Antonio Pea
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View article: Minimally invasive Distal Pancreatectomy eRgonOMic analysis – the DP-ROM trial: An explorative, prospective, observational, cohort study trial
Minimally invasive Distal Pancreatectomy eRgonOMic analysis – the DP-ROM trial: An explorative, prospective, observational, cohort study trial Open
Background Minimally invasive distal pancreatectomy (DP) improves patient outcomes but also introduces significant ergonomic challenges for surgeons. This study quantitatively compares the ergonomic stress and mental workload associated wi…
View article: Fatty Pancreas Disease: An Integrated Study on Frozen Tissues Shows Distinct Compartments of Interlobular/Intralobular, Intra-Acinar, and Intra-Islet Fat Deposition
Fatty Pancreas Disease: An Integrated Study on Frozen Tissues Shows Distinct Compartments of Interlobular/Intralobular, Intra-Acinar, and Intra-Islet Fat Deposition Open
Obesity-related diseases and perturbations of fat metabolism represent some of the most common health challenges. In this complex scenario, recent evidence has suggested the emergence of a condition related to fat accumulation in the pancr…
View article: The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms<sup>†</sup>
The importance of tumor microenvironment modulations in the progression of pancreatic intraductal papillary mucinous neoplasms<sup>†</sup> Open
Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have attracted substantial attention since they represent the most prevalent macroscopic precursor of pancreatic cancer. Most lesions show an epithelium with low‐grade dyspla…
View article: Exploring chatbot applications in pancreatic disease treatment: potential and pitfalls
Exploring chatbot applications in pancreatic disease treatment: potential and pitfalls Open
Aim : The use of chatbots to respond across various domains is becoming more integrated into daily life, potentially replacing traditional search engines. The study aimed to investigate the performance of different large language models (L…
View article: An Antibiotic Stewardship Program in Pancreatic Surgery
An Antibiotic Stewardship Program in Pancreatic Surgery Open
Importance Antimicrobial stewardship (AMS) programs optimize antibiotic use and mitigate antimicrobial resistance. The literature on the efficacy of AMS programs in pancreatic surgery is limited. Objective To investigate the association of…
View article: Surgical and Oncological Outcomes of Minimally Invasive Left Pancreatectomy for Pancreatic Cancer: Robotic vs. Laparoscopic Approach
Surgical and Oncological Outcomes of Minimally Invasive Left Pancreatectomy for Pancreatic Cancer: Robotic vs. Laparoscopic Approach Open
Objective: This study compares the surgical and oncological outcomes of minimally invasive robotic (RLP) and laparoscopic (LLP) left pancreatectomy in pancreatic cancer (PC) patients. Methods: Data from patients who underwent minimally inv…
View article: Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization
Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization Open
Mucinous cystic neoplasms (MCNs) of the pancreas are macroscopic precursors of pancreatic cancer. A similar cystic lesion but lacking the ovarian‐type subepithelial stroma has been recently defined as a simple mucinous cyst (SMC); however,…
View article: Mutational signatures define immune and Wnt-associated subtypes of ampullary carcinoma
Mutational signatures define immune and Wnt-associated subtypes of ampullary carcinoma Open
Background and objective Ampullary carcinoma (AMPAC) taxonomy is based on morphology and immunohistochemistry. This classification lacks prognostic reliability and unique genetic associations. We applied an approach of integrative genomics…
View article: GNA15 signaling facilitates the initial phases of pancreas cell transformation and is associated with the basal-like/squamous subtype
GNA15 signaling facilitates the initial phases of pancreas cell transformation and is associated with the basal-like/squamous subtype Open
Curative intervention of pancreatic ductal adenocarcinoma (PDAC) remains substantially precluded because cancer cells typically spread asymptomatically before diagnosis. We previously described GNA15 ectopic expression in neoplastic and pr…
View article: Clonal evolutionary analysis reveals patterns of malignant transformation in pancreatic cancer from Intraductal Papillary Mucinous IPMN Neoplasms (IPMN)
Clonal evolutionary analysis reveals patterns of malignant transformation in pancreatic cancer from Intraductal Papillary Mucinous IPMN Neoplasms (IPMN) Open
