Aliya Khan
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View article: Patient-Reported Outcomes in Palopegteriparatide-Treated Adults with Hypoparathyroidism: PaTH Forward Trial Extension
Patient-Reported Outcomes in Palopegteriparatide-Treated Adults with Hypoparathyroidism: PaTH Forward Trial Extension Open
Context Individuals with hypoparathyroidism experience a range of physical and cognitive symptoms and reduced quality of life (QoL) despite management with conventional therapy (active vitamin D and calcium). Objective This analysis invest…
View article: Current and Emerging Treatments For the Management of Hypoparathyroidism
Current and Emerging Treatments For the Management of Hypoparathyroidism Open
Chronic hypoparathyroidism is a rare endocrine disorder marked by parathyroid hormone (PTH) deficiency, leading to hypocalcemia and its associated complications. Conventional therapy with oral calcium and active vitamin D fails to address …
View article: SUN-711 Clinical Presenting Features, Biochemical, Radiological, and Genetic Characteristics of Four Male Patients with Osteopetrosis from a Canadian Tertiary Center.
SUN-711 Clinical Presenting Features, Biochemical, Radiological, and Genetic Characteristics of Four Male Patients with Osteopetrosis from a Canadian Tertiary Center. Open
Disclosure: M.H. Alabdely: None. D.S. Ali: None. M. Brandi: None. A.A. Khan: None. Background: Osteopetrosis (OPT) is a rare bone disease associated with decreased osteoclast-mediated bone resorption. OPT is caused by various mutations whi…
View article: SUN-749 Impact of Treatment with Burosumab versus Conventional Therapy on Patient-Important Outcomes in Adult X-Linked Hypophosphatemia: A Retrospective and Prospective Cohort Study
SUN-749 Impact of Treatment with Burosumab versus Conventional Therapy on Patient-Important Outcomes in Adult X-Linked Hypophosphatemia: A Retrospective and Prospective Cohort Study Open
Disclosure: D.S. Ali: None. A. Kubba: None. M.H. Alabdely: None. R. Alnajimi: None. A.A. Alraddadi: None. E. Morgante: None. M. Brandi: Takeda, Eli Lilly & Company, Calcilytix, Kyowa Kirin, UCB, Abiogen, Alexion, Amolyt, Amorphical, Bruno …
View article: SUN-759 Real-World Outcomes in Late Adolescence Among Individuals With X-linked Hypophosphatemia (XLH): Results From the XLH Disease Monitoring Program
SUN-759 Real-World Outcomes in Late Adolescence Among Individuals With X-linked Hypophosphatemia (XLH): Results From the XLH Disease Monitoring Program Open
Disclosure: A.A. Khan: Ascendis, Takeda, Amolyt, Bridge Bio, Alexion Pharmaceuticals, Inc. E.A. Imel: Kyowa Kirin, Ultragenyx. L.M. Ward: Kyowa Kirin, Ultragenyx. T.O. Carpenter: Kyowa Kirin, Ultragenyx. J. Simmons: Kyowa Kirin, Ultragenyx…
View article: OR10-05 Efficacy and Safety of Palopegteriparatide Treatment in Adults With Hypoparathyroidism: 3-Year Results From The Phase 3 PaTHway Trial
OR10-05 Efficacy and Safety of Palopegteriparatide Treatment in Adults With Hypoparathyroidism: 3-Year Results From The Phase 3 PaTHway Trial Open
Disclosure: A.A. Khan: Alexion Pharmaceuticals, Inc., Amgen Inc, Amolyt Pharma, Ascendis Pharma. B.L. Clarke: Amolyt Pharma, Ascendis Pharma, EnteraBio, Extend Bio, Takeda. M.R. Rubin: Ascendis Pharma, MBX Biosciences. P.E. Schwarz: Aventi…
View article: SUN-757 Sustained Improvements in Patient-Reported Outcomes Across Age Groups in Burosumab-Treated X-linked Hypophosphatemia (XLH): Results From the XLH Disease Monitoring Program
SUN-757 Sustained Improvements in Patient-Reported Outcomes Across Age Groups in Burosumab-Treated X-linked Hypophosphatemia (XLH): Results From the XLH Disease Monitoring Program Open
