Joseph A. Murray
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View article: O022 Sleep disturbance amongst university students: a cross-sectional questionnaire-based study
O022 Sleep disturbance amongst university students: a cross-sectional questionnaire-based study Open
Introduction A particularly at-risk population for sleep disorders is university students, who are biologically and environmentally predisposed to insomnia and delayed sleep–wake phase disorder (DSWPD). The present study aims to assess the…
View article: GLI3 Is Required for M2 Macrophage Polarization and M2-Mediated Waldenström Macroglobulinemia Growth and Survival
GLI3 Is Required for M2 Macrophage Polarization and M2-Mediated Waldenström Macroglobulinemia Growth and Survival Open
Waldenstrom macroglobulinemia (WM) is a non-Hodgkin B-cell lymphoma, characterized by bone marrow infiltration with plasma cells and lymphocytes. The tumor microenvironment (TME) plays an important role in mediating WM cell biology, but th…
View article: Laboratory Testing for Celiac Disease: Clinical and Methodological Considerations
Laboratory Testing for Celiac Disease: Clinical and Methodological Considerations Open
Background Celiac disease (CeD) has an estimated prevalence of 1%–3%. The classical clinical presentation is malabsorption, but now patients may present with more subtle symptoms such as constipation, osteoporosis, or iron deficiency anemi…
View article: A36 EFFECT OF FIBRE SUPPLEMENTATION IN CELIAC DISEASE: IMPLICATIONS FOR MUCOSAL HEALING
A36 EFFECT OF FIBRE SUPPLEMENTATION IN CELIAC DISEASE: IMPLICATIONS FOR MUCOSAL HEALING Open
Background Celiac disease (CeD) is a T-cell mediated enteropathy driven by gluten in genetically susceptible individuals. Mucosal inflammation persists for years even when treated with a gluten-free diet (GFD). Although patients may be adv…
View article: Dynamics of Serologic Change to Gluten in Celiac Disease Patients
Dynamics of Serologic Change to Gluten in Celiac Disease Patients Open
Serologic measures of tissue transglutaminase (tTG) immunoglobulin A (IgA) and deamidated gliadin peptide (DGP) IgA and immunoglobulin G (IgG) are hallmark tests utilized when diagnosing individuals for celiac disease (CeD) and for monitor…
View article: Dynamics of Serologic Change to Gluten in Celiac Disease Patients
Dynamics of Serologic Change to Gluten in Celiac Disease Patients Open
Serologic measures of tissue transglutaminase (tTG) immunoglobulin A (IgA) and deamidated gliadin peptide (DGP) IgA and immunoglobulin G (IgG) are hallmark tests utilized when diagnosing individuals for celiac disease (CeD) and for monitor…
View article: Efficacy of Antiobesity Medications in Patients With Celiac Disease on a Gluten-free Diet
Efficacy of Antiobesity Medications in Patients With Celiac Disease on a Gluten-free Diet Open
Goals: We aim to describe the weight loss outcomes of patients with celiac disease (CeD) taking antiobesity medications (AOMs) and compare it with the weight loss outcomes of patients without CeD taking AOMs. Background: Increasing rates o…
View article: A population-based nationwide study on total colectomy for ulcerative colitis and risk of ten prevalent inflammatory or autoimmune diseases
A population-based nationwide study on total colectomy for ulcerative colitis and risk of ten prevalent inflammatory or autoimmune diseases Open
The risk of IAD was higher for patients who underwent TC for UC compared to patients who did not.KEY MESSAGESWhat is already known?o The gut microbiome plays an important role in host immune homeostasis, and changes in gut bacterial divers…
View article: Strain-tunable Berry curvature in quasi-two-dimensional chromium telluride
Strain-tunable Berry curvature in quasi-two-dimensional chromium telluride Open
Magnetic transition metal chalcogenides form an emerging platform for exploring spin-orbit driven Berry phase phenomena owing to the nontrivial interplay between topology and magnetism. Here we show that the anomalous Hall effect in pristi…
View article: ‘ACOPP’ chemotherapy for older and less fit patients with Hodgkin lymphoma—a multicentre, retrospective study
‘ACOPP’ chemotherapy for older and less fit patients with Hodgkin lymphoma—a multicentre, retrospective study Open
Introduction: Patients (pts) aged ≥60 years comprise 20%–30% of classical Hodgkin lymphoma (cHL) diagnoses, but are significantly underrepresented in clinical trials and outcomes for this group have not improved in line with advances seen …
View article: Data from Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted?
Data from Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted? Open
This perspective on the report by Beatty et al. in this issue of the journal (beginning on page 438) discusses the prevention of cancer through vaccination strategies that target antigens associated with tumor promotion and progression. Su…
View article: Related Article from Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted?
Related Article from Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted? Open
Related Article from Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted?
View article: Related Article from Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted?
Related Article from Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted? Open
Related Article from Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted?
View article: Data from Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted?
Data from Vaccine Prevention of Cancer: Can Endogenous Antigens Be Targeted? Open
This perspective on the report by Beatty et al. in this issue of the journal (beginning on page 438) discusses the prevention of cancer through vaccination strategies that target antigens associated with tumor promotion and progression. Su…
View article: DOP16 Anti-integrin αvβ6 autoantibodies predate Ulcerative Colitis diagnosis by up to 10 years and are associated with adverse disease-related outcomes
DOP16 Anti-integrin αvβ6 autoantibodies predate Ulcerative Colitis diagnosis by up to 10 years and are associated with adverse disease-related outcomes Open
Background Biomarkers for predicting the development of Ulcerative Colitis (UC) and disease-related complications are lacking. Anti-integrin αvβ6 IgG autoantibodies (anti-αvβ6) have been recently described in patients diagnosed with UC. He…
View article: Anti-integrin αvβ6 autoantibodies are a novel predictive biomarker in ulcerative colitis
Anti-integrin αvβ6 autoantibodies are a novel predictive biomarker in ulcerative colitis Open
Background and Aims Better biomarkers for prediction of ulcerative colitis (UC) development and prognostication are needed. Anti-integrin αvβ6 autoantibodies (anti-αvβ6) have been described in UC patients. Here, we tested for the presence …
View article: Effect of Esophagogastroduodenoscopy Volume and Gastric/Esophageal Pathology on the Rate of Lymphocytic Duodenosis Reporting in Children and Adolescents
Effect of Esophagogastroduodenoscopy Volume and Gastric/Esophageal Pathology on the Rate of Lymphocytic Duodenosis Reporting in Children and Adolescents Open
Background It is not clear if the increase in the number of esophagogastroduodenoscopies (EGDs) performed has any significant effect on the rate of lymphocytic duodenosis (LD) reporting in children and adolescents and whether it correlates…
View article: Dr. Jeffrey L. Conklin memoriam
Dr. Jeffrey L. Conklin memoriam Open
Dr. Jeffrey L. Conklin was born in Iowa City, Iowa, on February 20, 1950, the state in which he spent his formative years. He completed his undergraduate studies at the University of Iowa with a Bachelor of Science degree in journalism tha…