Alessandra Perna
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View article: Potential role of Aliskiren in cancer modulation compared to other Renin-Angiotensin inhibitors: an in-depth review
Potential role of Aliskiren in cancer modulation compared to other Renin-Angiotensin inhibitors: an in-depth review Open
While the oncogenic effects of ACEi and ARBs on cancer remain inconclusive, Aliskiren emerges as an antihypertensive drug potentially able to interfere with pro-oncogenic signaling. Nonetheless, its limited evidence base underscores the ur…
View article: #3217 Incremental hemodialysis with tight control of overhydration as an option for pregnant woman in RRT
#3217 Incremental hemodialysis with tight control of overhydration as an option for pregnant woman in RRT Open
Background and Aims Pregnancy in patients with CKD with or without RRT is uncommon and carries a high risk of pregnancy interruption. The management of pregnant women in RRT is challenging in order to achieve adequate purification and opti…
View article: #1925 Genetically unresolved kidney cystic patients: the neglected population
#1925 Genetically unresolved kidney cystic patients: the neglected population Open
Background and Aims Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent genetic kidney disorder, characterized by age-dependent bilateral cysts formation and progressive decline of renal function. About 80% of cases …
View article: Genome-Based Advances in Modeling Renal Ciliopathies and Enhancing Patient Care
Genome-Based Advances in Modeling Renal Ciliopathies and Enhancing Patient Care Open
Background: Genetic diseases collectively affect more than 300 million individuals worldwide, posing a significant health burden, as diagnosis is often challenging and therapeutic options are limited. Recent genetic technological advanceme…
View article: Cystinuria: A Genetic and Molecular View – What Is Known about Animal Models and Cells
Cystinuria: A Genetic and Molecular View – What Is Known about Animal Models and Cells Open
Background: Cystinuria is a rare genetic tubulopathy caused by mutations on SLC7A9 and SLC3A1 genes encoding for the apical membrane rBAT/b0,+AT transporter. The mean worldwide frequency of cystinuria is estimated to be 1:7,000 with signif…
View article: CFHR5 Nephropathy Case Report: A Novel Variant Characterized by Tubulointerstitial Kidney Disease
CFHR5 Nephropathy Case Report: A Novel Variant Characterized by Tubulointerstitial Kidney Disease Open
Introduction: CFHR5 nephropathy is considered a subtype of C3 glomerulopathy. It was originally described in Greek Cypriot families and it is characterized by the time with the development of microscopic hematuria and proteinuria associate…
View article: The role of the intestinal microbiome in cognitive decline in patients with kidney disease
The role of the intestinal microbiome in cognitive decline in patients with kidney disease Open
Cognitive decline is frequently seen in patients with chronic kidney disease (CKD). The causes of cognitive decline in these patients are likely to be multifactorial, including vascular disease, uraemic toxins, blood–brain barrier leakage,…
View article: Cognitive impairment in kidney transplanted patients
Cognitive impairment in kidney transplanted patients Open
Chronic kidney disease affects almost all of the organs. Recently, more attention has been paid to the kidney and the central nervous system connections. In patients on kidney replacement therapy, including kidney transplantation, there is…
View article: Care pathways for patients with cognitive impairment and chronic kidney disease
Care pathways for patients with cognitive impairment and chronic kidney disease Open
Various epidemiological datasets and pathophysiological hypotheses have highlighted a significant link between chronic kidney disease (CKD) and cognitive impairment (CI); each condition can potentially exacerbate the other. Here, we review…
View article: Chemotherapy-related cognitive impairment and kidney dysfunction
Chemotherapy-related cognitive impairment and kidney dysfunction Open
Cancer and kidney diseases (KD) intersect in many ways resulting in worse outcomes. Both conditions are correlated with cognitive impairment, which can be exacerbated in cancer patients by known effects of many antineoplastic drugs on cogn…
View article: Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD
Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD Open
Chronic kidney disease (CKD) is commonly accompanied by cognitive dysfunction and dementia, which, in turn, increase the risk of hospitalization, cardiovascular events and death. Over the last 30 years, only four studies focused on genetic…
View article: Big databases and biobanks for studying the links between CKD, cognitive impairment, and dementia
Big databases and biobanks for studying the links between CKD, cognitive impairment, and dementia Open
Research on cognitive function in individuals with chronic kidney disease (CKD) is critical due to the significant public health challenge posed by both CKD and cognitive impairment. CKD affects approximately 10–15% of the adult population…
View article: Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors
Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors Open
Chronic kidney disease is associated with cognitive impairment although the underlying mechanisms are still not fully understood. Characterization and efficient monitoring of the cognitive impact of kidney disease and ensuing therapies are…