Disclosure: A.A. Khan: Ascendis, Alexion Pharmaceuticals, Inc., Amolyt, Bridge Bio, Takeda. T.O. Carpenter: Kyowa Kirin, Ultragenyx. J. Simmons: Kyowa Kirin, Ultragenyx. H. Cassinelli: None. E.A. Imel: Kyowa Kirin, Ultragenyx. P.F. Florenz…
View article: SAT-739 Case Report: Autosomal Dominant Hypocalcemia Type 2 In A 43-year-old Male Presenting At A Tertiary Canadian Medical Center
SAT-739 Case Report: Autosomal Dominant Hypocalcemia Type 2 In A 43-year-old Male Presenting At A Tertiary Canadian Medical Center Open
Disclosure: M.H. Alabdely: None. A.A. Khan: None. Background: Autosomal dominant hypocalcemia (ADH) type 1 and type 2 are rare disorders caused by gain-of-function variants that activate the calcium sensing receptor (CASR) gene, leading to…
View article: SAT-743 HDR Syndrome: Phenotypic Variations and Autoimmune Manifestations Within One Kindred
SAT-743 HDR Syndrome: Phenotypic Variations and Autoimmune Manifestations Within One Kindred Open
Disclosure: A.A. Alraddadi: None. D.S. Ali: None. A.A. Khan: Takeda, Ascendis, Amolyt, Amgen Inc, Alexion,Calcilytix. Background: HDR syndrome or Barakat syndrome is a rare autosomal dominant disorder caused by pathogenic variants in GATA3…
View article: SAT-778 Bone Mineral Density Changes in Postmenopausal Women Switching from 30 mg Denosumab to Intravenous Zoledronic Acid: A Prospective Observational Study
SAT-778 Bone Mineral Density Changes in Postmenopausal Women Switching from 30 mg Denosumab to Intravenous Zoledronic Acid: A Prospective Observational Study Open
Disclosure: D.S. Ali: None. Z. Chung: None. L. Kamel: None. A.A. Khan: Takeda, research funds, research funds from Ascendis, Amolyt. Background: In postmenopausal women with osteoporosis, discontinuation of denosumab (Dmab), has been assoc…
View article: SUN-765 Retrospective Analysis of Pregnancy and Neonatal Outcomes in Hypoparathyroidism from the PARADIGHM Registry
SUN-765 Retrospective Analysis of Pregnancy and Neonatal Outcomes in Hypoparathyroidism from the PARADIGHM Registry Open
Disclosure: D.S. Ali: None. Z. Chung: None. L. Kamel: None. S. Björnsdottir: Shire. B.L. Clarke: Shire, Takeda, Ascendis, Calcilytix. S. Hahner: None. L.C. Hofbauer: Amgen Inc, Ascendis, UCB, Ascendis, Amolyte. P. Houillier: None. S.W. Ing…
View article: Acute Complications in Hemodialysis: Frequency, Patterns, and Clinical Implications
Acute Complications in Hemodialysis: Frequency, Patterns, and Clinical Implications Open
Chronic Kidney Disease (CKD) is a progressive and irreversible condition increasingly recognized as a global public health challenge. Hemodialysis, though life-sustaining, is frequently associated with acute complications that compromise p…
View article: Health-related quality of life in a cohort of 1070 patients with hypoparathyroidism
Health-related quality of life in a cohort of 1070 patients with hypoparathyroidism Open
Objective To describe clinical and biochemical characteristics, including health-related quality of life (HRQoL), in patients with chronic hypoparathyroidism (cHypoPT) who were receiving conventional therapy (calcium and active vitamin D),…
View article: Selective Visibility of Western Media: A Critical Discourse Analysis of AI’s Responses on the Palestine and Ukraine Conflicts
Selective Visibility of Western Media: A Critical Discourse Analysis of AI’s Responses on the Palestine and Ukraine Conflicts Open
This study investigates how artificial intelligence (AI) discerns and reproduces the patterns of selective visibility in Western media coverage of two major global conflicts: Palestine–Israel and Russia–Ukraine. The primary aim is to exami…
