W. Wirth
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View article: The Impact of varus and valgus alignment on knee cartilage quality assessed by magnetic resonance imaging: insights from the IMI-APPROACH cohort
The Impact of varus and valgus alignment on knee cartilage quality assessed by magnetic resonance imaging: insights from the IMI-APPROACH cohort Open
Lower limb malalignment, particularly intra-articular malalignment, is associated with compartment-specific lower cartilage quality, as reflected by longer T2 values. Distinguishing between bony and intra-articular malalignment, rather tha…
View article: Do rates of femorotibial cartilage loss in Kellgren-Lawrence 2 and 3 knees differ between those with mild-moderate vs. severe patellofemoral structural damage? – Data from the FNIH and IMI-APPROACH cohorts
Do rates of femorotibial cartilage loss in Kellgren-Lawrence 2 and 3 knees differ between those with mild-moderate vs. severe patellofemoral structural damage? – Data from the FNIH and IMI-APPROACH cohorts Open
Screening for PF cartilage damage and BMLs does not appear to be required in a disease-modifying OA drug trial.
View article: Early revision in total joint arthroplasty surgery – a narrative review
Early revision in total joint arthroplasty surgery – a narrative review Open
Purpose Revision surgery is widely recognized as the main performance index for Total Joint Arthroplasty (TJA). Whereas long-term revision rate is used for measuring implant durability, “early revision” is still not clearly defined, with t…
View article: Magnetic Resonance Imaging Biomarkers of Knee Osteoarthritis Progression
Magnetic Resonance Imaging Biomarkers of Knee Osteoarthritis Progression Open
Objective The Foundation for the National Institutes of Health (FNIH) OA Biomarkers Consortium aims to identify, develop, and qualify biomarkers to support drug development in knee osteoarthritis (OA). The project's second phase, the PROGR…
View article: Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without
Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without Open
Substantially greater cartilage thickness loss was detected in knees reaching vKR case status defined by patient-reported clinical criteria vs. vKR controls. This was found independently of whether this status was maintained at a later ann…
View article: Comparison between coronal FLASH and sagittal double echo steady state MRI in detecting longitudinal cartilage thickness change by fully automated segmentation – Data from the FNIH biomarker cohort
Comparison between coronal FLASH and sagittal double echo steady state MRI in detecting longitudinal cartilage thickness change by fully automated segmentation – Data from the FNIH biomarker cohort Open
Clinicaltrials.gov identification: NCT00080171.
View article: A fully-automated technique for cartilage morphometry in knees with severe radiographic osteoarthritis – Method development and validation
A fully-automated technique for cartilage morphometry in knees with severe radiographic osteoarthritis – Method development and validation Open
CNN-based segmentation combined with registration-based post-processing for accurate delineation of tABs/dABs substantially improves fully-automated (longitudinal) analysis of cartilage and subchondral bone morphology in knees with severe …
View article: Fluctuation of Bone Marrow Lesions and Inflammatory MRI Markers over 2 Years and Concurrent Associations with Quantitative Cartilage Loss
Fluctuation of Bone Marrow Lesions and Inflammatory MRI Markers over 2 Years and Concurrent Associations with Quantitative Cartilage Loss Open
Objective To assess whether change of semiquantitatively magnetic resonance imaging (MRI)-defined bone marrow lesions (BMLs) and inflammatory markers is associated with change in quantitatively-assessed cartilage loss in the femorotibial j…
View article: Unbiased analysis of knee cartilage thickness change over three years after sprifermin vs. placebo treatment – A post-hoc analysis from the phase 2B FORWARD study
Unbiased analysis of knee cartilage thickness change over three years after sprifermin vs. placebo treatment – A post-hoc analysis from the phase 2B FORWARD study Open
FORWARD is the first study evaluating post-treatment benefits of a potential disease modifying osteoarthritis drug. Cartilage thickness gained with 100 μg sprifermin at Y2 is maintained to Y5 and thus appears viable and sustainable.This i…
View article: Clinical validation of fully automated laminar knee cartilage transverse relaxation time (T2) analysis in anterior cruciate ligament (ACL)-injured knees— on behalf of the osteoarthritis (OA)-Bio consortium
Clinical validation of fully automated laminar knee cartilage transverse relaxation time (T2) analysis in anterior cruciate ligament (ACL)-injured knees— on behalf of the osteoarthritis (OA)-Bio consortium Open
BACKGROUND: Magnetic resonance imaging (MRI) cartilage transverse relaxation time (T2) reflects cartilage composition, mechanical properties, and early osteoarthritis (OA). T2 analysis requires cartilage segmentation. In this study, we cli…
View article: Sexual dimorphism in articular tissue anatomy – Key to understanding sex differences in osteoarthritis?
Sexual dimorphism in articular tissue anatomy – Key to understanding sex differences in osteoarthritis? Open
Sex-specific differences were clearly observed for JSW, meniscus damage, ligament size, and cartilage morphometry (volume, thickness, and surface areas) but not for cartilage composition. Ligament and cartilage measures were smaller in wom…
View article: Is detection of disease-modifying osteoarthritis drug treatment more effective when performing cartilage morphometry without blinding to MR image acquisition order?
Is detection of disease-modifying osteoarthritis drug treatment more effective when performing cartilage morphometry without blinding to MR image acquisition order? Open
These results do not reveal that detection of proposed DMOAD treatment is enhanced with MRIs read unblinded to order; rather, the sensitivity is similar to blinded analysis. Choices on blinded vs. unblinded analysis may thus be based on ot…
View article: Sexual dimorphism in peri-articular tissue anatomy – More keys to understanding sex-differences in osteoarthritis?
Sexual dimorphism in peri-articular tissue anatomy – More keys to understanding sex-differences in osteoarthritis? Open
Relevant sex-specific differences exist for 3D bone shape and IPFP size, even after normalization to body weight. Presence of effusion- and Hoffa-synovitis is associated with greater risk of incident knee osteoarthritis in overweight women…