Nabeela Mughal
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View article: Exploring UK medical schools’ perception and intent for teaching on antimicrobial resistance and stewardship
Exploring UK medical schools’ perception and intent for teaching on antimicrobial resistance and stewardship Open
Background Antimicrobial resistance (AMR) is a key global public health threat. Developing healthcare worker awareness and knowledge in AMR and antimicrobial stewardship (AMS) are UK national action plan targets. Competency frameworks have…
View article: Correction: Cost-effectiveness of rapid, ICU-based, syndromic PCR in hospital-acquired pneumonia: analysis of the INHALE WP3 multi-centre RCT
Correction: Cost-effectiveness of rapid, ICU-based, syndromic PCR in hospital-acquired pneumonia: analysis of the INHALE WP3 multi-centre RCT Open
View article: Cost-effectiveness of rapid, ICU-based, syndromic PCR in hospital-acquired pneumonia: analysis of the INHALE WP3 multi-centre RCT
Cost-effectiveness of rapid, ICU-based, syndromic PCR in hospital-acquired pneumonia: analysis of the INHALE WP3 multi-centre RCT Open
Background Hospital-acquired and ventilator-associated pneumonia (HAP and VAP) are pneumonias arising > 48 h after admission or intubation respectively. Conventionally, HAP/VAP patients are given broad-spectrum empiric antibiotics at clini…
View article: Evolving antimicrobial resistance of extensively drug-resistant Gram-negative severe infections associated with conflict wounds in Ukraine: an observational study
Evolving antimicrobial resistance of extensively drug-resistant Gram-negative severe infections associated with conflict wounds in Ukraine: an observational study Open
View article: INHALE WP3, a multicentre, open-label, pragmatic randomised controlled trial assessing the impact of rapid, ICU-based, syndromic PCR, versus standard-of-care on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia
INHALE WP3, a multicentre, open-label, pragmatic randomised controlled trial assessing the impact of rapid, ICU-based, syndromic PCR, versus standard-of-care on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia Open
View article: Point-of-care tests, diagnostic uncertainty and antimicrobial stewardship in the ICU: procalcitonin or PCR to aid antibiotic-stop decisions – an observational cohort study
Point-of-care tests, diagnostic uncertainty and antimicrobial stewardship in the ICU: procalcitonin or PCR to aid antibiotic-stop decisions – an observational cohort study Open
Objectives Intensive care unit (ICU) clinicians stop antibiotics more often, with a negative infection: point-of-care test (PCR-POCT). Simulated cases of diagnostic uncertainty regarding infection resolution led clinicians to choose option…
View article: Conflict and catastrophe-related severe burn injuries: A challenging setting for antimicrobial decision-making
Conflict and catastrophe-related severe burn injuries: A challenging setting for antimicrobial decision-making Open
Severe burns are a major component of conflict-related injuries and can result in high rates of mortality. Conflict and disaster-related severe burn injuries present unique challenges in logistic, diagnostic and treatment options, while wi…
View article: Comparison of Outcomes of Intravenous Dexamethasone Versus Placebo as Adjunct to Local Anaesthetic Brachial Plexus Block for Upper Limb Surgery
Comparison of Outcomes of Intravenous Dexamethasone Versus Placebo as Adjunct to Local Anaesthetic Brachial Plexus Block for Upper Limb Surgery Open
Introduction: Dexamethasone has been tested in combination with different local anesthetics with varying degree of results including increase in intensity and duration of block. Objectives: To compare the outcomes of intravenous dexamethas…
View article: A case of ceftriaxone-induced immune haemolytic anaemia in an ambulatory care setting
A case of ceftriaxone-induced immune haemolytic anaemia in an ambulatory care setting Open
Background: Drug-induced immune haemolytic anaemia (DIIHA) is a rare adverse effect which varies between mild to fatal (Garratty, 2010). One of the most common class of drugs reported to cause severe DIIHA are the second and third generati…
View article: WHY STOP? A prospective observational vignette-based study to determine the cognitive-behavioural effects of rapid diagnostic PCR-based point-of-care test results on antibiotic cessation in ICU infections
WHY STOP? A prospective observational vignette-based study to determine the cognitive-behavioural effects of rapid diagnostic PCR-based point-of-care test results on antibiotic cessation in ICU infections Open
Objectives Point-of-care tests (POCTs) for infection offer accurate rapid diagnostics but do not consistently improve antibiotic stewardship (ASP) of suspected ventilator-associated pneumonia. We aimed to measure the effect of a negative P…
View article: Infection Point of Care Tests (POCT) in simulated vignettes can improve the education of Antibiotic Stewardship Programmes. An observational comparative study of Clinicians vs Medical Students
Infection Point of Care Tests (POCT) in simulated vignettes can improve the education of Antibiotic Stewardship Programmes. An observational comparative study of Clinicians vs Medical Students Open
Background Point of Care Tests (POCTs) offer accurate rapid diagnostics for infections but have not improved antibiotic-free-days. This has been attributed to clinician prescribing behaviour rather than test performance. Hypothesising expe…
View article: National action plans for antimicrobial resistance and variations in surveillance data platforms
National action plans for antimicrobial resistance and variations in surveillance data platforms Open
The considerable heterogeneity of nationally submitted data to commonly used antimicrobial resistance surveillance platforms compromises their validity, thus undermining local and global antimicrobial resistance strategies. Hence, we need …
View article: Hybrid immunity in older adults is associated with reduced SARS-CoV-2 infections following BNT162b2 COVID-19 immunisation
Hybrid immunity in older adults is associated with reduced SARS-CoV-2 infections following BNT162b2 COVID-19 immunisation Open