View article: A COMPARATIVE STUDY OF BIERS BLOCK USING LIGNOCAINE & LIGNOCAINE WITH DEXMEDETOMIDINE
A COMPARATIVE STUDY OF BIERS BLOCK USING LIGNOCAINE & LIGNOCAINE WITH DEXMEDETOMIDINE Open
Background: Intravenous regional anaesthesia (IVRA) using Biers Block is a simple and effective technique for short-duration surgeries of the upper limb. Lignocaine is a commonly used local anesthetic for IVRA. Adding dexmedetomidine, an a…
View article: rhPTH(1-84) for hypoparathyroidism: a randomized study of patient-reported outcomes
rhPTH(1-84) for hypoparathyroidism: a randomized study of patient-reported outcomes Open
Objective To assess the impact of recombinant human parathyroid hormone (1-84) [rhPTH(1-84)] compared with placebo, in combination with conventional therapy with vitamin D and/or calcium supplements, on health-related quality of life (HRQo…
View article: Bone status in patients with chronic hypoparathyroidism: results from the Italian HypoparaNET database
Bone status in patients with chronic hypoparathyroidism: results from the Italian HypoparaNET database Open
Background Chronic hypoparathyroidism (HypoPT) is a rare endocrine condition, having variable etiology, characterized by low parathyroid hormone levels, leading to reduced calcium levels and increased phosphorus values in the blood. Bone h…
View article: <b>PREVALENCE OF ALLERGIC: BRONCHO-PULMONARY ASPERGILLOSIS IN PATIENTS WITH PULMONARY TUBERCULOSIS</b>
<b>PREVALENCE OF ALLERGIC: BRONCHO-PULMONARY ASPERGILLOSIS IN PATIENTS WITH PULMONARY TUBERCULOSIS</b> Open
Background: Allergic Bronchopulmonary Aspergillosis (ABPA) is a hypersensitivity airway disease caused by Aspergillus species, and is common in chronic lung disease patients such as Pulmonary Tuberculosis (TB). In TB patients, the immunoco…
View article: Best practice recommendations for the diagnosis and management of hypoparathyroidism
Best practice recommendations for the diagnosis and management of hypoparathyroidism Open
These best practice recommendations provide a framework for HypoPT diagnosis and management, emphasizing individualized care, role of DNA analysis in the diagnosis of nonsurgical HypoPT, and role of PTH or PTH analogue therapy as appropria…
View article: Real-world effectiveness of burosumab vs oral phosphate and active vitamin D in adults with X-linked hypophosphatemia
Real-world effectiveness of burosumab vs oral phosphate and active vitamin D in adults with X-linked hypophosphatemia Open
In X-linked hypophosphatemia (XLH), PHEX gene variants lead to elevated FGF23 production, resulting in hypophosphatemia, osteomalacia, osteomalacia-related fractures, osteoarthritis, enthesopathy, spinal stenosis, and symptoms of pain, sti…
View article: X-Linked Hypophosphatemia Management in Adults: An International Working Group Clinical Practice Guideline
X-Linked Hypophosphatemia Management in Adults: An International Working Group Clinical Practice Guideline Open
Purpose An international working group (IWG) consisting of experts in X-linked hypophosphatemia (XLH) developed global guidelines providing a comprehensive, evidence-based approach to XLH diagnosis, management, and monitoring. Methods The …
View article: Frequency of folate deficiency in chronic kidney disease patients on maintenance hemodialysis.
Frequency of folate deficiency in chronic kidney disease patients on maintenance hemodialysis. Open
Objective: To determine the frequency of folate deficiency in chronic kidney disease patients on maintenance hemodialysis presenting to Nephrology OPD of Khyber Teaching Hospital Peshawar. Study Design: Descriptive, Cross sectional. Period…