Anna‐Carin Olin
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View article: Phospholipid composition in small airway lining fluid among tunnel construction workers exposed to respirable crystalline silica
Phospholipid composition in small airway lining fluid among tunnel construction workers exposed to respirable crystalline silica Open
Objective To explore if the phospholipid composition in the small airway lining fluid differed between a group of tunnel construction workers exposed to respirable crystalline silica (RCS) and a reference group. Methods In total, 19 health…
View article: Occupational exposure to welding fumes associated with pulmonary surfactant lipid compositional changes, inflammatory activity and pulmonary functioning.
Occupational exposure to welding fumes associated with pulmonary surfactant lipid compositional changes, inflammatory activity and pulmonary functioning. Open
Objective To investigate alterations in the respiratory tract lining fluid phospholipids and their association with pulmonary function in welding fume-exposed workers. Method Particles in exhaled air were collected from 134 subjects. Pulmo…
View article: Changes in the pulmonary surfactant in patients with mild to moderate COVID-19
Changes in the pulmonary surfactant in patients with mild to moderate COVID-19 Open
Introduction Changes in the pulmonary surfactant have been seen in severe COVID-19, but data on mild to moderate COVID-19 is scarce. The aim of this study was to explore the protein and phospholipid profiles in the small airways in patient…
View article: Prevalence of Myocardial Infarction With Obstructive and Non-Obstructive Coronary Arteries in a Middle-Aged Population With Chronic Airflow Limitation: A Cross-Sectional Study
Prevalence of Myocardial Infarction With Obstructive and Non-Obstructive Coronary Arteries in a Middle-Aged Population With Chronic Airflow Limitation: A Cross-Sectional Study Open
Middle-aged people with CAL have an almost doubled risk of both MI-CAD and MINOCA, compared with people without CAL. In contrast to people without CAL, the risk of MINOCA is increased in men and the risk of MI-CAD is increased in women. In…
View article: Proteins associated with preserved ratio impaired spirometry
Proteins associated with preserved ratio impaired spirometry Open
Background Preserved ratio impaired spirometry (PRISm) is a spirometry pattern of interest regarding incident airflow obstruction and higher mortality risk. We applied a proteomic approach to gain more insight into the biological mechanism…
View article: Chronic Airflow Limitation, Emphysema, and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-aged Population
Chronic Airflow Limitation, Emphysema, and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-aged Population Open
Rationale: Chronic obstructive pulmonary disease (COPD) includes respiratory symptoms and chronic airflow limitation (CAL). In some cases, emphysema and impaired diffusing capacity of the lung for carbon monoxide (DlCO) are present, but ch…
View article: Restrictive Spirometric Pattern and Preserved Ratio Impaired Spirometry in a Population Aged 50–64 Years
Restrictive Spirometric Pattern and Preserved Ratio Impaired Spirometry in a Population Aged 50–64 Years Open
Rationale: Knowledge regarding the prevalence and shared and unique characteristics of the restrictive spirometric pattern (RSP) and preserved ratio impaired spirometry (PRISm) is lacking for a general population investigated with post-bro…
View article: Comparison of associations between alcohol consumption and metabolic syndrome according to three definitions: The Swedish INTERGENE study
Comparison of associations between alcohol consumption and metabolic syndrome according to three definitions: The Swedish INTERGENE study Open
Our study shows that alcohol-related associations differ by definition of MetS. The finding that individuals with the most stringently defined MetS may benefit from alcohol consumption calls for further well-controlled studies.