Intraductal papillary mucinous neoplasms (IPMNs) are critical precursors to pancreatic ductal adenocarcinoma (PDAC), a highly lethal cancer due to late detection and rapid progression. Using multi-region whole-genome and transcriptome sequ…
View article: Integrating metabolic profiling of pancreatic juice with transcriptomic analysis of pancreatic cancer tissue identifies distinct clinical subgroups
Integrating metabolic profiling of pancreatic juice with transcriptomic analysis of pancreatic cancer tissue identifies distinct clinical subgroups Open
Introduction Metabolic reprogramming is a hallmark feature of pancreatic ductal adenocarcinoma (PDAC). A pancreatic juice (PJ) metabolic signature has been reported to be prognostic of oncological outcome for PDAC. Integration of PJ profil…
View article: Implications of pregnancy on MCN of the pancreas: A multicentric case-control study
Implications of pregnancy on MCN of the pancreas: A multicentric case-control study Open
Perigestational MCN are associated to increased cyst diameter, and in the subset of patients affected by MCN during gestation a high rate of growth was observed. Patients with a MCN and pregnancy desire should undergo multidisciplinary cou…
View article: Neuroendocrine Neoplasms of the Digestive System
Neuroendocrine Neoplasms of the Digestive System Open
The digestive system represents the most common localization for neuroendocrine neoplasms (NEN) in the human body. Despite a common classification and some unifying characteristics, for example the tissue and serum markers used for their i…
View article: Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy
Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy Open
Objective Cytotoxic agents are the cornerstone of treatment for patients with advanced intrahepatic cholangiocarcinoma (iCCA), despite heterogeneous benefit. We hypothesised that the pretreatment molecular profiles of diagnostic biopsies c…
View article: Clinical and Genomic Characterization of Pancreatic Ductal Adenocarcinoma with Signet-Ring/Poorly Cohesive Cells
Clinical and Genomic Characterization of Pancreatic Ductal Adenocarcinoma with Signet-Ring/Poorly Cohesive Cells Open
Signet-ring cell (SRC)/poorly cohesive cell carcinoma is an aggressive variant of pancreatic ductal adenocarcinoma (PDAC). This study aimed to clarify its clinicopathologic and molecular profiles based on a multi-institutional cohort of 20…
View article: Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in non-functional pancreatic neuroendocrine tumors
Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in non-functional pancreatic neuroendocrine tumors Open
DAXX/ATRX expression and ALT status can be accurately evaluated in a preoperative setting on EUS-FNB samples, potentially improving the identification of patients with increased risk and poorer prognosis.
View article: Long-term organoid culture of a small intestinal neuroendocrine tumor
Long-term organoid culture of a small intestinal neuroendocrine tumor Open
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare and highly heterogeneous neoplasms whose incidence has markedly increased over the last decades. A grading system based on the tumor cells’ proliferation index predicts high-…
View article: Integrative characterization of intraductal tubulopapillary neoplasm (ITPN) of the pancreas and associated invasive adenocarcinoma
Integrative characterization of intraductal tubulopapillary neoplasm (ITPN) of the pancreas and associated invasive adenocarcinoma Open
Pancreatic intraductal tubulopapillary neoplasm (ITPN) is a recently recognized intraductal neoplasm. This study aimed to clarify the clinicopathologic and molecular features of this entity, based on a multi-institutional cohort of 16 panc…
View article: Loss of FGFR4 promotes the malignant phenotype of PDAC
Loss of FGFR4 promotes the malignant phenotype of PDAC Open
Transcriptomic analyses of pancreatic ductal adenocarcinoma (PDAC) have identified two major epithelial subtypes with distinct biology and clinical behaviours. Here, we aimed to clarify the role of FGFR1 and FGFR4 in the definition of aggr…
View article: Artificial intelligence in oncology: current applications and future perspectives
Artificial intelligence in oncology: current applications and future perspectives Open
Artificial intelligence (AI) is concretely reshaping the landscape and horizons of oncology, opening new important opportunities for improving the management of cancer patients. Analysing the AI-based devices that have already obtained the…