View article: Haematological and hepatic adverse effects of ceftriaxone in ambulatory care: a dual-centre retrospective observational analysis of standard vs high dose
Haematological and hepatic adverse effects of ceftriaxone in ambulatory care: a dual-centre retrospective observational analysis of standard vs high dose Open
View article: Rapid reconfiguration of sexual health services in response to UK autochthonous transmission of mpox (monkeypox)
Rapid reconfiguration of sexual health services in response to UK autochthonous transmission of mpox (monkeypox) Open
View article: Need for standardized vancomycin dosing for coagulase-negative staphylococci in hospitalized infants
Need for standardized vancomycin dosing for coagulase-negative staphylococci in hospitalized infants Open
View article: Novel inhaled antifungal for pseudomembranous<i>Aspergillus</i>tracheobronchitis complicating connective tissue disease
Novel inhaled antifungal for pseudomembranous<i>Aspergillus</i>tracheobronchitis complicating connective tissue disease Open
Introduction It has been estimated that over one-third of all Americans die from diseases that are, in part, brought on by behaviors that compromise their health. Mokdad, Mark, Stroup & Gerberding (2000) recently reported that tobacco, poo…
View article: Evaluating the long-term impact of an antimicrobial stewardship programme in a Central London mixed medical and surgical intensive care unit
Evaluating the long-term impact of an antimicrobial stewardship programme in a Central London mixed medical and surgical intensive care unit Open
Background Antimicrobial overuse causes increased antimicrobial resistance in ICUs; antimicrobial stewardship programmes (ASPs) aim to optimize usage. Following an MDR Acinetobacter baumannii (MRAb) outbreak in 2008, an ASP was implemented…
View article: WHY STOP? Quantifying Cognitive-Behavioural factors that influence the impact of PCR-POCT results on antibiotic cessation in ICU
WHY STOP? Quantifying Cognitive-Behavioural factors that influence the impact of PCR-POCT results on antibiotic cessation in ICU Open
INTRODUCTION: Rapid Point of Care Tests for infection (POCT) do not consistently improve antibiotic stewardship (ASP) of suspected ICU infection. We measured 1) the effect of a negative PCR-POCT on antibiotic stop decisions, and 2) clinico…
View article: Early identification of high-risk individuals for monoclonal antibody therapy and prophylaxis is feasible by SARS-CoV-2 anti-spike antibody specific lateral flow assay
Early identification of high-risk individuals for monoclonal antibody therapy and prophylaxis is feasible by SARS-CoV-2 anti-spike antibody specific lateral flow assay Open
View article: Optimization of antimicrobial dosing in patients with acute kidney injury: a single-centre observational study
Optimization of antimicrobial dosing in patients with acute kidney injury: a single-centre observational study Open
Background Acute kidney injury (AKI) is a potential complication of systemic infection. Optimizing antimicrobial dosing in this dynamic state can be challenging with sub- or supra-therapeutic dosing risking treatment failure or toxicity, r…
View article: Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London, UK: an observational analysis
Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London, UK: an observational analysis Open
View article: Transmission of monkeypox virus through sexual contact – A novel route of infection
Transmission of monkeypox virus through sexual contact – A novel route of infection Open
View article: Evaluating the performance characteristics of five lateral flow assays for the detection of the SARS-CoV-2 nucleocapsid antigen
Evaluating the performance characteristics of five lateral flow assays for the detection of the SARS-CoV-2 nucleocapsid antigen Open
View article: “It's always hard being a mom, but the pandemic has made everything harder”: A qualitative exploration of the experiences of perinatal women during the COVID-19 pandemic
“It's always hard being a mom, but the pandemic has made everything harder”: A qualitative exploration of the experiences of perinatal women during the COVID-19 pandemic Open
View article: Epidemiological Characteristics and Clinical Features of Confirmed Human Monkeypox Virus Cases in Individuals Attending a Sexual Health Centre in London, United Kingdom
Epidemiological Characteristics and Clinical Features of Confirmed Human Monkeypox Virus Cases in Individuals Attending a Sexual Health Centre in London, United Kingdom Open
View article: COVID-19 Prognostic Models: A Pro-con Debate for Machine Learning vs. Traditional Statistics
COVID-19 Prognostic Models: A Pro-con Debate for Machine Learning vs. Traditional Statistics Open
The SARS-CoV-2 virus, which causes the COVID-19 pandemic, has had an unprecedented impact on healthcare requiring multidisciplinary innovation and novel thinking to minimize impact and improve outcomes. Wide-ranging disciplines have collab…
View article: Healthcare worker perceptions of routine asymptomatic SARS-CoV-2 screening using lateral flow assays: A qualitative analysis across two London hospitals.
Healthcare worker perceptions of routine asymptomatic SARS-CoV-2 screening using lateral flow assays: A qualitative analysis across two London hospitals. Open
View article: Evaluating The Performance Characteristics of Five Lateral Flow Assays for The Detection of The SARS- CoV-2 Nucleocapsid Antigen
Evaluating The Performance Characteristics of Five Lateral Flow Assays for The Detection of The SARS- CoV-2 Nucleocapsid Antigen Open
Introduction : In response to the COVID-19 pandemic, lateral flow assays (LFAs) for the detection of SARS-CoV-2 antigen have been proposed as a complementary option to the more costly and time consuming reverse-transcriptase polymerase cha…
View article: Procalcitonin to Guide Antibacterial Prescribing in Patients Hospitalised with COVID-19
Procalcitonin to Guide Antibacterial Prescribing in Patients Hospitalised with COVID-19 Open
Antibacterial prescribing in patients presenting with COVID-19 remains discordant to rates of bacterial co-infection. Implementing diagnostic tests to exclude bacterial infection may aid reduction in antibacterial prescribing. (1) Method: …