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View article: Editorial: Robotics in laboratory automation
Editorial: Robotics in laboratory automation Open
The increasing complexity of modern life science laboratories presents unique challenges for automation and robotics that extend beyond traditional industrial applications. As laboratory workflows become increasingly intricate, the integra…
View article: Maternal and Perinatal Outcomes of Preeclampsia: A Case-Control Study at a Tertiary Hospital in Lagos, Nigeria
Maternal and Perinatal Outcomes of Preeclampsia: A Case-Control Study at a Tertiary Hospital in Lagos, Nigeria Open
Aim: Preeclampsia is a global burden leading to maternal and perinatal morbidity and mortality. It is peculiar to human pregnancy with adverse consequences. The study aims to compare the clinical characteristics and complications between w…
View article: Measurement and prediction of small molecule retention by Gram-negative bacteria based on a large-scale LC/MS screen
Measurement and prediction of small molecule retention by Gram-negative bacteria based on a large-scale LC/MS screen Open
The challenge of assessing intracellular accumulation represents a major hurdle to the discovery of new antibiotics with Gram-negative activity. To address this, a high-throughput assay was developed to measure compound uptake and retentio…
View article: Patient Outcomes after Surgical Repair of Acromioclavicular Joint Using Cerclage-Wire Figure of ‘8’ Technique at Kumi Orthopaedic Center; A Retrospective Consecutive Case Series
Patient Outcomes after Surgical Repair of Acromioclavicular Joint Using Cerclage-Wire Figure of ‘8’ Technique at Kumi Orthopaedic Center; A Retrospective Consecutive Case Series Open
Introduction: Proposed surgical methods for the repair of Acromio-clavicular Joint (ACJ) vary widely. However, the currently available treatment modalities require high technology e.g. specialised sutures that impose a high financial burde…
View article: Investigating the effects of Lonchocarpus cyanencens aqueous leaf extracts on the histology of the cardiovascular system in normal albino Wistar rats
Investigating the effects of Lonchocarpus cyanencens aqueous leaf extracts on the histology of the cardiovascular system in normal albino Wistar rats Open
The shrub tree Lonchocarpus cyanescens is one of the herbal remedies traditionally used in Nigeria to promote human health. In the western part of the nation Nigeria, it is used to treat diabetes mellitus. Investigating the histomorphologi…
View article: Predicting Foot Salvageability in Diabetic Foot Lesion: Comparison of Benin Diabetic Foot Severity Score and Wagner System
Predicting Foot Salvageability in Diabetic Foot Lesion: Comparison of Benin Diabetic Foot Severity Score and Wagner System Open
BACKGROUND: A diabetic foot lesion is a disabling and chronic complication of diabetes mellitus. It has been found to be relatively common in the University of Benin Teaching Hospital Benin City. An aid for making decision on choice, modal…
View article: Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors
Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP2 and EP4 receptors Open
Pathological features of pulmonary fibrosis include accumulation of myofibroblasts and increased extracellular matrix (ECM) deposition in lung tissue. Contractile α-smooth muscle actin (α-SMA)-expressing myofibroblasts that produce and sec…
View article: The Screening Compound Collection: A Key Asset for Drug Discovery
The Screening Compound Collection: A Key Asset for Drug Discovery Open
In this case study on an essential instrument of modern drug discovery, we summarize our successful efforts in the last four years toward enhancing the Actelion screening compound collection. A key organizational step was the establishment…