Paul A. Haynes
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View article: Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations
Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations Open
Acute myeloid leukemia (AML) remains a formidable clinical challenge due to genetic heterogeneity, high relapse rates, and toxicities associated with conventional chemotherapies. Rationally designed drug combinations offer improved efficac…
View article: Quantitative Proteomics of Cochlear Tissues: Bilateral Comparisons in Guinea Pigs and Rats
Quantitative Proteomics of Cochlear Tissues: Bilateral Comparisons in Guinea Pigs and Rats Open
The cochlea, an incredibly sensitive sensory system, detects sound waves and converts them into electrical signals the brain recognizes as sound. Damage to cochlear hair cells can release proteins, triggering biological responses that may …
View article: Uncovering the antifungal potential of Cannabidiol and Cannabidivarin
Uncovering the antifungal potential of Cannabidiol and Cannabidivarin Open
Fungal infections pose a major threat to human health with increasing incidence of antifungal resistance globally. Despite the need for novel antifungal drugs, few are currently in clinical development. Here we evaluate the antifungal acti…
View article: Comparative Proteomics of Resistant and Susceptible Strains of <i>Frankliniella occidentalis</i> to Abamectin
Comparative Proteomics of Resistant and Susceptible Strains of <i>Frankliniella occidentalis</i> to Abamectin Open
Western flower thrips, Frankliniella occidentalis ( Thysanoptera : Thripidae) is an invasive agricultural pest with developed resistance to abamectin in some strains due to frequent treatment with the pesticide. In this study, we examined …
View article: Integrated proteome and metabolome analysis of the penultimate internodes revealing remobilization efficiency in contrasting barley genotypes under water stress
Integrated proteome and metabolome analysis of the penultimate internodes revealing remobilization efficiency in contrasting barley genotypes under water stress Open
The remobilization of stored assimilates from stems to seeds plays a pivotal role in augmenting barley yield, particularly under water stress conditions. This study examines the molecular mechanisms underlying stem reserve utilization by c…
View article: Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations
Shifting Beyond Classical Drug Synergy in Combinatorial Therapy through Solubility Alterations Open
Acute myeloid leukemia (AML) remains a formidable clinical challenge due to genetic heterogeneity, high relapse rates, and toxicities associated with conventional chemotherapies. Rationally designed drug combinations offer improved efficac…
View article: The Current State of Proteomics and Metabolomics for Inner Ear Health and Disease
The Current State of Proteomics and Metabolomics for Inner Ear Health and Disease Open
Characterising inner ear disorders represents a significant challenge due to a lack of reliable experimental procedures and identified biomarkers. It is also difficult to access the complex microenvironments of the inner ear and investigat…
View article: A universal protocol for high-quality DNA and RNA isolation from diverse plant species
A universal protocol for high-quality DNA and RNA isolation from diverse plant species Open
Next-generation sequencing demands high-quality nucleic acid, yet isolating DNA and RNA is often challenging, particularly from plant tissues. Despite advances in developing various kits and reagents, these products are tailored to isolati…
View article: Proteome-Wide Profiling Using Sample Multiplexing of a Human Cell Line Treated with Cannabidiol (CBD) and Tetrahydrocannabinol (THC)
Proteome-Wide Profiling Using Sample Multiplexing of a Human Cell Line Treated with Cannabidiol (CBD) and Tetrahydrocannabinol (THC) Open
Cannabis has been used historically for both medicinal and recreational purposes, with the most notable cannabinoids being cannabidiol (CBD) and tetrahydrocannabinol (THC). Although their therapeutic effects have been well studied and thei…
View article: Effect of ABA Pre-Treatment on Rice Plant Transcriptome Response to Multiple Abiotic Stress
Effect of ABA Pre-Treatment on Rice Plant Transcriptome Response to Multiple Abiotic Stress Open
Half of the world’s population depends on rice plant cultivation, yet environmental stresses continue to substantially impact the production of one of our most valuable staple foods. The aim of this study was to investigate the changes in …
View article: Amyloid-beta and tau protein beyond Alzheimer’s disease
Amyloid-beta and tau protein beyond Alzheimer’s disease Open
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, the…
View article: Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases
Apolipoprotein ε in Brain and Retinal Neurodegenerative Diseases Open
Alzheimer's disease (AD) is the most common form of dementia that remains incurable and has become a major medical, social, and economic challenge worldwide. AD is characterized by pathological hallmarks of senile plaques (SP) and neurofib…
View article: 11th Asia Oceania Human Proteome Organization Congress Report
11th Asia Oceania Human Proteome Organization Congress Report Open
As the first in-person Asia Oceania Human Proteomics Organization (AOHUPO) congress since 2018, the 11th AOHUPO congress was an opportune time for the research community to reconnect and to renew friendships after the long period of restri…
View article: Pre-Treatment of Rice Plants with ABA Makes Them More Tolerant to Multiple Abiotic Stress
Pre-Treatment of Rice Plants with ABA Makes Them More Tolerant to Multiple Abiotic Stress Open
Multiple abiotic stress is known as a type of environmental unfavourable condition maximizing the yield and growth gap of crops compared with the optimal condition in both natural and cultivated environments. Rice is the world’s most impor…
View article: Oxidative Stress Induced Dysfunction of Protein Synthesis in 661W Mice Photoreceptor Cells
Oxidative Stress Induced Dysfunction of Protein Synthesis in 661W Mice Photoreceptor Cells Open
Photoreceptor cells are highly susceptible to oxidative-stress-induced damage due to their high metabolic rate. Oxidative stress plays a key role in driving pathological events in several different ocular diseases, which lead to retinal de…
View article: Unique and Shared Proteome Responses of Rice Plants (Oryza sativa) to Individual Abiotic Stresses
Unique and Shared Proteome Responses of Rice Plants (Oryza sativa) to Individual Abiotic Stresses Open
Food safety of staple crops such as rice is of global concern and is at the top of the policy agenda worldwide. Abiotic stresses are one of the main limitations to optimizing yields for sustainability, food security and food safety. We ana…
View article: Habibpourmehraban et al Supplementary data file updated 25Nov2022
Habibpourmehraban et al Supplementary data file updated 25Nov2022 Open
Supplementary data for a publication submitted to International Journal of Molecular Sciences, Habibpourmehraban et al, November 2022. This version updated to also include raw data from parallel reaction monitoring experiments.
