Syed A. Quadri
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View article: 2Combination casdatifan plus cabozantinib in previously treated patients with clear cell renal cell carcinoma: results from an expansion cohort of ARC-20 (NCT05536141)
2Combination casdatifan plus cabozantinib in previously treated patients with clear cell renal cell carcinoma: results from an expansion cohort of ARC-20 (NCT05536141) Open
Background Hypoxia-inducible factor 2-alpha (HIF-2α) is highly dysregulated in clear cell renal cell carcinoma (ccRCC), resulting in increased expression of proteins involved with angiogenesis, proliferation, and cancer cell survival. Casd…
View article: Multiple Disease Prediction Using Machine Learning Algorithm (XGBoost Algorithm)
Multiple Disease Prediction Using Machine Learning Algorithm (XGBoost Algorithm) Open
Every day, many individuals encounter different illnesses. The prognosis of a disease is the most pivotal part of treatment. The enormous increase in healthcare and medical data has enabled accurate medical data analysis, which aids in ear…
View article: Assessment of the impact of training tools on healthcare workers for PCV introduction in Maharashtra, India during the COVID-19 pandemic
Assessment of the impact of training tools on healthcare workers for PCV introduction in Maharashtra, India during the COVID-19 pandemic Open
Background: Pneumococcal Conjugate Vaccine (PCV) is a costly vaccine and poor and vulnerable communities can't afford it in private sector. The Indian government introduced the Pneumococcal Conjugate Vaccine into the Universal Immunization…
View article: A Case Report on Cerebellar Ataxia – HIV Induced Chronic Cerebellitis
A Case Report on Cerebellar Ataxia – HIV Induced Chronic Cerebellitis Open
HIV-induced cerebellar complications, which are often manifested as ataxia, typically occur from cerebellar lesions resulting from opportunistic infections, vasculitis, or neoplastic processes. A 59yrs old male patient known to have HIV in…
View article: Automated detection of immune effector cell‐associated neurotoxicity syndrome via quantitative <scp>EEG</scp>
Automated detection of immune effector cell‐associated neurotoxicity syndrome via quantitative <span>EEG</span> Open
Objective To develop an automated, physiologic metric of immune effector cell‐associated neurotoxicity syndrome among patients undergoing chimeric antigen receptor‐T cell therapy. Methods We conducted a retrospective observational cohort s…
View article: Left Atrial Appendage – the Watchman Device
Left Atrial Appendage – the Watchman Device Open
Aim:The aim of this study was to evaluate the safety and effectiveness of LAA closure in nonvalvular AF patients who were ineligible for warfarin medication.Atrial fibrillation (AF) is the most frequently encountered cardiac arrhythmia.It …
View article: Sound and light levels in intensive care units in a large urban hospital in the United States
Sound and light levels in intensive care units in a large urban hospital in the United States Open
Intensive care units (ICUs) may disrupt sleep. Quantitative ICU studies of concurrent and continuous sound and light levels and timings remain sparse in part due to the lack of ICU equipment that monitors sound and light. Here, we describe…
View article: Patterns of Care in Patients with Basilar Artery Occlusion (BAO): A Population-Based Study
Patterns of Care in Patients with Basilar Artery Occlusion (BAO): A Population-Based Study Open
Basilar artery occlusion (BAO) is associated with high morbidity and mortality. Endovascular therapy (EVT) has been shown to be beneficial in acute BAO patients. This retrospective observational study used the National Inpatient Sample (NI…
View article: Sleep staging in the ICU with heart rate variability and breathing signals. An exploratory cross-sectional study using deep neural networks
Sleep staging in the ICU with heart rate variability and breathing signals. An exploratory cross-sectional study using deep neural networks Open
Introduction: To measure sleep in the intensive care unit (ICU), full polysomnography is impractical, while activity monitoring and subjective assessments are severely confounded. However, sleep is an intensely networked state, and reflect…
View article: EMBOT: STOCK PREDICTION, CRYPTO PREDICTION AND ROBOT TRADING SYSTEM USING ML AND RPA
EMBOT: STOCK PREDICTION, CRYPTO PREDICTION AND ROBOT TRADING SYSTEM USING ML AND RPA Open
Because of the clear financial advantages, stock and cryptocurrency predictions have long drawn investors interested in stock exchanges and share markets. It is a significant area of study for finance as well. The ability to accurately pre…
