‐printed conical plaq…
View article: AAPM TG 236 Report 236: Recommendations on volume-image-based treatment planning, dosimetry, and quality management for HDR intracavitary brachytherapy: Part I breast
AAPM TG 236 Report 236: Recommendations on volume-image-based treatment planning, dosimetry, and quality management for HDR intracavitary brachytherapy: Part I breast Open
This is a zipped file for Appendix A.1 DVH validation using reference DCIOM datasets for AAPM TG report 236: Part I. Intracavitary breast brachytherapy. One can download and unzip the file. These are CT images and a structure file in DICOM…
View article: AAPM TG 236 Report 236: Recommendations on volume-image-based treatment planning, dosimetry, and quality management for HDR intracavitary brachytherapy: Part I breast
AAPM TG 236 Report 236: Recommendations on volume-image-based treatment planning, dosimetry, and quality management for HDR intracavitary brachytherapy: Part I breast Open
This is a zipped file for Appendix A.1 DVH validation using reference DCIOM datasets for AAPM TG report 236: Part I. Intracavitary breast brachytherapy. One can download and unzip the file. These are CT images and a structure file in DICOM…
View article: Actinium-225 Targeted Agents: Where Are We Now?
Actinium-225 Targeted Agents: Where Are We Now? Open
View article: Feasibility evaluation of novel AI‐based deep‐learning contouring algorithm for radiotherapy
Feasibility evaluation of novel AI‐based deep‐learning contouring algorithm for radiotherapy Open
Purpose To evaluate the clinical feasibility of the Siemens Healthineers AI‐Rad Companion Organs RT VA30A (Organs‐RT) auto‐contouring algorithm for organs at risk (OARs) of the pelvis, thorax, and head and neck (H&N). Methods Computed tomo…
View article: A MC‐based anthropomorphic test case for commissioning model‐based dose calculation in interstitial breast 192‐Ir HDR brachytherapy
A MC‐based anthropomorphic test case for commissioning model‐based dose calculation in interstitial breast 192‐Ir HDR brachytherapy Open
Purpose To provide the first clinical test case for commissioning of 192 Ir brachytherapy model‐based dose calculation algorithms (MBDCAs) according to the AAPM TG‐186 report workflow. Acquisition and Validation Methods A computational pat…
View article: Erratum: “AAPM task group report 303 endorsed by the ABS: MRI implementation in HDR brachytherapy—Considerations from simulation to treatment” https://doi.org/10.1002/mp.15713
Erratum: “AAPM task group report 303 endorsed by the ABS: MRI implementation in HDR brachytherapy—Considerations from simulation to treatment” https://doi.org/10.1002/mp.15713 Open
View article: AAPM task group report 303 endorsed by the ABS: MRI implementation in HDR brachytherapy—Considerations from simulation to treatment
AAPM task group report 303 endorsed by the ABS: MRI implementation in HDR brachytherapy—Considerations from simulation to treatment Open
The task group (TG) on magnetic resonance imaging (MRI) implementation in high‐dose‐rate (HDR) brachytherapy (BT)—Considerations from simulation to treatment, TG 303, was constituted by the American Association of Physicists in Medicine's …
View article: The American Brachytherapy Society consensus statement for permanent implant brachytherapy using Yttrium-90 microsphere radioembolization for liver tumors
The American Brachytherapy Society consensus statement for permanent implant brachytherapy using Yttrium-90 microsphere radioembolization for liver tumors Open
View article: Low dose rate brachytherapy for primary treatment of localized prostate cancer: A systemic review and executive summary of an evidence-based consensus statement
Low dose rate brachytherapy for primary treatment of localized prostate cancer: A systemic review and executive summary of an evidence-based consensus statement Open
View article: Issue Information
Issue Information Open
View article: Issue Information
Issue Information Open
and Rest of World), €2155 (Europe), £1591 (UK
View article: Dosimetric Characterization of an Abscopal Response in a Patient With Oligometastatic Melanoma Undergoing Concurrent Treatment With Pembrolizumab and Stereotactic Body Radiotherapy (SBRT)
Dosimetric Characterization of an Abscopal Response in a Patient With Oligometastatic Melanoma Undergoing Concurrent Treatment With Pembrolizumab and Stereotactic Body Radiotherapy (SBRT) Open
Patient History and TreatmentHere we report a dosimetric characterization of a possible abscopal response in a 57-year-old female with oligometastatic melanoma.Recently, preclinical and clinical evidence has shown that a synergy may exist …
View article: Dose volume histogram‐based optimization of image reconstruction parameters for quantitative <sup>90</sup>Y‐<scp>PET</scp> imaging
Dose volume histogram‐based optimization of image reconstruction parameters for quantitative <sup>90</sup>Y‐<span>PET</span> imaging Open
Purpose 90 Y‐microsphere radioembolization or selective internal radiation therapy is increasingly being used as a treatment option for tumors that are not candidates for surgery and external beam radiation therapy. Recently, volumetric 90…
View article: The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules
The Impact of Radiation on the Tumor Microenvironment: Effect of Dose and Fractionation Schedules Open
In addition to inducing lethal DNA damage in tumor and stromal cells, radiation can alter the interactions of tumor cells with their microenvironment. Recent technological advances in planning and delivery of external beam radiotherapy hav…
View article: 2017 American Brachytherapy Society’s Annual Meeting Report
2017 American Brachytherapy Society’s Annual Meeting Report Open
The American Brachytherapy Society (ABS) and its membership seeks to benefit patients by promoting the highest possible standard for brachytherapy practice, support health care professionals through the encouragement of state of the art te…
View article: Evaluation of a deterministic grid-based Boltzmann solver (GBBS) for voxel-level absorbed dose calculations in nuclear medicine
Evaluation of a deterministic grid-based Boltzmann solver (GBBS) for voxel-level absorbed dose calculations in nuclear medicine Open
To evaluate the 3D Grid-based Boltzmann Solver (GBBS) code ATTILA (®) for coupled electron and photon transport in the nuclear medicine energy regime for electron (beta, Auger and internal conversion electrons) and photon (gamma, x-ray) so…
View article: Dosimetric Impact of SAVITM Breast Applicator Position Near Tissue Heterogeneities
Dosimetric Impact of SAVITM Breast Applicator Position Near Tissue Heterogeneities Open
View article: PO-0979: LTB control and toxicity for Favorable and Intmed Risk pts using real time IO-PSI prostate BT alone
PO-0979: LTB control and toxicity for Favorable and Intmed Risk pts using real time IO-PSI prostate BT alone Open
View article: Interpreting reported absorbed doses for 90Y microsphere therapy: 120 Gy does not equal 120 Gy
Interpreting reported absorbed doses for 90Y microsphere therapy: 120 Gy does not equal 120 Gy Open
View article: Learning anatomy changes from patient populations to create artificial CT images for voxel‐level validation of deformable image registration
Learning anatomy changes from patient populations to create artificial CT images for voxel‐level validation of deformable image registration Open
The purpose of this study was to develop an approach to generate artificial computed tomography (CT) images with known deformation by learning the anatomy changes in a patient population for voxel‐level validation of deformable image regis…
View article: Boosting Response: The Impact of Immune Checkpoint Inhibitors on Radiation Treatment Schedules
Boosting Response: The Impact of Immune Checkpoint Inhibitors on Radiation Treatment Schedules Open
1Department of Radiation Oncology, Christiana Care Health Services Inc., Newark DE 19713, USA 2Center for Translational Cancer Research, Helen F Graham Cancer Center and Research Institute, Christiana Care Health Services Inc., Newark DE 1…