View article: Habibpourmehraban et al Supplementary data file updated 25Nov2022
Habibpourmehraban et al Supplementary data file updated 25Nov2022 Open
Supplementary data for a publication submitted to International Journal of Molecular Sciences, Habibpourmehraban et al, November 2022. This version updated to also include raw data from parallel reaction monitoring experiments.
View article: Habibpourmehraban et al Oct 2022 Supplementary Data S1
Habibpourmehraban et al Oct 2022 Supplementary Data S1 Open
This file contains details of proteins and differentially expressed proteins identified and quantified in a study conducted by Fatemeh Habibpourmehraban at Macquarie University on proteomics analysis of stress response in Oryza sativa rice…
View article: Habibpourmehraban et al Oct 2022 Supplementary Data S1
Habibpourmehraban et al Oct 2022 Supplementary Data S1 Open
This file contains details of proteins and differentially expressed proteins identified and quantified in a study conducted by Fatemeh Habibpourmehraban at Macquarie University on proteomics analysis of stress response in Oryza sativa rice…
View article: Unique and shared proteome responses of rice plants (<i>Oryza sativa</i>) to individual abiotic stresses
Unique and shared proteome responses of rice plants (<i>Oryza sativa</i>) to individual abiotic stresses Open
Food safety of staple crops such as rice is of global concern and is at the top of the policy agenda worldwide. Abiotic stresses are one of the main limitations to optimizing yields for sustainability, food security and food safety. We ana…
View article: Proteomic analysis of the meristematic root zone in contrasting genotypes reveals new insights in drought tolerance in rice
Proteomic analysis of the meristematic root zone in contrasting genotypes reveals new insights in drought tolerance in rice Open
Drought is responsible for major losses in rice production. Root tips contain meristematic and elongation zones that play major roles in determination of root traits and adaptive strategies to drought. In this study we analysed two contras…
View article: Fingolimod effects on the brain are mediated through biochemical modulation of bioenergetics, autophagy, and neuroinflammatory networks
Fingolimod effects on the brain are mediated through biochemical modulation of bioenergetics, autophagy, and neuroinflammatory networks Open
Fingolimod (FTY720) is an oral drug approved by the Food and Drug Administration (FDA) for management of multiple sclerosis (MS) symptoms, which has also shown beneficial effects against Alzheimer's (AD) and Parkinson's (PD) diseases patho…
View article: Species identification of early colonial bone artefacts excavated from Pyrmont, Australia, by mass spectrometric identification of collagen peptides
Species identification of early colonial bone artefacts excavated from Pyrmont, Australia, by mass spectrometric identification of collagen peptides Open
Zooarchaeology by Mass Spectrometry (ZooMS) is a rapidly developing and increasingly utilised peptide mass fingerprinting (PMF) technique that analyses Collagen 1A1 and 1A2 marker peptides for the genus- or species-level identification of …
View article: Key Genes and Biochemical Networks in Various Brain Regions Affected in Alzheimer’s Disease
Key Genes and Biochemical Networks in Various Brain Regions Affected in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is one of the most complicated progressive neurodegenerative brain disorders, affecting millions of people around the world. Ageing remains one of the strongest risk factors associated with the disease and the incr…
View article: Genome-Wide Expression Analysis of Root Tips in Contrasting Rice Genotypes Revealed Novel Candidate Genes for Water Stress Adaptation
Genome-Wide Expression Analysis of Root Tips in Contrasting Rice Genotypes Revealed Novel Candidate Genes for Water Stress Adaptation Open
Root system architecture (RSA) is an important agronomic trait with vital roles in plant productivity under water stress conditions. A deep and branched root system may help plants to avoid water stress by enabling them to acquire more wat…
View article: Multiple Abiotic Stresses Applied Simultaneously Elicit Distinct Responses in Two Contrasting Rice Cultivars
Multiple Abiotic Stresses Applied Simultaneously Elicit Distinct Responses in Two Contrasting Rice Cultivars Open
Rice crops are often subject to multiple abiotic stresses simultaneously in both natural and cultivated environments, resulting in yield reductions beyond those expected from single stress. We report physiological changes after a 4 day exp…