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View article: Consensus to Conquer Challenges in Influenza Immunization in Pulmonology Practice in India: Proceedings of the Congregation on Influenza Vaccination in Chronic Lung Diseases (CIRCLE) Expert Committee Meet
Consensus to Conquer Challenges in Influenza Immunization in Pulmonology Practice in India: Proceedings of the Congregation on Influenza Vaccination in Chronic Lung Diseases (CIRCLE) Expert Committee Meet Open
Influenza remains a major health concern, especially for patients with chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Despite clear evidence of its benefits, annual influenza vaccination rates…
View article: Concordance between FVC and FEV <sub>6</sub> for identifying chronic airflow obstruction and spirometric restriction in the Burden of Obstructive Lung Disease (BOLD) study
Concordance between FVC and FEV <sub>6</sub> for identifying chronic airflow obstruction and spirometric restriction in the Burden of Obstructive Lung Disease (BOLD) study Open
Introduction We investigated whether the forced expiratory volume in 6 s (FEV 6 ) can be used as a surrogate for the forced vital capacity (FVC). Methods The Burden of Obstructive Lung Disease is a multinational cohort study. At baseline, …
View article: Association between smoking behaviors and COPD in Kashmir: a hospital-based study
Association between smoking behaviors and COPD in Kashmir: a hospital-based study Open
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. This study investigates the association between smoking, dietary habits, and urinary cotinine levels with COPD in a tertiary …
View article: Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis
Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis Open
We previously reported that Tibetan-specific variant of prolyl-hydroxylase-2 (PHD2) D4E;C127S protects highlanders from hypoxia-triggered pathologies by destabilizing hypoxia-inducible factor (HIF)-1α. Others have reported that stabilized …
View article: Fibular length and vital capacity in the multinational Burden of Obstructive Lung Disease follow-up study
Fibular length and vital capacity in the multinational Burden of Obstructive Lung Disease follow-up study Open
The association between long bone length and vital capacity was consistently small and non-significant in this multinational study https://bit.ly/43FmQnH
View article: Quality of life associated with chronic cough in the multinational Burden of Obstructive Lung Disease study: a cross-sectional study
Quality of life associated with chronic cough in the multinational Burden of Obstructive Lung Disease study: a cross-sectional study Open
Background Chronic cough (CC) can impact daily life and persist for years. Its prevalence varies globally, but whether quality of life in CC also varies across regions is unknown. This study investigates the association of CC with mental a…
View article: 50,000 years of evolutionary history of India: Impact on health and disease variation
50,000 years of evolutionary history of India: Impact on health and disease variation Open
India has been underrepresented in genomic surveys. We generated whole-genome sequences from 2,762 individuals in India, capturing the genetic diversity across most geographic regions, linguistic groups, and historically underrepresented c…
View article: Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study: A cross-sectional analysis
Quality of life associated with breathlessness in the multinational Burden of Obstructive Lung Disease (BOLD) study: A cross-sectional analysis Open
Quality of life is worse in people with breathlessness, but this association varies widely across the world.