View article: Detailed characterization and impact of small airway dysfunction in school-age asthma
Detailed characterization and impact of small airway dysfunction in school-age asthma Open
Discordant oscillometry and MBW abnormality suggests they reflect different aspects of SAD, serving as complementary tools. Key asthma clinical features, like reversibility, had stronger correlation with MBW-derived Scond than oscillometry…
View article: Respiratory function after 30+ years following sulfur mustard exposure in survivors in Sweden
Respiratory function after 30+ years following sulfur mustard exposure in survivors in Sweden Open
Background Sulfur mustard (SM) exposure causes acute and chronic respiratory diseases. The extent of small airway dysfunction (SAD) in individuals exposed to SM is unclear. This study evaluated and compared SAD in SM-exposed and SM-unexpos…
View article: Impaired function in the lung periphery following COVID‐19 is associated with lingering breathing difficulties
Impaired function in the lung periphery following COVID‐19 is associated with lingering breathing difficulties Open
Lingering breathing difficulties are common after COVID‐19. However, the underlying causes remains unclear, with spirometry often being normal. We hypothesized that small airway dysfunction (SAD) can partly explain these symptoms. We exami…
View article: Low birthweight and maternal smoking as predictors of infant lung function from a South African birth cohort within low socioeconomic communities
Low birthweight and maternal smoking as predictors of infant lung function from a South African birth cohort within low socioeconomic communities Open
Background. Early assessment of infant lung function (ILF) is necessary to improve our understanding of factors that determine long- term respiratory health.
Objective. To identify predictors of lung function among infants aged 6 …
View article: Occupational exposure and health surveys at metal additive manufacturing facilities
Occupational exposure and health surveys at metal additive manufacturing facilities Open
Introduction Additive manufacturing is a novel state-of-the art technology with significant economic and practical advantages, including the ability to produce complex structures on demand while reducing the need of stocking materials and …
View article: Comparative modelling study of exposure to respiratory aerosols in an office, meeting room, commuter train, and lunch room
Comparative modelling study of exposure to respiratory aerosols in an office, meeting room, commuter train, and lunch room Open
The data set contains all input and output files from a comparative study on indoor transmission of infectious diseases. The study comprises - 4 indoor environments: Public transport (commuter train), shared office, meeting room, lunch roo…
View article: Comparative modelling study of exposure to respiratory aerosols in an office, meeting room, commuter train, and lunch room
Comparative modelling study of exposure to respiratory aerosols in an office, meeting room, commuter train, and lunch room Open
The data set contains all input and output files from a comparative study on indoor transmission of infectious diseases. The study comprises - 4 indoor environments: Public transport (commuter train), shared office, meeting room, lunch roo…
View article: An explorative study on respiratory health among operators working in polymer additive manufacturing
An explorative study on respiratory health among operators working in polymer additive manufacturing Open
Additive manufacturing (AM), or 3D printing, is a growing industry involving a wide range of different techniques and materials. The potential toxicological effects of emissions produced in the process, involving both ultrafine particles a…
View article: Activation of the Complement and Coagulation Systems in the Small Airways in Asthma
Activation of the Complement and Coagulation Systems in the Small Airways in Asthma Open
Background: Several studies have shown the importance of the complement and coagulation systems in the pathogenesis of asthma. Objectives: We explored whether we could detect differentially abundant complement and coagulation proteins in t…
View article: A novel non-invasive method allowing for discovery of pathologically relevant proteins from small airways
A novel non-invasive method allowing for discovery of pathologically relevant proteins from small airways Open
Background There is a lack of early and precise biomarkers for personalized respiratory medicine. Breath contains an aerosol of droplet particles, which are formed from the epithelial lining fluid when the small airways close and re-open d…
View article: Inflammatory cytokines can be monitored in exhaled breath particles following segmental and inhalation endotoxin challenge in healthy volunteers
Inflammatory cytokines can be monitored in exhaled breath particles following segmental and inhalation endotoxin challenge in healthy volunteers Open
Particles in exhaled air (PEx) are generated when collapsed small airways reopen during breathing. PEx can be noninvasively collected by particle impaction, allowing the analysis of undiluted epithelial lining fluid (ELF). We used the endo…
View article: Surfactant protein A in particles in exhaled air and plasma
Surfactant protein A in particles in exhaled air and plasma Open
Respiratory tract lining fluid (RTLF) is an important component of the lung epithelial barrier. Pathological changes in RTLF may cause increased permeability of the epithelial barrier, but changes within RTLF are difficult to assess non-in…