Alan C. Perkins
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View article: P008 Sleep in the ICU: comparing PSG & structured observation
P008 Sleep in the ICU: comparing PSG & structured observation Open
Introduction Patients in Intensive Care Units (ICU) frequently suffer from disturbed sleep and are often prescribed sleep-promoting medications. Assessing the effectiveness of these medications in the ICU by polysomnography (PSG) is diffic…
View article: P084 Does OSA endotype impact the incidence of atrial fibrillation and the severity of atrial remodelling? A retrospective cohort study.
P084 Does OSA endotype impact the incidence of atrial fibrillation and the severity of atrial remodelling? A retrospective cohort study. Open
Background Multiple studies have suggested that the prevalent sleep disorder obstructive sleep apnoea (OSA) plays a key role in initiating and progressing atrial fibrillation (AF) as well as impacting the response to arrhythmia pharmaco- a…
View article: P055 Impact of humidification on bacterial filters and delivered pressures of PAP devices
P055 Impact of humidification on bacterial filters and delivered pressures of PAP devices Open
Background In typical sleep laboratories, PAP devices are used on multiple patients in short periods of time. Some manufacturers recommend the use of bacterial filters to prevent cross contamination. Bacterial filters are known to increase…
View article: P007 Evaluating concordance of actigraphy and sleep-diaries in a clinical setting
P007 Evaluating concordance of actigraphy and sleep-diaries in a clinical setting Open
Introduction Actigraphy and sleep diaries are recommended by both the ICSD-3 and AASM. However, actigraphy provides a significant operational burden. We aimed to evaluate concordance between these tests. Methods 60 sleep studies with concu…
View article: P089 12 month experience of a subsidised mandibular advancement splint program.
P089 12 month experience of a subsidised mandibular advancement splint program. Open
Background Obstructive sleep apnoea (OSA) is a common condition with the potential for significant morbidity and mortality. Mandibular advancement splints (MAS) are an alternative to continuous positive airway pressure in appropriately sel…
View article: Safety, biodistribution and radiation dosimetry of the Arg-Gly-Asp peptide 99mTc-maraciclatide in healthy volunteers
Safety, biodistribution and radiation dosimetry of the Arg-Gly-Asp peptide 99mTc-maraciclatide in healthy volunteers Open
Background 99m Tc-Maraciclatide is a radiolabelled RGD (Arg-Gly-Asp) peptide that binds with high affinity to α v β 3 and α v β 5 integrins, common receptors upregulated in disease states involving angiogenesis and inflammation. As such, i…
View article: Development and physicochemical characterization of a biodegradable microspheres formulation loaded with samarium‐153 and doxorubicin for chemo‐radioembolization of liver tumours
Development and physicochemical characterization of a biodegradable microspheres formulation loaded with samarium‐153 and doxorubicin for chemo‐radioembolization of liver tumours Open
Transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) are promising treatments for unresectable liver tumours. Some recent studies suggested that combining TACE and TARE in one treatment course might improve tre…
View article: Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non‐diabetic dyspeptic patients
Tolerability, gastric emptying patterns, and symptoms during the Nottingham Test Meal in 330 secondary care non‐diabetic dyspeptic patients Open
Background Scintigraphy is used for overall assessment of gastric emptying. Adherence to an international consensus protocol is recommended to ensure quality; however, this has not been widely adopted because preparation of the “egg‐beater…
View article: Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research
Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research Open
Drug absorption following oral administration is determined by complex and dynamic interactions between gastrointestinal (GI) physiology, the drug, and its formulation. Since many of these interactions are not fully understood, the COST ac…
View article: P159 Successful treatment of sleep disordered breathing improves comorbidities in patients with nocturia
P159 Successful treatment of sleep disordered breathing improves comorbidities in patients with nocturia Open
Introduction Sleep disordered breathing (SDB) has been shown to increase nocturia (waking with the need to void urine) frequency. Nocturia negatively affects sleep, autonomic dysfunction, mental health and mortality. Nocturia and these co-…
View article: O045 Anxiety and daytime sleepiness scores have a weak but statistically significant correlation with apnoea-hypopnoea index
O045 Anxiety and daytime sleepiness scores have a weak but statistically significant correlation with apnoea-hypopnoea index Open
Background Previous datasets demonstrate inconsistent relationships between apnoea-hypopnoea index (AHI) and questionnaire measures of daytime sleepiness, anxiety and depression. Methods 1149 consecutive diagnostic polysomnograms at a quat…
View article: P138 Nocturnal oxygen desaturation and MET call criteria during in-laboratory sleep studies
P138 Nocturnal oxygen desaturation and MET call criteria during in-laboratory sleep studies Open
Introduction Patients undergoing sleep studies can experience frequent and profound oxygen desaturation. Most hospitals have standard MET (Medical Emergency Team) call criteria which obligate a response to severe oxygen desaturation. At ou…
View article: Feasibility Study of a New Magnetic Resonance Imaging Mini‐capsule Device to Measure Whole Gut Transit Time in Paediatric Constipation
Feasibility Study of a New Magnetic Resonance Imaging Mini‐capsule Device to Measure Whole Gut Transit Time in Paediatric Constipation Open
Objective: In England, 27,500 children are referred annually to hospital with constipation. An objective measure of whole gut transit time (WGTT) could aid management. The current standard WGTT assessment, the x‐ray radiopaque marker (ROM)…
View article: Gastric emptying: a dog’s dinner
Gastric emptying: a dog’s dinner Open
aRadiological Sciences, School of Medicine, University of Nottingham, Queen’s Medical Centre, Nottingham bMedical Physics and Clinical Engineering, Nottingham University Hospitals NHS Trust cNIHR Nottingham Biomedical Research Centre (BRC)…
View article: Simultaneous Measurement of Gastric Emptying of a Soup Test Meal Using MRI and Gamma Scintigraphy
Simultaneous Measurement of Gastric Emptying of a Soup Test Meal Using MRI and Gamma Scintigraphy Open
Measurement of gastric emptying is of clinical value for a range of conditions. Gamma scintigraphy (GS) has an established role, but the use of magnetic resonance imaging (MRI) has recently increased. Previous comparison studies between MR…
View article: The effectiveness of a novel sleep clinical pathway in an inpatient musculoskeletal rehabilitation cohort: A pilot randomized controlled trial
The effectiveness of a novel sleep clinical pathway in an inpatient musculoskeletal rehabilitation cohort: A pilot randomized controlled trial Open
The sleep clinical pathway did not improve sleep quality compared with standard care. Larger studies and studies with alternate methodology such as "cluster randomization" are needed.