View article: Severity Scale of Influenza and Acute Respiratory Illness Hospitalizations to Support Viral Genomic Surveillance: A Global Influenza Hospital Surveillance Network Pilot Study
Severity Scale of Influenza and Acute Respiratory Illness Hospitalizations to Support Viral Genomic Surveillance: A Global Influenza Hospital Surveillance Network Pilot Study Open
Background This study aimed to establish a Severity Scale for influenza and other acute respiratory infections (ARI), requiring hospitalization, for surveillance and research purposes (the SevScale). Such a scale could aid the interpretati…
View article: The Global Influenza Hospital Surveillance Network: A Multicountry Public Health Collaboration
The Global Influenza Hospital Surveillance Network: A Multicountry Public Health Collaboration Open
Respiratory viruses represent a significant public health threat. There is the need for robust and coordinated surveillance to guide global health responses. Established in 2012, the Global Influenza Hospital Surveillance Network (GIHSN) a…
View article: Nebulization Optimization for Management of Obstructive Airway Disorders: An Expert Review (NOVA-ER)
Nebulization Optimization for Management of Obstructive Airway Disorders: An Expert Review (NOVA-ER) Open
Background: Nebulization therapy is an essential inhalation technique for managing obstructive airway diseases such as asthma, bronchiectasis, and chronic obstructive pulmonary disease (COPD). In Indian clinical settings, factors such as d…
View article: Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study
Lung function and onset of cardiometabolic diseases in the longitudinal Burden of Obstructive Lung Disease study Open
Introduction Previous population-based studies, mainly from high-income countries, have shown that a higher forced vital capacity (FVC) is associated with a lower risk of developing cardiometabolic diseases. The aim of this study was to as…
View article: A 7-point evidence-based care discharge protocol for patients hospitalized for exacerbation of COPD: consensus strategy and expert recommendation
A 7-point evidence-based care discharge protocol for patients hospitalized for exacerbation of COPD: consensus strategy and expert recommendation Open
Acute exacerbations of COPD (ECOPD) are an important event in the life of a COPD patient as it causes significant deterioration of physical, mental, and social health, hastens disease progression, increases the risk of dying and causes a h…
View article: Geographical variation in lung function: Results from the multicentric cross-sectional BOLD study
Geographical variation in lung function: Results from the multicentric cross-sectional BOLD study Open
Spirometry is used to determine what is "unusual" lung function compared with what is "usual" for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volum…
View article: A Study on The Evaluation of The Echocardiographic Measurements in Normal Healthy Adult Population of Saharanpur District
A Study on The Evaluation of The Echocardiographic Measurements in Normal Healthy Adult Population of Saharanpur District Open
Echocardiography is a widely utilized, non-invasive imaging modality essential for diagnosing and monitoring cardiovascular diseases. Echocardiographic measurements provide detailed structural and functional insights into the heart, aiding…
View article: Prevalence, Phenotypes, and Comorbidities of Polycystic Ovary Syndrome Among Indian Women
Prevalence, Phenotypes, and Comorbidities of Polycystic Ovary Syndrome Among Indian Women Open
Importance The prevalence of polycystic ovary syndrome (PCOS) varies across the globe. Indian studies on PCOS are limited by poor design, small sizes, regional representations, and varying methods. Objectives To estimate the nationwide pre…
View article: Estimating the clinical and economic burden of community-acquired pneumonia (CAP) among adult patients in India using the CAP burden of illness questionnaire
Estimating the clinical and economic burden of community-acquired pneumonia (CAP) among adult patients in India using the CAP burden of illness questionnaire Open
Background Community-acquired pneumonia (CAP), a prevalent lower respiratory tract infection, poses a significant health and economic burden. This study explores the clinical and economic implications of CAP among adults in diverse medical…
View article: Optimal spirometry thresholds for the prediction of chronic airflow obstruction: a multinational longitudinal study
Optimal spirometry thresholds for the prediction of chronic airflow obstruction: a multinational longitudinal study Open
Introduction Chronic airflow obstruction is key for COPD diagnosis, but strategies for its early detection are limited. We aimed to define the optimal z-score thresholds for spirometry parameters to discriminate chronic airflow obstruction…
View article: Assessment of obstructive airway disease in the multicenter SWORD survey India
Assessment of obstructive airway disease in the multicenter SWORD survey India Open
Background and Objectives: The study aimed to assess the control of asthma and the severity of chronic obstructive pulmonary disease (COPD) and evaluate the adequacy of treatment in patients presenting to the outpatient department (OPD) ac…
View article: Expert panel opinion on adult pneumococcal vaccination in the post-COVID era (NAP- EXPO Recommendations-2024)
Expert panel opinion on adult pneumococcal vaccination in the post-COVID era (NAP- EXPO Recommendations-2024) Open
Introduction: Pneumococcal diseases pose a significant public health concern in India, with substantial morbidity and mortality, with the elderly and those with coexisting medical conditions being most at risk. Pneumococcus was also seen t…