Alexander Opitz
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View article: Simulation of evoked responses to transcranial magnetic stimulation using a multiscale cortical circuit model
Simulation of evoked responses to transcranial magnetic stimulation using a multiscale cortical circuit model Open
This validated multiscale model provides mechanistic insights into TMS-evoked cortical dynamics, demonstrating how direct neuronal activation cascades through synaptic networks to generate characteristic population responses. The framework…
View article: Simulation of evoked responses to transcranial magnetic stimulation using a multiscale cortical circuit model
Simulation of evoked responses to transcranial magnetic stimulation using a multiscale cortical circuit model Open
Background Transcranial magnetic stimulation (TMS) is a widely used non-invasive brain stimulation technique, but the neural circuits activated by TMS remain poorly understood. Previous modeling approaches have been limited to either simpl…
View article: Bayesian Temporal Prediction: A Robust Algorithm for Real-time EEG Phase-dependent Brain Stimulation.
Bayesian Temporal Prediction: A Robust Algorithm for Real-time EEG Phase-dependent Brain Stimulation. Open
The widespread adoption of BTP in research and clinical settings has the potential to enhance treatment efficacy and minimize inter- and intra-individual variability in brain stimulation interventions.
View article: MRI-individualized, multi-electrode tACS enhances the induced electrical field strength in the targeted area of mild cognitive impairment patients
MRI-individualized, multi-electrode tACS enhances the induced electrical field strength in the targeted area of mild cognitive impairment patients Open
Anatomical variations can significantly impact the electrical field strength induced by transcranial electrical stimulation (tACS) in the brain of MCI patients.
View article: Layers of the monkey visual cortex are selectively modulated during electrical stimulation
Layers of the monkey visual cortex are selectively modulated during electrical stimulation Open
The mammalian neocortex, organized into six cellular layers or laminae, forms a cortical network within layers. Layer-specific computations are crucial for sensory processing of visual stimuli within the primary visual cortex. Laminar reco…
View article: Human head models and populational framework for simulating brain stimulations
Human head models and populational framework for simulating brain stimulations Open
Noninvasive brain stimulation (NIBS) is pivotal in studying human brain-behavior relations and treating brain disorders. NIBS effectiveness relies on informed targeting of specific brain regions, a challenge due to anatomical differences b…
View article: Targeting VMPFC‐amygdala circuit with TMS in substance use disorder: A mechanistic framework
Targeting VMPFC‐amygdala circuit with TMS in substance use disorder: A mechanistic framework Open
The ventromedial prefrontal cortex (VMPFC), located along the medial aspect of the frontal area, plays a critical role in regulating arousal/emotions. Its intricate connections with subcortical structures, including the striatum and amygda…
View article: Home‐Based Multifocal Brain Circuit‐Based Neuromodulation Combining tACS and tDCS in Older Adults with Alzheimer’s Disease
Home‐Based Multifocal Brain Circuit‐Based Neuromodulation Combining tACS and tDCS in Older Adults with Alzheimer’s Disease Open
Background Alzheimer’s disease (AD) affects over 55 million people worldwide and is characterized by abnormal deposition of amyloid‐β and tau in the brain causing neuronal damage and disrupting transmission within brain circuits. Episodic …
View article: State-Dependent Motor Cortex Stimulation Reveals Distinct Mechanisms for Corticospinal Excitability and Cortical Responses
State-Dependent Motor Cortex Stimulation Reveals Distinct Mechanisms for Corticospinal Excitability and Cortical Responses Open
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation method that modulates brain activity by inducing electric fields in the brain. Real-time, state-dependent stimulation with TMS has shown that neural oscillation pha…
View article: Real-time TMS-EEG for brain state-controlled research and precision treatment: a narrative review and guide
Real-time TMS-EEG for brain state-controlled research and precision treatment: a narrative review and guide Open
Transcranial magnetic stimulation (TMS) modulates neuronal activity, but the efficacy of an open-loop approach is limited due to the brain state’s dynamic nature. Real-time integration with electroencephalography (EEG) increases experiment…
View article: Layer-specific dynamics of local field potentials in monkey V1 during electrical stimulation
Layer-specific dynamics of local field potentials in monkey V1 during electrical stimulation Open
The mammalian neocortex, organized into six cellular layers or laminae, forms a cortical network within layers. Layer specific computations are crucial for sensory processing of visual stimuli within primary visual cortex. Laminar recordin…
View article: Abnormal mu rhythm state-related cortical and corticospinal responses in chronic stroke
Abnormal mu rhythm state-related cortical and corticospinal responses in chronic stroke Open
The motor cortex’s activity is state-dependent. Specifically, the sensorimotor mu rhythm phase relates to fluctuating levels of primary motor cortex (M1) excitability, previously demonstrated in young and healthy volunteers. However, it is…
View article: Data Sources on the 19th and Early 20th Century German Capital Market: Challenges and Opportunities
Data Sources on the 19th and Early 20th Century German Capital Market: Challenges and Opportunities Open
This article provides a comprehensive overview of the most important sources and data available for the German capital market, highlighting their capabilities and limitations. We focus on firm-specific information related to stock corporat…