View article: Bidirectionality of smoking and depression in adolescents: a systematic review
Bidirectionality of smoking and depression in adolescents: a systematic review Open
Introduction Recently, evidence has been accumulating that both smoking and mental health disorders are continuously increasing among adolescents. This systematic review elucidates the research into evidence of the direction of the associa…
View article: Forecasting immune effector cell-associated neurotoxicity syndrome after chimeric antigen receptor t-cell therapy
Forecasting immune effector cell-associated neurotoxicity syndrome after chimeric antigen receptor t-cell therapy Open
Background Immune effector cell-associated neurotoxicity syndrome (ICANS) is a clinical and neuropsychiatric syndrome that can occur days to weeks following administration chimeric antigen receptor (CAR) T-cell therapy. Manifestations of I…
View article: Aerococcus Urinae Endocarditis: A Case Report and Literature Review
Aerococcus Urinae Endocarditis: A Case Report and Literature Review Open
A 75-year-old male, with a past medical history of chronic kidney disease stage 3 (CKD3) and a recent diagnosis of bilateral hydronephrosis and Foley catheter placement, presented to the emergency department for fever. Blood cultures grew …
View article: OS02.6.A Lacosamide in monotherapy in brain tumour-related epilepsy (BTRE): results from an Italian multicentre retrospective study
OS02.6.A Lacosamide in monotherapy in brain tumour-related epilepsy (BTRE): results from an Italian multicentre retrospective study Open
Background Lacosamide (LCM) is a third-generation anti-seizure medication (ASM) approved for focal onset epilepsy in patients aged ≥4 years. Previous studies have reported an efficacy of LCM as add-on treatment in brain tumour-related epil…
View article: Bidirectionality of smoking and depression in adolescents: a systematic review
Bidirectionality of smoking and depression in adolescents: a systematic review Open
The relationship between smoking and depression in the literature does not reflect the cause-effect relationship. The lack of evidence on the direction of the association may reflect futile study designs, confounding factors and/or use of …
View article: Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S).
Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S). Open
The E-CAM-S is an automated, physiologic measure of delirium severity that predicts clinical outcomes with a level of performance comparable to conventional interview-based clinical assessment.
View article: Sleep in the Intensive Care Unit through the Lens of Breathing and Heart Rate Variability: A Cross-Sectional Study
Sleep in the Intensive Care Unit through the Lens of Breathing and Heart Rate Variability: A Cross-Sectional Study Open
Background Full polysomnography, the gold standard of sleep measurement, is impractical for widespread use in the intensive care unit (ICU). Wrist-worn actigraphy and subjective sleep assessments do not measure sleep physiology adequately.…
View article: Cytokines, brain proteins, and growth factors in acute stroke patients: A pilot study
Cytokines, brain proteins, and growth factors in acute stroke patients: A pilot study Open
Background: Immunomodulation and cell signaling involve several cytokines, proteins, and other mediators released in response to the trauma, inflammation, or other insults to the central nervous system. This pilot study is part of the regi…
View article: Hypertension and obesity in living kidney donors
Hypertension and obesity in living kidney donors Open
Over the past few decades, the shortage in the kidney donor pool as compared to the increasing number of candidates on the kidney transplant waitlist led to loosening of kidney donors' acceptance criteria. Hypertension and obesity represen…
View article: The Emerging Role of Magnetic Resonance Imaging-Guided Focused Ultrasound in Functional Neurosurgery
The Emerging Role of Magnetic Resonance Imaging-Guided Focused Ultrasound in Functional Neurosurgery Open
Functional disorders of the central nervous system (CNS) are diverse in terms of their etiology and symptoms, however, they can be quite debilitating. Many functional neurological disorders can progress to a level where pharmaceuticals and…
View article: Cytokine Registry In Stroke Patients (CRISP)
Cytokine Registry In Stroke Patients (CRISP) Open
Inflammation is an important pathophysiological process after an acute stroke (AS). Pro- and anti-inflammatory molecules (cytokines and interleukins) are the key players during this mechanism. Emerging evidence indicate that these molecule…