Michael A. O’Reilly
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View article: Whole genome transcriptomics reveal distinct atrial versus ventricular responses to neonatal hyperoxia
Whole genome transcriptomics reveal distinct atrial versus ventricular responses to neonatal hyperoxia Open
Preterm infants often require oxygen (hyperoxia) at birth, but early exposure increases the risk of heart failure later in life. Previously, we showed neonatal mice exposed to hyperoxia develop adult diastolic dysfunction and heart failure…
View article: Building Career Paths for Ph.D., Basic and Translational Scientists in Clinical Departments in the United States: An Official American Thoracic Society Workshop Report
Building Career Paths for Ph.D., Basic and Translational Scientists in Clinical Departments in the United States: An Official American Thoracic Society Workshop Report Open
Rationale: To identify barriers and opportunities for Ph.D., basic and translational scientists to be fully integrated into clinical units. Objectives: In 2022, an ad hoc committee of the American Thoracic Society developed a project propo…
View article: Neonatal hypoxic ischemic encephalopathy increases acute kidney injury urinary biomarkers in a rat model
Neonatal hypoxic ischemic encephalopathy increases acute kidney injury urinary biomarkers in a rat model Open
Hypoxic ischemic encephalopathy (HIE) is associated with acute kidney injury (AKI) in neonates with birth asphyxia. This study aimed to utilize urinary biomarkers to characterize AKI in an established neonatal rat model of HIE. Day 7 Sprag…
View article: Diacetyl inhalation impairs airway epithelial repair in mice infected with influenza A virus
Diacetyl inhalation impairs airway epithelial repair in mice infected with influenza A virus Open
Bronchiolitis obliterans (BO) is a debilitating disease of the small airways that can develop following exposure to toxic chemicals as well as respiratory tract infections. BO development is strongly associated with diacetyl (DA) inhalatio…
View article: Ataxia telangiectasia mutated is required for efficient proximal airway epithelial cell regeneration following influenza A virus infection
Ataxia telangiectasia mutated is required for efficient proximal airway epithelial cell regeneration following influenza A virus infection Open
Children and young adults with mutant forms of ataxia telangiectasia mutated (ATM), a kinase involved in DNA damage signaling and mitochondrial homeostasis, suffer from recurrent respiratory infections, immune deficiencies, and obstructive…
View article: Neonatal Hyperoxia Activates Activating Transcription Factor 4 to Stimulate Folate Metabolism and Alveolar Epithelial Type 2 Cell Proliferation
Neonatal Hyperoxia Activates Activating Transcription Factor 4 to Stimulate Folate Metabolism and Alveolar Epithelial Type 2 Cell Proliferation Open
Oxygen supplementation in preterm infants disrupts alveolar epithelial type 2 (AT2) cell proliferation through poorly understood mechanisms. Here, newborn mice are used to understand how hyperoxia stimulates an early aberrant wave of AT2 c…
View article: Low-dose hyperoxia primes airways for fibrosis in mice after influenza A infection
Low-dose hyperoxia primes airways for fibrosis in mice after influenza A infection Open
It is well known that supplemental oxygen used to treat preterm infants in respiratory distress is associated with permanently disrupting lung development and the host response to influenza A virus (IAV). However, many infants who go home …
View article: Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis
Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis Open
Preterm birth increases the risk for pulmonary hypertension and heart failure in adulthood. Oxygen therapy can damage the immature cardiopulmonary system and may be partially responsible for the cardiovascular disease in adults born preter…
View article: Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice
Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice Open
The severity of COVID-19 lung disease is higher in the elderly and people with pre-existing co-morbidities. People who were born preterm may be at greater risk for COVID-19 because their early exposure to oxygen at birth increases their ri…
View article: Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis Open
The cell type specific sequences of transcriptional programs during lung regeneration have remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, we resolved transcriptional dynamics for 28 cell types. …
View article: Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A Infection
Low Dose Hyperoxia Primes Airways for Fibrosis in Mice after Influenza A Infection Open
It is well known that supplemental oxygen used to treat preterm infants in respiratory distress is associated with permanently disrupting lung development and the host response to influenza A virus (IAV). However, many infants who go home …
View article: Neonatal hyperoxia inhibits proliferation of atrial cardiomyocytes by suppressing fatty acid synthesis
Neonatal hyperoxia inhibits proliferation of atrial cardiomyocytes by suppressing fatty acid synthesis Open
Preterm birth increases the risk for pulmonary hypertension and heart failure in adulthood. Oxygen therapy can damage the immature cardiopulmonary system and may be partially responsible for the cardiovascular disease in adults born preter…
View article: Tumor Necrosis Factor Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease–Associated Pulmonary Arterial Hypertension
Tumor Necrosis Factor Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease–Associated Pulmonary Arterial Hypertension Open
Objective Connective tissue disease ( CTD )–associated pulmonary arterial hypertension ( PAH ) is the second most common etiology of PAH and carries a poor prognosis. Recently, it has been shown that female human tumor necrosis factor ( TN…
View article: Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection
Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection Open
Ataxia-telangiectasia (A-T), caused by mutations in the A-T mutated ( ATM) gene, is a neurodegenerative disorder affecting ∼1 in 40,000–100,000 children. Recurrent respiratory infections are a common and challenging comorbidity, often lead…
View article: Lung‐Derived SOD3 Attenuates Neurovascular Injury After Transient Global Cerebral Ischemia
Lung‐Derived SOD3 Attenuates Neurovascular Injury After Transient Global Cerebral Ischemia Open
Background Systemic innate immune priming is a recognized sequela of post‐ischemic neuroinflammation and contributor to delayed neurodegeneration. Given mounting evidence linking acute stroke with reactive lung inflammation, we asked wheth…
View article: Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasia
Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasia Open
RNAseq using PBMCs from subjects with classic A-T uncovered differential expression of immune response genes and biological processes associated with inflammation, immune regulation, and cancer. Follow-up of A-T subjects over a 4-6 year pe…
View article: Lung-Specific Extracellular Superoxide Dismutase Improves Cognition of Adult Mice Exposed to Neonatal Hyperoxia
Lung-Specific Extracellular Superoxide Dismutase Improves Cognition of Adult Mice Exposed to Neonatal Hyperoxia Open
Lung and brain development is often altered in infants born preterm and exposed to excess oxygen, and this can lead to impaired lung function and neurocognitive abilities later in life. Oxygen-derived reactive oxygen species and the ensuin…