View article: Cholinergic system in patients with chronic kidney disease: cognitive and renal implications
Cholinergic system in patients with chronic kidney disease: cognitive and renal implications Open
Cholinergic synapses are widespread throughout the human central nervous system. Their high density in the thalamus, neocortex, limbic system and striatum suggests that cholinergic transmission plays a vital role in memory, attention, lear…
View article: CKD in Bardet-Biedl Syndrome: Evidence Supporting Multifactorial Etiology
CKD in Bardet-Biedl Syndrome: Evidence Supporting Multifactorial Etiology Open
The present study suggests that BBS is a condition of vulnerability to develop kidney disease, and that age, hypertension and obesity are associated with eGFR decline in adult patients with BBS. Whether effective interventions to treat mod…
View article: Cognitive impairment in CKD patients: a guidance document by the CONNECT network
Cognitive impairment in CKD patients: a guidance document by the CONNECT network Open
Cognitive impairment is a prevalent and debilitating complication in patients with chronic kidney disease (CKD). This position paper, developed by the Cognitive Decline in Nephro-Neurology: European Cooperative Target network, provides gui…
View article: Effects of Rheopheresis in dialysis patients with peripheral artery disease and diabetic foot ulcers: A multicentric Italian study
Effects of Rheopheresis in dialysis patients with peripheral artery disease and diabetic foot ulcers: A multicentric Italian study Open
Background Peripheral artery disease (PAD) in hemodialysis (HD) patients has a significant social impact due to its prevalence, poor response to standard therapy and dismal prognosis. Rheopheresis is indicated by guidelines for PAD treatme…
View article: Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease
Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease Open
The relationship between chronic kidney disease (CKD) and cognitive function has received increased attention in recent years. Antibacterial agents (ABs) represent a critical component of therapy regimens in patients with CKD due to increa…
View article: #851 Effects of gliflozins on endothelial cells: in vitro and clinical evidence
#851 Effects of gliflozins on endothelial cells: in vitro and clinical evidence Open
Background and Aims Gliflozins are a class drugs widely used in diabetes as they act as sodium-glucose co-transporter type 2 inhibitors (SGLT2i). Irrespective from glycaemic control, SGLT2i are known to possess kidney and heart protective …
View article: #883 P-cresyl sulphate and Indoxyl sulphate: two uremic toxins stimulating colon cancer progression in patients with chronic renal failure
#883 P-cresyl sulphate and Indoxyl sulphate: two uremic toxins stimulating colon cancer progression in patients with chronic renal failure Open
Background and Aims Chronic kidney disease (CKD) leads to the accumulation and production of uremic toxins, such as Indoxyl Sulphate (IS) and P-cresyl sulphate (p-CS). These toxins have been found to activate various processes that promote…
View article: #1792 Phenotypic variability in PAX2-related nephropathies: a monocentric study
#1792 Phenotypic variability in PAX2-related nephropathies: a monocentric study Open
Background and Aims Pax2 mutations are known to cause kidney disease; both syndromic conditions, as kidney coloboma syndrome, and kidney specific disorders, as FSGS, have been described. Due to the rarity of Pax2-related nephropathies, dat…
View article: Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey
Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey Open
Background and hypothesis There seems to be a lack of consensus on the necessity and the modality of psychological and specifically cognitive assessment of candidates for kidney transplantation. Both points are often delegated to individua…
View article: WCN24-1267 EMPAGLIFLOZIN IMPROVES VITALITY AND PROTECT FROM ADVANCED GLYCATION END PRODUCTS IN ENDOTHELIAL CELLS
WCN24-1267 EMPAGLIFLOZIN IMPROVES VITALITY AND PROTECT FROM ADVANCED GLYCATION END PRODUCTS IN ENDOTHELIAL CELLS Open
Advanced glycation end products (AGEs) are non-enzymatic glycations of protein or lipids when exposed to sugars. AGEs are involved in several systemic conditions such as diabetes mellitus or ageing and in organ dysfunction of the brain (ne…
View article: Fabry Disease in Women: Genetic Basis, Available Biomarkers, and Clinical Manifestations
Fabry Disease in Women: Genetic Basis, Available Biomarkers, and Clinical Manifestations Open
Fabry Disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene on the X chromosome, leading to a deficiency in α-galactosidase A (AGAL) enzyme activity. This leads to the accumulation of glycosphingolipids, pri…
View article: Bone mineral density assessment in patients with cystinuria
Bone mineral density assessment in patients with cystinuria Open
Introduction Cystinuria is a rare genetic disease characterized by impaired tubular transport of cystine. Clinical features of cystinuria include mainly nephrolithiasis and its complications, although cystinuric patients may present with o…
View article: Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor
Drugs with a negative impact on cognitive function (Part 1): chronic kidney disease as a risk factor Open
People living with chronic kidney disease (CKD) frequently suffer from mild cognitive impairment and/or other neurocognitive disorders. This review in two parts will focus on adverse drug reactions resulting in cognitive impairment as a po…