View article: Characterisation of a near-infrared (NIR) fluorescence imaging systems intended for hybrid gamma-NIR fluorescence image guided surgery
Characterisation of a near-infrared (NIR) fluorescence imaging systems intended for hybrid gamma-NIR fluorescence image guided surgery Open
A novel hand-held hybrid optical-gamma camera (HGC) has previously been described that is capable of displaying co-aligned images from both modalities in a single imaging system. Here, a dedicated NIR imaging system for NIR fluorescence su…
View article: Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis
Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis Open
Nasal delivery of large peptides such as parathyroid 1-34 (PTH 1-34) can benefit from a permeation enhancer to promote absorption across the nasal mucosa into the bloodstream. Previously, we have published an encouraging bioavailability (7…
View article: Evaluation of organ doses following prostate treatment with permanent brachytherapy seeds: a Geant4 Monte Carlo simulation study
Evaluation of organ doses following prostate treatment with permanent brachytherapy seeds: a Geant4 Monte Carlo simulation study Open
This study aimed to evaluate the absorbed doses received by the organs at risk (OARs) following prostate treatment with permanent Iodine-125 ( 125 I) brachytherapy seeds. In order to simulate an enlarged abnormal prostate due to malignancy…
View article: Introducing stereotactic radiotherapy safely: credentialing centres and staff
Introducing stereotactic radiotherapy safely: credentialing centres and staff Open
Stereotactic radiotherapy treatments use high doses of radiation delivered in relatively few fractions compared with conventional radiotherapy. Specialist planning, immobilization and image guidance techniques are needed to achieve accurat…
View article: Operator motion effects of a small field of view hybrid gamma camera: to hold or not to hold, that is the question?
Operator motion effects of a small field of view hybrid gamma camera: to hold or not to hold, that is the question? Open
Recording gamma images using a hand held small field of view (SFOV) hybrid gamma camera requires a few minutes to complete an acquisition. Operator motion during image acquisition may deteriorate image quality and hence affect diagnostic a…
View article: Evaluation of organ doses following high dose rate (HDR) brachytherapy of breast cancer: a Geant4 Monte Carlo simulation study
Evaluation of organ doses following high dose rate (HDR) brachytherapy of breast cancer: a Geant4 Monte Carlo simulation study Open
This study aimed to evaluate the absorbed doses received by the organs at risk (OARs) following Iridium-192 ( 192 Ir) high dose rate (HDR) brachytherapy of the left breast. The MIRD5 adult female anthropomorphic phantom, readily available …
View article: Quantitative metrics for assessing IMRT plan conformity: A virtual phantom study
Quantitative metrics for assessing IMRT plan conformity: A virtual phantom study Open
Intensity Modulated Radiation Therapy (IMRT) is a complex form of radiation delivery for the treatment of malignant tumours and other diseases. In IMRT treatment planning, quantitative assessment is crucial to measure and improve the plan …
View article: Assessing a small field of view hybrid gamma camera for perioperative iodine-125 seed localisation
Assessing a small field of view hybrid gamma camera for perioperative iodine-125 seed localisation Open
The SFOV HGC could provide high resolution fused optical-gamma images of 125I radioactive seeds indicating the potential use in intraoperative surgical procedure such as RSL.
View article: A Survey on Social Media to Enhance the Cyber-PhysicalSocial Resilience of Smart Grid
A Survey on Social Media to Enhance the Cyber-PhysicalSocial Resilience of Smart Grid Open
Smart sensor that enables power grid resiliency at distribution network is a very expensive solution and its implementation has been very sluggish. Social media has great potential to become an alternate abstract information channel that c…
View article: Hypoxia imaging with [18F]HX4 PET in squamous cell head and neck cancers
Hypoxia imaging with [18F]HX4 PET in squamous cell head and neck cancers Open
The spectrum of [F]HX4 uptake in this small series of patients exemplifies the difference in oxygenation profiles between histologically similar tumours. Performing an additional PET scan with [F]HX4 prior to chemoradiotherapy treatment wa…